Aliases for OGA Gene
Aliases for OGA Gene
- O-GlcNAcase 2 3
- Nuclear Cytoplasmic O-GlcNAcase And Acetyltransferase 2 3 4
- Meningioma Expressed Antigen 5 (Hyaluronidase) 2 3 5
- N-Acetyl-Beta-D-Glucosaminidase 3 4
- Meningioma-Expressed Antigen 5 3 4
- N-Acetyl-Beta-Glucosaminidase 3 4
- Beta-N-Acetylglucosaminidase 3 4
- Beta-N-Acetylhexosaminidase 3 4
- Beta-Hexosaminidase 3 4
- MGEA5 3 5
External Ids for OGA Gene
- HGNC: 7056
- Entrez Gene: 10724
- Ensembl: ENSG00000198408
- OMIM: 604039
- UniProtKB: O60502
Previous HGNC Symbols for OGA Gene
- MGEA5
Summaries for OGA Gene
-
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
GeneCards Summary for OGA Gene
OGA (O-GlcNAcase) is a Protein Coding gene. Diseases associated with OGA include Gm2-Gangliosidosis, Ab Variant and Diabetes Mellitus, Insulin-Dependent, 24. Among its related pathways are Insulin resistance.
UniProtKB/Swiss-Prot for OGA Gene
-
Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
-
Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OGA Gene
Genomics for OGA Gene
GeneHancer (GH) Regulatory Elements for OGA Gene
Promoters and enhancers for OGA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around OGA on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for OGA Gene
Genomic Locations for OGA Gene
- chr10:101,784,443-101,818,709
- (GRCh38/hg38)
- Size:
- 34,267 bases
- Orientation:
- Minus strand
- chr10:103,544,200-103,578,696
- (GRCh37/hg19)
- Size:
- 34,497 bases
- Orientation:
- Minus strand
Genomic View for OGA Gene
Genes around OGA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q24.32 by Entrez Gene
- 10q24.32 by HGNC
- 10q24.32 by Ensembl
OGA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OGA Gene
Proteins for OGA Gene
-
Protein details for OGA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60502-OGA_HUMAN
- Recommended name:
- Protein O-GlcNAcase
- Protein Accession:
- O60502
- B7WPB9
- D3DR79
- E9PGF9
- O75166
- Q86WV0
- Q8IV98
- Q9BVA5
- Q9HAR0
Protein attributes for OGA Gene
- Size:
- 916 amino acids
- Molecular mass:
- 102915 Da
- Quaternary structure:
-
- Monomer (PubMed:11788610). Interacts with CLOCK (By similarity).
- SequenceCaution:
-
- Sequence=AAH47877.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA31654.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for OGA Gene
Post-translational modifications for OGA Gene
- Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for OGA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for OGA
- Invitrogen Antibodies for OGA (AFLGC-MGEA5)
- GeneTex MGEA5 Antibody for OGA
Protein Products
-
OriGene Purified Proteins for OGA
- Search Origene for MassSpec and Protein Over-expression Lysates for OGA
- Origene Custom Protein Services for OGA
- Search GeneTex for Proteins for OGA
-
Abcam proteins for OGA
Assay Products
No data available for DME Specific Peptides for OGA Gene
Domains & Families for OGA Gene
Gene Families for OGA Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for OGA Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for OGA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O60502- Family:
-
- Belongs to the glycosyl hydrolase 84 family.
Function for OGA Gene
Molecular function for OGA Gene
- UniProtKB/Swiss-Prot Function:
- Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
- UniProtKB/Swiss-Prot Function:
- Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.
- UniProtKB/Swiss-Prot CatalyticActivity:
- [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine.
- UniProtKB/Swiss-Prot CatalyticActivity:
- [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H(2)O = [protein]-L-threonine + N-acetyl-D-glucosamine.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by N-acetylglucosamine and not N-acetylgalactosamine.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=1.1 mM for pNP-GlcNAc {ECO:0000269 PubMed:11788610}; Vmax=652 umol/min/mg enzyme with pNP-GLcNAc as substrate {ECO:0000269 PubMed:11788610}; pH dependence: Optimum pH is 5.7-7. {ECO:0000269 PubMed:11148210};
Enzyme Numbers (IUBMB) for OGA Gene
Phenotypes From GWAS Catalog for OGA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004415 | hyalurononglucosaminidase activity | TAS | 9811929 |
| GO:0016231 | beta-N-acetylglucosaminidase activity | IDA | 11148210 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA | -- |
| GO:0102166 | [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity | IEA | -- |
Phenotypes for OGA Gene
- MGI mutant phenotypes for OGA:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for OGA:
Animal Model Products
-
Taconic Biosciences Mouse Models for OGA
- Cyagen custom Knockout/knockin (KOKI) mouse models for OGA
-
CRISPR Products
-
OriGene CRISPR knockouts for OGA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OGA
- genomics-online: gRNA clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- Applied Biological Materials CRISPR for OGA
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for OGA
miRNA for OGA Gene
- miRTarBase miRNAs that target OGA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OGA
- Browse OriGene Inhibitory RNA Products For OGA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OGA
- genomics-online: shRNA clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
Clone Products
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OGA
- genomics-online: cdna clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- orf clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- Applied Biological Materials Clones for OGA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for OGA
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OGA Gene
Localization for OGA Gene
Subcellular locations from UniProtKB/Swiss-Prot for OGA Gene
- Isoform 3: Nucleus.
- Isoform 1: Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| plasma membrane | 3 |
| lysosome | 3 |
| extracellular | 2 |
| mitochondrion | 2 |
| endosome | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | 11148210 |
| GO:0016020 | membrane | HDA | 19946888 |
Pathways & Interactions for OGA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Insulin resistance | ||
Pathways by source for OGA Gene
1 BioSystems pathway for OGA Gene
1 KEGG pathway for OGA Gene
Interacting Proteins for OGA Gene
GPS-Prot Interaction Network for OGA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006044 | N-acetylglucosamine metabolic process | IDA | 11148210 |
| GO:0006493 | protein O-linked glycosylation | NAS | 26363795 |
| GO:0006516 | glycoprotein catabolic process | TAS | 9811929 |
| GO:0006517 | protein deglycosylation | IDA | 11148210 |
| GO:0008152 | metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for OGA Gene
Drugs & Compounds for OGA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Streptozocin | Approved, Investigational | Pharma | Target | Antibiotic and antitumor agent | 11 | |
| Water | Approved | Pharma | 0 | |||
| N-Acetyl-D-glucosamine | Approved, Investigational | Nutra | 0 | |||
| Coenzyme A | Investigational | Nutra | 0 | |||
| (Z)-Pugnac | Pharma | Inhibitor of O-GlcNAcase and β-hexosaminidase | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| acetyl-coa |
|
72-89-9 |
|
Drug Products
Transcripts for OGA Gene
mRNA/cDNA for OGA Gene
- (5) REFSEQ mRNAs :
- (692) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000361464 5155 bps (uc001ktv.3)
- ENST00000462994 1088 bps (uc057voe.1)
- ENST00000482611 1664 bps (uc001ktu.3)
- ENST00000357797 3263 bps (uc009xws.3)
- ENST00000494347 712 bps (uc057vof.1)
CRISPR Products
-
OriGene CRISPR knockouts for OGA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OGA
- genomics-online: gRNA clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- Applied Biological Materials CRISPR for OGA
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for OGA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OGA
- Browse OriGene Inhibitory RNA Products For OGA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OGA
- genomics-online: shRNA clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
Clone Products
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OGA
- genomics-online: cdna clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- orf clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- Applied Biological Materials Clones for OGA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for OGA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Endocardial Tube Cells Endocardium
NURSA nuclear receptor signaling pathways regulating expression of OGA Gene:
OGAmRNA Expression by UniProt/SwissProt for OGA Gene:
O60502-OGA_HUMAN
Tissue specificity:
Ubiquitous. Shows highest expression in the brain, placenta and pancreas.
Evidence on tissue expression from TISSUES for OGA Gene
- Nervous system(5)
- Eye(4.6)
- Skin(4.6)
- Stomach(4.6)
- Lung(4.1)
- Kidney(4)
- Intestine(3.5)
- Urine(3.5)
- Blood(3)
- Heart(2.9)
- Liver(2.8)
- Spleen(2.7)
- Bone marrow(2.6)
- Muscle(2.6)
Primer Products
-
OriGene qPCR primer pairs for OGA
- genomics-online: primer clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OGA Gene
Orthologs for OGA Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MGEA5 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | MGEA5 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MGEA5 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MGEA5 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Mgea5 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Mgea5 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | MGEA5 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MGEA5 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mgea5 33 |
|
||
| Str.17607 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.17870 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mgea5 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Oga 34 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002287 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | oga-1 34 33 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for OGA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for OGA Gene
- ENSEMBL:
- Gene Tree for OGA (if available)
- TreeFam:
- Gene Tree for OGA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for OGA: view image
Paralogs for OGA Gene
No data available for Paralogs for OGA Gene
Variants for OGA Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000059290 | -- | 101,817,285(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000224430 | -- | 101,804,565(-) | G/A | intron_variant | |
| rs1000234527 | -- | 101,810,934(-) | G/A | intron_variant | |
| rs1000349212 | -- | 101,798,596(-) | T/C | intron_variant | |
| rs1000403832 | -- | 101,810,630(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv171n67 | CNV | gain | 20364138 |
| esv1006576 | CNV | deletion | 20482838 |
Residual Variation Intolerance Score:
9.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.95;
36.18% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for OGA Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- OGA
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGA Gene
Disorders for OGA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gm2-gangliosidosis, ab variant |
|
|
| diabetes mellitus, insulin-dependent, 24 |
|
|
| urinary system disease |
|
|
| meningioma, familial |
|
|
| renal tuberculosis |
|
|
Search OGA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for OGA
No data available for UniProtKB/Swiss-Prot and Genatlas for OGA Gene
Publications for OGA Gene
- Novel immunogenic antigen homologous to hyaluronidase in meningioma. (PMID: 9811929) Heckel D … Meese E (Human molecular genetics 1998) 2 3 4 22 58
- Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase. (PMID: 11341771) Comtesse N … Meese E (Biochemical and biophysical research communications 2001) 3 4 22 58
- Human OGA binds substrates in a conserved peptide recognition groove. (PMID: 20863279) Schimpl M … van Aalten DM (The Biochemical journal 2010) 3 4 58
- Isoforms of human O-GlcNAcase show distinct catalytic efficiencies. (PMID: 20673219) Li J … Wang P (Biochemistry. Biokhimiia 2010) 3 4 58
- The histone acetyltransferase NCOAT contains a zinc finger-like motif involved in substrate recognition. (PMID: 16356930) Toleman CA … Kudlow JE (The Journal of biological chemistry 2006) 2 3 58
Products for OGA Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for OGA
- Search Origene for MassSpec and Protein Over-expression Lysates for OGA
- Origene Custom Protein Services for OGA
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OGA
- Browse OriGene Inhibitory RNA Products For OGA
- OriGene qPCR primer pairs for OGA
- OriGene CRISPR knockouts for OGA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For OGA
- GenScript: Next-day shipping of latest version cDNA ORF clones for OGA in any vector
- GenScript Custom Purified and Recombinant Proteins Services for OGA
- GenScript Custom Assay Services for OGA
- GenScript Custom overexpressing Cell Line Services for OGA
- GenScript: Design CRISPR guide RNA sequences for OGA
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for OGA
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for OGA
- Novus Biologicals proteins and lysates for OGA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for OGA
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for OGA
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for OGA (AFLGC-MGEA5)
- Cyagen custom Knockout/knockin (KOKI) mouse models for OGA
- antibodies-online: Search results for 22 available MGEA5 Antibodies ranked by validation data
- Compare Top MGEA5 Antibodies
- antibodies-online: Search results for available MGEA5 related products ranked by validation data
- antibodies-online: Search results for 5 available MGEA5 Proteins ranked by validation data
- Compare Top MGEA5 Proteins
- GeneTex MGEA5 Antibody for OGA
- Search GeneTex for Proteins for OGA
- Horizon Cell Lines for OGA
- genomics-online: cdna clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
- Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- orf clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
- Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- genomics-online: gRNA clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
- Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- genomics-online: primer clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
- Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- genomics-online: shRNA clones - Search results for 88 available MGEA5 gene related products
- Overview of 88 available MGEA5 gene related products
- Recommended
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- pCMV6-XL4
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-C-shLenti
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OGA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OGA
- GeneCopoeia miRNA 3'UTR Target clone products for OGA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OGA
Sources for OGA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt