Aliases for OGA Gene
- O-GlcNAcase 2 3 5
- Nuclear Cytoplasmic O-GlcNAcase And Acetyltransferase 2 3 4
- Meningioma Expressed Antigen 5 (Hyaluronidase) 2 3
- N-Acetyl-Beta-D-Glucosaminidase 3 4
- Meningioma-Expressed Antigen 5 3 4
- N-Acetyl-Beta-Glucosaminidase 3 4
- Beta-N-Acetylglucosaminidase 3 4
- Beta-N-Acetylhexosaminidase 3 4
- Beta-Hexosaminidase 3 4
External Ids for OGA Gene
Previous HGNC Symbols for OGA Gene
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
GeneCards Summary for OGA Gene
OGA (O-GlcNAcase) is a Protein Coding gene. Diseases associated with OGA include Danubian Endemic Familial Nephropathy and Gm2-Gangliosidosis, Ab Variant. Among its related pathways are Insulin resistance.
UniProtKB/Swiss-Prot Summary for OGA Gene
[Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
[Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.