Aliases for OGFOD2 Gene
Aliases for OGFOD2 Gene
External Ids for OGFOD2 Gene
- HGNC: 25823
- Entrez Gene: 79676
- Ensembl: ENSG00000111325
- UniProtKB: Q6N063
Previous GeneCards Identifiers for OGFOD2 Gene
- GC12P122025
- GC12P123459
- GC12P120420
Summaries for OGFOD2 Gene
GeneCards Summary for OGFOD2 Gene
OGFOD2 (2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
Additional gene information for OGFOD2 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGFOD2 Gene
Genomics for OGFOD2 Gene
GeneHancer (GH) Regulatory Elements for OGFOD2 Gene
Promoters and enhancers for OGFOD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around OGFOD2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the OGFOD2 gene promoter:
Regulatory Element Products
Genomic Locations for OGFOD2 Gene
Genomic Locations for OGFOD2 Gene
- chr12:122,974,580-122,980,043
- (GRCh38/hg38)
- Size:
- 5,464 bases
- Orientation:
- Plus strand
- chr12:123,459,127-123,464,590
- (GRCh37/hg19)
Genomic View for OGFOD2 Gene
Genes around OGFOD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by Ensembl
- 12q24.31 by Entrez Gene
- 12q24.31 by HGNC
OGFOD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OGFOD2 Gene
Proteins for OGFOD2 Gene
-
Protein details for OGFOD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6N063-OGFD2_HUMAN
- Recommended name:
- 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
- Protein Accession:
- Q6N063
- B3KT24
- Q4KN13
- Q6N023
- Q9H8K6
Protein attributes for OGFOD2 Gene
- Size:
- 350 amino acids
- Molecular mass:
- 38996 Da
- Cofactor:
- Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
- Cofactor:
- Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAE45849.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=CAE45849.1; Type=Frameshift; Positions=104; Evidence={ECO:0000305};
Protein Expression for OGFOD2 Gene
Post-translational modifications for OGFOD2 Gene
No Post-translational modifications
Other Protein References for OGFOD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for OGFOD2
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-
Abcam antibodies for OGFOD2
- Invitrogen Antibodies for OGFOD2
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-
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Protein Products
-
OriGene Purified Proteins for OGFOD2
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-
Abcam proteins for OGFOD2
Assay Products
No data available for DME Specific Peptides for OGFOD2 Gene
Domains & Families for OGFOD2 Gene
Gene Families for OGFOD2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for OGFOD2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for OGFOD2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6N063- Family:
-
- Belongs to the OGFOD2 family.
Function for OGFOD2 Gene
Enzyme Numbers (IUBMB) for OGFOD2 Gene
Phenotypes From GWAS Catalog for OGFOD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005506 | iron ion binding | IEA | -- |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | -- |
| GO:0031418 | L-ascorbic acid binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for OGFOD2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for OGFOD2 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for OGFOD2
- genomics-online: gRNA clones - Search results for 106 available OGFOD2 gene related products
- Overview of 106 available OGFOD2 gene related products
- Applied Biological Materials CRISPR for OGFOD2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for OGFOD2
- GenScript: Design CRISPR guide RNA sequences for OGFOD2
miRNA for OGFOD2 Gene
- miRTarBase miRNAs that target OGFOD2
miRNA Products
- Search ViGene Biosciences for OGFOD2
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 106 available OGFOD2 gene related products
- Overview of 106 available OGFOD2 gene related products
-
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Clone Products
- Sino Biological Human cDNA Clone for OGFOD2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for OGFOD2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for OGFOD2
-
ViGene Biosciences adenoviral particle packaged cDNA for OGFOD2 gene
-
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-
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No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OGFOD2 Gene
Localization for OGFOD2 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| extracellular | 2 |
| cytosol | 2 |
- Nuclear bodies (3)
- Nucleoplasm (3)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OGFOD2 Gene
Pathways & Interactions for OGFOD2 Gene
No Data Available
Interacting Proteins for OGFOD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for OGFOD2 Gene
Drugs & Compounds for OGFOD2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Vitamin C | Approved | Nutra | Target | 581,581 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Fe2+ |
|
15438-31-0 |
|
Transcripts for OGFOD2 Gene
mRNA/cDNA for OGFOD2 Gene
- (7) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (25) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for OGFOD2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for OGFOD2
- genomics-online: gRNA clones - Search results for 106 available OGFOD2 gene related products
- Overview of 106 available OGFOD2 gene related products
- Applied Biological Materials CRISPR for OGFOD2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for OGFOD2
- GenScript: Design CRISPR guide RNA sequences for OGFOD2
miRNA Products
- Search ViGene Biosciences for OGFOD2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OGFOD2
- Browse OriGene Inhibitory RNA Products For OGFOD2
- genomics-online: shRNA clones - Search results for 106 available OGFOD2 gene related products
- Overview of 106 available OGFOD2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for OGFOD2 gene
Clone Products
- Sino Biological Human cDNA Clone for OGFOD2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for OGFOD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for OGFOD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for OGFOD2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | ^ | 9a | · | 9b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 9c | · | 9d | · | 9e | ^ | 10a | · | 10b | · | 10c |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | |||||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: | |||||||||||
| SP13: | |||||||||||
| SP14: | |||||||||||
| SP15: | |||||||||||
| SP16: |
Expression for OGFOD2 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (50.0) and Liver (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OGFOD2 Gene
NURSA nuclear receptor signaling pathways regulating expression of OGFOD2 Gene:
OGFOD2SOURCE GeneReport for Unigene cluster for OGFOD2 Gene:
Hs.524817Evidence on tissue expression from TISSUES for OGFOD2 Gene
- Nervous system(4.5)
- Intestine(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for OGFOD2
-
OriGene qPCR primer pairs for OGFOD2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OGFOD2 Gene
Orthologs for OGFOD2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | OGFOD2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | OGFOD2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | OGFOD2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ogfod2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ogfod2 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | OGFOD2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | OGFOD2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | OGFOD2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | OGFOD2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ogfod2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ogfod2 33 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G22950 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for OGFOD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for OGFOD2 Gene
No data available for Paralogs for OGFOD2 Gene
Variants for OGFOD2 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000288082 | -- | 122,975,098(+) | C/T | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000623774 | -- | 122,974,052(+) | AAATAAATAAA/AAATAAA | upstream_transcript_variant | |
| rs1001007711 | -- | 122,973,489(+) | G/A | upstream_transcript_variant | |
| rs1002014766 | -- | 122,974,914(+) | G/T | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1002122209 | -- | 122,973,717(+) | C/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.98;
36.65% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for OGFOD2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- OGFOD2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGFOD2 Gene
Disorders for OGFOD2 Gene
Additional Disease Information for OGFOD2
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for OGFOD2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OGFOD2 Gene
Publications for OGFOD2 Gene
- Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PMID: 21507922) Ramsuran V … Ndung'u T (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
- Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3 58
- Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S … Sullivan PF (Nature genetics 2013) 3 58
Products for OGFOD2 Gene
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- Invitrogen Antibodies for OGFOD2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for OGFOD2
- VectorBuilder custom plasmid, inducible vectors for OGFOD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for OGFOD2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available OGFOD2 related products ranked by validation data
- antibodies-online: Search results for available OGFOD2 related products ranked by validation data
- antibodies-online: Search results for available OGFOD2 related products ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for OGFOD2 gene
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- Overview of 106 available OGFOD2 gene related products
- genomics-online: shRNA clones - Search results for 106 available OGFOD2 gene related products
- Overview of 106 available OGFOD2 gene related products
Sources for OGFOD2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
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