The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] See more...

Aliases for OIP5 Gene

Aliases for OIP5 Gene

  • Opa Interacting Protein 5 2 3 5
  • Cancer/Testis Antigen 86 2 3 4
  • MIS18B 2 3 4
  • CT86 2 3 4
  • Opa-Interacting Protein 5 3 4
  • Protein Mis18-Beta 3 4
  • HMIS18beta 2 3
  • MIS18 Kinetochore Protein Homolog B (S. Pombe) 2
  • MIS18 Kinetochore Protein Homolog B 3
  • LAP2alpha Interactor-25 3
  • 5730547N13Rik 3
  • MIS18beta 3
  • LINT-25 3
  • OIP-5 4
  • OIP5 5

External Ids for OIP5 Gene

Previous GeneCards Identifiers for OIP5 Gene

  • GC15M036969
  • GC15M034497
  • GC15M039180
  • GC15M039317
  • GC15M039389
  • GC15M041601
  • GC15M018455

Summaries for OIP5 Gene

Entrez Gene Summary for OIP5 Gene

  • The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for OIP5 Gene

OIP5 (Opa Interacting Protein 5) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Chromosome Maintenance. An important paralog of this gene is MIS18A.

UniProtKB/Swiss-Prot Summary for OIP5 Gene

  • Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OIP5 Gene

Genomics for OIP5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OIP5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OIP5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OIP5

Top Transcription factor binding sites by QIAGEN in the OIP5 gene promoter:
  • AREB6
  • Bach1
  • Bach2
  • Cart-1
  • CBF(2)
  • MyoD
  • NF-Y
  • Pax-5

Genomic Locations for OIP5 Gene

Latest Assembly
chr15:41,309,273-41,332,591
(GRCh38/hg38)
Size:
23,319 bases
Orientation:
Minus strand

Previous Assembly
chr15:41,601,471-41,624,789
(GRCh37/hg19 by Entrez Gene)
Size:
23,319 bases
Orientation:
Minus strand

chr15:41,601,466-41,624,819
(GRCh37/hg19 by Ensembl)
Size:
23,354 bases
Orientation:
Minus strand

Genomic View for OIP5 Gene

Genes around OIP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OIP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OIP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OIP5 Gene

Proteins for OIP5 Gene

  • Protein details for OIP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43482-MS18B_HUMAN
    Recommended name:
    Protein Mis18-beta
    Protein Accession:
    O43482
    Secondary Accessions:
    • Q96BX7

    Protein attributes for OIP5 Gene

    Size:
    229 amino acids
    Molecular mass:
    24691 Da
    Quaternary structure:
    • Homodimer, and heterodimer with MIS18A (PubMed:17199038, PubMed:26921242). Identified in a complex containing MIS18A, OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4 (PubMed:17199038). Binds outer membrane protein OpaP from Neisseria gonorrhoeae (in vitro) (PubMed:9466265).
    SequenceCaution:
    • Sequence=AAC39561.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OIP5 Gene

Post-translational modifications for OIP5 Gene

  • Ubiquitination at Lys215 and Lys226
  • Modification sites at PhosphoSitePlus

Other Protein References for OIP5 Gene

No data available for DME Specific Peptides for OIP5 Gene

Domains & Families for OIP5 Gene

Gene Families for OIP5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OIP5 Gene

Suggested Antigen Peptide Sequences for OIP5 Gene

GenScript: Design optimal peptide antigens:
  • Opa-interacting protein 5 (MS18B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43482

UniProtKB/Swiss-Prot:

MS18B_HUMAN :
  • Belongs to the mis18 family.
Family:
  • Belongs to the mis18 family.
genes like me logo Genes that share domains with OIP5: view

Function for OIP5 Gene

Molecular function for OIP5 Gene

UniProtKB/Swiss-Prot Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Phenotypes From GWAS Catalog for OIP5 Gene

Gene Ontology (GO) - Molecular Function for OIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12620389
GO:0042802 identical protein binding IPI 17199038
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OIP5: view
genes like me logo Genes that share phenotypes with OIP5: view

miRNA for OIP5 Gene

miRTarBase miRNAs that target OIP5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OIP5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OIP5 Gene

Localization for OIP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OIP5 Gene

Nucleus. Chromosome. Chromosome, centromere. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OIP5 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA,IBA 21873635
GO:0000785 chromatin IDA 17284516
GO:0005634 nucleus IEA,IDA 17284516
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with OIP5: view

Pathways & Interactions for OIP5 Gene

genes like me logo Genes that share pathways with OIP5: view

Gene Ontology (GO) - Biological Process for OIP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IBA 21873635
GO:0007154 cell communication NAS 9466265
GO:0034080 CENP-A containing nucleosome assembly IBA,TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with OIP5: view

No data available for SIGNOR curated interactions for OIP5 Gene

Drugs & Compounds for OIP5 Gene

No Compound Related Data Available

Transcripts for OIP5 Gene

mRNA/cDNA for OIP5 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OIP5

Alternative Splicing Database (ASD) splice patterns (SP) for OIP5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for OIP5 Gene

GeneLoc Exon Structure for
OIP5

Expression for OIP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OIP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OIP5 Gene

This gene is overexpressed in Testis (x11.7) and Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for OIP5 Gene

This gene is overexpressed in Fetal ovary (32.0), Testis (21.1), and Ovary (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OIP5 Gene



Protein tissue co-expression partners for OIP5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OIP5

SOURCE GeneReport for Unigene cluster for OIP5 Gene:

Hs.661645

Evidence on tissue expression from TISSUES for OIP5 Gene

  • Nervous system(4)
  • Kidney(2.8)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with OIP5: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OIP5 Gene

Orthologs for OIP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OIP5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OIP5 29 30
  • 99.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OIP5 29 30
  • 86.32 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OIP5 29 30
  • 86.03 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Oip5 29 16 30
  • 80.13 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia OIP5 30
  • 36 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OIP5 30
  • 26 (a)
OneToOne
Chicken
(Gallus gallus)
Aves OIP5 29 30
  • 57 (n)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii oip5 30
  • 27 (a)
OneToOne
Species where no ortholog for OIP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OIP5 Gene

ENSEMBL:
Gene Tree for OIP5 (if available)
TreeFam:
Gene Tree for OIP5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OIP5: view image
Alliance of Genome Resources:
Additional Orthologs for OIP5

Paralogs for OIP5 Gene

Paralogs for OIP5 Gene

Pseudogenes.org Pseudogenes for OIP5 Gene

genes like me logo Genes that share paralogs with OIP5: view

Variants for OIP5 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OIP5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OIP5 Gene

Variant ID Type Subtype PubMed ID
dgv2580n100 CNV gain 25217958
esv25344 CNV gain 19812545
esv2661625 CNV deletion 23128226
esv2667320 CNV deletion 23128226
esv2749606 CNV deletion 23290073
esv3552362 CNV deletion 23714750
esv3636241 CNV gain 21293372
esv3636242 CNV loss 21293372
nsv1039283 CNV gain 25217958
nsv1045455 CNV gain 25217958
nsv1138358 CNV deletion 24896259

Variation tolerance for OIP5 Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OIP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OIP5
Leiden Open Variation Database (LOVD)
OIP5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OIP5 Gene

Disorders for OIP5 Gene

Additional Disease Information for OIP5

No disorders were found for OIP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OIP5 Gene

Publications for OIP5 Gene

  1. Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. (PMID: 17199038) Fujita Y … Yanagida M (Developmental cell 2007) 2 3 4
  2. Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. (PMID: 9466265) Williams JM … Rest RF (Molecular microbiology 1998) 2 3 4
  3. Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization. (PMID: 26921242) Subramanian L … Arockia Jeyaprakash A (EMBO reports 2016) 3 4
  4. OIP5 is a highly expressed potential therapeutic target for colorectal and gastric cancers. (PMID: 20510019) Chun HK … Lee HG (BMB reports 2010) 3 22
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for OIP5 Gene

Sources for OIP5 Gene