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Aliases for OLA1 Gene

Aliases for OLA1 Gene

  • Obg Like ATPase 1 2 3 5
  • GTP-Binding Protein 9 (Putative) 2 3
  • GTPBP9 3 4
  • DOC45 3 4
  • DNA Damage-Regulated Overexpressed In Cancer 45 Protein 3
  • DNA Damage-Regulated Overexpressed In Cancer 45 4
  • Homologous Yeast-44.2 Protein 3
  • GTP-Binding Protein PTD004 3
  • GTP-Binding Protein 9 4
  • Obg-Like ATPase 1 3
  • PTD004 3
  • GBP45 3
  • GTBP9 3

External Ids for OLA1 Gene

Previous HGNC Symbols for OLA1 Gene

  • GTPBP9

Previous GeneCards Identifiers for OLA1 Gene

  • GC02M174646
  • GC02M174937
  • GC02M166816

Summaries for OLA1 Gene

Entrez Gene Summary for OLA1 Gene

  • This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]

GeneCards Summary for OLA1 Gene

OLA1 (Obg Like ATPase 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include GTP binding and ribosome binding.

UniProtKB/Swiss-Prot for OLA1 Gene

  • Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.

Gene Wiki entry for OLA1 Gene

Additional gene information for OLA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLA1 Gene

Genomics for OLA1 Gene

GeneHancer (GH) Regulatory Elements for OLA1 Gene

Promoters and enhancers for OLA1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J174246 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 655.3 +0.6 575 2.6 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 OLA1 SP3 ENSG00000271151 CIR1 SP9 RN7SL65P
GH02J174249 Enhancer 0.4 ENCODE 650.7 -1.1 -1070 0.2 MZF1 ZMYM3 ZNF644 OLA1 ENSG00000201088 GC02M174265
GH02J174325 Promoter/Enhancer 1.3 Ensembl ENCODE 10.3 -77.5 -77500 0.8 ATF1 RB1 ARNT ZNF335 ZNF121 POLR2B EGR1 ZNF143 ATF7 EGR2 LINC01305 OLA1 GPR155 SP9
GH02J174175 Enhancer 1.1 VISTA UCNEbase ENCODE 10.5 +71.5 71459 2.6 PRDM6 RFX1 POLR2A HLF IKZF1 SETDB1 TRIM28 OLA1 ENSG00000270799 RN7SL65P
GH02J174117 Enhancer 0.8 Ensembl ENCODE 9.8 +130.1 130068 2.2 SMARCE1 MEIS2 JUN EP300 ETS1 FOSL1 JUND SMARCA4 FOS FOSL2 OLA1 GC02P174107 GC02P174142
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OLA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OLA1 gene promoter:
  • USF1
  • USF-1
  • Tal-1beta
  • ITF-2
  • COMP1
  • HNF-4alpha1
  • HNF-4alpha2
  • TBP
  • AREB6
  • S8

Genomic Locations for OLA1 Gene

Genomic Locations for OLA1 Gene
176,252 bases
Minus strand
176,252 bases
Minus strand

Genomic View for OLA1 Gene

Genes around OLA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLA1 Gene

Proteins for OLA1 Gene

  • Protein details for OLA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Obg-like ATPase 1
    Protein Accession:
    Secondary Accessions:
    • D7EHM2
    • Q5BJD7
    • Q8NCI8
    • Q96CU1
    • Q96SV2
    • Q9P1D3
    • Q9UNY9
    • Q9Y6G4

    Protein attributes for OLA1 Gene

    396 amino acids
    Molecular mass:
    44744 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for OLA1 Gene

    Alternative splice isoforms for OLA1 Gene


neXtProt entry for OLA1 Gene

Post-translational modifications for OLA1 Gene

  • Ubiquitination at Lys281, isoforms=2, 3190, and Lys83
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OLA1 Gene

Domains & Families for OLA1 Gene

Gene Families for OLA1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for OLA1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
  • Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
genes like me logo Genes that share domains with OLA1: view

Function for OLA1 Gene

Molecular function for OLA1 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
UniProtKB/Swiss-Prot Induction:
Strongly down-regulated by DNA damage-inducing agents.

Phenotypes From GWAS Catalog for OLA1 Gene

Gene Ontology (GO) - Molecular Function for OLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0005524 ATP binding IDA,IEA 17430889
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016887 ATPase activity IDA,IEA 17430889
genes like me logo Genes that share ontologies with OLA1: view
genes like me logo Genes that share phenotypes with OLA1: view

Animal Models for OLA1 Gene

MGI Knock Outs for OLA1:
  • Ola1 Ola1<tm1.2Zshi>

Animal Model Products

  • Taconic Biosciences Mouse Models for OLA1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OLA1 Gene

Localization for OLA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLA1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm. {ECO:0000255 HAMAP-Rule:MF_03167}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLA1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA,IEA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with OLA1: view

Pathways & Interactions for OLA1 Gene

genes like me logo Genes that share pathways with OLA1: view

Gene Ontology (GO) - Biological Process for OLA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0046034 ATP metabolic process IDA 17430889
genes like me logo Genes that share ontologies with OLA1: view

No data available for SIGNOR curated interactions for OLA1 Gene

Drugs & Compounds for OLA1 Gene

(4) Drugs for OLA1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Guanosine triphosphate Experimental Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for OLA1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with OLA1: view

Transcripts for OLA1 Gene

mRNA/cDNA for OLA1 Gene

Unigene Clusters for OLA1 Gene

Obg-like ATPase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLA1

Alternative Splicing Database (ASD) splice patterns (SP) for OLA1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - - - -
SP6: -
SP7: - -

Relevant External Links for OLA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OLA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OLA1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OLA1 Gene

Protein tissue co-expression partners for OLA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OLA1 Gene:


SOURCE GeneReport for Unigene cluster for OLA1 Gene:


mRNA Expression by UniProt/SwissProt for OLA1 Gene:

Tissue specificity: Expressed in all tissues tested but its expression is more abundant in testis, liver, lung, and brain. Overexpressed in several malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus.

Evidence on tissue expression from TISSUES for OLA1 Gene

  • Nervous system(4.9)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with OLA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLA1 Gene

Orthologs for OLA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OLA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OLA1 34 33
  • 100 (n)
(Canis familiaris)
Mammalia OLA1 34 33
  • 97.14 (n)
(Bos Taurus)
Mammalia OLA1 34 33
  • 96.46 (n)
(Ornithorhynchus anatinus)
Mammalia OLA1 34
  • 94 (a)
(Mus musculus)
Mammalia Ola1 16 34 33
  • 93.43 (n)
(Rattus norvegicus)
Mammalia Ola1 33
  • 92.93 (n)
(Monodelphis domestica)
Mammalia OLA1 34
  • 89 (a)
(Gallus gallus)
Aves OLA1 34 33
  • 86.2 (n)
(Anolis carolinensis)
Reptilia OLA1 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ola1 33
  • 80.98 (n)
Str.9014 33
African clawed frog
(Xenopus laevis)
Amphibia MGC54033 33
(Danio rerio)
Actinopterygii ola1 34 33
  • 76.18 (n)
wufc66b09 33
fruit fly
(Drosophila melanogaster)
Insecta CG1354 34 33
  • 64.6 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000672 33
  • 64.08 (n)
(Caenorhabditis elegans)
Secernentea ola-1 34
  • 68 (a)
tag-210 33
  • 63.27 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OLA1 36 34 33
  • 58.64 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03608g 33
  • 57.59 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL192W 33
  • 54.19 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G30580 33
  • 62.41 (n)
(Glycine max)
eudicotyledons Gma.2708 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.724 33
(Oryza sativa)
Liliopsida Os08g0199300 33
  • 61.48 (n)
Os.9634 33
(Hordeum vulgare)
Liliopsida Hv.3018 33
(Triticum aestivum)
Liliopsida Ta.2982 33
(Zea mays)
Liliopsida Zm.968 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5782 34
  • 71 (a)
Cin.3463 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC27E2.03c 33
  • 58.14 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02044 33
  • 55.58 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3463 33
Species where no ortholog for OLA1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for OLA1 Gene

Gene Tree for OLA1 (if available)
Gene Tree for OLA1 (if available)
Evolutionary constrained regions (ECRs) for OLA1: view image

Paralogs for OLA1 Gene

(1) SIMAP similar genes for OLA1 Gene using alignment to 4 proteins:

  • J3KQ32_HUMAN
genes like me logo Genes that share paralogs with OLA1: view

No data available for Paralogs for OLA1 Gene

Variants for OLA1 Gene

Sequence variations from dbSNP and Humsavar for OLA1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs193920787 uncertain-significance, Malignant tumor of prostate 174,082,006(-) A/C coding_sequence_variant, missense_variant
VAR_036613 A breast cancer sample p.Glu168Gln
rs1000047476 -- 174,188,152(-) T/C intron_variant
rs1000057129 -- 174,203,794(-) G/A intron_variant
rs1000077388 -- 174,194,765(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OLA1 Gene

Variant ID Type Subtype PubMed ID
dgv2096n106 CNV deletion 24896259
esv2721155 CNV deletion 23290073
esv3438023 CNV insertion 20981092
esv3560566 CNV deletion 23714750
esv3593399 CNV gain 21293372
esv3593400 CNV loss 21293372
esv3866 CNV loss 18987735
esv5452 CNV loss 19470904
esv991222 CNV deletion 20482838
nsv1071639 CNV deletion 25765185
nsv1129210 CNV insertion 24896259
nsv3040 CNV deletion 18451855
nsv477550 CNV novel sequence insertion 20440878
nsv954712 CNV deletion 24416366

Variation tolerance for OLA1 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.65; 72.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OLA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLA1 Gene

Disorders for OLA1 Gene

Additional Disease Information for OLA1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OLA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLA1 Gene

Publications for OLA1 Gene

  1. Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins. (PMID: 17430889) Koller-Eichhorn R … Kambach C (The Journal of biological chemistry 2007) 2 3 4 58
  2. Regulation of cell-matrix adhesion by OLA1, the Obg-like ATPase 1. (PMID: 24486488) Jeyabal PV … Shi ZZ (Biochemical and biophysical research communications 2014) 2 3 58
  3. DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies. (PMID: 20053727) Sun H … Huang Y (Molecular cancer research : MCR 2010) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for OLA1 Gene

Sources for OLA1 Gene

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