The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence o... See more...

Aliases for OGFR Gene

Aliases for OGFR Gene

  • Opioid Growth Factor Receptor 2 3 4 5
  • Zeta-Type Opioid Receptor 3 4
  • Protein 7-60 3 4
  • OGFr 4

External Ids for OGFR Gene

Previous GeneCards Identifiers for OGFR Gene

  • GC20P061313
  • GC20P062115
  • GC20P062162
  • GC20P060906
  • GC20P061436
  • GC20P058154

Summaries for OGFR Gene

Entrez Gene Summary for OGFR Gene

  • The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for OGFR Gene

OGFR (Opioid Growth Factor Receptor) is a Protein Coding gene. Diseases associated with OGFR include Keratopathy and Malignant Granular Cell Myoblastoma. Among its related pathways are TGF-Beta Pathway and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include opioid receptor activity. An important paralog of this gene is OGFRL1.

UniProtKB/Swiss-Prot Summary for OGFR Gene

  • Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.

Gene Wiki entry for OGFR Gene

Additional gene information for OGFR Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OGFR Gene

Genomics for OGFR Gene

GeneHancer (GH) Regulatory Elements for OGFR Gene

Promoters and enhancers for OGFR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OGFR on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OGFR

Top Transcription factor binding sites by QIAGEN in the OGFR gene promoter:
  • Brachyury
  • CP2
  • HNF-4alpha1
  • HNF-4alpha2
  • Ik-3
  • Pax-4a
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OGFR Gene

Genomic Locations for OGFR Gene
chr20:62,804,825-62,814,000
(GRCh38/hg38)
Size:
9,176 bases
Orientation:
Plus strand
chr20:61,436,177-61,445,352
(GRCh37/hg19)
Size:
9,176 bases
Orientation:
Plus strand

Genomic View for OGFR Gene

Genes around OGFR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGFR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGFR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFR Gene

Proteins for OGFR Gene

  • Protein details for OGFR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZT2-OGFR_HUMAN
    Recommended name:
    Opioid growth factor receptor
    Protein Accession:
    Q9NZT2
    Secondary Accessions:
    • O96029
    • Q4VXW5
    • Q96CM2
    • Q9BQW1
    • Q9H4H0
    • Q9H7J5
    • Q9NZT3
    • Q9NZT4

    Protein attributes for OGFR Gene

    Size:
    677 amino acids
    Molecular mass:
    73325 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD03737.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAD03745.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for OGFR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGFR Gene

Post-translational modifications for OGFR Gene

  • Ubiquitination at Lys158, Lys218, and Lys291
  • Modification sites at PhosphoSitePlus

Other Protein References for OGFR Gene

No data available for DME Specific Peptides for OGFR Gene

Domains & Families for OGFR Gene

Gene Families for OGFR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OGFR Gene

Blocks:
  • Opioid growth factor receptor (OGFr) conserved region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OGFR Gene

GenScript: Design optimal peptide antigens:
  • Zeta-type opioid receptor (OGFR_HUMAN)
  • OGFR protein (Q05BV5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NZT2

UniProtKB/Swiss-Prot:

OGFR_HUMAN :
  • Belongs to the opioid growth factor receptor family.
Family:
  • Belongs to the opioid growth factor receptor family.
genes like me logo Genes that share domains with OGFR: view

Function for OGFR Gene

Molecular function for OGFR Gene

UniProtKB/Swiss-Prot Function:
Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.

Phenotypes From GWAS Catalog for OGFR Gene

Gene Ontology (GO) - Molecular Function for OGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004985 opioid receptor activity IEA,NAS 10677613
GO:0005515 protein binding IPI 21044950
GO:0038023 signaling receptor activity IEA --
genes like me logo Genes that share ontologies with OGFR: view
genes like me logo Genes that share phenotypes with OGFR: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OGFR

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OGFR Gene

Localization for OGFR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGFR Gene

Cytoplasm. Nucleus. Note=The OGF/OGFR complex is probably translocated to the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OGFR gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OGFR: view

Pathways & Interactions for OGFR Gene

PathCards logo

SuperPathways for OGFR Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.62
.61
.60
.57
2 CREB Pathway
.68
.68
.63
3 PAK Pathway
.56
.56
4 TGF-Beta Pathway
.60
.60
5 NF-KappaB Family Pathway
.72
.72
genes like me logo Genes that share pathways with OGFR: view

Pathways by source for OGFR Gene

29 Qiagen pathways for OGFR Gene
  • Actin-Based Motility by Rho Family GTPases
  • Activation of PKC through GPCR
  • Antioxidant Action of Vitamin-C
  • Apoptotic Pathways in Synovial Fibroblasts
  • Breast Cancer Regulation by Stathmin1

Gene Ontology (GO) - Biological Process for OGFR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 10677613
GO:0038003 opioid receptor signaling pathway IEA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with OGFR: view

No data available for SIGNOR curated interactions for OGFR Gene

Drugs & Compounds for OGFR Gene

(1) Drugs for OGFR Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with OGFR: view

Transcripts for OGFR Gene

mRNA/cDNA for OGFR Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGFR Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - - -
SP3: -
SP4:
SP5: - -
SP6: -

Relevant External Links for OGFR Gene

GeneLoc Exon Structure for
OGFR

Expression for OGFR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OGFR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OGFR Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for OGFR Gene

This gene is overexpressed in Lymph node (12.6), Peripheral blood mononuclear cells (11.2), Blymphocyte (8.1), and Monocytes (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OGFR Gene



Protein tissue co-expression partners for OGFR Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OGFR

SOURCE GeneReport for Unigene cluster for OGFR Gene:

Hs.67896

mRNA Expression by UniProt/SwissProt for OGFR Gene:

Q9NZT2-OGFR_HUMAN
Tissue specificity: Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.

Evidence on tissue expression from TISSUES for OGFR Gene

  • Skin(4.6)
  • Liver(4.3)
  • Spleen(4.3)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with OGFR: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OGFR Gene

Orthologs for OGFR Gene

This gene was present in the common ancestor of chordates.

Orthologs for OGFR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGFR 31 30
  • 97.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OGFR 31 30
  • 85.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OGFR 31 30
  • 77.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ogfr 17 31 30
  • 71.27 (n)
rat
(Rattus norvegicus)
Mammalia Ogfr 30
  • 71.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 52 (a)
OneToMany
-- 31
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia OGFR 31
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves OGFR 31 30
  • 51.18 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OGFR 31
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17622 30
zebrafish
(Danio rerio)
Actinopterygii OGFR (3 of 4) 31
  • 39 (a)
OneToMany
ogfr 31
  • 33 (a)
OneToMany
ogfrl2 31
  • 31 (a)
OneToMany
OGFR (4 of 4) 31
  • 28 (a)
OneToMany
Species where no ortholog for OGFR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFR Gene

ENSEMBL:
Gene Tree for OGFR (if available)
TreeFam:
Gene Tree for OGFR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OGFR: view image

Paralogs for OGFR Gene

Paralogs for OGFR Gene

(1) SIMAP similar genes for OGFR Gene using alignment to 3 proteins:

  • OGFR_HUMAN
  • Q05BV5_HUMAN
  • Q4VXW3_HUMAN

Pseudogenes.org Pseudogenes for OGFR Gene

genes like me logo Genes that share paralogs with OGFR: view

Variants for OGFR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OGFR Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
737241 Likely Benign: not provided 62,807,529(+) C/G INTRON_VARIANT
rs6122313 - p.Arg545Ser
rs6122315 - p.Ser577Thr

Additional dbSNP identifiers (rs#s) for OGFR Gene

Structural Variations from Database of Genomic Variants (DGV) for OGFR Gene

Variant ID Type Subtype PubMed ID
esv2722837 CNV deletion 23290073
nsv1073081 CNV deletion 25765185
nsv1144941 CNV deletion 24896259
nsv428380 CNV loss 18775914
nsv459065 CNV gain 19166990
nsv470558 CNV loss 18288195
nsv586496 CNV gain 21841781
nsv834027 CNV loss 17160897
nsv953302 CNV deletion 24416366
nsv9825 CNV gain 18304495

Variation tolerance for OGFR Gene

Gene Damage Index Score: 4.86; 67.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OGFR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OGFR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGFR Gene

Disorders for OGFR Gene

MalaCards: The human disease database

(3) MalaCards diseases for OGFR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
keratopathy
malignant granular cell myoblastoma
  • granular cell tumor, malignant
pancreatic cancer
  • pancreatic carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search OGFR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OGFR

genes like me logo Genes that share disorders with OGFR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OGFR Gene

Publications for OGFR Gene

  1. Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans. (PMID: 10677613) Zagon IS … McLaughlin PJ (Brain research 2000) 2 3 4 23 54
  2. The biology of the opioid growth factor receptor (OGFr). (PMID: 11890982) Zagon IS … McLaughlin PJ (Brain research. Brain research reviews 2002) 3 4 23 54
  3. Antagonism of the Met5-enkephalin-opioid growth factor receptor-signaling axis promotes MSC to differentiate into osteoblasts. (PMID: 26687326) Thakur NA … Margulies BS (Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2016) 2 3 54
  4. The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer. (PMID: 19923357) Avella DM … Staveley-O'Carroll KF (American journal of physiology. Regulatory, integrative and comparative physiology 2010) 3 23 54
  5. The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation. (PMID: 18923142) Cheng F … Zagon IS (Molecular biology of the cell 2009) 3 23 54

Products for OGFR Gene

Sources for OGFR Gene