This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multipl... See more...

Aliases for OGN Gene

Aliases for OGN Gene

  • Osteoglycin 2 3 4 5
  • Mimecan 2 3 4
  • SLRR3A 2 3 4
  • OIF 2 3 4
  • Osteoinductive Factor 3 4
  • Mimecan Proteoglycan 2 3
  • Corneal Keratan Sulfate Proteoglycan 3
  • Osteoglycin (Osteoinductive Factor) 2
  • OGN 5
  • OG 3

External Ids for OGN Gene

Previous GeneCards Identifiers for OGN Gene

  • GC09M085972
  • GC09M086874
  • GC09M088445
  • GC09M090487
  • GC09M092225
  • GC09M094187
  • GC09M095146
  • GC09M064823

Summaries for OGN Gene

Entrez Gene Summary for OGN Gene

  • This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for OGN Gene

OGN (Osteoglycin) is a Protein Coding gene. Diseases associated with OGN include Inhibited Male Orgasm and Cornea Plana. Among its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is EPYC.

UniProtKB/Swiss-Prot Summary for OGN Gene

  • Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

Gene Wiki entry for OGN Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OGN Gene

Genomics for OGN Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OGN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J092402 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.5 1511 3.6 ZNF629 RFX1 CEBPB ZNF10 ZNF316 MAFK KLF8 CEBPG ZNF366 PRDM6 OGN piR-38736-017 NOL8 CENPP
GH09J092405 Promoter/Enhancer 1.3 EPDnew FANTOM5 ENCODE dbSUPER 605.5 -1.8 -1818 2.1 PKNOX1 POLR2A FOXJ2 FOXK2 USF1 MNT ELF1 USF2 SPI1 MAX OGN CENPP NOL8 OMD
GH09J092291 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.6 +110.9 110923 5.6 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 REST ZNF629 IARS1 MIR3651 SNORA84 lnc-CENPP-17 lnc-NOL8-1 NOL8 MTND4P15 CENPP OGN MTCO3P29
GH09J092478 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 15.1 -77.4 -77387 6.2 ARNT RELB RUNX3 OSR2 ZBTB40 JUN JUND FOSL1 MAX MXI1 ASPN CENPP OGN lnc-ECM2-1 OMD
GH09J092423 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -21.1 -21108 4.6 YY1 POLR2A OMD CENPP NOL8 OGN ECM2 lnc-ECM2-2 ASPN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OGN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OGN

Top Transcription factor binding sites by QIAGEN in the OGN gene promoter:
  • AML1a
  • AP-1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • POU2F1
  • POU2F1a
  • SRY

Genomic Locations for OGN Gene

Genomic Locations for OGN Gene
chr9:92,383,268-92,404,699
(GRCh38/hg38)
Size:
21,432 bases
Orientation:
Minus strand
chr9:95,146,249-95,166,978
(GRCh37/hg19)
Size:
20,730 bases
Orientation:
Minus strand

Genomic View for OGN Gene

Genes around OGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGN Gene

Proteins for OGN Gene

  • Protein details for OGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20774-MIME_HUMAN
    Recommended name:
    Mimecan
    Protein Accession:
    P20774
    Secondary Accessions:
    • Q6FIB0
    • Q9UF90
    • Q9UNK5

    Protein attributes for OGN Gene

    Size:
    298 amino acids
    Molecular mass:
    33922 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OGN Gene

Post-translational modifications for OGN Gene

  • N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • Glycosylation at Thr80, Asn214, and Asn258
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • MIME_HUMAN (767)

Other Protein References for OGN Gene

No data available for DME Specific Peptides for OGN Gene

Domains & Families for OGN Gene

Gene Families for OGN Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for OGN Gene

InterPro:
Blocks:
  • Cysteine-rich flanking region, N-terminal
  • Leucine-rich repeat signature
ProtoNet:

Suggested Antigen Peptide Sequences for OGN Gene

GenScript: Design optimal peptide antigens:
  • cDNA PSEC0219 fis, clone HEMBA1005229, highly similar to Mimecan (A8K0R3_HUMAN)
  • Osteoinductive factor (MIME_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P20774

UniProtKB/Swiss-Prot:

MIME_HUMAN :
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
genes like me logo Genes that share domains with OGN: view

Function for OGN Gene

Molecular function for OGN Gene

UniProtKB/Swiss-Prot Function:
Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

Phenotypes From GWAS Catalog for OGN Gene

Gene Ontology (GO) - Molecular Function for OGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 17474147
GO:0008083 growth factor activity IEA --
GO:0030021 extracellular matrix structural constituent conferring compression resistance RCA 20551380
genes like me logo Genes that share ontologies with OGN: view
genes like me logo Genes that share phenotypes with OGN: view

Animal Models for OGN Gene

MGI Knock Outs for OGN:
  • Ogn Ogn<tm1b(KOMP)Wtsi>
  • Ogn Ogn<tm1Hds>
  • Ogn Ogn<tm1Eta>

Animal Model Products

CRISPR Products

miRNA for OGN Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OGN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OGN Gene

Localization for OGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OGN gene
Compartment Confidence
extracellular 5
lysosome 4
golgi apparatus 4
plasma membrane 2
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA,TAS --
GO:0005615 extracellular space HDA 20551380
GO:0005796 Golgi lumen TAS --
GO:0043202 lysosomal lumen TAS --
GO:0062023 colocalizes_with collagen-containing extracellular matrix HDA 20551380
genes like me logo Genes that share ontologies with OGN: view

Pathways & Interactions for OGN Gene

PathCards logo

SuperPathways for OGN Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
3 ERK Signaling
.61
.61
.58
.51
.49
4 Nanog in Mammalian ESC Pluripotency
.62
.62
.59
.48
5 CREB Pathway
.68
.68
.63
.50
genes like me logo Genes that share pathways with OGN: view

Pathways by source for OGN Gene

54 Qiagen pathways for OGN Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

Gene Ontology (GO) - Biological Process for OGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0042340 keratan sulfate catabolic process TAS --
GO:0048662 negative regulation of smooth muscle cell proliferation ISS --
genes like me logo Genes that share ontologies with OGN: view

No data available for SIGNOR curated interactions for OGN Gene

Drugs & Compounds for OGN Gene

(1) Drugs for OGN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for OGN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OGN: view

Transcripts for OGN Gene

mRNA/cDNA for OGN Gene

3 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OGN

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGN Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2: - -
SP3:

Relevant External Links for OGN Gene

GeneLoc Exon Structure for
OGN

Expression for OGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OGN Gene

This gene is overexpressed in Artery - Aorta (x12.5) and Artery - Coronary (x11.7).

Protein differential expression in normal tissues from HIPED for OGN Gene

This gene is overexpressed in Adipocyte (10.2) and Gallbladder (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OGN Gene



Protein tissue co-expression partners for OGN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OGN

SOURCE GeneReport for Unigene cluster for OGN Gene:

Hs.109439

mRNA Expression by UniProt/SwissProt for OGN Gene:

P20774-MIME_HUMAN
Tissue specificity: Bone.

Evidence on tissue expression from TISSUES for OGN Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Muscle(3.1)
  • Heart(3)
  • Eye(2.5)
  • Skin(2.5)
  • Blood(2.4)
  • Bone(2.4)
  • Intestine(2.1)
  • Kidney(2.1)
  • Gall bladder(2.1)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with OGN: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OGN Gene

Orthologs for OGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for OGN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OGN 30 31
  • 99.89 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OGN 30 31
  • 92.37 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OGN 30 31
  • 90.57 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ogn 30 17 31
  • 88.7 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ogn 30
  • 88.7 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia OGN 31
  • 74 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OGN 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves OGN 30 31
  • 70.47 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia OGN 31
  • 59 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ogn 30
  • 69.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia ogn-prov 30
Zebrafish
(Danio rerio)
Actinopterygii ogn 30 31
  • 64.97 (n)
OneToMany
OGN (1 of 2) 31
  • 56 (a)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7827 30
Species where no ortholog for OGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OGN Gene

ENSEMBL:
Gene Tree for OGN (if available)
TreeFam:
Gene Tree for OGN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OGN: view image

Paralogs for OGN Gene

Paralogs for OGN Gene

(2) SIMAP similar genes for OGN Gene using alignment to 3 proteins:

  • MIME_HUMAN
  • A8K0R3_HUMAN
  • Q5TBF5_HUMAN
genes like me logo Genes that share paralogs with OGN: view

Variants for OGN Gene

Additional dbSNP identifiers (rs#s) for OGN Gene

Structural Variations from Database of Genomic Variants (DGV) for OGN Gene

Variant ID Type Subtype PubMed ID
esv3891693 CNV gain 25118596
nsv1047337 CNV loss 25217958
nsv1053205 CNV loss 25217958
nsv1128504 CNV deletion 24896259

Variation tolerance for OGN Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OGN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OGN Gene

Disorders for OGN Gene

MalaCards: The human disease database

(12) MalaCards diseases for OGN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
inhibited male orgasm
  • male orgasmic disorder
cornea plana
  • flat cornea
adjustment disorder
  • adjustment disease
plantar fascial fibromatosis
  • dupuytren's contracture of foot
psammomatous meningioma
- elite association - COSMIC cancer census association via MalaCards
Search OGN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OGN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with OGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OGN Gene

Publications for OGN Gene

  1. Molecular cloning of a novel bone-forming compound: osteoinductive factor. (PMID: 2372374) Madisen L … Purchio AF (DNA and cell biology 1990) 2 3 4 23
  2. Mutations in KERA, encoding keratocan, cause cornea plana. (PMID: 10802664) Pellegata NS … de la Chapelle A (Nature genetics 2000) 3 4 23
  3. The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon. (PMID: 10373482) Tasheva ES … Conrad GW (The Journal of biological chemistry 1999) 3 4 23
  4. Candidate gene study to investigate the genetic determinants of normal variation in central corneal thickness. (PMID: 20360993) Dimasi DP … Craig JE (Molecular vision 2010) 3 23
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41

Products for OGN Gene

Sources for OGN Gene