Aliases for OGG1 Gene
External Ids for OGG1 Gene
Previous GeneCards Identifiers for OGG1 Gene
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]
GeneCards Summary for OGG1 Gene
OGG1 (8-Oxoguanine DNA Glycosylase) is a Protein Coding gene. Diseases associated with OGG1 include Renal Cell Carcinoma, Nonpapillary and Clear Cell Renal Cell Carcinoma. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Recognition and association of DNA glycosylase with site containing an affected pyrimidine. Gene Ontology (GO) annotations related to this gene include microtubule binding and endonuclease activity.
UniProtKB/Swiss-Prot Summary for OGG1 Gene
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.