This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] See more...

Aliases for ODF4 Gene

Aliases for ODF4 Gene

  • Outer Dense Fiber Of Sperm Tails 4 2 3 5
  • Outer Dense Fiber Of Sperm Tails Protein 4 3 4
  • Testis-Specific Protein Oppo 1 3 4
  • Outer Dense Fiber Protein 4 3 4
  • Cancer/Testis Antigen 136 2 3
  • HOPPO1 3 4
  • OPPO1 3 4
  • Cancer/Testis Antigen 134 3
  • Outer Dense Fiber 4 3
  • CT134 3
  • CT136 3

External Ids for ODF4 Gene

Previous GeneCards Identifiers for ODF4 Gene

  • GC17P008978
  • GC17P008186
  • GC17P008443
  • GC17P008183
  • GC17P008243

Summaries for ODF4 Gene

Entrez Gene Summary for ODF4 Gene

  • This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for ODF4 Gene

ODF4 (Outer Dense Fiber Of Sperm Tails 4) is a Protein Coding gene. Diseases associated with ODF4 include Suppression Of Tumorigenicity 12.

UniProtKB/Swiss-Prot Summary for ODF4 Gene

  • Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.

Additional gene information for ODF4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ODF4 Gene

Genomics for ODF4 Gene

GeneHancer (GH) Regulatory Elements for ODF4 Gene

Promoters and enhancers for ODF4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J008338 Promoter/Enhancer 1.2 FANTOM5 Ensembl ENCODE 514.4 -1.2 -1233 1.1 EP300 ZIC2 CTBP1 ZBTB17 MAX PBX2 SPI1 NFE2 ATF4 MEIS2 ODF4 ENSG00000266279 ENSG00000212206 NDEL1 KDM6B PER1
GH17J008341 Enhancer 0.6 Ensembl ENCODE 514.3 +1.7 1650 0.6 TEAD4 TCF12 TAF1 ZNF362 IKZF1 ODF4 ENSG00000212206 piR-58297-211
GH17J008337 Promoter 0.4 Ensembl 500.7 -1.9 -1936 0.2 ZBTB17 ENSG00000266279 ODF4
GH17J008339 Promoter 0.3 EPDnew 500.7 -0.1 -105 0.1 ODF4 ENSG00000266279
GH17J008364 Enhancer 0.9 FANTOM5 Ensembl ENCODE 57.4 +26.1 26144 2.4 STAT3 STAT1 ATF2 JUN FOS POLR2A CEBPB ZNF600 ENSG00000265749 RF00017-2273 piR-31432-273 piR-53431-275 ODF4 CCDC42 SPDYE4 ENSG00000212206 ENSG00000226871 RNF222
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ODF4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ODF4

Top Transcription factor binding sites by QIAGEN in the ODF4 gene promoter:
  • AhR
  • AP-1
  • AP-4
  • AREB6
  • c-Myb
  • E47
  • Evi-1
  • HTF
  • Tal-1beta

Genomic Locations for ODF4 Gene

Genomic Locations for ODF4 Gene
chr17:8,339,837-8,346,048
(GRCh38/hg38)
Size:
6,212 bases
Orientation:
Plus strand
chr17:8,243,182-8,249,364
(GRCh37/hg19)
Size:
6,183 bases
Orientation:
Plus strand

Genomic View for ODF4 Gene

Genes around ODF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF4 Gene

Proteins for ODF4 Gene

  • Protein details for ODF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2E3-ODFP4_HUMAN
    Recommended name:
    Outer dense fiber protein 4
    Protein Accession:
    Q2M2E3
    Secondary Accessions:
    • Q8J021

    Protein attributes for ODF4 Gene

    Size:
    257 amino acids
    Molecular mass:
    29233 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ODF4 Gene

Post-translational modifications for ODF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ODF4 Gene

No data available for DME Specific Peptides for ODF4 Gene

Domains & Families for ODF4 Gene

Gene Families for ODF4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ODF4 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for ODF4 Gene

GenScript: Design optimal peptide antigens:
  • Outer dense fiber 4 (C3TX97_HUMAN)
  • Testis-specific protein oppo 1 (ODFP4_HUMAN)
genes like me logo Genes that share domains with ODF4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ODF4 Gene

Function for ODF4 Gene

Molecular function for ODF4 Gene

UniProtKB/Swiss-Prot Function:
Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton.

Phenotypes From GWAS Catalog for ODF4 Gene

Gene Ontology (GO) - Molecular Function for ODF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23355646
genes like me logo Genes that share ontologies with ODF4: view
genes like me logo Genes that share phenotypes with ODF4: view

Animal Models for ODF4 Gene

MGI Knock Outs for ODF4:
  • Odf4 Odf4<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ODF4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ODF4 Gene

Localization for ODF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ODF4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ODF4 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ODF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ODF4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ODF4 Gene

Pathways & Interactions for ODF4 Gene

PathCards logo

SuperPathways for ODF4 Gene

No Data Available

Interacting Proteins for ODF4 Gene

;

Gene Ontology (GO) - Biological Process for ODF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ODF4: view

No data available for Pathways by source and SIGNOR curated interactions for ODF4 Gene

Drugs & Compounds for ODF4 Gene

No Compound Related Data Available

Transcripts for ODF4 Gene

mRNA/cDNA for ODF4 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ODF4

Alternative Splicing Database (ASD) splice patterns (SP) for ODF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for ODF4 Gene

GeneLoc Exon Structure for
ODF4

Expression for ODF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ODF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ODF4 Gene

This gene is overexpressed in Testis (x49.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ODF4

SOURCE GeneReport for Unigene cluster for ODF4 Gene:

Hs.186045

mRNA Expression by UniProt/SwissProt for ODF4 Gene:

Q2M2E3-ODFP4_HUMAN
Tissue specificity: Expressed in testis and sperm; especially localized to sperm tail (at protein level).
genes like me logo Genes that share expression patterns with ODF4: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ODF4 Gene

Orthologs for ODF4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ODF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODF4 31 30
  • 98.57 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Odf4 30
  • 69.82 (n)
mouse
(Mus musculus)
Mammalia Odf4 17 31 30
  • 66.5 (n)
dog
(Canis familiaris)
Mammalia ODF4 31 30
  • 66.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ODF4 31
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ODF4 31
  • 18 (a)
OneToOne
Species where no ortholog for ODF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ODF4 Gene

ENSEMBL:
Gene Tree for ODF4 (if available)
TreeFam:
Gene Tree for ODF4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ODF4: view image

Paralogs for ODF4 Gene

No data available for Paralogs for ODF4 Gene

Variants for ODF4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ODF4 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs12601097 - p.Val98Met
rs12936935 - p.Tyr139Cys
rs12943505 - p.Trp34Arg

Additional dbSNP identifiers (rs#s) for ODF4 Gene

Structural Variations from Database of Genomic Variants (DGV) for ODF4 Gene

Variant ID Type Subtype PubMed ID
dgv70n73 CNV deletion 24416366
esv1978259 CNV deletion 18987734
esv2555685 CNV deletion 19546169
esv2715613 CNV deletion 23290073
esv3554097 CNV deletion 23714750
esv3639881 CNV gain 21293372
esv3639883 CNV loss 21293372
esv989739 CNV deletion 20482838
nsv1141774 CNV deletion 24896259
nsv1151481 CNV deletion 26484159
nsv1967 CNV deletion 18451855
nsv457664 CNV gain 19166990
nsv512476 CNV loss 21212237
nsv574337 CNV gain 21841781

Variation tolerance for ODF4 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.68; 65.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ODF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ODF4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF4 Gene

Disorders for ODF4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ODF4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
suppression of tumorigenicity 12
  • st12
- elite association - COSMIC cancer census association via MalaCards
Search ODF4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ODF4

genes like me logo Genes that share disorders with ODF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ODF4 Gene

Publications for ODF4 Gene

  1. Molecular cloning and characterization of the human orthologue of the oppo 1 gene encoding a sperm tail protein. (PMID: 12728016) Kitamura K … Nishimune Y (Molecular human reproduction 2003) 3 4 23 54
  2. Cancer-Testis Antigens as New Candidate Diagnostic Biomarkers for Transitional Cell Carcinoma of Bladder. (PMID: 29058301) Afsharpad M … Modarressi MH (Pathology oncology research : POR 2019) 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Identification of sperm head proteins involved in zona pellucida binding. (PMID: 23355646) Petit FM … Auer J (Human reproduction (Oxford, England) 2013) 3 54
  5. Expression of splice variants of cancer-testis genes ODF3 and ODF4 in the testis of a prostate cancer patient. (PMID: 23096689) Ghafouri-Fard S … Modarressi MH (Genetics and molecular research : GMR 2012) 3 54

Products for ODF4 Gene

Sources for ODF4 Gene