Aliases for OLAH Gene

Aliases for OLAH Gene

  • Oleoyl-ACP Hydrolase 2 3 4 5
  • S-Acyl Fatty Acid Synthase Thioesterase, Medium Chain 2 3 4
  • Thioesterase Domain-Containing Protein 1 3 4
  • Oleoyl-Acyl-Carrier-Protein Hydrolase 2 3
  • Augmented In Rheumatoid Arthritis 1 3 4
  • Thioesterase Domain Containing 1 2 3
  • Thioesterase II 3 4
  • Thioesterase 2 3 4
  • THEDC1 3 4
  • AURA1 3 4
  • SAST 2 3
  • TE2 3 4
  • EC 3.1.2.14 4
  • FLJ11106 2
  • OLAH 5

External Ids for OLAH Gene

Previous HGNC Symbols for OLAH Gene

  • THEDC1

Previous GeneCards Identifiers for OLAH Gene

  • GC10P015126
  • GC10P014996
  • GC10P015074

Summaries for OLAH Gene

GeneCards Summary for OLAH Gene

OLAH (Oleoyl-ACP Hydrolase) is a Protein Coding gene. Diseases associated with OLAH include Rheumatoid Arthritis and Arthritis. Among its related pathways are Fatty acid biosynthesis (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and myristoyl-[acyl-carrier-protein] hydrolase activity.

UniProtKB/Swiss-Prot Summary for OLAH Gene

  • Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16).

Additional gene information for OLAH Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OLAH Gene

Genomics for OLAH Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OLAH Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J015043 Promoter/Enhancer 0.8 EPDnew Ensembl 600.4 +11.5 11477 1 CEBPA CEBPB NR3C1 GABPA TRIM24 ATF4 CEBPG OLAH ACBD7 GAPDHP45 RPP38 RPP38-DT DCLRE1CP1 RF00017-600 ACBD7-DCLRE1CP1
GH10J015032 Promoter 0.3 EPDnew 600.7 0.0 -48 0.1 OLAH DCLRE1CP1 piR-57133-044 ACBD7-DCLRE1CP1 DCLRE1C
GH10J015120 Enhancer 1.1 FANTOM5 Ensembl ENCODE 10.5 +90.5 90450 4.3 ATF7 FOXA1 ZNF143 TCF12 IKZF2 RCOR1 TRIM22 PKNOX1 RELA ARID3A RPP38-DT ACBD7 RPP38 GAPDHP45 DCLRE1CP1 OLAH lnc-NMT2-2 LOC107984210 lnc-RPP38-1 NMT2
GH10J015151 Enhancer 1 Ensembl ENCODE 10.5 +120.2 120224 2.1 GATAD2A REST SOX13 RCOR2 RXRB IRF2 SP1 GABPA TCF7 YY1 RPP38 GAPDHP45 RPP38-DT OLAH CDNF HSPA14 ACBD7 PPIAP30 NMT2 LOC107984210
GH10J015106 Enhancer 0.9 Ensembl ENCODE 10.5 +74.9 74865 1.4 GATAD2A CTCF PRDM10 IKZF1 JUND FOXA1 ZNF143 REST RAD21 IKZF2 OLAH RPP38-DT RPP38 ACBD7 LOC105376431 lnc-RPP38-1 lnc-NMT2-2 NMT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OLAH on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OLAH

Top Transcription factor binding sites by QIAGEN in the OLAH gene promoter:
  • Bach1
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)
  • YY1

Genomic Locations for OLAH Gene

Genomic Locations for OLAH Gene
chr10:15,032,224-15,073,853
(GRCh38/hg38)
Size:
41,630 bases
Orientation:
Plus strand
chr10:15,074,226-15,115,851
(GRCh37/hg19)
Size:
41,626 bases
Orientation:
Plus strand

Genomic View for OLAH Gene

Genes around OLAH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLAH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLAH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLAH Gene

Proteins for OLAH Gene

  • Protein details for OLAH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV23-SAST_HUMAN
    Recommended name:
    S-acyl fatty acid synthase thioesterase, medium chain
    Protein Accession:
    Q9NV23
    Secondary Accessions:
    • Q5VUB6
    • Q9NUW1

    Protein attributes for OLAH Gene

    Size:
    265 amino acids
    Molecular mass:
    29931 Da
    Quaternary structure:
    • Interacts (via C-terminus) with FASN.

    Three dimensional structures from OCA and Proteopedia for OLAH Gene

    Alternative splice isoforms for OLAH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLAH Gene

Post-translational modifications for OLAH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OLAH Gene

Domains & Families for OLAH Gene

Gene Families for OLAH Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for OLAH Gene

InterPro:
Blocks:
  • Thioesterase
ProtoNet:

Suggested Antigen Peptide Sequences for OLAH Gene

GenScript: Design optimal peptide antigens:
  • Thioesterase domain-containing protein 1 (SAST_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NV23

UniProtKB/Swiss-Prot:

SAST_HUMAN :
  • Belongs to the thioesterase family.
Family:
  • Belongs to the thioesterase family.
genes like me logo Genes that share domains with OLAH: view

Function for OLAH Gene

Molecular function for OLAH Gene

UniProtKB/Swiss-Prot Function:
Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP]; Xref=Rhea:RHEA:15057, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:9924, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:64479, ChEBI:CHEBI:78783; EC=3.1.2.14; Evidence={ECO:0000269|PubMed:26663084};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=decanoyl-CoA + H2O = CoA + decanoate + H(+); Xref=Rhea:RHEA:40059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence={ECO:0000250|UniProtKB:P08635};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence={ECO:0000250|UniProtKB:P08635};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence={ECO:0000250|UniProtKB:P08635};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; Evidence={ECO:0000250|UniProtKB:P08635};.

Enzyme Numbers (IUBMB) for OLAH Gene

Phenotypes From GWAS Catalog for OLAH Gene

Gene Ontology (GO) - Molecular Function for OLAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity IEA --
GO:0016295 myristoyl-[acyl-carrier-protein] hydrolase activity IEA,IDA 26663084
GO:0016296 palmitoyl-[acyl-carrier-protein] hydrolase activity IEA,IDA 26663084
GO:0016297 acyl-[acyl-carrier-protein] hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with OLAH: view
genes like me logo Genes that share phenotypes with OLAH: view

Animal Models for OLAH Gene

MGI Knock Outs for OLAH:
  • Olah Olah<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLAH

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OLAH Gene

Localization for OLAH Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLAH Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLAH gene
Compartment Confidence
cytosol 4
mitochondrion 1
nucleus 1
plasma membrane 0
extracellular 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for OLAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with OLAH: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OLAH Gene

Pathways & Interactions for OLAH Gene

genes like me logo Genes that share pathways with OLAH: view

Interacting Proteins for OLAH Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000367462 Q9NV23-SAST_HUMAN for OLAH Gene via STRING IID

Gene Ontology (GO) - Biological Process for OLAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0008610 lipid biosynthetic process IBA 21873635
GO:0009058 biosynthetic process IEA --
genes like me logo Genes that share ontologies with OLAH: view

No data available for SIGNOR curated interactions for OLAH Gene

Drugs & Compounds for OLAH Gene

(7) Drugs for OLAH Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lauric acid Approved, Experimental Pharma Agonist 0
oleic acid Approved, Investigational, Vet_approved Pharma Agonist, Full agonist, Activator, Activation 0
Palmitic Acid Approved Pharma Agonist, Full agonist 27
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with OLAH: view

Transcripts for OLAH Gene

mRNA/cDNA for OLAH Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLAH

Alternative Splicing Database (ASD) splice patterns (SP) for OLAH Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for OLAH Gene

GeneLoc Exon Structure for
OLAH

Expression for OLAH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OLAH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLAH Gene

This gene is overexpressed in Whole Blood (x36.6) and Testis (x4.2).

Protein differential expression in normal tissues from HIPED for OLAH Gene

This gene is overexpressed in Milk (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OLAH Gene



Protein tissue co-expression partners for OLAH Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OLAH

SOURCE GeneReport for Unigene cluster for OLAH Gene:

Hs.24309

mRNA Expression by UniProt/SwissProt for OLAH Gene:

Q9NV23-SAST_HUMAN
Tissue specificity: Detected both in lactating and non-lactating breast epithelium (at protein level) (PubMed:6589427). Isoform 2 is up-regulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients (PubMed:17082220).

Evidence on tissue expression from TISSUES for OLAH Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with OLAH: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OLAH Gene

Orthologs for OLAH Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLAH Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OLAH 30 31
  • 97.48 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Olah 30 17 31
  • 72.7 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olah 30
  • 70.47 (n)
Cow
(Bos Taurus)
Mammalia OLAH 31
  • 52 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia OLAH 31
  • 49 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OLAH 31
  • 42 (a)
OneToOne
Chicken
(Gallus gallus)
Aves OLAH 30 31
  • 59.67 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia olah 30
  • 57.47 (n)
Zebrafish
(Danio rerio)
Actinopterygii olah 30 31
  • 51.47 (n)
OneToOne
Species where no ortholog for OLAH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OLAH Gene

ENSEMBL:
Gene Tree for OLAH (if available)
TreeFam:
Gene Tree for OLAH (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OLAH: view image

Paralogs for OLAH Gene

No data available for Paralogs for OLAH Gene

Variants for OLAH Gene

Additional dbSNP identifiers (rs#s) for OLAH Gene

Structural Variations from Database of Genomic Variants (DGV) for OLAH Gene

Variant ID Type Subtype PubMed ID
nsv831793 CNV loss 17160897
nsv831794 CNV loss 17160897

Variation tolerance for OLAH Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OLAH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLAH

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OLAH Gene

Disorders for OLAH Gene

MalaCards: The human disease database

(4) MalaCards diseases for OLAH Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • ra
arthritis
  • inflammatory disorder of joint
paronychia
  • fungal nail infection
wolff-parkinson-white syndrome
  • wpw syndrome
- elite association - COSMIC cancer census association via MalaCards
Search OLAH in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OLAH

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with OLAH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OLAH Gene

Publications for OLAH Gene

  1. Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE. (PMID: 26663084) Ritchie MK … Lowther WT (The Journal of biological chemistry 2016) 3 4
  2. Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients. (PMID: 17082220) Nakamura N … Ochi T (DNA research : an international journal for rapid publication of reports on genes and genomes 2006) 3 4
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for OLAH Gene

Sources for OLAH Gene