Aliases for OGT Gene
Aliases for OGT Gene
- O-Linked N-Acetylglucosamine (GlcNAc) Transferase 2 3 5
- O-Linked N-Acetylglucosamine (GlcNAc) Transferase (UDP-N-Acetylglucosamine:Polypeptide-N-Acetylglucosaminyl Transferase) 2 3
- UDP-N-Acetylglucosamine:Polypeptide-N-Acetylglucosaminyl Transferase 2 3
- O-Linked N-Acetylglucosamine Transferase 110 KDa Subunit 3 4
- O-GlcNAc Transferase Subunit P110 3 4
- Uridinediphospho-N-Acetylglucosamine:Polypeptide Beta-N-Acetylglucosaminyl Transferase 3
- UDP-N-Acetylglucosamine--Peptide N-Acetylglucosaminyltransferase 110 KDa Subunit 3
- O-GlcNAc Transferase P110 Subunit 3
External Ids for OGT Gene
- HGNC: 8127
- Entrez Gene: 8473
- Ensembl: ENSG00000147162
- OMIM: 300255
- UniProtKB: O15294
Previous GeneCards Identifiers for OGT Gene
- GC0XP066927
- GC0XP068231
- GC0XP068986
- GC0XP069619
- GC0XP070535
- GC0XP070669
- GC0XP070752
- GC0XP064568
Summaries for OGT Gene
-
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for OGT Gene
OGT (O-Linked N-Acetylglucosamine (GlcNAc) Transferase) is a Protein Coding gene. Diseases associated with OGT include Mental Retardation, X-Linked 106 and Adams-Oliver Syndrome. Among its related pathways are Metabolism of proteins and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include identical protein binding and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is TMTC3.
UniProtKB/Swiss-Prot for OGT Gene
-
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:26678539). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1 (PubMed:26678539). Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:26678539). Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (PubMed:26678539). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the Thr-308 phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of Ser-112 of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (PubMed:22121020, PubMed:23353889). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). O-GlcNAcylation of Ser-75 of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (PubMed:24474760). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver. Stabilizes clock proteins ARNTL/BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation. Promotes the CLOCK-ARNTL/BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2 (PubMed:12150998, PubMed:18288188, PubMed:19377461, PubMed:19451179, PubMed:20018868, PubMed:20200153, PubMed:21285374, PubMed:15361863). O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (PubMed:21285374, PubMed:28584052, PubMed:28302723).
-
Isoform 2: the mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGT Gene
Genomics for OGT Gene
GeneHancer (GH) Regulatory Elements for OGT Gene
Promoters and enhancers for OGT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around OGT on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the OGT gene promoter:
-
- AP-1
- CUTL1
Regulatory Element Products
Genomic Locations for OGT Gene
Genomic Locations for OGT Gene
- chrX:71,533,062-71,575,897
- (GRCh38/hg38)
- Size:
- 42,836 bases
- Orientation:
- Plus strand
- chrX:70,752,912-70,795,747
- (GRCh37/hg19)
- Size:
- 42,836 bases
- Orientation:
- Plus strand
Genomic View for OGT Gene
Genes around OGT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq13.1 by Entrez Gene
- Xq13.1 by HGNC
- Xq13.1 by Ensembl
OGT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OGT Gene
Proteins for OGT Gene
-
Protein details for OGT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15294-OGT1_HUMAN
- Recommended name:
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
- Protein Accession:
- O15294
- Q7Z3K0
- Q8WWM8
- Q96CC1
- Q9UG57
Protein attributes for OGT Gene
- Size:
- 1046 amino acids
- Molecular mass:
- 116925 Da
- Quaternary structure:
-
- Heterotrimer; consists of one 78 kDa subunit and two 110 kDa subunits dimerized via TPR repeats 6 and 7. Component of a THAP1/THAP3-HCFC1-OGT complex (PubMed:20200153). Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 (PubMed:20018852). Interacts directly with HCFC1; the interaction O-glycosylates HCFC1, regulates its proteolytic processing and transcriptional activity and, in turn, stabilizes OGT in the nucleus (PubMed:12670868, PubMed:20200153, PubMed:21285374, PubMed:23353889). Interacts (via TPRs 1-6) with SIN3A; the interaction mediates transcriptional repression in parallel with histone deacetylase (PubMed:12150998). Interacts (via TPR 5-6) with TET1, TET2 and TET3 (PubMed:23353889, PubMed:23222540). Interacts (via TPR repeats 6 and 7) with ATXN10 (By similarity). Interacts with histone H2B (PubMed:22121020). Interacts with ARNTL/BMAL1 (By similarity). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (By similarity). Interacts with SINHCAF (By similarity). Component of a complex composed of KMT2E/MLL5 (isoform 3), OGT (isoform 1) and USP7; the complex stabilizes KMT2E/MLL5, preventing KMT2E/MLL5 ubiquitination and proteosomal-mediated degradation (PubMed:26678539). Isoform 1 interacts (via TRP repeats) with isoform 3 KMT2E/MLL5 (via N-terminus) (PubMed:26678539, PubMed:23629655). Isoform 1 interacts with USP7 (PubMed:26678539).
Three dimensional structures from OCA and Proteopedia for OGT Gene
Protein Expression for OGT Gene
Post-translational modifications for OGT Gene
- Ubiquitinated, leading to its proteasomal degradation.
- Phosphorylation on Ser-3 or Ser-4 by GSK3-beta positively regulates its activity.
- Glycosylation at Ser4 and isoforms=33
- Ubiquitination at Lys1010, isoforms=3, 2, 4971, isoforms=3, 2, 4742, isoforms=3, 2, 4724, isoforms=3, 2, 4644, Lys337, Lys168, isoforms=3100, isoforms=383, and isoforms=16
- Modification sites at PhosphoSitePlus
Other Protein References for OGT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for OGT
- Novus Biologicals Antibodies for OGT
-
Abcam antibodies for OGT
- Invitrogen Antibodies for OGT (AFLGC-OGT)
- GeneTex OGT Antibody for OGT
-
Santa Cruz Biotechnology (SCBT) Antibodies for OGT
- Sino Biological Antibodies for OGT
Protein Products
- R&D Systems Proteins and Enzymes for OGT (O-GlcNAc Transferase/OGT)
- Search Origene for MassSpec and Protein Over-expression Lysates for OGT
- Origene Custom Protein Services for OGT
- Search GeneTex for Proteins for OGT
-
Abcam proteins for OGT
Assay Products
No data available for DME Specific Peptides for OGT Gene
Domains & Families for OGT Gene
Gene Families for OGT Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for OGT Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for OGT Gene
Graphical View of Domain Structure for InterPro Entry
O15294UniProtKB/Swiss-Prot:
OGT1_HUMAN :- The TPR repeat domain is required for substrate binding and oligomerization.
- Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
- Domain:
-
- The TPR repeat domain is required for substrate binding and oligomerization.
- Family:
-
- Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
Function for OGT Gene
Molecular function for OGT Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc) (PubMed:26678539). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1 (PubMed:26678539). Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing (PubMed:26678539). Probably by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (PubMed:26678539). Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the Thr-308 phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity (PubMed:22923583). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Plays a key role in chromatin structure by mediating O-GlcNAcylation of Ser-112 of histone H2B: recruited to CpG-rich transcription start sites of active genes via its interaction with TET proteins (TET1, TET2 or TET3) (PubMed:22121020, PubMed:23353889). As part of the NSL complex indirectly involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). O-GlcNAcylation of Ser-75 of EZH2 increases its stability, and facilitating the formation of H3K27me3 by the PRC2/EED-EZH2 complex (PubMed:24474760). Regulates circadian oscillation of the clock genes and glucose homeostasis in the liver. Stabilizes clock proteins ARNTL/BMAL1 and CLOCK through O-glycosylation, which prevents their ubiquitination and subsequent degradation. Promotes the CLOCK-ARNTL/BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2 and CRY1/2 (PubMed:12150998, PubMed:18288188, PubMed:19377461, PubMed:19451179, PubMed:20018868, PubMed:20200153, PubMed:21285374, PubMed:15361863). O-glycosylates HCFC1 and regulates its proteolytic processing and transcriptional activity (PubMed:21285374, PubMed:28584052, PubMed:28302723).
- UniProtKB/Swiss-Prot Function:
- Isoform 2: the mitochondrial isoform (mOGT) is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line.
- UniProtKB/Swiss-Prot CatalyticActivity:
- UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine.
- UniProtKB/Swiss-Prot CatalyticActivity:
- UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Subject to product inhibition by UDP.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=1.8 uM for UDP-N-acetyl-D-glucosamine {ECO:0000269 PubMed:21240259};
- UniProtKB/Swiss-Prot Induction:
- Induction of the nucleocytoplasmic OGT (ncOGT) isoform in the liver on glucose deprivation is mediated by the decreased hexosamine biosynthesis pathway (HBP) flux.
- GENATLAS Biochemistry:
- O-linked N-acetylglucosamine (GlcNAc) transferase,putative part of a glucose-responsive pathway implicated in the pathogenesis of diabetes mellitus
Enzyme Numbers (IUBMB) for OGT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA,IPI | 12150998 |
| GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding | IDA | 18288188 |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0008375 | acetylglucosaminyltransferase activity | TAS | 9083068 |
| GO:0016262 | protein N-acetylglucosaminyltransferase activity | IMP | 26678539 |
Phenotypes for OGT Gene
- MGI mutant phenotypes for OGT:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for OGT:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability in esophageal squamous lineage
- Increased Nanog expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV-LREV ) gene expression
- Decreased hepcidin::fluc mRNA expression
- Increased transferrin (TF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for OGT
-
CRISPR Products
-
OriGene CRISPR knockouts for OGT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OGT
- genomics-online: gRNA clones - Search results for 113 available OGT gene related products
- Overview of 113 available OGT gene related products
- Applied Biological Materials CRISPR for OGT
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for OGT
- GenScript: Design CRISPR guide RNA sequences for OGT
miRNA for OGT Gene
- miRTarBase miRNAs that target OGT
-
- hsa-mir-671-5p (MIRT039274)
- hsa-mir-125a-5p (MIRT045697)
- hsa-mir-92a-3p (MIRT049427)
- hsa-mir-26a-5p (MIRT050178)
- hsa-mir-15a-5p (MIRT110051)
- hsa-mir-16-5p (MIRT110052)
- hsa-mir-103a-3p (MIRT110053)
- hsa-mir-107 (MIRT110054)
- hsa-mir-15b-5p (MIRT110055)
- hsa-mir-195-5p (MIRT110056)
- hsa-mir-424-5p (MIRT110057)
- hsa-mir-486-3p (MIRT110058)
- hsa-mir-497-5p (MIRT110059)
- hsa-mir-3154 (MIRT110060)
- hsa-mir-3179 (MIRT110061)
- hsa-mir-4688 (MIRT110062)
- hsa-mir-6079 (MIRT110063)
- hsa-mir-6743-5p (MIRT110065)
- hsa-mir-6828-5p (MIRT110066)
- hsa-mir-6838-5p (MIRT110067)
- hsa-mir-1226-5p (MIRT110071)
- hsa-mir-1256 (MIRT110072)
- hsa-mir-3616-3p (MIRT110074)
- hsa-mir-4761-3p (MIRT110078)
- hsa-mir-141-3p (MIRT176070)
- hsa-mir-200a-3p (MIRT176071)
- hsa-mir-34c-3p (MIRT176072)
- hsa-mir-6757-3p (MIRT176076)
- hsa-mir-8081 (MIRT229911)
- hsa-mir-651-3p (MIRT366928)
- hsa-mir-3153 (MIRT366929)
- hsa-mir-4668-5p (MIRT366931)
- hsa-mir-4694-3p (MIRT366932)
- hsa-mir-5093 (MIRT366933)
- hsa-mir-6733-5p (MIRT366934)
- hsa-mir-6739-5p (MIRT366935)
- hsa-mir-9500 (MIRT366936)
- hsa-mir-541-5p (MIRT440064)
- hsa-mir-432-5p (MIRT440065)
- hsa-mir-4776-5p (MIRT445702)
- hsa-mir-627-5p (MIRT445703)
- hsa-mir-937-5p (MIRT445704)
- hsa-mir-3619-3p (MIRT445705)
- hsa-mir-5702 (MIRT445706)
- hsa-mir-548c-3p (MIRT445707)
- hsa-mir-526b-5p (MIRT449611)
- hsa-mir-5584-5p (MIRT471751)
- hsa-mir-4271 (MIRT471752)
- hsa-mir-6754-5p (MIRT471753)
- hsa-mir-4270 (MIRT471754)
- hsa-mir-4441 (MIRT471755)
- hsa-mir-211-3p (MIRT471756)
- hsa-mir-7850-5p (MIRT506328)
- hsa-mir-512-5p (MIRT574543)
- hsa-mir-4287 (MIRT574544)
- hsa-mir-6734-5p (MIRT574545)
- hsa-mir-6834-5p (MIRT574546)
- hsa-mir-4721 (MIRT574547)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OGT
- Browse OriGene Inhibitory RNA Products For OGT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OGT
- genomics-online: shRNA clones - Search results for 113 available OGT gene related products
- Overview of 113 available OGT gene related products
Clone Products
- Sino Biological Human cDNA Clone for OGT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OGT
- Applied Biological Materials Clones for OGT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OGT Gene
Localization for OGT Gene
Subcellular locations from UniProtKB/Swiss-Prot for OGT Gene
- Nucleus. Cytoplasm. Note=Predominantly localizes to the nucleus. {ECO:0000269 PubMed:26678539}.
- Isoform 2: Mitochondrion. Membrane. Note=Associates with the mitochondrial inner membrane.
- Isoform 3: Cytoplasm. Nucleus. Cell membrane. Note=Mostly in the nucleus. Retained in the nucleus via interaction with HCFC1. After insulin induction, translocated from the nucleus to the cell membrane via phophatidylinisotide binding. Colocalizes with AKT1 at the plasma membrane.
- Isoform 4: Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| extracellular | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Nucleoplasm (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000123 | histone acetyltransferase complex | IDA | 20018852 |
| GO:0005634 | nucleus | TAS,IDA | 21285374 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
Pathways & Interactions for OGT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin organization | ||
| 2 | Insulin resistance | ||
| 3 | Metabolism of proteins | ||
| 4 | Other types of O-glycan biosynthesis | ||
| 5 | Glucose / Energy Metabolism | ||
Pathways by source for OGT Gene
3 BioSystems pathways for OGT Gene
7 Reactome pathways for OGT Gene
2 KEGG pathways for OGT Gene
1 Cell Signaling Technology pathway for OGT Gene
UniProtKB/Swiss-Prot O15294-OGT1_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for OGT Gene
Selected Interacting proteins:
O15294-OGT1_HUMAN
ENSP00000362824
for OGT Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for OGT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006110 | regulation of glycolytic process | IDA | 22923583 |
| GO:0006111 | regulation of gluconeogenesis | ISS | -- |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IMP | 26678539 |
| GO:0006486 | protein glycosylation | IEA | -- |
Drugs & Compounds for OGT Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Lactosamine |
|
13000-25-4 |
|
|||
| Uridine diphosphate-N-acetylgalactosamine |
|
7277-98-7 |
|
|||
| Uridine diphosphate-N-acetylglucosamine |
|
528-04-1 |
|
Drug Products
Transcripts for OGT Gene
mRNA/cDNA for OGT Gene
- (5) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (422) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000373719 5461 bps (uc004eaa.3)
- ENST00000488174 7243 bps (uc064zvt.1)
- ENST00000373701 3310 bps (uc004eab.3)
- ENST00000472270 689 bps (uc064zvu.1)
- ENST00000498566 601 bps (uc064zvv.1)
Unigene Clusters for OGT Gene
CRISPR Products
-
OriGene CRISPR knockouts for OGT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OGT
- genomics-online: gRNA clones - Search results for 113 available OGT gene related products
- Overview of 113 available OGT gene related products
- Applied Biological Materials CRISPR for OGT
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for OGT
- GenScript: Design CRISPR guide RNA sequences for OGT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OGT
- Browse OriGene Inhibitory RNA Products For OGT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OGT
- genomics-online: shRNA clones - Search results for 113 available OGT gene related products
- Overview of 113 available OGT gene related products
Clone Products
- Sino Biological Human cDNA Clone for OGT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OGT
- Applied Biological Materials Clones for OGT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | · | 21c | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | · | 24c | ^ | 25 | ^ | 26 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||
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| SP12: | - | ||||||||||||||||||||||||||||||
| SP13: |
Expression for OGT Gene
This gene is overexpressed in Lymph node (14.0) and Frontal cortex (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OGT Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of OGT Gene:
OGTSOURCE GeneReport for Unigene cluster for OGT Gene:
Hs.405410mRNA Expression by UniProt/SwissProt for OGT Gene:
O15294-OGT1_HUMAN
Tissue specificity:
Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta. Present in trace amounts in lung and liver.
Evidence on tissue expression from TISSUES for OGT Gene
- Nervous system(4.9)
- Liver(4.6)
- Intestine(4.5)
- Pancreas(4.5)
- Lung(3)
- Heart(2.9)
- Muscle(2.9)
- Blood(2.7)
- Kidney(2.4)
- Skin(2.3)
Primer Products
-
OriGene qPCR primer pairs for OGT
-
OriGene qPCR primer pairs and template standards for OGT
- genomics-online: primer clones - Search results for 113 available OGT gene related products
- Overview of 113 available OGT gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OGT Gene
Orthologs for OGT Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | OGT 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | OGT 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | OGT 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ogt 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ogt 33 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | OGT 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | OGT 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | OGT 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ogt 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.25936 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ogt.2 34 |
|
OneToMany | |
| ogt.1 34 33 |
|
OneToMany | |||
| wufr75f09 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10249 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | sxc 34 33 |
|
OneToOne | |
| Ogt 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006254 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | K04G7.3 35 |
|
|
|
| ogt-1 34 33 |
|
OneToOne | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | SEC 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.28845 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os.45968 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| Cin.15222 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.15222 33 |
|
- Species where no ortholog for OGT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for OGT Gene
- ENSEMBL:
- Gene Tree for OGT (if available)
- TreeFam:
- Gene Tree for OGT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for OGT: view image
Paralogs for OGT Gene
Variants for OGT Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs797044898 | uncertain-significance, Inborn genetic diseases | 71,555,236(+) | G/A | coding_sequence_variant, intron_variant, missense_variant | |
| rs943295842 | pathogenic, MENTAL RETARDATION, X-LINKED 106 | 71,544,561(+) | T/C/G | intron_variant | |
| VAR_074019 | Mental retardation, X-linked 106 (MRX106) [MIM:300997] | p.Ala319Thr | |||
| VAR_079183 | Mental retardation, X-linked 106 (MRX106) [MIM:300997] | p.Arg284Pro | |||
| VAR_079254 | Mental retardation, X-linked 106 (MRX106) [MIM:300997] | p.Leu254Phe |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1584074 | OTHER | inversion | 17803354 |
| esv2740213 | CNV | deletion | 23290073 |
| esv33082 | CNV | loss | 17666407 |
| esv3574043 | CNV | loss | 25503493 |
Residual Variation Intolerance Score:
5.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.24;
5.33% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for OGT Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGT Gene
Disorders for OGT Gene
(5) MalaCards diseases for OGT Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mental retardation, x-linked 106 |
|
|
| adams-oliver syndrome |
|
|
| spinocerebellar ataxia 10 |
|
|
| bardet-biedl syndrome 4 |
|
|
| alzheimer disease |
|
Search OGT in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
OGT1_HUMAN- Note=Regulation of OGT activity and altered O-GlcNAcylations are implicated in diabetes and Alzheimer disease. O-GlcNAcylation of AKT1 affects insulin signaling and, possibly diabetes. Reduced O-GlcNAcylations and resulting increased phosphorylations of MAPT/TAU are observed in Alzheimer disease (AD) brain cerebrum.
- Mental retardation, X-linked 106 (MRX106) [MIM:300997]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269 PubMed:26273451, ECO:0000269 PubMed:28302723, ECO:0000269 PubMed:28584052}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for OGT
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for OGT Gene
Publications for OGT Gene
- The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias. (PMID: 20200153) Mazars R … Girard JP (The Journal of biological chemistry 2010) 3 4 22 58
- Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. (PMID: 18288188) Yang X … Evans RM (Nature 2008) 3 4 22 58
- Human O-GlcNAc transferase (OGT): genomic structure, analysis of splice variants, fine mapping in Xq13.1. (PMID: 11773972) Nolte D … Müller U (Mammalian genome : official journal of the International Mammalian Genome Society 2002) 3 4 22 58
- Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression. (PMID: 12150998) Yang X … Kudlow JE (Cell 2002) 3 4 22 58
- O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats. (PMID: 9083068) Lubas WA … Hanover JA (The Journal of biological chemistry 1997) 2 3 4 58
Products for OGT Gene
- Browse R&D Systems for Antibodies
- R&D Systems Proteins and Enzymes for OGT (O-GlcNAc Transferase/OGT)
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- Browse OriGene ELISA Kits
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- Browse OriGene Inhibitory RNA Products For OGT
- OriGene qPCR primer pairs for OGT
- OriGene qPCR primer pairs and template standards for OGT
- OriGene CRISPR knockouts for OGT
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For OGT
- GenScript: Next-day shipping of latest version cDNA ORF clones for OGT in any vector
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- GenScript: Design CRISPR guide RNA sequences for OGT
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for OGT
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- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for OGT
- Novus Biologicals lysates and proteins for OGT
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam proteins for OGT
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- Invitrogen Antibodies for OGT (AFLGC-OGT)
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- antibodies-online: Search results for 140 available OGT Antibodies ranked by validation data
- Compare Top OGT Antibodies
- antibodies-online: Search results for 4 available OGT Elisa Kits ranked by validation data
- Compare Top OGT Elisa Kits
- Recommended
- antibodies-online: Search results for 5 available OGT Proteins ranked by validation data
- Compare Top OGT Proteins
- GeneTex OGT Antibody for OGT
- Search GeneTex for Proteins for OGT
- Santa Cruz Biotechnology (SCBT) Antibodies for OGT
- Search Santa Cruz Biotechnology (SCBT) for OGT siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for OGT
- genomics-online: cdna clones - Search results for 113 available OGT gene related products
- Overview of 113 available OGT gene related products
- orf clones - Search results for 113 available OGT gene related products
- Overview of 113 available OGT gene related products
- genomics-online: gRNA clones - Search results for 113 available OGT gene related products
- Overview of 113 available OGT gene related products
- genomics-online: primer clones - Search results for 113 available OGT gene related products
- Overview of 113 available OGT gene related products
- genomics-online: shRNA clones - Search results for 113 available OGT gene related products
- Overview of 113 available OGT gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OGT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OGT
- GeneCopoeia miRNA 3'UTR Target clone products for OGT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OGT
Sources for OGT Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt