Aliases for ODR4 Gene

Aliases for ODR4 Gene

  • Odr-4 GPCR Localization Factor Homolog 2 3 5
  • LAG1-Interacting Protein 2 3 4
  • Transactivated By Recombinant Transforming Growth Factor Beta 1 2 3
  • Transactivated By Transforming Growth Factor Beta Protein 1 3 4
  • Protein Odr-4 Homolog 3 4
  • C1orf27 3 4
  • TTG1 3 4
  • Transactivated By Recombinant Transforming Growth Factor Beta 3
  • Chromosome 1 Open Reading Frame 27 2
  • Odorant Response Abnormal 4 3
  • HODR-4 4
  • Odr-4 3
  • TTG1A 4

External Ids for ODR4 Gene

Previous HGNC Symbols for ODR4 Gene

  • C1orf27

Summaries for ODR4 Gene

GeneCards Summary for ODR4 Gene

ODR4 (Odr-4 GPCR Localization Factor Homolog) is a Protein Coding gene. Diseases associated with ODR4 include Acrofacial Dysostosis 1, Nager Type and Acrofacial Dysostosis.

UniProtKB/Swiss-Prot Summary for ODR4 Gene

  • May play a role in the trafficking of a subset of G-protein coupled receptors.

Additional gene information for ODR4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ODR4 Gene

Genomics for ODR4 Gene

GeneHancer (GH) Regulatory Elements for ODR4 Gene

Promoters and enhancers for ODR4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J186373 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 508.1 -0.5 -457 4.2 ZBTB40 ZNF217 EP300 CTCF NRF1 TCF12 POLR2G USF1 SP1 PHF8 TPR ODR4 OCLM ENSG00000228238 RF00001-024
GH01J186033 Enhancer 0.6 Ensembl 32.7 -341.6 -341557 0.4 ZNF300 ZNF662 ZNF195 NFIC PBX2 NR2F2 FOS NFIB TCF7L2 GATA2 ODR4 LOC100422414 OCLM TPR piR-32559-026 piR-40678-001 HMCN1
GH01J186302 Enhancer 0.9 Ensembl ENCODE 10.8 -70.6 -70557 9.6 CTCF SMC3 FOXA2 ZNF316 MAFF CEBPG MAFK PBX2 GATA3 FOXA1 ODR4 PACERR HSALNG0009079-001 HSALNG0009079-002 PRG4
GH01J186404 Enhancer 0.8 Ensembl ENCODE 10.9 +29.1 29086 1.4 CTCF FOXA1 RAD21 TRIM22 SMC3 GABPA TAL1 IRF4 GTF3C2 JUN ODR4 OCLM RF00017-424 NONHSAG003746.2
GH01J186617 Enhancer 1 FANTOM5 ENCODE 7.9 +242.8 242765 1.2 REST BCL11A CTCF CEBPB SPI1 EZH2 BATF GABPA ELF1 MAX lnc-PTGS2-11 PTGS2 ODR4 PACERR PLA2G4A KP992443 LOC100131939 PDC-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ODR4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ODR4

Genomic Locations for ODR4 Gene

Genomic Locations for ODR4 Gene
chr1:186,375,758-186,421,378
(GRCh38/hg38)
Size:
45,621 bases
Orientation:
Plus strand
chr1:186,344,890-186,390,510
(GRCh37/hg19)
Size:
45,621 bases
Orientation:
Plus strand

Genomic View for ODR4 Gene

Genes around ODR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODR4 Gene

Proteins for ODR4 Gene

  • Protein details for ODR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SWX8-ODR4_HUMAN
    Recommended name:
    Protein odr-4 homolog
    Protein Accession:
    Q5SWX8
    Secondary Accessions:
    • B4DNY0
    • E9PFR7
    • Q19CC6
    • Q8WYB6
    • Q9BTS2
    • Q9H6A6
    • Q9NX06

    Protein attributes for ODR4 Gene

    Size:
    454 amino acids
    Molecular mass:
    51103 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15356.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ODR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ODR4 Gene

Post-translational modifications for ODR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ODR4 Gene

No data available for DME Specific Peptides for ODR4 Gene

Domains & Families for ODR4 Gene

Gene Families for ODR4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ODR4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ODR4 Gene

GenScript: Design optimal peptide antigens:
  • Transactivated by transforming growth factor beta protein 1 (ODR4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5SWX8

UniProtKB/Swiss-Prot:

ODR4_HUMAN :
  • Belongs to the ODR-4 family.
Family:
  • Belongs to the ODR-4 family.
genes like me logo Genes that share domains with ODR4: view

Function for ODR4 Gene

Molecular function for ODR4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the trafficking of a subset of G-protein coupled receptors.

Phenotypes From GWAS Catalog for ODR4 Gene

genes like me logo Genes that share phenotypes with ODR4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ODR4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ODR4 Gene

Localization for ODR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ODR4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ODR4 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ODR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ODR4: view

Pathways & Interactions for ODR4 Gene

PathCards logo

SuperPathways for ODR4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ODR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008104 protein localization IBA 21873635
genes like me logo Genes that share ontologies with ODR4: view

No data available for Pathways by source and SIGNOR curated interactions for ODR4 Gene

Drugs & Compounds for ODR4 Gene

No Compound Related Data Available

Transcripts for ODR4 Gene

mRNA/cDNA for ODR4 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ODR4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODR4 Gene

No ASD Table

Relevant External Links for ODR4 Gene

GeneLoc Exon Structure for
ODR4

Expression for ODR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ODR4

mRNA Expression by UniProt/SwissProt for ODR4 Gene:

Q5SWX8-ODR4_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ODR4 Gene

  • Liver(4.3)
  • Lung(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ODR4: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ODR4 Gene

Orthologs for ODR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ODR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1orf27 31
  • 100 (a)
OneToOne
C1H1orf27 30
  • 99.85 (n)
cow
(Bos Taurus)
Mammalia C16H1orf27 30
  • 90.82 (n)
C1orf27 31
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C7H1orf27 30
  • 90.68 (n)
C1orf27 31
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC003331 31 30
  • 87.84 (n)
OneToOne
Odr4 17
rat
(Rattus norvegicus)
Mammalia RGD1307830 30
  • 87.4 (n)
oppossum
(Monodelphis domestica)
Mammalia C1orf27 31
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf27 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves C8H1ORF27 31 30
  • 69.88 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf27 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf27 30
  • 59.55 (n)
Str.15466 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.10013 30
zebrafish
(Danio rerio)
Actinopterygii zgc:63674 30
  • 53.71 (n)
C2H1orf27 31
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006119 30
  • 41.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10616 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 22 (a)
OneToOne
Species where no ortholog for ODR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ODR4 Gene

ENSEMBL:
Gene Tree for ODR4 (if available)
TreeFam:
Gene Tree for ODR4 (if available)

Paralogs for ODR4 Gene

No data available for Paralogs for ODR4 Gene

Variants for ODR4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ODR4 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs12084264 - p.Ser251Cys

Additional dbSNP identifiers (rs#s) for ODR4 Gene

Structural Variations from Database of Genomic Variants (DGV) for ODR4 Gene

Variant ID Type Subtype PubMed ID
esv2762201 CNV gain 21179565
esv3575361 CNV gain 25503493
esv3890826 CNV gain 25118596
nsv1012164 CNV gain 25217958
nsv548399 CNV loss 21841781

Variation tolerance for ODR4 Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.53; 85.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ODR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ODR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODR4 Gene

Disorders for ODR4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ODR4 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search ODR4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ODR4

genes like me logo Genes that share disorders with ODR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ODR4 Gene

Publications for ODR4 Gene

  1. Ubiquitously expressed GPCR membrane-trafficking orthologs. (PMID: 15718105) Lehman CW … Komives CF (Genomics 2005) 2 3 4 54
  2. An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism. (PMID: 24603482) Chen C … de Bono M (PLoS genetics 2014) 2 3 54
  3. Protein expression, genomic structure, and polymorphisms of oculomedin. (PMID: 12868032) Fujiwara N … Ohtsuki H (Ophthalmic genetics 2003) 2 3 54
  4. Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability. (PMID: 30194290) Adhikari H … Counter CM (Nature communications 2018) 3 54
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54

Products for ODR4 Gene

Sources for ODR4 Gene