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Aliases for OGFR Gene

Aliases for OGFR Gene

  • Opioid Growth Factor Receptor 2 3 3 5
  • Zeta-Type Opioid Receptor 3 4
  • Protein 7-60 3 4
  • OGFr 4

External Ids for OGFR Gene

Previous GeneCards Identifiers for OGFR Gene

  • GC20P061313
  • GC20P062115
  • GC20P062162
  • GC20P060906
  • GC20P061436
  • GC20P058154

Summaries for OGFR Gene

Entrez Gene Summary for OGFR Gene

  • The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for OGFR Gene

OGFR (Opioid Growth Factor Receptor) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include opioid receptor activity. An important paralog of this gene is OGFRL1.

UniProtKB/Swiss-Prot for OGFR Gene

  • Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.

Gene Wiki entry for OGFR Gene

Additional gene information for OGFR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFR Gene

Genomics for OGFR Gene

GeneHancer (GH) Regulatory Elements for OGFR Gene

Promoters and enhancers for OGFR Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J062803 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 671.4 +0.7 744 3.7 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF263 OGFR OGFR-AS1 DIDO1 RTEL1 GMEB2 ARFGAP1 ARFRP1 YTHDF1 TAF4 MRGBP
GH20J062793 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.9 -9.0 -8999 5 HDGF CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B MRGBP LOC105372716 DIDO1 OGFR YTHDF1 RPS21 LSM14B LAMA5 TAF4 RTEL1
GH20J062649 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 21 -152.7 -152733 4.7 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A FEZF1 ENSG00000276317 ENSG00000277496 OGFR YTHDF1 OGFR-AS1 MTG2 MIR1-1 MIR1-1HG MIR1-1HG-AS1 DIDO1
GH20J062738 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.1 -64.1 -64141 4.9 ATF1 PKNOX1 SIN3A IRF4 ZNF766 GLIS2 ELK1 ZNF143 ATF7 FOS OGFR NTSR1 LINC00659 LINC00686 OGFR-AS1 MIR1-1 MIR1-1HG-AS1 MIR1-1HG ENSG00000229882 ENSG00000232121
GH20J062641 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.3 -159.4 -159443 8 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 SLCO4A1 MRGBP TAF4 GMEB2 SLCO4A1-AS1 OGFR OGFR-AS1 MIR1-1 MIR1-1HG MIR1-1HG-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OGFR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OGFR gene promoter:
  • Pax-4a
  • PPAR-gamma2
  • PPAR-gamma1
  • POU2F1a
  • POU2F1
  • HNF-4alpha2
  • HNF-4alpha1
  • CP2
  • Brachyury
  • Ik-3

Genomic Locations for OGFR Gene

Genomic Locations for OGFR Gene
9,176 bases
Plus strand
9,176 bases
Plus strand

Genomic View for OGFR Gene

Genes around OGFR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGFR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFR Gene

Proteins for OGFR Gene

  • Protein details for OGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Opioid growth factor receptor
    Protein Accession:
    Secondary Accessions:
    • O96029
    • Q4VXW5
    • Q96CM2
    • Q9BQW1
    • Q9H4H0
    • Q9H7J5
    • Q9NZT3
    • Q9NZT4

    Protein attributes for OGFR Gene

    677 amino acids
    Molecular mass:
    73325 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD03737.1; Type=Frameshift; Positions=1, 181; Evidence={ECO:0000305}; Sequence=AAD03745.1; Type=Frameshift; Positions=1, 181; Evidence={ECO:0000305}; Sequence=CAC28882.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for OGFR Gene


neXtProt entry for OGFR Gene

Post-translational modifications for OGFR Gene

  • Ubiquitination at Lys291, Lys218, and Lys158
  • Modification sites at PhosphoSitePlus

Other Protein References for OGFR Gene

No data available for DME Specific Peptides for OGFR Gene

Domains & Families for OGFR Gene

Gene Families for OGFR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OGFR Gene

Suggested Antigen Peptide Sequences for OGFR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the opioid growth factor receptor family.
  • Belongs to the opioid growth factor receptor family.
genes like me logo Genes that share domains with OGFR: view

Function for OGFR Gene

Molecular function for OGFR Gene

UniProtKB/Swiss-Prot Function:
Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.

Phenotypes From GWAS Catalog for OGFR Gene

Gene Ontology (GO) - Molecular Function for OGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004985 opioid receptor activity NAS 10677613
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with OGFR: view
genes like me logo Genes that share phenotypes with OGFR: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OGFR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OGFR Gene

Localization for OGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGFR Gene

Cytoplasm. Nucleus. Note=The OGF/OGFR complex is probably translocated to the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OGFR gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OGFR: view

Pathways & Interactions for OGFR Gene

genes like me logo Genes that share pathways with OGFR: view

Gene Ontology (GO) - Biological Process for OGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 10677613
GO:0038003 opioid receptor signaling pathway IEA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with OGFR: view

No data available for SIGNOR curated interactions for OGFR Gene

Drugs & Compounds for OGFR Gene

(1) Drugs for OGFR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with OGFR: view

Transcripts for OGFR Gene

mRNA/cDNA for OGFR Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(201) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OGFR Gene

Opioid growth factor receptor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGFR Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - - -
SP3: -
SP5: - -
SP6: -

Relevant External Links for OGFR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OGFR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OGFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OGFR Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for OGFR Gene

This gene is overexpressed in Lymph node (12.6), Peripheral blood mononuclear cells (11.2), Blymphocyte (8.1), and Monocytes (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OGFR Gene

Protein tissue co-expression partners for OGFR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OGFR Gene:


SOURCE GeneReport for Unigene cluster for OGFR Gene:


mRNA Expression by UniProt/SwissProt for OGFR Gene:

Tissue specificity: Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.

Evidence on tissue expression from TISSUES for OGFR Gene

  • Skin(4.6)
  • Liver(4.3)
  • Spleen(4.3)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with OGFR: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OGFR Gene

Orthologs for OGFR Gene

This gene was present in the common ancestor of chordates.

Orthologs for OGFR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OGFR 34 33
  • 97.08 (n)
(Canis familiaris)
Mammalia OGFR 34 33
  • 85.89 (n)
(Bos Taurus)
Mammalia OGFR 34 33
  • 77.73 (n)
(Mus musculus)
Mammalia Ogfr 16 34 33
  • 71.27 (n)
(Rattus norvegicus)
Mammalia Ogfr 33
  • 71.23 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
-- 34
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia OGFR 34
  • 50 (a)
(Gallus gallus)
Aves OGFR 34 33
  • 51.18 (n)
(Anolis carolinensis)
Reptilia OGFR 34
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17622 33
(Danio rerio)
Actinopterygii OGFR (3 of 4) 34
  • 39 (a)
ogfr 34
  • 33 (a)
ogfrl2 34
  • 31 (a)
OGFR (4 of 4) 34
  • 28 (a)
Species where no ortholog for OGFR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFR Gene

Gene Tree for OGFR (if available)
Gene Tree for OGFR (if available)
Evolutionary constrained regions (ECRs) for OGFR: view image

Paralogs for OGFR Gene

Paralogs for OGFR Gene

(1) SIMAP similar genes for OGFR Gene using alignment to 3 proteins:

  • Q05BV5_HUMAN
  • Q4VXW3_HUMAN Pseudogenes for OGFR Gene

genes like me logo Genes that share paralogs with OGFR: view

Variants for OGFR Gene

Sequence variations from dbSNP and Humsavar for OGFR Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000234821 -- 62,807,370(+) C/T intron_variant
rs1000334423 -- 62,812,138(+) G/A intron_variant
rs1000523811 -- 62,806,246(+) G/A/C intron_variant
rs1000677977 -- 62,811,081(+) G/A intron_variant
rs1000719986 -- 62,813,854(+) G/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for OGFR Gene

Variant ID Type Subtype PubMed ID
esv2722837 CNV deletion 23290073
nsv1073081 CNV deletion 25765185
nsv1144941 CNV deletion 24896259
nsv428380 CNV loss 18775914
nsv459065 CNV gain 19166990
nsv470558 CNV loss 18288195
nsv586496 CNV gain 21841781
nsv834027 CNV loss 17160897
nsv953302 CNV deletion 24416366
nsv9825 CNV gain 18304495

Variation tolerance for OGFR Gene

Gene Damage Index Score: 4.86; 67.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OGFR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGFR Gene

Disorders for OGFR Gene

Additional Disease Information for OGFR

No disorders were found for OGFR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OGFR Gene

Publications for OGFR Gene

  1. Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans. (PMID: 10677613) Zagon IS … McLaughlin PJ (Brain research 2000) 2 3 4 22 58
  2. The biology of the opioid growth factor receptor (OGFr). (PMID: 11890982) Zagon IS … McLaughlin PJ (Brain research. Brain research reviews 2002) 3 4 22 58
  3. Antagonism of the Met5-enkephalin-opioid growth factor receptor-signaling axis promotes MSC to differentiate into osteoblasts. (PMID: 26687326) Thakur NA … Margulies BS (Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2016) 2 3 58
  4. The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer. (PMID: 19923357) Avella DM … Staveley-O'Carroll KF (American journal of physiology. Regulatory, integrative and comparative physiology 2010) 3 22 58
  5. Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis. (PMID: 19835629) McLaughlin PJ … Goldenberg D (BMC cancer 2009) 3 22 58

Products for OGFR Gene

Sources for OGFR Gene

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