OGA Gene (Protein Coding)

O-GlcNAcase

GC10M101785
GIFtS:
33
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008] See more...

Aliases for OGA Gene

Aliases for OGA Gene

  • O-GlcNAcase 2 3 5
  • Nuclear Cytoplasmic O-GlcNAcase And Acetyltransferase 2 3 4
  • Meningioma Expressed Antigen 5 (Hyaluronidase) 2 3
  • N-Acetyl-Beta-D-Glucosaminidase 3 4
  • Meningioma-Expressed Antigen 5 3 4
  • N-Acetyl-Beta-Glucosaminidase 3 4
  • Beta-N-Acetylglucosaminidase 3 4
  • Beta-N-Acetylhexosaminidase 3 4
  • Beta-Hexosaminidase 3 4
  • Protein O-GlcNAcase 3 4
  • MGEA5 3 4
  • NCOAT 3 4
  • MEA5 3 4
  • Hyaluronidase In Meningioma 3
  • Bifunctional Protein NCOAT 3
  • EC 3.2.1.169 4
  • KIAA0679 4
  • HEXC 4

External Ids for OGA Gene

Previous HGNC Symbols for OGA Gene

  • MGEA5

Summaries for OGA Gene

Entrez Gene Summary for OGA Gene

  • The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

GeneCards Summary for OGA Gene

OGA (O-GlcNAcase) is a Protein Coding gene. Diseases associated with OGA include Danubian Endemic Familial Nephropathy and Gm2-Gangliosidosis, Ab Variant. Among its related pathways are Insulin resistance.

UniProtKB/Swiss-Prot Summary for OGA Gene

  • [Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
  • [Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.

Gene Wiki entry for OGA Gene

Additional gene information for OGA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OGA Gene

Genomics for OGA Gene

GeneHancer (GH) Regulatory Elements for OGA Gene

Promoters and enhancers for OGA Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10J101814 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.6 1600 5.9 RXRA FOXK2 ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A NRF1 MYC POLR2G KCNIP2-AS1 OGA HPS6 PPRC1 MRPL43 GBF1 LDB1 TWNK SUFU NPM3
GH10J102000 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.1 -183.0 -182991 7.8 RXRA SP1 EP300 ZNF623 RFX1 RELA MEF2C TRIM22 BCL11A ZNF266 HPS6 LDB1 PPRC1 ARMH3 KCNIP2-AS1 KCNIP2 ARL3 GBF1 OGA NFKB2
GH10J102007 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.5 -190.3 -190292 5.6 CTCF JUND TEAD4 FOS RCOR1 RAD21 TRIM22 TEAD1 DEK SMC3 HPS6 KCNIP2 ARMH3 KCNIP2-AS1 OGA FGF8 POLL DPCD piR-33614-033 ENSG00000222430
GH10J102111 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2.7 -299.0 -299025 11.6 EP300 CTCF SIN3A NRF1 TCF12 POLR2G USF1 SP1 PHF8 TEAD4 LDB1 PPRC1 HPS6 NFKB2 GBF1 NOLC1 BORCS7 C10orf95 KCNIP2-AS1 KCNIP2
GH10J101692 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 1.2 +124.3 124320 3.2 HNRNPK ZBTB40 NRF1 TCF12 POLR2G USF1 GTF2E2 PHF8 ZFX ZNF639 ENSG00000286489 FBXW4 MRPL43 PPRC1 LDB1 GBF1 ENSG00000272572 HPS6 TWNK SUFU
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OGA on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OGA

Genomic Locations for OGA Gene

Genomic Locations for OGA Gene
chr10:101,784,443-101,818,709
(GRCh38/hg38)
Size:
34,267 bases
Orientation:
Minus strand
chr10:103,544,200-103,578,696
(GRCh37/hg19)
Size:
34,497 bases
Orientation:
Minus strand

Genomic View for OGA Gene

Genes around OGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OGA Gene

Proteins for OGA Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for OGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60502-OGA_HUMAN
    Recommended name:
    Protein O-GlcNAcase
    Protein Accession:
    O60502
    Secondary Accessions:
    • B7WPB9
    • D3DR79
    • E9PGF9
    • O75166
    • Q86WV0
    • Q8IV98
    • Q9BVA5
    • Q9HAR0

    Protein attributes for OGA Gene

    Size:
    916 amino acids
    Molecular mass:
    102915 Da
    Quaternary structure:
    • Monomer (PubMed:11788610). Interacts with CLOCK (By similarity).
    • (Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein Tax; this interaction increases Tax interacting partner CREB1 O-GlcNAcylation.
    SequenceCaution:
    • Sequence=AAH47877.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA31654.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OGA Gene

    Alternative splice isoforms for OGA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGA Gene

Post-translational modifications for OGA Gene

  • Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.
  • Glycosylation at Ser405
  • Ubiquitination at Lys87, Lys240, Lys297, Lys723, Lys858, and Lys869
  • Modification sites at PhosphoSitePlus

Other Protein References for OGA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OGA Gene

Domains & Families for OGA Gene

Gene Families for OGA Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for OGA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OGA Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54806, highly similar to Homo sapiens meningioma expressed antigen 5 (MGEA5), mRNA (B4DYV7_HUMAN)
  • Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60502

UniProtKB/Swiss-Prot:

OGA_HUMAN :
  • Belongs to the glycosyl hydrolase 84 family.
Family:
  • Belongs to the glycosyl hydrolase 84 family.
genes like me logo Genes that share domains with OGA: view

Function for OGA Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for OGA Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
UniProtKB/Swiss-Prot Function:
[Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine; Xref=Rhea:RHEA:48876, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12251, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:90838, ChEBI:CHEBI:506227; EC=3.2.1.169; Evidence={ECO:0000269 PubMed:11148210, ECO:0000269 PubMed:11788610, ECO:0000269 PubMed:18586680, ECO:0000269 PubMed:20863279, ECO:0000269 PubMed:22365600, ECO:0000305 PubMed:20673219};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine; Xref=Rhea:RHEA:48892, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:12252, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:90840, ChEBI:CHEBI:506227; EC=3.2.1.169; Evidence={ECO:0000269 PubMed:11148210, ECO:0000269 PubMed:11788610, ECO:0000269 PubMed:18586680, ECO:0000269 PubMed:20863279, ECO:0000269 PubMed:22365600, ECO:0000305 PubMed:20673219};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-acetylglucosamine and not N-acetylgalactosamine.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.1 mM for pNP-GlcNAc {ECO:0000269 PubMed:11788610}; Vmax=652 umol/min/mg enzyme with pNP-GLcNAc as substrate {ECO:0000269 PubMed:11788610}; pH dependence: Optimum pH is 5.7-7. {ECO:0000269 PubMed:11148210};

Enzyme Numbers (IUBMB) for OGA Gene

Phenotypes From GWAS Catalog for OGA Gene

Gene Ontology (GO) - Molecular Function for OGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004415 hyalurononglucosaminidase activity TAS 9811929
GO:0016231 beta-N-acetylglucosaminidase activity IBA,IDA 11148210
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0102166 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity IEA --
genes like me logo Genes that share ontologies with OGA: view
genes like me logo Genes that share phenotypes with OGA: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OGA Gene

Localization for OGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGA Gene

[Isoform 3]: Nucleus.
[Isoform 1]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OGA gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
lysosome 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 11148210
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with OGA: view

Pathways & Interactions for OGA Gene

PathCards logo

SuperPathways for OGA Gene

genes like me logo Genes that share pathways with OGA: view

Pathways by source for OGA Gene

1 BioSystems pathway for OGA Gene
1 KEGG pathway for OGA Gene

Gene Ontology (GO) - Biological Process for OGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006044 N-acetylglucosamine metabolic process IDA 11148210
GO:0006493 protein O-linked glycosylation NAS 26363795
GO:0006516 glycoprotein catabolic process TAS 9811929
GO:0006517 protein deglycosylation IDA 11148210
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with OGA: view

No data available for SIGNOR curated interactions for OGA Gene

Drugs & Compounds for OGA Gene

Products:

  1. Drug

(7) Drugs for OGA Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Streptozocin Approved, Investigational Pharma Target Antibiotic and antitumor agent 12
Water Approved Pharma 0
N-Acetyl-D-glucosamine Approved, Investigational Nutra 0
Coenzyme A Investigational Nutra 0
(Z)-Pugnac Pharma Inhibitor of O-GlcNAcase and β-hexosaminidase 0

(1) Additional Compounds for OGA Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
 72-89-9

(3) ApexBio Compounds for OGA Gene

Compound Action Cas Number
(Z)-Pugnac Inhibitor of O-GlcNAcase and β-hexosaminidase 132489-69-1
GlcNAcstatin Selective O-GlcNAcase inhibitor 922163-64-2
Thiamet G O-GlcNAcase inhibitor, potent and selective 1009816-48-1
genes like me logo Genes that share compounds with OGA: view

Drug Products

Transcripts for OGA Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for OGA Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OGA Gene

No ASD Table

Relevant External Links for OGA Gene

GeneLoc Exon Structure for
OGA

Expression for OGA Gene

Products:

  1. Primer

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OGA

mRNA Expression by UniProt/SwissProt for OGA Gene:

O60502-OGA_HUMAN
Tissue specificity: Ubiquitous. Shows highest expression in the brain, placenta and pancreas.

Evidence on tissue expression from TISSUES for OGA Gene

  • Nervous system(5)
  • Eye(4.6)
  • Skin(4.6)
  • Stomach(4.6)
  • Lung(4.1)
  • Kidney(4)
  • Intestine(3.5)
  • Urine(3.5)
  • Blood(3)
  • Heart(2.9)
  • Liver(2.8)
  • Spleen(2.7)
  • Bone marrow(2.6)
  • Muscle(2.6)
genes like me logo Genes that share expression patterns with OGA: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OGA Gene

Orthologs for OGA Gene

This gene was present in the common ancestor of animals.

Orthologs for OGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MGEA5 31 30
  • 99.71 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 97 (a)
 OneToMany
-- 31
  • 91 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia MGEA5 31
  • 96 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia MGEA5 31 30
  • 94.98 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia MGEA5 31 30
  • 94.43 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Mgea5 30
  • 91.01 (n)
mouse
(Mus musculus)
 Mammalia Mgea5 31 30
  • 90.83 (n)
 OneToOne
Oga 17
chicken
(Gallus gallus)
 Aves MGEA5 31 30
  • 81.21 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MGEA5 31
  • 87 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mgea5 30
  • 74.4 (n)
Str.17607 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.17870 30
zebrafish
(Danio rerio)
 Actinopterygii mgea5 31 30
  • 74.44 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Oga 31 30
  • 52.81 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002287 30
  • 52.42 (n)
worm
(Caenorhabditis elegans)
 Secernentea oga-1 31 30
  • 45.28 (n)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 41 (a)
 OneToOne
Species where no ortholog for OGA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OGA Gene

ENSEMBL:
Gene Tree for OGA (if available)
TreeFam:
Gene Tree for OGA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OGA: view image

Paralogs for OGA Gene

No data available for Paralogs for OGA Gene

Variants for OGA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OGA Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
725503 Benign: not provided 101,813,613(-) T/G INTRON_VARIANT
750052 Likely Benign: not provided 101,806,151(-) T/C INTRON_VARIANT
773006 Likely Benign: not provided 101,800,403(-) G/A INTRON_VARIANT
rs17853930 - p.Glu602Lys
rs3740421 - p.Gly46Glu

Additional dbSNP identifiers (rs#s) for OGA Gene

Structural Variations from Database of Genomic Variants (DGV) for OGA Gene

Variant ID Type Subtype PubMed ID
dgv171n67 CNV gain 20364138
esv1006576 CNV deletion 20482838

Variation tolerance for OGA Gene

Residual Variation Intolerance Score: 9.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OGA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGA Gene

Disorders for OGA Gene

MalaCards: The human disease database

(15) MalaCards diseases for OGA Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
danubian endemic familial nephropathy
  • defn
gm2-gangliosidosis, ab variant
  • hexosaminidase activator deficiency
gm2 gangliosidosis
  • gangliosidosis gm2
sandhoff disease
  • gm2-gangliosidosis, type ii
diabetes mellitus, insulin-dependent, 24
  • iddm24
- elite association - COSMIC cancer census association via MalaCards
Search OGA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OGA

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OGA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OGA Gene

Publications for OGA Gene

  1. Novel immunogenic antigen homologous to hyaluronidase in meningioma. (PMID: 9811929) Heckel D … Meese E (Human molecular genetics 1998) 2 3 4 23 54
  2. Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase. (PMID: 11341771) Comtesse N … Meese E (Biochemical and biophysical research communications 2001) 3 4 23 54
  3. Hijacking of the O-GlcNAcZYME complex by the HTLV-1 Tax oncoprotein facilitates viral transcription. (PMID: 28742148) Groussaud D … Issad T (PLoS pathogens 2017) 3 4 54
  4. Human OGA binds substrates in a conserved peptide recognition groove. (PMID: 20863279) Schimpl M … van Aalten DM (The Biochemical journal 2010) 3 4 54
  5. Isoforms of human O-GlcNAcase show distinct catalytic efficiencies. (PMID: 20673219) Li J … Wang P (Biochemistry. Biokhimiia 2010) 3 4 54

ExternalLinks

View latest publications for OGA gene in Mastermind

Products for OGA Gene

Sources for OGA Gene