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Aliases for ODF3L1 Gene

Aliases for ODF3L1 Gene

  • Outer Dense Fiber Of Sperm Tails 3 Like 1 2 3 5

External Ids for ODF3L1 Gene

Previous GeneCards Identifiers for ODF3L1 Gene

  • GC15P073804
  • GC15P073805
  • GC15P076016
  • GC15P052772

Summaries for ODF3L1 Gene

GeneCards Summary for ODF3L1 Gene

ODF3L1 (Outer Dense Fiber Of Sperm Tails 3 Like 1) is a Protein Coding gene. An important paralog of this gene is ODF3L2.

Additional gene information for ODF3L1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODF3L1 Gene

Genomics for ODF3L1 Gene

GeneHancer (GH) Regulatory Elements for ODF3L1 Gene

Promoters and enhancers for ODF3L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I075722 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 -0.2 -181 2.6 HDGF ATF1 KLF17 ZNF76 SIN3A BMI1 BRCA1 RFX5 GLIS2 FOS ODF3L1 ENSG00000261043 MIR631 GC15P075718
GH15I074936 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.9 -786.3 -786273 2.6 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 COX5A SIN3A ENSG00000260274 MAN2C1 FBXO22 DNM1P35 ENSG00000203392 RPP25 EDC3 CLK3
GH15I074904 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.9 -817.6 -817553 2.9 HDGF PKNOX1 SMAD1 SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF213 ZNF207 FAM219B RPP25 DNM1P35 ULK3 ODF3L1 GC15P074895
GH15I074768 Enhancer 1.1 Ensembl ENCODE 9.9 -954.9 -954942 0.5 PKNOX1 ATF1 SIN3A GLIS2 ZNF213 ARID2 ZNF143 KLF13 ZNF214 NCOA1 MAN2C1 SIN3A ENSG00000260274 EDC3 DNM1P35 ENSG00000203392 CLK3 PML COMMD4 SNX33
GH15I075699 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 6.3 -22.0 -22043 5.4 HDGF RB1 KLF17 GLIS2 EGR1 SCRT2 IKZF2 SCRT1 MAZ CBFA2T3 ENSG00000261043 MIR631 MAN2C1 ODF3L1 CSPG4 SNX33 SIN3A C15orf39 ENSG00000203392
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ODF3L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ODF3L1 gene promoter:

Genomic Locations for ODF3L1 Gene

Genomic Locations for ODF3L1 Gene
chr15:75,723,944-75,727,688
(GRCh38/hg38)
Size:
3,745 bases
Orientation:
Plus strand
chr15:76,016,318-76,020,029
(GRCh37/hg19)

Genomic View for ODF3L1 Gene

Genes around ODF3L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODF3L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODF3L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF3L1 Gene

Proteins for ODF3L1 Gene

  • Protein details for ODF3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXM7-OD3L1_HUMAN
    Recommended name:
    Outer dense fiber protein 3-like protein 1
    Protein Accession:
    Q8IXM7

    Protein attributes for ODF3L1 Gene

    Size:
    274 amino acids
    Molecular mass:
    31065 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ODF3L1 Gene

Post-translational modifications for ODF3L1 Gene

No Post-translational modifications

Other Protein References for ODF3L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ODF3L1 Gene

Domains & Families for ODF3L1 Gene

Gene Families for ODF3L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ODF3L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ODF3L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXM7

UniProtKB/Swiss-Prot:

OD3L1_HUMAN :
  • Belongs to the ODF3 family.
Family:
  • Belongs to the ODF3 family.
genes like me logo Genes that share domains with ODF3L1: view

Function for ODF3L1 Gene

Phenotypes for ODF3L1 Gene

genes like me logo Genes that share phenotypes with ODF3L1: view

Animal Model Products

miRNA for ODF3L1 Gene

miRTarBase miRNAs that target ODF3L1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ODF3L1 Gene

Localization for ODF3L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ODF3L1 gene
Compartment Confidence
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ODF3L1 Gene

Pathways & Interactions for ODF3L1 Gene

SuperPathways for ODF3L1 Gene

No Data Available

Interacting Proteins for ODF3L1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000329584%0d%0a9606.ENSP00000344742%0d%0a9606.ENSP00000366030%0d%0a
Selected Interacting proteins: Q8IXM7-OD3L1_HUMAN ENSP00000329584 for ODF3L1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ODF3L1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ODF3L1 Gene

Drugs & Compounds for ODF3L1 Gene

No Compound Related Data Available

Transcripts for ODF3L1 Gene

mRNA/cDNA for ODF3L1 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ODF3L1 Gene

Outer dense fiber of sperm tails 3-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODF3L1 Gene

No ASD Table

Relevant External Links for ODF3L1 Gene

GeneLoc Exon Structure for
ODF3L1
ECgene alternative splicing isoforms for
ODF3L1

Expression for ODF3L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ODF3L1 Gene

mRNA differential expression in normal tissues according to GTEx for ODF3L1 Gene

This gene is overexpressed in Testis (x26.2).

NURSA nuclear receptor signaling pathways regulating expression of ODF3L1 Gene:

ODF3L1

SOURCE GeneReport for Unigene cluster for ODF3L1 Gene:

Hs.144348
genes like me logo Genes that share expression patterns with ODF3L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ODF3L1 Gene

Orthologs for ODF3L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ODF3L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODF3L1 33 34
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia ODF3L1 33 34
  • 84.18 (n)
mouse
(Mus musculus)
Mammalia Odf3l1 33 16 34
  • 81.27 (n)
rat
(Rattus norvegicus)
Mammalia Odf3l1 33
  • 79.2 (n)
oppossum
(Monodelphis domestica)
Mammalia ODF3L1 34
  • 58 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ODF3L1 34
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ODF3L1 34
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ODF3L1 34
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii odf3l2 33
  • 47.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10252 34
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10233 34
  • 35 (a)
OneToMany
Species where no ortholog for ODF3L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ODF3L1 Gene

ENSEMBL:
Gene Tree for ODF3L1 (if available)
TreeFam:
Gene Tree for ODF3L1 (if available)

Paralogs for ODF3L1 Gene

Paralogs for ODF3L1 Gene

(2) SIMAP similar genes for ODF3L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ODF3L1: view

Variants for ODF3L1 Gene

Sequence variations from dbSNP and Humsavar for ODF3L1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000691984 -- 75,726,905(+) C/A/T intron_variant
rs1001124188 -- 75,726,516(+) G/C intron_variant
rs1001687671 -- 75,725,422(+) G/A intron_variant
rs1001718807 -- 75,725,196(+) G/C/T coding_sequence_variant, synonymous_variant
rs1002669849 -- 75,723,829(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ODF3L1 Gene

Variant ID Type Subtype PubMed ID
nsv527186 CNV loss 19592680
nsv1116463 OTHER inversion 24896259
esv2749895 CNV deletion 23290073
esv2749894 CNV deletion 23290073

Variation tolerance for ODF3L1 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.37; 76.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ODF3L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ODF3L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF3L1 Gene

Disorders for ODF3L1 Gene

Additional Disease Information for ODF3L1

No disorders were found for ODF3L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ODF3L1 Gene

Publications for ODF3L1 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ODF3L1 Gene

Sources for ODF3L1 Gene

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