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Aliases for OIP5 Gene

Aliases for OIP5 Gene

  • Opa Interacting Protein 5 2 3 5
  • Cancer/Testis Antigen 86 2 3 4
  • Opa-Interacting Protein 5 3 4
  • MIS18B 3 4
  • CT86 3 4
  • MIS18 Kinetochore Protein Homolog B (S. Pombe) 2
  • MIS18 Kinetochore Protein Homolog B 3
  • LAP2alpha Interactor-25 3
  • Protein Mis18-Beta 3
  • 5730547N13Rik 3
  • HMIS18beta 3
  • MIS18beta 3
  • LINT-25 3
  • OIP-5 4

External Ids for OIP5 Gene

Previous GeneCards Identifiers for OIP5 Gene

  • GC15M036969
  • GC15M034497
  • GC15M039180
  • GC15M039317
  • GC15M039389
  • GC15M041601
  • GC15M018455

Summaries for OIP5 Gene

Entrez Gene Summary for OIP5 Gene

  • The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for OIP5 Gene

OIP5 (Opa Interacting Protein 5) is a Protein Coding gene. Among its related pathways are Chromosome Maintenance and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for OIP5 Gene

  • Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Additional gene information for OIP5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OIP5 Gene

Genomics for OIP5 Gene

GeneHancer (GH) Regulatory Elements for OIP5 Gene

Promoters and enhancers for OIP5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I041330 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.3 -266 4.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 OIP5 NUSAP1 NDUFAF1 DNAJC17 ENSG00000259211 INO80 GANC LOC105370795 VPS39 MAPKBP1
GH15I041543 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.8 -211.5 -211505 1.7 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 ZNF143 ZHX2 RPAP1 LTK DNAJC17 INO80 RAD51 GANC RAD51-AS1 LOC105370795 MGA OIP5
GH15I041282 Promoter/Enhancer 1.6 Ensembl ENCODE 12.1 +47.9 47932 3.7 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B OIP5-AS1 NDUFAF1 INO80 MGA GANC BAHD1 ENSG00000259211 RPAP1 DNAJC17 LOC105370795
GH15I041259 Enhancer 1.1 Ensembl ENCODE 10.5 +73.3 73327 2 PKNOX1 FOXA2 MLX ARID4B DMAP1 BRCA1 ZNF48 YY1 RXRA SP5 PIR32693 GC15M041269 GC15M041267 GC15M041266 GC15M041265 GC15M041264 GC15M041263 GC15M041262 GC15M041261 EXD1
GH15I041290 Enhancer 0.9 Ensembl ENCODE 12.1 +41.1 41076 1.9 PKNOX1 EBF1 IRF4 ZNF121 ATF7 IKZF2 BCLAF1 RUNX3 SMARCA5 ZNF687 NDUFAF1 OIP5 NUSAP1 CHP1 EXD1 RNU6-1169P RTF1 ZFYVE19 OIP5-AS1 PIR39466
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OIP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OIP5 gene promoter:

Genomic Locations for OIP5 Gene

Genomic Locations for OIP5 Gene
23,462 bases
Minus strand

Genomic View for OIP5 Gene

Genes around OIP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OIP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OIP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OIP5 Gene

Proteins for OIP5 Gene

  • Protein details for OIP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Mis18-beta
    Protein Accession:
    Secondary Accessions:
    • Q96BX7

    Protein attributes for OIP5 Gene

    229 amino acids
    Molecular mass:
    24691 Da
    Quaternary structure:
    • Homodimer, and heterodimer with MIS18A (PubMed:17199038, PubMed:26921242). Identified in a complex containing MIS18A, OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4 (PubMed:17199038). Binds outer membrane protein OpaP from Neisseria gonorrhoeae (in vitro) (PubMed:9466265).
    • Sequence=AAC39561.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OIP5 Gene

Post-translational modifications for OIP5 Gene

Other Protein References for OIP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OIP5 Gene

Domains & Families for OIP5 Gene

Gene Families for OIP5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OIP5 Gene

Suggested Antigen Peptide Sequences for OIP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mis18 family.
  • Belongs to the mis18 family.
genes like me logo Genes that share domains with OIP5: view

Function for OIP5 Gene

Molecular function for OIP5 Gene

UniProtKB/Swiss-Prot Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Phenotypes From GWAS Catalog for OIP5 Gene

Gene Ontology (GO) - Molecular Function for OIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12620389
GO:0042802 identical protein binding IPI 17199038
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OIP5: view
genes like me logo Genes that share phenotypes with OIP5: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OIP5 Gene

Localization for OIP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OIP5 Gene

Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OIP5 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IBA --
GO:0000785 chromatin IDA 17284516
GO:0005634 nucleus IDA 17284516
GO:0005654 nucleoplasm IDA,TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with OIP5: view

Pathways & Interactions for OIP5 Gene

genes like me logo Genes that share pathways with OIP5: view

Gene Ontology (GO) - Biological Process for OIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IBA --
GO:0007154 cell communication NAS 9466265
GO:0034080 CENP-A containing nucleosome assembly TAS,IBA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with OIP5: view

No data available for SIGNOR curated interactions for OIP5 Gene

Drugs & Compounds for OIP5 Gene

No Compound Related Data Available

Transcripts for OIP5 Gene

mRNA/cDNA for OIP5 Gene

Unigene Clusters for OIP5 Gene

Opa interacting protein 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OIP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: -

Relevant External Links for OIP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OIP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OIP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OIP5 Gene

This gene is overexpressed in Testis (x11.7) and Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for OIP5 Gene

This gene is overexpressed in Fetal ovary (32.0), Testis (21.1), and Ovary (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OIP5 Gene

Protein tissue co-expression partners for OIP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OIP5 Gene:


SOURCE GeneReport for Unigene cluster for OIP5 Gene:


Evidence on tissue expression from TISSUES for OIP5 Gene

  • Nervous system(3.8)
  • Kidney(2.4)
genes like me logo Genes that share expression patterns with OIP5: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OIP5 Gene

Orthologs for OIP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OIP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OIP5 33 34
  • 99.42 (n)
(Bos Taurus)
Mammalia OIP5 33 34
  • 86.32 (n)
(Canis familiaris)
Mammalia OIP5 33 34
  • 86.03 (n)
(Mus musculus)
Mammalia Oip5 33 16 34
  • 80.13 (n)
(Ornithorhynchus anatinus)
Mammalia OIP5 34
  • 36 (a)
(Monodelphis domestica)
Mammalia OIP5 34
  • 26 (a)
(Gallus gallus)
Aves OIP5 33 34
  • 57 (n)
(Danio rerio)
Actinopterygii oip5 34
  • 27 (a)
Species where no ortholog for OIP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OIP5 Gene

Gene Tree for OIP5 (if available)
Gene Tree for OIP5 (if available)

Paralogs for OIP5 Gene Pseudogenes for OIP5 Gene

genes like me logo Genes that share paralogs with OIP5: view

No data available for Paralogs for OIP5 Gene

Variants for OIP5 Gene

Sequence variations from dbSNP and Humsavar for OIP5 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000030820 -- 41,332,748(-) T/A upstream_transcript_variant
rs1000065734 -- 41,330,863(-) A/G intron_variant
rs1000135518 -- 41,333,171(-) G/C upstream_transcript_variant
rs1000258415 -- 41,310,291(-) A/G intron_variant
rs1000308565 -- 41,323,488(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OIP5 Gene

Variant ID Type Subtype PubMed ID
esv25344 CNV gain 19812545
esv2661625 CNV deletion 23128226
esv2667320 CNV deletion 23128226
esv2749606 CNV deletion 23290073
esv3552362 CNV deletion 23714750
esv3636241 CNV gain 21293372
esv3636242 CNV loss 21293372
nsv1039283 CNV gain 25217958
nsv1045455 CNV gain 25217958
nsv1138358 CNV deletion 24896259
dgv2580n100 CNV gain 25217958

Variation tolerance for OIP5 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OIP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OIP5 Gene

Disorders for OIP5 Gene

Additional Disease Information for OIP5

No disorders were found for OIP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OIP5 Gene

Publications for OIP5 Gene

  1. Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. (PMID: 17199038) Fujita Y … Yanagida M (Developmental cell 2007) 2 3 4 58
  2. Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. (PMID: 9466265) Williams JM … Rest RF (Molecular microbiology 1998) 2 3 4 58
  3. Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization. (PMID: 26921242) Subramanian L … Arockia Jeyaprakash A (EMBO reports 2016) 3 4 58
  4. OIP5 is a highly expressed potential therapeutic target for colorectal and gastric cancers. (PMID: 20510019) Chun HK … Lee HG (BMB reports 2010) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for OIP5 Gene

Sources for OIP5 Gene

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