This is a conserved gene that produces a long non-coding RNA that maintains cell proliferation in embryonic stem cells. This RNA can bind to and negatively regulate the activity of multiple cellular RNAs and microRNAs, including cyclin G associated kinase and ELAV like RNA binding protein 1. [provided by RefSeq, Dec 2017] See more...

Aliases for OIP5-AS1 Gene

Subcategory (RNA class) for OIP5-AS1 Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for OIP5-AS1 Gene

  • OIP5 Antisense RNA 1 2 3 5
  • OIP5 Antisense RNA 1 (Non-Protein Coding) 2 3
  • OIP5-AS1 2 168
  • HSALNG0105343 167
  • NONHSAG016639 92
  • Linc-OIP5 3
  • Cyrano 3

External Ids for OIP5-AS1 Gene

Previous GeneCards Identifiers for OIP5-AS1 Gene

  • GC15P041577

Summaries for OIP5-AS1 Gene

Entrez Gene Summary for OIP5-AS1 Gene

  • This is a conserved gene that produces a long non-coding RNA that maintains cell proliferation in embryonic stem cells. This RNA can bind to and negatively regulate the activity of multiple cellular RNAs and microRNAs, including cyclin G associated kinase and ELAV like RNA binding protein 1. [provided by RefSeq, Dec 2017]

GeneCards Summary for OIP5-AS1 Gene

OIP5-AS1 (OIP5 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with OIP5-AS1 include Hepatoblastoma and Glioma.

Additional gene information for OIP5-AS1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OIP5-AS1 Gene

Genomics for OIP5-AS1 Gene

GeneHancer (GH) Regulatory Elements for OIP5-AS1 Gene

Promoters and enhancers for OIP5-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J041282 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.8 759 3.8 ZBTB40 NRF1 MYC USF1 POLR2G SP1 GTF2E2 PHF8 FOS ZFX RTF1 ENSG00000285920 OIP5-AS1 lnc-OIP5-3 piR-30188-067 piR-53338-044 NDUFAF1 MGA INO80 BAHD1
GH15J041230 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 5.3 -51.8 -51753 4 RXRA HNRNPK CTCF SIN3A NRF1 TCF12 USF1 POLR2G SP1 NCOR1 CHP1 EXD1 lnc-OIP5-2 INO80 MGA DNAJC17 NDUFAF1 CHST14 ENSG00000261002 ENSG00000259211
GH15J040959 Enhancer 0.9 Ensembl ENCODE dbSUPER 11 -323.5 -323501 2.1 ZIC2 UBTF ZBTB17 SMARCC1 POLR2A NR3C1 POLR2G ZFHX2 MAX TBP OIP5-AS1 NDUFAF1 EHD4-AS1 SPINT1 LOC105370789 lnc-INO80-1
GH15J040856 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.4 -423.3 -423281 8.4 ZNF217 CTCF USF1 ZIC2 REST MYC TGIF2 RAD21 EP300 CTBP1 CCDC32 ZFYVE19 SPINT1 PAK6 OIP5-AS1 lnc-VPS18-3 RHOV
GH15J040850 Enhancer 0.8 ENCODE dbSUPER 5.7 -433.0 -432965 1.3 NCOR1 SAP130 SMAD4 EHMT2 RARA TFAP4 NR2F6 NFIL3 TEAD3 ZNF580 OIP5-AS1 HSALNG0105299 SPINT1 SPINT1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OIP5-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OIP5-AS1 Gene

Genomic Locations for OIP5-AS1 Gene
chr15:41,283,963-41,508,868
(GRCh38/hg38)
Size:
224,906 bases
Orientation:
Plus strand
chr15:41,576,188-41,601,901
(GRCh37/hg19)
Size:
25,714 bases
Orientation:
Plus strand

Genomic View for OIP5-AS1 Gene

Genes around OIP5-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OIP5-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OIP5-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OIP5-AS1 Gene

Proteins for OIP5-AS1 Gene

Post-translational modifications for OIP5-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for OIP5-AS1 Gene

Domains & Families for OIP5-AS1 Gene

Gene Families for OIP5-AS1 Gene

genes like me logo Genes that share domains with OIP5-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for OIP5-AS1 Gene

Function for OIP5-AS1 Gene

Phenotypes From GWAS Catalog for OIP5-AS1 Gene

Phenotypes for OIP5-AS1 Gene

genes like me logo Genes that share phenotypes with OIP5-AS1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OIP5-AS1 Gene

Localization for OIP5-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OIP5-AS1 gene
Compartment Confidence
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for OIP5-AS1 Gene

Pathways & Interactions for OIP5-AS1 Gene

PathCards logo

SuperPathways for OIP5-AS1 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for OIP5-AS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for OIP5-AS1 Gene

Drugs & Compounds for OIP5-AS1 Gene

No Compound Related Data Available

Transcripts for OIP5-AS1 Gene

mRNA/cDNA for OIP5-AS1 Gene

40 RNACentral transcripts :
4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
14 NONCODE transcripts :
30 LncBook transcripts :
36 LNCipedia transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for OIP5-AS1 Gene

No ASD Table

Relevant External Links for OIP5-AS1 Gene

GeneLoc Exon Structure for
OIP5-AS1

Expression for OIP5-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OIP5-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for OIP5-AS1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OIP5-AS1

SOURCE GeneReport for Unigene cluster for OIP5-AS1 Gene:

Hs.380164
genes like me logo Genes that share expression patterns with OIP5-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OIP5-AS1 Gene

Orthologs for OIP5-AS1 Gene

Evolution for OIP5-AS1 Gene

ENSEMBL:
Gene Tree for OIP5-AS1 (if available)
TreeFam:
Gene Tree for OIP5-AS1 (if available)

No data available for Orthologs for OIP5-AS1 Gene

Paralogs for OIP5-AS1 Gene

No data available for Paralogs for OIP5-AS1 Gene

Variants for OIP5-AS1 Gene

Additional dbSNP identifiers (rs#s) for OIP5-AS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OIP5-AS1 Gene

Variant ID Type Subtype PubMed ID
dgv2580n100 CNV gain 25217958
esv3552361 CNV deletion 23714750
nsv1045455 CNV gain 25217958
nsv1113704 CNV deletion 24896259
nsv952612 CNV duplication 24416366
nsv984057 CNV duplication 23825009

Additional Variant Information for OIP5-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OIP5-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for OIP5-AS1 Gene

Disorders for OIP5-AS1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for OIP5-AS1 Gene - From: LncRNADisease and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OIP5-AS1

genes like me logo Genes that share disorders with OIP5-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OIP5-AS1 Gene

Publications for OIP5-AS1 Gene

  1. Knockdown of linc-OIP5 inhibits proliferation and migration of glioma cells through down-regulation of YAP-NOTCH signaling pathway. (PMID: 28189759) Hu GW … Lang HL (Gene 2017) 2 3 54
  2. Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution. (PMID: 22196729) Ulitsky I … Bartel DP (Cell 2011) 2 3 54
  3. Downregulation of long non-coding RNA Opa interacting protein 5-antisense RNA 1 inhibits breast cancer progression by targeting sex-determining region Y-box 2 by microRNA-129-5p upregulation. (PMID: 30443959) Zeng H … Wang S (Cancer science 2019) 3 54
  4. Long noncoding RNA OIP5-AS1 accelerates CDK14 expression to promote osteosarcoma tumorigenesis via targeting miR-223. (PMID: 30119217) Dai J … Tang X (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 54
  5. PIWIL3/OIP5-AS1/miR-367-3p/CEBPA feedback loop regulates the biological behavior of glioma cells. (PMID: 29464001) Liu X … Liu Y (Theranostics 2018) 3 54

Products for OIP5-AS1 Gene

Sources for OIP5-AS1 Gene