Aliases for ODF3L2 Gene

Aliases for ODF3L2 Gene

  • Outer Dense Fiber Of Sperm Tails 3 Like 2 2 3 5
  • Outer Dense Fiber Protein 3-Like Protein 2 3 4
  • C19orf19 3 4
  • Chromosome 19 Open Reading Frame 19 2

External Ids for ODF3L2 Gene

Previous HGNC Symbols for ODF3L2 Gene

  • C19orf19

Previous GeneCards Identifiers for ODF3L2 Gene

  • GC19M000417
  • GC19M000234

Summaries for ODF3L2 Gene

GeneCards Summary for ODF3L2 Gene

ODF3L2 (Outer Dense Fiber Of Sperm Tails 3 Like 2) is a Protein Coding gene. Diseases associated with ODF3L2 include Type 1 Diabetes Mellitus 15 and Type 1 Diabetes Mellitus 5. An important paralog of this gene is ODF3L1.

Additional gene information for ODF3L2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ODF3L2 Gene

Genomics for ODF3L2 Gene

GeneHancer (GH) Regulatory Elements for ODF3L2 Gene

Promoters and enhancers for ODF3L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J000474 Promoter 0.9 EPDnew Ensembl 500.7 +0.1 67 0.2 FOXP2 ZKSCAN8 UBTF ODF3L2 SHC2 lnc-SHC2-2
GH19J000487 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.7 -14.4 -14356 3.7 HNRNPK EP300 NRF1 POLR2G SP1 GTF2E2 PHF8 SIX5 ZFX ZIC2 MADCAM1 NONHSAG024290.2 TMEM259 SHC2 GRIN3B ENSG00000266933 DAZAP1 CIRBP MIER2 MED16
GH19J000867 Enhancer 0.9 FANTOM5 Ensembl 4.9 -392.5 -392520 1 HNRNPK ZIC2 ZNF423 SRSF1 POLR2A POLR2G ZFHX2 PTBP1 CBX1 SUPT5H lnc-MED16-1 piR-57460-321 CFD MED16 ODF3L2 ATP5F1D GPX4 TPGS1 CNN2 POLRMT
GH19J000569 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.8 -98.3 -98296 7.3 EP300 SIN3A TCF12 NRF1 MYC POLR2G USF1 GTF2E2 PHF8 TEAD4 ENSG00000267751 BSG LOC105372233 HSALNG0122893 TMEM259 DAZAP1 MIER2 PTBP1 GRIN3B ENSG00000267317
GH19J000441 Enhancer 0.6 FANTOM5 Ensembl 5.2 +33.6 33633 1.5 NR2F2 ZBTB17 HIC1 KLF1 ZNF366 SHC2 ODF3L2 FGF22 HCN2 PALM C2CD4C piR-35319 HSALNG0122869 lnc-ODF3L2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ODF3L2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ODF3L2

Top Transcription factor binding sites by QIAGEN in the ODF3L2 gene promoter:
  • AhR
  • AP-4
  • Arnt
  • COMP1
  • E2F
  • E2F-1
  • p53
  • Sox9
  • SRF
  • SRF (504 AA)

Genomic Locations for ODF3L2 Gene

Genomic Locations for ODF3L2 Gene
11,638 bases
Minus strand
11,638 bases
Minus strand

Genomic View for ODF3L2 Gene

Genes around ODF3L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODF3L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODF3L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF3L2 Gene

Proteins for ODF3L2 Gene

  • Protein details for ODF3L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Outer dense fiber protein 3-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q3SX65
    • Q8N1L2

    Protein attributes for ODF3L2 Gene

    289 amino acids
    Molecular mass:
    30781 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ODF3L2 Gene


neXtProt entry for ODF3L2 Gene

Post-translational modifications for ODF3L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ODF3L2 Gene

No data available for DME Specific Peptides for ODF3L2 Gene

Domains & Families for ODF3L2 Gene

Gene Families for ODF3L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ODF3L2 Gene


Suggested Antigen Peptide Sequences for ODF3L2 Gene

GenScript: Design optimal peptide antigens:
  • Outer dense fiber protein 3-like protein 2 (OD3L2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ODF3 family.
  • Belongs to the ODF3 family.
genes like me logo Genes that share domains with ODF3L2: view

Function for ODF3L2 Gene

Phenotypes From GWAS Catalog for ODF3L2 Gene

genes like me logo Genes that share phenotypes with ODF3L2: view

Animal Models for ODF3L2 Gene

MGI Knock Outs for ODF3L2:
  • Odf3l2 Odf3l2<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ODF3L2 Gene

Localization for ODF3L2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ODF3L2 gene
Compartment Confidence
cytoskeleton 5
extracellular 2
nucleus 2
cytosol 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for ODF3L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005881 cytoplasmic microtubule IDA 23264731
genes like me logo Genes that share ontologies with ODF3L2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ODF3L2 Gene

Pathways & Interactions for ODF3L2 Gene

PathCards logo

SuperPathways for ODF3L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ODF3L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ODF3L2 Gene

Drugs & Compounds for ODF3L2 Gene

No Compound Related Data Available

Transcripts for ODF3L2 Gene

mRNA/cDNA for ODF3L2 Gene

5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODF3L2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP1: -
SP2: - -

Relevant External Links for ODF3L2 Gene

GeneLoc Exon Structure for

Expression for ODF3L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ODF3L2 Gene

mRNA differential expression in normal tissues according to GTEx for ODF3L2 Gene

This gene is overexpressed in Testis (x32.5) and Muscle - Skeletal (x7.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ODF3L2

SOURCE GeneReport for Unigene cluster for ODF3L2 Gene:


Evidence on tissue expression from TISSUES for ODF3L2 Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with ODF3L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ODF3L2 Gene

Orthologs for ODF3L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ODF3L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ODF3L2 31
  • 98 (a)
(Canis familiaris)
Mammalia ODF3L2 31 30
  • 83.52 (n)
(Bos Taurus)
Mammalia ODF3L2 31
  • 81 (a)
(Rattus norvegicus)
Mammalia Odf3l2 30
  • 79.76 (n)
(Mus musculus)
Mammalia Odf3l2 17 31 30
  • 79.64 (n)
(Monodelphis domestica)
Mammalia ODF3L2 31
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia ODF3L2 31
  • 52 (a)
(Anolis carolinensis)
Reptilia ODF3L2 31
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia odf3l2 30
  • 52.73 (n)
(Danio rerio)
Actinopterygii odf3l2 31
  • 44 (a)
ODF3L2 (1 of 2) 31
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10252 31 30
  • 44.18 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001620 30
  • 44.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10233 31
  • 35 (a)
Species where no ortholog for ODF3L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ODF3L2 Gene

Gene Tree for ODF3L2 (if available)
Gene Tree for ODF3L2 (if available)
Evolutionary constrained regions (ECRs) for ODF3L2: view image

Paralogs for ODF3L2 Gene

Paralogs for ODF3L2 Gene

(3) SIMAP similar genes for ODF3L2 Gene using alignment to 1 proteins:

  • OD3L2_HUMAN Pseudogenes for ODF3L2 Gene

genes like me logo Genes that share paralogs with ODF3L2: view

Variants for ODF3L2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ODF3L2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs34551779 - p.Val135Ala

Additional dbSNP identifiers (rs#s) for ODF3L2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ODF3L2 Gene

Variant ID Type Subtype PubMed ID
dgv1013e212 CNV gain 25503493
dgv1672n106 CNV deletion 24896259
dgv6155n54 CNV loss 21841781
dgv6160n54 CNV gain 21841781
esv1002488 CNV deletion 20482838
esv1405790 CNV deletion 17803354
esv1453393 CNV deletion 17803354
esv1506097 CNV insertion 17803354
esv23197 CNV gain 19812545
esv2671474 CNV deletion 23128226
esv28250 CNV gain+loss 19812545
esv33417 CNV gain+loss 17666407
esv996354 CNV deletion 20482838
nsv1071881 CNV deletion 25765185
nsv1118797 CNV deletion 24896259
nsv1140344 CNV deletion 24896259
nsv1152528 CNV deletion 26484159
nsv1152852 CNV deletion 26484159
nsv138206 CNV deletion 16902084
nsv138338 CNV insertion 16902084
nsv428360 CNV gain 18775914
nsv470101 CNV loss 18288195
nsv475045 CNV novel sequence insertion 20440878
nsv477965 CNV novel sequence insertion 20440878
nsv509712 CNV insertion 20534489
nsv577978 CNV gain 21841781
nsv578100 CNV gain 21841781
nsv953938 CNV deletion 24416366
nsv954621 CNV deletion 24416366

Variation tolerance for ODF3L2 Gene

Gene Damage Index Score: 6.34; 76.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ODF3L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF3L2 Gene

Disorders for ODF3L2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ODF3L2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
type 1 diabetes mellitus 15
  • diabetes mellitus, insulin-dependent, 15
type 1 diabetes mellitus 5
  • diabetes mellitus, insulin-dependent, 5
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ODF3L2

genes like me logo Genes that share disorders with ODF3L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ODF3L2 Gene

Publications for ODF3L2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. (PMID: 29229926) Lu H … Bohr VA (Nature communications 2017) 3 54
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54

Products for ODF3L2 Gene

Sources for ODF3L2 Gene