Aliases for OGFOD2 Gene

Aliases for OGFOD2 Gene

  • 2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 2 2 3 5
  • 2-Oxoglutarate And Iron-Dependent Oxygenase Domain-Containing Protein 2 3 4
  • 2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 2 2
  • EC 1.14.11.- 4

External Ids for OGFOD2 Gene

Previous GeneCards Identifiers for OGFOD2 Gene

  • GC12P122025
  • GC12P123459
  • GC12P120420

Summaries for OGFOD2 Gene

GeneCards Summary for OGFOD2 Gene

OGFOD2 (2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. An important paralog of this gene is ATP5MF-PTCD1.

Additional gene information for OGFOD2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OGFOD2 Gene

Genomics for OGFOD2 Gene

GeneHancer (GH) Regulatory Elements for OGFOD2 Gene

Promoters and enhancers for OGFOD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OGFOD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OGFOD2 gene promoter:
  • c-Ets-1
  • Nkx2-5
  • Sp1

Genomic Locations for OGFOD2 Gene

Genomic Locations for OGFOD2 Gene
chr12:122,974,580-122,980,043
(GRCh38/hg38)
Size:
5,464 bases
Orientation:
Plus strand
chr12:123,459,127-123,464,590
(GRCh37/hg19)
Size:
5,464 bases
Orientation:
Plus strand

Genomic View for OGFOD2 Gene

Genes around OGFOD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGFOD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGFOD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OGFOD2 Gene

Proteins for OGFOD2 Gene

  • Protein details for OGFOD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N063-OGFD2_HUMAN
    Recommended name:
    2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
    Protein Accession:
    Q6N063
    Secondary Accessions:
    • B3KT24
    • Q4KN13
    • Q6N023
    • Q9H8K6

    Protein attributes for OGFOD2 Gene

    Size:
    350 amino acids
    Molecular mass:
    38996 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Cofactor:
    Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAE45849.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=CAE45849.1; Type=Frameshift; Positions=104; Evidence={ECO:0000305};

    Alternative splice isoforms for OGFOD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGFOD2 Gene

Post-translational modifications for OGFOD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OGFOD2 Gene

Domains & Families for OGFOD2 Gene

Gene Families for OGFOD2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OGFOD2 Gene

Suggested Antigen Peptide Sequences for OGFOD2 Gene

GenScript: Design optimal peptide antigens:
  • 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (OGFD2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6N063

UniProtKB/Swiss-Prot:

OGFD2_HUMAN :
  • Belongs to the OGFOD2 family.
Family:
  • Belongs to the OGFOD2 family.
genes like me logo Genes that share domains with OGFOD2: view

Function for OGFOD2 Gene

Enzyme Numbers (IUBMB) for OGFOD2 Gene

Phenotypes From GWAS Catalog for OGFOD2 Gene

Gene Ontology (GO) - Molecular Function for OGFOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA --
GO:0031418 L-ascorbic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OGFOD2: view
genes like me logo Genes that share phenotypes with OGFOD2: view

Animal Model Products

CRISPR Products

miRNA for OGFOD2 Gene

miRTarBase miRNAs that target OGFOD2

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OGFOD2 Gene

Localization for OGFOD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OGFOD2 gene
Compartment Confidence
nucleus 3
extracellular 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OGFOD2 Gene

Pathways & Interactions for OGFOD2 Gene

PathCards logo

SuperPathways for OGFOD2 Gene

No Data Available

Interacting Proteins for OGFOD2 Gene

Gene Ontology (GO) - Biological Process for OGFOD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with OGFOD2: view

No data available for Pathways by source and SIGNOR curated interactions for OGFOD2 Gene

Drugs & Compounds for OGFOD2 Gene

(2) Drugs for OGFOD2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin C Approved Nutra Target 712,712
Iron Approved, Experimental Pharma 1452
genes like me logo Genes that share compounds with OGFOD2: view

Transcripts for OGFOD2 Gene

mRNA/cDNA for OGFOD2 Gene

(7) REFSEQ mRNAs :
(18) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(25) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGFOD2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: -
SP12: - - - - - - - - - -
SP13: - -
SP14: - - - - - - - -
SP15: - -
SP16:

ExUns: 9c · 9d · 9e ^ 10a · 10b · 10c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for OGFOD2 Gene

GeneLoc Exon Structure for
OGFOD2
ECgene alternative splicing isoforms for
OGFOD2

Expression for OGFOD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OGFOD2 Gene

Protein differential expression in normal tissues from HIPED for OGFOD2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (50.0) and Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OGFOD2 Gene



NURSA nuclear receptor signaling pathways regulating expression of OGFOD2 Gene:

OGFOD2

SOURCE GeneReport for Unigene cluster for OGFOD2 Gene:

Hs.524817

Evidence on tissue expression from TISSUES for OGFOD2 Gene

  • Nervous system(4.5)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with OGFOD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OGFOD2 Gene

Orthologs for OGFOD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OGFOD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OGFOD2 33 32
  • 98.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OGFOD2 33 32
  • 86.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OGFOD2 33 32
  • 86.23 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ogfod2 32
  • 85.07 (n)
mouse
(Mus musculus)
Mammalia Ogfod2 17 33 32
  • 83.56 (n)
oppossum
(Monodelphis domestica)
Mammalia OGFOD2 33
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OGFOD2 33
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves OGFOD2 33 32
  • 64.91 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OGFOD2 33
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ogfod2 32
  • 58.6 (n)
zebrafish
(Danio rerio)
Actinopterygii ogfod2 33 32
  • 58.36 (n)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G22950 32
  • 44.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 52 (a)
OneToOne
Species where no ortholog for OGFOD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OGFOD2 Gene

ENSEMBL:
Gene Tree for OGFOD2 (if available)
TreeFam:
Gene Tree for OGFOD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OGFOD2: view image

Paralogs for OGFOD2 Gene

Paralogs for OGFOD2 Gene

genes like me logo Genes that share paralogs with OGFOD2: view

Variants for OGFOD2 Gene

Sequence variations from dbSNP and Humsavar for OGFOD2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000288082 -- 122,975,098(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000623774 -- 122,974,052(+) AAATAAATAAA/AAATAAA upstream_transcript_variant
rs1001007711 -- 122,973,489(+) G/A upstream_transcript_variant
rs1002014766 -- 122,974,914(+) G/A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1002122209 -- 122,973,717(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OGFOD2 Gene

Variant ID Type Subtype PubMed ID
dgv22n68 CNV loss 17160897
nsv455732 CNV loss 19166990
nsv517200 CNV loss 19592680
nsv560492 CNV loss 21841781
nsv914 CNV insertion 18451855

Variation tolerance for OGFOD2 Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OGFOD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OGFOD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGFOD2 Gene

Disorders for OGFOD2 Gene

Additional Disease Information for OGFOD2

No disorders were found for OGFOD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OGFOD2 Gene

Publications for OGFOD2 Gene

  1. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PMID: 21507922) Ramsuran V … Ndung'u T (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011) 3 43 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 56
  4. ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. (PMID: 30232004) Abraham CG … Espinosa JM (Cell reports 2018) 3 56
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 56

Products for OGFOD2 Gene

Sources for OGFOD2 Gene