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Aliases for OGG1 Gene

Aliases for OGG1 Gene

  • 8-Oxoguanine DNA Glycosylase 2 3 5
  • 8-Hydroxyguanine DNA Glycosylase 2 3
  • MUTM 3 4
  • OGH1 3 4
  • DNA-Apurinic Or Apyrimidinic Site Lyase 3
  • N-Glycosylase/DNA Lyase 3
  • OGG1 Type 1e 2
  • OGG1 Type 1d 2
  • OGG1 Type 1g 2
  • OGG1 Type 1h 2
  • OGG1 Type 1f 3
  • AP Lyase 3
  • HOGG1 3
  • HMMH 3
  • MMH 4

External Ids for OGG1 Gene

Previous GeneCards Identifiers for OGG1 Gene

  • GC03P009720
  • GC03P009782
  • GC03P009766
  • GC03P009767
  • GC03P009768
  • GC03P009769
  • GC03P009770
  • GC03P009771
  • GC03P009772
  • GC03P009773
  • GC03P009774
  • GC03P009791
  • GC03P009727

Summaries for OGG1 Gene

Entrez Gene Summary for OGG1 Gene

  • This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

GeneCards Summary for OGG1 Gene

OGG1 (8-Oxoguanine DNA Glycosylase) is a Protein Coding gene. Diseases associated with OGG1 include Renal Cell Carcinoma, Nonpapillary and Renal Clear Cell Carcinoma. Among its related pathways are Depyrimidination and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include microtubule binding and endonuclease activity.

UniProtKB/Swiss-Prot for OGG1 Gene

  • DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3 to the lesion.

Gene Wiki entry for OGG1 Gene

Additional gene information for OGG1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGG1 Gene

Genomics for OGG1 Gene

GeneHancer (GH) Regulatory Elements for OGG1 Gene

Promoters and enhancers for OGG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I009745 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -1.3 -1274 5.9 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B OGG1 BRPF1 GHRLOS RAD18 SETD5 SEC13 THUMPD3-AS1 FANCD2 TADA3 ARPC4
GH03I009751 Enhancer 0.5 ENCODE 550.8 +1.9 1890 0 CREB1 ATF7 ATF2 EGR2 OGG1 CAMK1
GH03I009394 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 -351.0 -350953 9.8 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SETD5 THUMPD3-AS1 GC03P009403 BRPF1 RAD18 GHRLOS TTLL3 FANCD2 JAGN1 SEC13
GH03I010188 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +444.9 444901 12.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 POLR2B BRPF1 SETD5 IRAK2 GHRLOS LINC00852 TATDN2 FANCD2 GHRL TTLL3 SEC13
GH03I010505 Enhancer 0.9 dbSUPER 10.5 +757.3 757271 2.8 ELF3 FOXA2 ARID4B THRB ZSCAN9 RARA ETS1 YY1 TCF12 SLC30A9 TATDN2 EMC3-AS1 OGG1 GC03M010552 GC03P010586 ATP2B2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OGG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OGG1 gene promoter:

Genomic Locations for OGG1 Gene

Genomic Locations for OGG1 Gene
chr3:9,749,944-9,788,246
(GRCh38/hg38)
Size:
38,303 bases
Orientation:
Plus strand
chr3:9,791,628-9,829,903
(GRCh37/hg19)

Genomic View for OGG1 Gene

Genes around OGG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGG1 Gene

Proteins for OGG1 Gene

  • Protein details for OGG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15527-OGG1_HUMAN
    Recommended name:
    N-glycosylase/DNA lyase
    Protein Accession:
    O15527
    Secondary Accessions:
    • A8K1E3
    • O00390
    • O00670
    • O00705
    • O14876
    • O95488
    • P78554
    • Q9BW42
    • Q9UIK0
    • Q9UIK1
    • Q9UIK2
    • Q9UL34
    • Q9Y2C0
    • Q9Y2C1
    • Q9Y6C3
    • Q9Y6C4

    Protein attributes for OGG1 Gene

    Size:
    345 amino acids
    Molecular mass:
    38782 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB84013.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OGG1 Gene

    Alternative splice isoforms for OGG1 Gene

neXtProt entry for OGG1 Gene

Post-translational modifications for OGG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OGG1 Gene

Domains & Families for OGG1 Gene

Gene Families for OGG1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

O15527

UniProtKB/Swiss-Prot:

OGG1_HUMAN :
  • Belongs to the type-1 OGG1 family.
Family:
  • Belongs to the type-1 OGG1 family.
genes like me logo Genes that share domains with OGG1: view

Function for OGG1 Gene

Molecular function for OGG1 Gene

GENATLAS Biochemistry:
8oxo-7,8-dihydroxyguanine-DNA glycosylase/apurinic,apyrimidic lyase,mut M homolog,ubiquitously expressed with four alternatively spliced isoforms,yeast OGG1 ortholog,involved in the repair of oxidative DNA damage and in carcinogenesis
UniProtKB/Swiss-Prot CatalyticActivity:
The C-O-P bond 3 to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3-terminal unsaturated sugar and a product with a terminal 5-phosphate.
UniProtKB/Swiss-Prot Function:
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3 to the lesion.

Phenotypes From GWAS Catalog for OGG1 Gene

Gene Ontology (GO) - Molecular Function for OGG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003684 damaged DNA binding IDA 14706345
GO:0003824 catalytic activity IEA --
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity IEA --
GO:0004519 endonuclease activity TAS 9223305
genes like me logo Genes that share ontologies with OGG1: view
genes like me logo Genes that share phenotypes with OGG1: view

Human Phenotype Ontology for OGG1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for OGG1 Gene

MGI Knock Outs for OGG1:

Clone Products

  • Addgene plasmids for OGG1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for OGG1 Gene

Localization for OGG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGG1 Gene

Nucleus, nucleoplasm. Nucleus speckle. Nucleus matrix. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.
Isoform 1A: Nucleus.
Isoform 2A: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OGG1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OGG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19506022
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IEA --
GO:0016363 nuclear matrix IEA,IDA 17148573
GO:0016607 nuclear speck IEA,IDA 17148573
genes like me logo Genes that share ontologies with OGG1: view

Pathways & Interactions for OGG1 Gene

genes like me logo Genes that share pathways with OGG1: view

Gene Ontology (GO) - Biological Process for OGG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response IEA --
GO:0006281 DNA repair IEA --
GO:0006284 base-excision repair TAS 9190902
GO:0006289 nucleotide-excision repair IEA --
GO:0006355 regulation of transcription, DNA-templated IMP 8621488
genes like me logo Genes that share ontologies with OGG1: view

No data available for SIGNOR curated interactions for OGG1 Gene

Drugs & Compounds for OGG1 Gene

(21) Drugs for OGG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(40) Additional Compounds for OGG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OGG1: view

Transcripts for OGG1 Gene

Unigene Clusters for OGG1 Gene

8-oxoguanine DNA glycosylase:
Representative Sequences:

Clone Products

  • Addgene plasmids for OGG1

Alternative Splicing Database (ASD) splice patterns (SP) for OGG1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1:
SP2: -
SP3: -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -

Relevant External Links for OGG1 Gene

GeneLoc Exon Structure for
OGG1
ECgene alternative splicing isoforms for
OGG1

Expression for OGG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OGG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OGG1 Gene

This gene is overexpressed in Platelet (36.1), CD8 Tcells (20.7), and CD4 Tcells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OGG1 Gene



Protein tissue co-expression partners for OGG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OGG1 Gene:

OGG1

SOURCE GeneReport for Unigene cluster for OGG1 Gene:

Hs.380271

mRNA Expression by UniProt/SwissProt for OGG1 Gene:

O15527-OGG1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for OGG1 Gene

  • Nervous system(4.7)
  • Intestine(4.5)
  • Eye(4.2)
  • Lung(2.6)
  • Blood(2.4)
  • Kidney(2.4)
  • Liver(2.3)
  • Muscle(2)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for OGG1 Gene

Germ Layers:
  • mesoderm
Systems:
  • urinary
Regions:
Abdomen:
  • kidney
genes like me logo Genes that share expression patterns with OGG1: view

No data available for mRNA differential expression in normal tissues for OGG1 Gene

Orthologs for OGG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OGG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGG1 33 34
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia OGG1 33 34
  • 87.73 (n)
dog
(Canis familiaris)
Mammalia OGG1 33 34
  • 86.97 (n)
rat
(Rattus norvegicus)
Mammalia Ogg1 33
  • 84.66 (n)
mouse
(Mus musculus)
Mammalia Ogg1 33 16 34
  • 84.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OGG1 34
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OGG1 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves OGG1 33 34
  • 61.76 (n)
lizard
(Anolis carolinensis)
Reptilia OGG1 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ogg1 33
  • 59.72 (n)
zebrafish
(Danio rerio)
Actinopterygii ogg1 33 34
  • 58.36 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1191 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001854 33
  • 53.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ogg1 35 33 34
  • 45.81 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER127C 33
  • 50.22 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OGG1 33 34 36
  • 47.44 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05159g 33
  • 46.84 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons OGG1 33
  • 48.07 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03040 33
  • 54.24 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToOne
Species where no ortholog for OGG1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGG1 Gene

ENSEMBL:
Gene Tree for OGG1 (if available)
TreeFam:
Gene Tree for OGG1 (if available)

Paralogs for OGG1 Gene

No data available for Paralogs for OGG1 Gene

Variants for OGG1 Gene

Sequence variations from dbSNP and Humsavar for OGG1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs104893751 pathogenic, Clear cell carcinoma of kidney 9,750,423(+) G/A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000011737 -- 9,775,214(+) G/A/C genic_downstream_transcript_variant, intron_variant
rs1000111939 -- 9,781,199(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000142713 -- 9,780,889(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000246456 -- 9,786,647(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OGG1 Gene

Variant ID Type Subtype PubMed ID
nsv1008805 CNV gain 25217958
nsv1010768 CNV gain 25217958
nsv821982 CNV gain 20364138

Variation tolerance for OGG1 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.18; 51.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OGG1 Gene

Human Gene Mutation Database (HGMD)
OGG1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OGG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGG1 Gene

Disorders for OGG1 Gene

MalaCards: The human disease database

(25) MalaCards diseases for OGG1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma, nonpapillary
  • rcc
renal clear cell carcinoma
  • clear cell carcinoma of kidney
mucocele of appendix
  • appendicele mucocele
papillary adenoma
  • glandular papilloma
intracranial hypertension, idiopathic
  • pseudotumor cerebri
- elite association - COSMIC cancer census association via MalaCards
Search OGG1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

OGG1_HUMAN
  • Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Additional Disease Information for OGG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OGG1: view

No data available for Genatlas for OGG1 Gene

Publications for OGG1 Gene

  1. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. (PMID: 9207108) Rosenquist TA … Grollman AP (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 58
  2. The hOGG1 Ser326Cys polymorphism is not associated with sporadic Parkinson's disease. (PMID: 20193742) Coppedè F … Migliore L (Neuroscience letters 2010) 3 22 44 58
  3. The role of oxidative DNA damage, DNA repair, GSTM1, SOD2 and OGG1 polymorphisms in individual susceptibility to Barrett's esophagus. (PMID: 20056743) Kadioglu E … Karakaya AE (Toxicology and industrial health 2010) 3 22 44 58
  4. The Cys326 allele of the 8-oxoguanine DNA N-glycosylase 1 gene as a risk factor in smoking- and drinking-associated larynx cancer. (PMID: 19966524) Pawlowska E … Morawiec-Sztandera A (The Tohoku journal of experimental medicine 2009) 3 22 44 58
  5. hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type. (PMID: 19881468) Okasaka T … Tajima K (Journal of human genetics 2009) 3 22 44 58

Products for OGG1 Gene

  • Addgene plasmids for OGG1

Sources for OGG1 Gene

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