This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016] See more...

Aliases for OIT3 Gene

Aliases for OIT3 Gene

  • Oncoprotein Induced Transcript 3 2 3 5
  • LZP 2 3 4
  • Liver-Specific Zona Pellucida Domain-Containing Protein 3 4
  • Liver-Specific ZP Domain-Containing Protein 2 3
  • Oncoprotein-Induced Transcript 3 Protein 3 4
  • FLJ39116 2
  • OIT3 5

External Ids for OIT3 Gene

Previous GeneCards Identifiers for OIT3 Gene

  • GC10P073998
  • GC10P074323
  • GC10P074654
  • GC10P068647

Summaries for OIT3 Gene

Entrez Gene Summary for OIT3 Gene

  • This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]

GeneCards Summary for OIT3 Gene

OIT3 (Oncoprotein Induced Transcript 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is GP2.

UniProtKB/Swiss-Prot Summary for OIT3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OIT3 Gene

Genomics for OIT3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OIT3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J072893 Promoter/Enhancer 0.8 EPDnew Ensembl 250.7 +0.1 117 0.6 CEBPA ZBTB33 BCL6 CEBPB YY1 NR2F2 OIT3 piR-47132-001 PLA2G12B
GH10J072951 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 10.4 +60.3 60338 4.2 ATF2 ATF3 NFIC YY1 FOXA2 KDM6A RXRA SAP130 DMAP1 TEAD3 PLA2G12B CFAP70 NUDT13 OIT3 ECD DNAJB12 DNAJC9-AS1 HSALNG0078807
GH10J072845 Enhancer 1 FANTOM5 Ensembl ENCODE 11 -43.7 -43683 8.2 JUND CEBPB EP300 RFX5 NFE2 PRDM10 ZBTB33 ZNF133 MEIS2 ATF3 HSALNG0078804 MCU OIT3 DNAJB12 RNU6-805P ENSG00000226163 CFAP70 ZSWIM8 HSALNG0078805
GH10J071919 Enhancer 1 Ensembl ENCODE 9.3 -972.1 -972134 4.3 IKZF1 ZNF592 ZSCAN16 NFIC ZIC2 MBD2 TAF9B RUNX1 ZNF316 ZNF843 OIT3 VSIR PSAP HSALNG0078744 HSALNG0078746 CHST3
GH10J072782 Enhancer 1 FANTOM5 ENCODE CraniofacialAtlas 9.8 -109.7 -109658 3.6 ZNF600 ZNF341 ZBTB48 PKNOX1 EGR1 KLF1 EGR2 ZNF239 ZBTB17 PRDM10 DNAJB12 OIT3 ENSG00000226163 ENSG00000272627 HSALNG0078803 MCU
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OIT3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OIT3

Top Transcription factor binding sites by QIAGEN in the OIT3 gene promoter:
  • HOXA9
  • HOXA9B
  • LCR-F1
  • Meis-1
  • Meis-1b
  • p300
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT3

Genomic Locations for OIT3 Gene

Latest Assembly
39,453 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
39,298 bases
Plus strand

(GRCh37/hg19 by Ensembl)
39,453 bases
Plus strand

Genomic View for OIT3 Gene

Genes around OIT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OIT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OIT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OIT3 Gene

Proteins for OIT3 Gene

  • Protein details for OIT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oncoprotein-induced transcript 3 protein
    Protein Accession:
    Secondary Accessions:
    • A0AVP3
    • Q8N1M8

    Protein attributes for OIT3 Gene

    545 amino acids
    Molecular mass:
    60022 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OIT3 Gene


neXtProt entry for OIT3 Gene

Post-translational modifications for OIT3 Gene

  • Glycosylation at Asn89, Asn116, Asn184, Asn259, Asn291, and Asn299
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for OIT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for OIT3

No data available for DME Specific Peptides for OIT3 Gene

Domains & Families for OIT3 Gene

Gene Families for OIT3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for OIT3 Gene

  • Aspartic acid and asparagine hydroxylation site
  • EGF-like calcium-binding
  • Endoglin/CD105 antigen

Suggested Antigen Peptide Sequences for OIT3 Gene

GenScript: Design optimal peptide antigens:
  • Liver-specific zona pellucida domain-containing protein (OIT3_HUMAN)
genes like me logo Genes that share domains with OIT3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for OIT3 Gene

Function for OIT3 Gene

Molecular function for OIT3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in hepatocellular function and development.

Phenotypes From GWAS Catalog for OIT3 Gene

Gene Ontology (GO) - Molecular Function for OIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent IBA 21873635
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with OIT3: view
genes like me logo Genes that share phenotypes with OIT3: view

Animal Models for OIT3 Gene

MGI Knock Outs for OIT3:

Animal Models for research

  • Taconic Biosciences Mouse Models for OIT3

miRNA for OIT3 Gene

miRTarBase miRNAs that target OIT3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OIT3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OIT3 Gene

Localization for OIT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OIT3 Gene

Nucleus envelope. Note=Can be secreted into blood.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OIT3 gene
Compartment Confidence
extracellular 4
nucleus 3
plasma membrane 1
mitochondrion 1
golgi apparatus 1
lysosome 0

Gene Ontology (GO) - Cellular Components for OIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0009986 cell surface IBA 21873635
genes like me logo Genes that share ontologies with OIT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OIT3 Gene

Pathways & Interactions for OIT3 Gene

PathCards logo

SuperPathways for OIT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OIT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903118 urate homeostasis IEA --
genes like me logo Genes that share ontologies with OIT3: view

No data available for Pathways by source and SIGNOR curated interactions for OIT3 Gene

Drugs & Compounds for OIT3 Gene

No Compound Related Data Available

Transcripts for OIT3 Gene

mRNA/cDNA for OIT3 Gene

6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OIT3

Alternative Splicing Database (ASD) splice patterns (SP) for OIT3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP2: -

Relevant External Links for OIT3 Gene

GeneLoc Exon Structure for

Expression for OIT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OIT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OIT3 Gene

This gene is overexpressed in Liver (x33.8) and Spleen (x10.6).

Protein differential expression in normal tissues from HIPED for OIT3 Gene

This gene is overexpressed in Serum (49.8) and Plasma (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OIT3 Gene

Protein tissue co-expression partners for OIT3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OIT3

SOURCE GeneReport for Unigene cluster for OIT3 Gene:


mRNA Expression by UniProt/SwissProt for OIT3 Gene:

Tissue specificity: Liver-specific. Expressed only in the hepatocytes. Down-regulated in hepatocellular carcinoma (HCC) and HCC cell lines.

Evidence on tissue expression from TISSUES for OIT3 Gene

  • Liver(4.5)
  • Lung(4)
genes like me logo Genes that share expression patterns with OIT3: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OIT3 Gene

Orthologs for OIT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OIT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OIT3 29 30
  • 99.39 (n)
(Bos Taurus)
Mammalia -- 30
  • 93 (a)
OIT3 29
  • 90.27 (n)
-- 30
  • 56 (a)
(Canis familiaris)
Mammalia OIT3 29 30
  • 91.01 (n)
(Rattus norvegicus)
Mammalia Oit3 29
  • 86.61 (n)
(Mus musculus)
Mammalia Oit3 29 16 30
  • 85.63 (n)
(Ornithorhynchus anatinus)
Mammalia OIT3 30
  • 84 (a)
(Monodelphis domestica)
Mammalia OIT3 30
  • 72 (a)
(Gallus gallus)
Aves OIT3 29 30
  • 75.15 (n)
(Anolis carolinensis)
Reptilia OIT3 30
  • 76 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia oit3 29
  • 71.07 (n)
(Danio rerio)
Actinopterygii LOC100535938 29
  • 63.54 (n)
CU856520.1 30
  • 63 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 20 (a)
-- 30
  • 18 (a)
-- 30
  • 17 (a)
CSA.3943 30
  • 16 (a)
-- 30
  • 12 (a)
Species where no ortholog for OIT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OIT3 Gene

Gene Tree for OIT3 (if available)
Gene Tree for OIT3 (if available)
Evolutionary constrained regions (ECRs) for OIT3: view image
Alliance of Genome Resources:
Additional Orthologs for OIT3

Paralogs for OIT3 Gene

Paralogs for OIT3 Gene

genes like me logo Genes that share paralogs with OIT3: view

Variants for OIT3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OIT3 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs145480078 Uncertain Significance: Malignant tumor of prostate 72,932,484(+) C/T
NM_152635.3(OIT3):c.1598C>T (p.Thr533Met)
rs35089256 -- p.Ser237Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OIT3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OIT3 Gene

Variant ID Type Subtype PubMed ID
nsv528473 CNV gain 19592680
nsv948063 CNV duplication 23825009

Variation tolerance for OIT3 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OIT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OIT3 Gene

Disorders for OIT3 Gene

Additional Disease Information for OIT3

No disorders were found for OIT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OIT3 Gene

Publications for OIT3 Gene

  1. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. (PMID: 12939600) Xu ZG … Han ZG (Hepatology (Baltimore, Md.) 2003) 2 3 4 22
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. (PMID: 15589826) Yang H … Guo J (FEBS letters 2004) 3 22
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for OIT3 Gene

Sources for OIT3 Gene