Aliases for OGG1 Gene
External Ids for OGG1 Gene
Previous GeneCards Identifiers for OGG1 Gene
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]
GeneCards Summary for OGG1 Gene
OGG1 (8-Oxoguanine DNA Glycosylase) is a Protein Coding gene. Diseases associated with OGG1 include Clear Cell Renal Cell Carcinoma and Renal Cell Carcinoma, Nonpapillary. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Cleavage of the damaged pyrimidine. Gene Ontology (GO) annotations related to this gene include microtubule binding and endonuclease activity.
UniProtKB/Swiss-Prot Summary for OGG1 Gene
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.