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The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
OGA (O-GlcNAcase) is a Protein Coding gene. Diseases associated with OGA include Danubian Endemic Familial Nephropathy and Gm2 Gangliosidosis. Among its related pathways are Insulin resistance.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004415 | hyalurononglucosaminidase activity | TAS | 9811929 |
GO:0016231 | beta-N-acetylglucosaminidase activity | IBA,IDA | 11148210 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016798 | hydrolase activity, acting on glycosyl bonds | IEA | -- |
GO:0102166 | [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IDA | 11148210 |
GO:0016020 | membrane | HDA | 19946888 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Insulin resistance |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006044 | N-acetylglucosamine metabolic process | IDA | 11148210 |
GO:0006493 | protein O-linked glycosylation | NAS | 26363795 |
GO:0006516 | glycoprotein catabolic process | TAS | 9811929 |
GO:0006517 | protein deglycosylation | IDA | 11148210 |
GO:0008152 | metabolic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Streptozocin | Approved, Investigational | Pharma | Target | Antibiotic and antitumor agent | 13 | |
Water | Approved | Pharma | 0 | |||
N-Acetyl-D-glucosamine | Approved, Investigational | Nutra | 0 | |||
Coenzyme A | Investigational | Nutra | 0 | |||
Thiamet G | Pharma | O-GlcNAcase inhibitor, potent and selective | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
acetyl-coa |
|
72-89-9 |
|
Compound | Action | Cas Number |
---|---|---|
Thiamet G | O-GlcNAcase inhibitor, potent and selective | 1009816-48-1 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MGEA5 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | MGEA5 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MGEA5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MGEA5 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mgea5 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mgea5 30 31 |
|
OneToOne | |
Oga 17 |
|
||||
Chicken (Gallus gallus) |
Aves | MGEA5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MGEA5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mgea5 30 |
|
||
Str.17607 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.17870 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mgea5 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Oga 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002287 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | oga-1 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1277662599 | Likely Benign: not provided | 101,806,151(-) |
T/C NM_012215.5(OGA):c.653-8A>G |
||
rs139911468 | Likely Benign: not provided | 101,800,403(-) |
G/A NM_012215.5(OGA):c.1037-3C>T |
||
rs200540327 | Benign: not provided | 101,813,613(-) |
T/G NM_012215.5(OGA):c.200-7A>C |
||
rs17853930 | - |
p.Glu602Lys |
|||
rs3740421 | - |
p.Gly46Glu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv171n67 | CNV | gain | 20364138 |
esv1006576 | CNV | deletion | 20482838 |
Disorder | Aliases | PubMed IDs |
---|---|---|
danubian endemic familial nephropathy |
|
|
gm2 gangliosidosis |
|
|
sandhoff disease |
|
|
gm2-gangliosidosis, ab variant |
|
|
tay-sachs disease |
|
|