Aliases for OGFOD3 Gene

Aliases for OGFOD3 Gene

  • 2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 3 2 3 5
  • 2-Oxoglutarate And Iron-Dependent Oxygenase Domain-Containing Protein 3 3 4
  • C17orf101 3 4
  • 2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 3 2
  • PKHD Domain-Containing Transmembrane Protein C17orf101 3
  • Chromosome 17 Open Reading Frame 101 2
  • EC 1.14.11.- 4

External Ids for OGFOD3 Gene

Previous HGNC Symbols for OGFOD3 Gene

  • C17orf101

Previous GeneCards Identifiers for OGFOD3 Gene

  • GC17M080351
  • GC17M080353

Summaries for OGFOD3 Gene

GeneCards Summary for OGFOD3 Gene

OGFOD3 (2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

Additional gene information for OGFOD3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OGFOD3 Gene

Genomics for OGFOD3 Gene

GeneHancer (GH) Regulatory Elements for OGFOD3 Gene

Promoters and enhancers for OGFOD3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J082447 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 761.1 -31.3 -31270 4.1 ZNF24 SP1 ZBTB40 ZBTB6 MLX POLR2A ATF1 HCFC1 ZNF362 MYC CYBC1 OGFOD3 ENSG00000287193 lnc-C17orf62-6 TBCD ENSG00000262049 FAAP100 ENSG00000262663 NARF-IT1 ENSG00000265678
GH17J082417 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 764 -0.4 -352 2.9 ZNF24 SP1 SIX5 POLR2A HCFC1 MYC L3MBTL2 MAX SREBF1 MNT HEXD OGFOD3 ENSG00000201239 lnc-C17orf62-5 ALYREF ARL2BPP9 SECTM1 ENSG00000262147 ENSG00000262652 ENSG00000260563
GH17J082492 Promoter/Enhancer 2.4 EPDnew FANTOM5 ENCODE CraniofacialAtlas dbSUPER 45.8 -76.8 -76807 5.9 GTF3C2 ZNF785 SIN3A ZNF24 ZBTB40 CTCF ZBTB6 LCORL FOXA1 MLX FOXK2 TRX-CAT1-8 hsa-miR-1273e-032 piR-33437-002 piR-32374 ENSG00000260563 ENSG00000262049 ALYREF NARF-IT1 ARL2BPP9
GH17J082211 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 33.7 +202.7 202699 8.7 GTF3C2 SIN3A ZNF24 SP1 ZBTB40 SIX5 ZBTB6 LCORL MLX RBPJ CCDC57 ENSG00000264548 lnc-CCDC57-1 SLC16A3 ENSG00000262049 ENSG00000260563 ENSG00000262652 ARL2BPP9 ALYREF NARF-IT1
GH17J081916 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 36.1 +495.9 495929 13.4 SIN3A ZNF24 SP1 ZBTB40 CTCF ZBTB6 MLX RBPJ SMARCE1 POLR2A SIRT7 ENSG00000264769 MAFG TBCD CEP131 ENSG00000262049 HGS FAAP100 OGFOD3 ENSG00000260563
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OGFOD3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OGFOD3 Gene

Genomic Locations for OGFOD3 Gene
29,428 bases
Minus strand
29,428 bases
Minus strand

Genomic View for OGFOD3 Gene

Genes around OGFOD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGFOD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGFOD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFOD3 Gene

Proteins for OGFOD3 Gene

  • Protein details for OGFOD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • C9JDC8
    • Q8IZ37
    • Q9H6J2

    Protein attributes for OGFOD3 Gene

    319 amino acids
    Molecular mass:
    35646 Da
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OGFOD3 Gene


neXtProt entry for OGFOD3 Gene

Post-translational modifications for OGFOD3 Gene

  • Glycosylation at Asn215 and Asn267
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • OGFD3_HUMAN (981)

Other Protein References for OGFOD3 Gene

No data available for DME Specific Peptides for OGFOD3 Gene

Domains & Families for OGFOD3 Gene

Gene Families for OGFOD3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for OGFOD3 Gene

Suggested Antigen Peptide Sequences for OGFOD3 Gene

GenScript: Design optimal peptide antigens:
  • PKHD domain-containing transmembrane protein C17orf101 (CQ101_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the OGFOD3 family.
  • Belongs to the OGFOD3 family.
genes like me logo Genes that share domains with OGFOD3: view

Function for OGFOD3 Gene

Enzyme Numbers (IUBMB) for OGFOD3 Gene

Phenotypes From GWAS Catalog for OGFOD3 Gene

Gene Ontology (GO) - Molecular Function for OGFOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0031418 L-ascorbic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OGFOD3: view
genes like me logo Genes that share phenotypes with OGFOD3: view

Animal Models for OGFOD3 Gene

MGI Knock Outs for OGFOD3:
  • Ogfod3 Ogfod3<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OGFOD3 Gene

Localization for OGFOD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGFOD3 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OGFOD3 gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OGFOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OGFOD3: view

Pathways & Interactions for OGFOD3 Gene

PathCards logo

SuperPathways for OGFOD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OGFOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with OGFOD3: view

No data available for Pathways by source and SIGNOR curated interactions for OGFOD3 Gene

Drugs & Compounds for OGFOD3 Gene

No Compound Related Data Available

Transcripts for OGFOD3 Gene

mRNA/cDNA for OGFOD3 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGFOD3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - -

Relevant External Links for OGFOD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OGFOD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OGFOD3 Gene

Protein differential expression in normal tissues from HIPED for OGFOD3 Gene

This gene is overexpressed in Bone (27.6), Testis (7.7), and Adrenal (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OGFOD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OGFOD3 Gene:


SOURCE GeneReport for Unigene cluster for OGFOD3 Gene:


Evidence on tissue expression from TISSUES for OGFOD3 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with OGFOD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OGFOD3 Gene

Orthologs for OGFOD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for OGFOD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OGFOD3 33 32
  • 98.85 (n)
(Canis familiaris)
Mammalia OGFOD3 33 32
  • 84.39 (n)
(Bos Taurus)
Mammalia OGFOD3 33 32
  • 83.23 (n)
(Rattus norvegicus)
Mammalia Ogfod3 32
  • 82.06 (n)
(Mus musculus)
Mammalia Ogfod3 17 33 32
  • 81.32 (n)
(Ornithorhynchus anatinus)
Mammalia OGFOD3 33
  • 63 (a)
(Monodelphis domestica)
Mammalia OGFOD3 33
  • 57 (a)
(Gallus gallus)
Aves LOC769717 32
  • 73.72 (n)
  • 60 (a)
(Anolis carolinensis)
Reptilia OGFOD3 33
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ogfod3 32
  • 69.4 (n)
Str.15494 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.3868 32
(Danio rerio)
Actinopterygii zgc:195081 32
  • 59.25 (n)
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009177 32
  • 59.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 46 (a)
Cin.11708 32
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11708 32
Species where no ortholog for OGFOD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFOD3 Gene

Gene Tree for OGFOD3 (if available)
Gene Tree for OGFOD3 (if available)
Evolutionary constrained regions (ECRs) for OGFOD3: view image

Paralogs for OGFOD3 Gene

No data available for Paralogs for OGFOD3 Gene

Variants for OGFOD3 Gene

Sequence variations from dbSNP and Humsavar for OGFOD3 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1141463 benign, not specified 82,419,814(-) T/A/G upstream_transcript_variant
rs1000238115 -- 82,408,143(-) A/G intron_variant
rs1000242740 -- 82,402,655(-) G/C intron_variant
rs1000268363 -- 82,396,762(-) C/A intron_variant
rs1000437433 -- 82,418,905(-) G/A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OGFOD3 Gene

Variant ID Type Subtype PubMed ID
dgv1525n106 CNV deletion 24896259
esv21913 CNV gain+loss 19812545
esv2664023 CNV deletion 23128226
esv2672977 CNV deletion 23128226
esv2716501 CNV deletion 23290073
esv2716502 CNV deletion 23290073
esv2760445 CNV gain 21179565
esv2762577 CNV gain+loss 21179565
esv3554903 CNV deletion 23714750
esv3641423 CNV gain 21293372
nsv1059334 CNV gain 25217958
nsv1062980 CNV gain 25217958
nsv1067160 CNV loss 25217958
nsv1067194 CNV gain 25217958
nsv112498 CNV deletion 16902084
nsv1160502 CNV deletion 26073780
nsv428351 CNV gain 18775914
nsv469561 CNV loss 16826518
nsv828143 CNV loss 20364138
nsv833573 CNV loss 17160897
nsv952394 CNV deletion 24416366

Variation tolerance for OGFOD3 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.52; 82.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OGFOD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGFOD3 Gene

Disorders for OGFOD3 Gene

Additional Disease Information for OGFOD3

No disorders were found for OGFOD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OGFOD3 Gene

Publications for OGFOD3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 56
  2. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 56

Products for OGFOD3 Gene

Sources for OGFOD3 Gene