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Aliases for OGN Gene

Aliases for OGN Gene

  • Osteoglycin 2 3 4 5
  • Osteoinductive Factor 3 4
  • Mimecan Proteoglycan 2 3
  • SLRR3A 3 4
  • OIF 3 4
  • Corneal Keratan Sulfate Proteoglycan 3
  • Osteoglycin (Osteoinductive Factor) 2
  • Mimecan 3
  • OG 3

External Ids for OGN Gene

Previous GeneCards Identifiers for OGN Gene

  • GC09M085972
  • GC09M086874
  • GC09M088445
  • GC09M090487
  • GC09M092225
  • GC09M094187
  • GC09M095146
  • GC09M064823

Summaries for OGN Gene

Entrez Gene Summary for OGN Gene

  • This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for OGN Gene

OGN (Osteoglycin) is a Protein Coding gene. Diseases associated with OGN include Photokeratitis and Disease Of Mental Health. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Defective CHST6 causes MCDC1. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is EPYC.

UniProtKB/Swiss-Prot for OGN Gene

  • Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

Gene Wiki entry for OGN Gene

Additional gene information for OGN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGN Gene

Genomics for OGN Gene

GeneHancer (GH) Regulatory Elements for OGN Gene

Promoters and enhancers for OGN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I092405 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 555.6 -1.8 -1821 2.1 MEIS2 ZNF687 PKNOX1 USF1 ATF1 L3MBTL2 ZNF449 MAX MNT ELF1 OGN CENPP NOL8 OMD
GH09I092403 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 550.8 +0.2 214 1 MAFF ZNF316 CEBPB CEBPG MAFK EMSY OGN LOC100420779 CENPP
GH09I092402 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 550.8 +1.5 1467 0.8 RFX1 ZNF366 ZNF10 OGN LOC100420779 CENPP
GH09I092291 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.6 +110.7 110680 5.1 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IARS MIR3651 SNORA84 CENPP OGN SPTLC1 NOL8 IPPK
GH09I092478 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 15.1 -77.2 -77246 5.9 MXI1 PKNOX1 ARNT JUN MAX FEZF1 ZBTB40 BATF BCL11B FOSL1 ASPN CENPP OGN OMD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OGN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OGN gene promoter:

Genomic Locations for OGN Gene

Genomic Locations for OGN Gene
20,730 bases
Minus strand

Genomic View for OGN Gene

Genes around OGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGN Gene

Proteins for OGN Gene

  • Protein details for OGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6FIB0
    • Q9UF90
    • Q9UNK5

    Protein attributes for OGN Gene

    298 amino acids
    Molecular mass:
    33922 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OGN Gene

Post-translational modifications for OGN Gene

  • N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • Glycosylation at isoforms=80, Asn214, and Asn258
  • Modification sites at PhosphoSitePlus

Other Protein References for OGN Gene

No data available for DME Specific Peptides for OGN Gene

Domains & Families for OGN Gene

Gene Families for OGN Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for OGN Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
genes like me logo Genes that share domains with OGN: view

Function for OGN Gene

Molecular function for OGN Gene

UniProtKB/Swiss-Prot Function:
Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

Gene Ontology (GO) - Molecular Function for OGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with OGN: view
genes like me logo Genes that share phenotypes with OGN: view

Animal Models for OGN Gene

MGI Knock Outs for OGN:

Animal Model Products

miRNA for OGN Gene

miRTarBase miRNAs that target OGN

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OGN Gene

Localization for OGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OGN gene
Compartment Confidence
extracellular 5
lysosome 4
golgi apparatus 4
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IDA --
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space IDA 20551380
GO:0005796 Golgi lumen TAS --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
genes like me logo Genes that share ontologies with OGN: view

Pathways & Interactions for OGN Gene

genes like me logo Genes that share pathways with OGN: view

Gene Ontology (GO) - Biological Process for OGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 axonogenesis IBA --
GO:0010469 regulation of receptor activity IEA --
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0042340 keratan sulfate catabolic process TAS --
GO:0048662 negative regulation of smooth muscle cell proliferation ISS --
genes like me logo Genes that share ontologies with OGN: view

No data available for SIGNOR curated interactions for OGN Gene

Drugs & Compounds for OGN Gene

(1) Drugs for OGN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for OGN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OGN: view

Transcripts for OGN Gene

Unigene Clusters for OGN Gene

Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGN Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2: - -

Relevant External Links for OGN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OGN Gene

This gene is overexpressed in Artery - Aorta (x12.5) and Artery - Coronary (x11.7).

Protein differential expression in normal tissues from HIPED for OGN Gene

This gene is overexpressed in Adipocyte (10.2) and Gallbladder (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OGN Gene

Protein tissue co-expression partners for OGN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OGN Gene:


SOURCE GeneReport for Unigene cluster for OGN Gene:


mRNA Expression by UniProt/SwissProt for OGN Gene:

Tissue specificity: Bone.

Evidence on tissue expression from TISSUES for OGN Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Muscle(2.6)
  • Eye(2.2)
  • Heart(2.2)
  • Gall bladder(2.1)
  • Bone(2)
genes like me logo Genes that share expression patterns with OGN: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OGN Gene

Orthologs for OGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for OGN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OGN 33 34
  • 99.89 (n)
(Bos Taurus)
Mammalia OGN 33 34
  • 92.37 (n)
(Canis familiaris)
Mammalia OGN 33 34
  • 90.57 (n)
(Mus musculus)
Mammalia Ogn 33 16 34
  • 88.7 (n)
(Rattus norvegicus)
Mammalia LOC100910855 33
  • 88.7 (n)
(Ornithorhynchus anatinus)
Mammalia OGN 34
  • 74 (a)
(Monodelphis domestica)
Mammalia OGN 34
  • 73 (a)
(Gallus gallus)
Aves OGN 33 34
  • 70.47 (n)
(Anolis carolinensis)
Reptilia OGN 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ogn 33
  • 69.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia ogn-prov 33
(Danio rerio)
Actinopterygii ogn 33 34
  • 64.97 (n)
OGN (1 of 2) 34
  • 56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7827 33
Species where no ortholog for OGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGN Gene

Gene Tree for OGN (if available)
Gene Tree for OGN (if available)

Paralogs for OGN Gene

Paralogs for OGN Gene

(2) SIMAP similar genes for OGN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OGN: view

Variants for OGN Gene

Sequence variations from dbSNP and Humsavar for OGN Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000015031 -- 92,384,132(-) T/C 3_prime_UTR_variant
rs1000060549 -- 92,391,450(-) G/A intron_variant
rs1000070619 -- 92,388,167(-) TTTTTTTTT/TTTTTTTT/TTTTTTTTTT intron_variant
rs1000140589 -- 92,404,846(-) T/C upstream_transcript_variant
rs1000448408 -- 92,383,707(-) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for OGN Gene

Variant ID Type Subtype PubMed ID
esv3891693 CNV gain 25118596
nsv1047337 CNV loss 25217958
nsv1053205 CNV loss 25217958
nsv1128504 CNV deletion 24896259

Variation tolerance for OGN Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGN Gene

Disorders for OGN Gene

MalaCards: The human disease database

(2) MalaCards diseases for OGN Gene - From: DISEASES

Disorder Aliases PubMed IDs
disease of mental health
  • mental health
- elite association - COSMIC cancer census association via MalaCards
Search OGN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OGN

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OGN Gene

Publications for OGN Gene

  1. Molecular cloning of a novel bone-forming compound: osteoinductive factor. (PMID: 2372374) Madisen L … Purchio AF (DNA and cell biology 1990) 2 3 4 22 58
  2. Mutations in KERA, encoding keratocan, cause cornea plana. (PMID: 10802664) Pellegata NS … de la Chapelle A (Nature genetics 2000) 3 4 22 58
  3. The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon. (PMID: 10373482) Tasheva ES … Conrad GW (The Journal of biological chemistry 1999) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for OGN Gene

Sources for OGN Gene

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