OGA Gene (Protein Coding)

O-GlcNAcase

GC10M101785
GIFtS:
33
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008] See more...

Aliases for OGA Gene

Aliases for OGA Gene

  • O-GlcNAcase 2 3 5
  • Nuclear Cytoplasmic O-GlcNAcase And Acetyltransferase 2 3 4
  • NCOAT 2 3 4
  • MEA5 2 3 4
  • Meningioma Expressed Antigen 5 (Hyaluronidase) 2 3
  • N-Acetyl-Beta-D-Glucosaminidase 3 4
  • Meningioma-Expressed Antigen 5 3 4
  • N-Acetyl-Beta-Glucosaminidase 3 4
  • Beta-N-Acetylglucosaminidase 3 4
  • Beta-N-Acetylhexosaminidase 3 4
  • Protein O-GlcNAcase 3 4
  • Beta-Hexosaminidase 3 4
  • MGEA5 3 4
  • Hyaluronidase In Meningioma 3
  • Bifunctional Protein NCOAT 3
  • EC 3.2.1.169 4
  • KIAA0679 4
  • HEXC 4
  • OGA 5

External Ids for OGA Gene

Previous HGNC Symbols for OGA Gene

  • MGEA5

Summaries for OGA Gene

Entrez Gene Summary for OGA Gene

  • The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

GeneCards Summary for OGA Gene

OGA (O-GlcNAcase) is a Protein Coding gene. Diseases associated with OGA include Danubian Endemic Familial Nephropathy and Gm2 Gangliosidosis. Among its related pathways are Insulin resistance.

UniProtKB/Swiss-Prot Summary for OGA Gene

  • [Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
  • [Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.

Gene Wiki entry for OGA Gene

Additional gene information for OGA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OGA Gene

Genomics for OGA Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OGA Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10J101814 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.6 1600 5.9 BCLAF1 SP1 ZNF207 IKZF1 NCOR1 ZNF600 MYC SIX5 SSRP1 JUND KCNIP2-AS1 OGA HPS6 PPRC1 MRPL43 GBF1 LDB1 TWNK SUFU NPM3
GH10J102131 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 20.4 -314.9 -314857 3.5 BCLAF1 ZNF207 MYC ZNF654 IKZF1 ZNF600 SIX5 ZNF580 ZNF592 KLF9 PPRC1 NOLC1 OGA HPS6 SFXN2 GBF1 LDB1 ARL3 KCNIP2-AS1 BORCS7
GH10J101828 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.6 -12.1 -12073 4.8 SP1 ZNF207 ZNF600 ZNF580 ATF2 ZNF223 ZSCAN16 ZIC2 ZBTB10 SIN3A PPRC1 LDB1 LZTS2 GBF1 MRPL43 HPS6 NOLC1 SUFU ENSG00000272572 SLF2
GH10J101692 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.9 +124.3 124320 3.2 BCLAF1 MYC IKZF1 ZNF600 ZNF580 ZNF592 POLR2A ZNF10 ZIC2 ZBTB10 ENSG00000286489 FBXW4 HSALNG0080233 PPRC1 GBF1 MRPL43 LDB1 ENSG00000272572 HPS6 OGA
GH10J102054 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.2 -237.0 -236987 2.6 BCLAF1 SP1 ZNF207 MYC SIX5 JUND ZNF592 KLF9 POLR2A BRCA1 ARMH3 lnc-HPS6-4 OGA NOLC1 KCNIP2 piR-43583-059
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OGA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OGA

Genomic Locations for OGA Gene

Latest Assembly
chr10:101,784,443-101,818,709
(GRCh38/hg38)
Size:
34,267 bases
Orientation:
Minus strand

Previous Assembly
chr10:103,544,207-103,578,201
(GRCh37/hg19 by Entrez Gene)
Size:
33,995 bases
Orientation:
Minus strand

chr10:103,544,200-103,578,696
(GRCh37/hg19 by Ensembl)
Size:
34,497 bases
Orientation:
Minus strand

Genomic View for OGA Gene

Genes around OGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OGA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OGA Gene

Proteins for OGA Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for OGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60502-OGA_HUMAN
    Recommended name:
    Protein O-GlcNAcase
    Protein Accession:
    O60502
    Secondary Accessions:
    • B7WPB9
    • D3DR79
    • E9PGF9
    • O75166
    • Q86WV0
    • Q8IV98
    • Q9BVA5
    • Q9HAR0

    Protein attributes for OGA Gene

    Size:
    916 amino acids
    Molecular mass:
    102915 Da
    Quaternary structure:
    • Monomer (PubMed:11788610). Interacts with CLOCK (By similarity).
    • (Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein Tax; this interaction increases Tax interacting partner CREB1 O-GlcNAcylation.
    SequenceCaution:
    • Sequence=AAH47877.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA31654.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OGA Gene

    Alternative splice isoforms for OGA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OGA Gene

Post-translational modifications for OGA Gene

  • Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.
  • Glycosylation at Ser405
  • Ubiquitination at Lys87, Lys240, Lys297, Lys723, Lys858, and Lys869
  • Modification sites at PhosphoSitePlus

Other Protein References for OGA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OGA Gene

Domains & Families for OGA Gene

Gene Families for OGA Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for OGA Gene

InterPro:

Suggested Antigen Peptide Sequences for OGA Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54806, highly similar to Homo sapiens meningioma expressed antigen 5 (MGEA5), mRNA (B4DYV7_HUMAN)
  • Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60502

UniProtKB/Swiss-Prot:

OGA_HUMAN :
  • Belongs to the glycosyl hydrolase 84 family.
Family:
  • Belongs to the glycosyl hydrolase 84 family.
genes like me logo Genes that share domains with OGA: view

Function for OGA Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for OGA Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
UniProtKB/Swiss-Prot Function:
[Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine; Xref=Rhea:RHEA:48876, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:12251, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:90838, ChEBI:CHEBI:506227; EC=3.2.1.169; Evidence={ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11788610, ECO:0000269|PubMed:18586680, ECO:0000269|PubMed:20863279, ECO:0000269|PubMed:22365600, ECO:0000305|PubMed:20673219};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine; Xref=Rhea:RHEA:48892, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:12252, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:90840, ChEBI:CHEBI:506227; EC=3.2.1.169; Evidence={ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11788610, ECO:0000269|PubMed:18586680, ECO:0000269|PubMed:20863279, ECO:0000269|PubMed:22365600, ECO:0000305|PubMed:20673219};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.1 mM for pNP-GlcNAc {ECO:0000269|PubMed:11788610}; Vmax=652 umol/min/mg enzyme with pNP-GLcNAc as substrate {ECO:0000269|PubMed:11788610}; pH dependence: Optimum pH is 5.7-7. {ECO:0000269|PubMed:11148210};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-acetylglucosamine and not N-acetylgalactosamine.

Enzyme Numbers (IUBMB) for OGA Gene

Phenotypes From GWAS Catalog for OGA Gene

Gene Ontology (GO) - Molecular Function for OGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004415 hyalurononglucosaminidase activity TAS 9811929
GO:0016231 beta-N-acetylglucosaminidase activity IBA,IDA 11148210
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0102166 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity IEA --
genes like me logo Genes that share ontologies with OGA: view
genes like me logo Genes that share phenotypes with OGA: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OGA

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OGA Gene

Localization for OGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for OGA Gene

[Isoform 3]: Nucleus.
[Isoform 1]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OGA gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
lysosome 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 11148210
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with OGA: view

Pathways & Interactions for OGA Gene

PathCards logo

SuperPathways for OGA Gene

genes like me logo Genes that share pathways with OGA: view

Pathways by source for OGA Gene

1 BioSystems pathway for OGA Gene
1 KEGG pathway for OGA Gene

Gene Ontology (GO) - Biological Process for OGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006044 N-acetylglucosamine metabolic process IDA 11148210
GO:0006493 protein O-linked glycosylation NAS 26363795
GO:0006516 glycoprotein catabolic process TAS 9811929
GO:0006517 protein deglycosylation IDA 11148210
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with OGA: view

No data available for SIGNOR curated interactions for OGA Gene

Drugs & Compounds for OGA Gene

Products:

  1. Drug products for research

(5) Drugs for OGA Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Streptozocin Approved, Investigational Pharma Target Antibiotic and antitumor agent 13
Water Approved Pharma 0
N-Acetyl-D-glucosamine Approved, Investigational Nutra 0
Coenzyme A Investigational Nutra 0
Thiamet G Pharma O-GlcNAcase inhibitor, potent and selective 0

(1) Additional Compounds for OGA Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • AcCoA
  • Acetyl coenzyme A
  • S-Acetyl-CoA
  • S-Acetyl-coenzyme A
  • Ac-CoA
 72-89-9

(1) ApexBio Compounds for OGA Gene

Compound Action Cas Number
Thiamet G O-GlcNAcase inhibitor, potent and selective 1009816-48-1
genes like me logo Genes that share compounds with OGA: view

Drug products for research

Transcripts for OGA Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for OGA Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OGA

Alternative Splicing Database (ASD) splice patterns (SP) for OGA Gene

No ASD Table

Relevant External Links for OGA Gene

GeneLoc Exon Structure for
OGA

Expression for OGA Gene

Products:

  1. Primer products for research

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OGA

mRNA Expression by UniProt/SwissProt for OGA Gene:

O60502-OGA_HUMAN
Tissue specificity: Ubiquitous. Shows highest expression in the brain, placenta and pancreas.

Evidence on tissue expression from TISSUES for OGA Gene

  • Nervous system(5)
  • Eye(4.7)
  • Skin(4.7)
  • Stomach(4.7)
  • Lung(4.1)
  • Intestine(3.8)
  • Kidney(3.7)
  • Heart(3.2)
  • Spleen(3)
  • Urine(3)
  • Bone marrow(3)
  • Muscle(3)
  • Liver(2.9)
  • Blood(2.9)
  • Lymph node(2.7)
  • Pancreas(2.3)
  • Thyroid gland(2.3)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with OGA: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OGA Gene

Orthologs for OGA Gene

This gene was present in the common ancestor of animals.

Orthologs for OGA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MGEA5 29 30
  • 99.71 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 97 (a)
 OneToMany
-- 30
  • 91 (a)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia MGEA5 30
  • 96 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MGEA5 29 30
  • 94.98 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MGEA5 29 30
  • 94.43 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mgea5 29
  • 91.01 (n)
Mouse
(Mus musculus)
 Mammalia Mgea5 29 30
  • 90.83 (n)
 OneToOne
Oga 16
Chicken
(Gallus gallus)
 Aves MGEA5 29 30
  • 81.21 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MGEA5 30
  • 87 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia mgea5 29
  • 74.4 (n)
Str.17607 29
African clawed frog
(Xenopus laevis)
 Amphibia Xl.17870 29
Zebrafish
(Danio rerio)
 Actinopterygii mgea5 29 30
  • 74.44 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta Oga 29 30
  • 52.81 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002287 29
  • 52.42 (n)
Worm
(Caenorhabditis elegans)
 Secernentea oga-1 29 30
  • 45.28 (n)
 OneToOne
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 41 (a)
 OneToOne
Species where no ortholog for OGA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for OGA Gene

ENSEMBL:
Gene Tree for OGA (if available)
TreeFam:
Gene Tree for OGA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OGA: view image
Alliance of Genome Resources:
Additional Orthologs for OGA

Paralogs for OGA Gene

No data available for Paralogs for OGA Gene

Variants for OGA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OGA Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs1277662599 Likely Benign: not provided 101,806,151(-) T/C
NM_012215.5(OGA):c.653-8A>G
rs139911468 Likely Benign: not provided 101,800,403(-) G/A
NM_012215.5(OGA):c.1037-3C>T
rs200540327 Benign: not provided 101,813,613(-) T/G
NM_012215.5(OGA):c.200-7A>C
rs17853930 -- p.Glu602Lys
rs3740421 -- p.Gly46Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OGA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OGA Gene

Variant ID Type Subtype PubMed ID
dgv171n67 CNV gain 20364138
esv1006576 CNV deletion 20482838

Variation tolerance for OGA Gene

Residual Variation Intolerance Score: 9.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OGA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OGA
Leiden Open Variation Database (LOVD)
OGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OGA Gene

Disorders for OGA Gene

MalaCards: The human disease database

(24) MalaCards diseases for OGA Gene - From: COP and GCD

Disorder Aliases PubMed IDs
danubian endemic familial nephropathy
  • defn
gm2 gangliosidosis
  • gangliosidosis gm2
sandhoff disease
  • gm2-gangliosidosis, type ii
gm2-gangliosidosis, ab variant
  • hexosaminidase activator deficiency
tay-sachs disease
  • tsd
- elite association - COSMIC cancer census association via MalaCards
Search OGA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OGA

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OGA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OGA Gene

Publications for OGA Gene

  1. Novel immunogenic antigen homologous to hyaluronidase in meningioma. (PMID: 9811929) Heckel D … Meese E (Human molecular genetics 1998) 2 3 4 22
  2. Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase. (PMID: 11341771) Comtesse N … Meese E (Biochemical and biophysical research communications 2001) 3 4 22
  3. Hijacking of the O-GlcNAcZYME complex by the HTLV-1 Tax oncoprotein facilitates viral transcription. (PMID: 28742148) Groussaud D … Issad T (PLoS pathogens 2017) 3 4
  4. Human OGA binds substrates in a conserved peptide recognition groove. (PMID: 20863279) Schimpl M … van Aalten DM (The Biochemical journal 2010) 3 4
  5. Isoforms of human O-GlcNAcase show distinct catalytic efficiencies. (PMID: 20673219) Li J … Wang P (Biochemistry. Biokhimiia 2010) 3 4

ExternalLinks

View latest publications for OGA gene in Mastermind

Products for OGA Gene

Sources for OGA Gene