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Aliases for ODF3B Gene

Aliases for ODF3B Gene

  • Outer Dense Fiber Of Sperm Tails 3B 2 3 5
  • Outer Dense Fiber Protein 3-Like Protein 3 3 4
  • ODF3L3 3 4
  • Outer Dense Fiber Protein 3B 3
  • Orf2 5 To PD-ECGF/TP 3

External Ids for ODF3B Gene

Previous GeneCards Identifiers for ODF3B Gene

  • GC22M049317
  • GC22M050968
  • GC22M033859

Summaries for ODF3B Gene

GeneCards Summary for ODF3B Gene

ODF3B (Outer Dense Fiber Of Sperm Tails 3B) is a Protein Coding gene. An important paralog of this gene is ODF3.

Additional gene information for ODF3B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODF3B Gene

Genomics for ODF3B Gene

GeneHancer (GH) Regulatory Elements for ODF3B Gene

Promoters and enhancers for ODF3B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I050523 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.9 2876 12.1 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 SCO2 TYMP ODF3B RABL2B ENSG00000272821 SYCE3 BRD1 CHKB ENSG00000272836 PLXNB2
GH22I050536 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 28.9 -11.1 -11086 13.7 HDGF FOXA2 PKNOX1 SMAD1 ARNT ARID4B SIN3A IRF4 YY1 SLC30A9 LOC105373098 TYMP ODF3B ENSG00000272821 CPT1B SCO2 CHKB SYCE3 ARSA TUBGCP6
GH22I050292 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 +231.5 231473 17.7 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 PLXNB2 PIM3 BRD1 NCAPH2 RABL2B TYMP TUBGCP6 DENND6B LOC105373100 ODF3B
GH22I050398 Enhancer 1.2 FANTOM5 Ensembl ENCODE 13.2 +132.9 132893 2.4 CTCF FOXA2 USF1 SAP130 ARID4B MAX ZIC2 RAD21 YY1 HNF4G GC22P050399 TYMP ODF3B MIOX PIM3 PLXNB2 TRABD CHKB SCO2 HDAC10
GH22I050188 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.1 +341.5 341501 5.6 HDGF PKNOX1 ATF1 SIN3A ZNF2 IRF4 ZNF766 GLIS2 ZNF143 KLF7 TRABD ENSG00000273188 TUBGCP6 MAPK12 HDAC10 BRD1 ENSG00000273253 MAPK11 PLXNB2 MLC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ODF3B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ODF3B gene promoter:

Genomic Locations for ODF3B Gene

Genomic Locations for ODF3B Gene
chr22:50,529,710-50,532,580
(GRCh38/hg38)
Size:
2,871 bases
Orientation:
Minus strand
chr22:50,968,139-50,971,009
(GRCh37/hg19)

Genomic View for ODF3B Gene

Genes around ODF3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODF3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODF3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF3B Gene

Proteins for ODF3B Gene

  • Protein details for ODF3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MYP8-ODF3B_HUMAN
    Recommended name:
    Outer dense fiber protein 3B
    Protein Accession:
    A8MYP8
    Secondary Accessions:
    • A0PK18

    Protein attributes for ODF3B Gene

    Size:
    253 amino acids
    Molecular mass:
    27280 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ODF3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ODF3B Gene

Post-translational modifications for ODF3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ODF3B Gene

No data available for DME Specific Peptides for ODF3B Gene

Domains & Families for ODF3B Gene

Gene Families for ODF3B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ODF3B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ODF3B Gene

Graphical View of Domain Structure for InterPro Entry

A8MYP8

UniProtKB/Swiss-Prot:

ODF3B_HUMAN :
  • Belongs to the ODF3 family.
Family:
  • Belongs to the ODF3 family.
genes like me logo Genes that share domains with ODF3B: view

Function for ODF3B Gene

Phenotypes From GWAS Catalog for ODF3B Gene

Phenotypes for ODF3B Gene

GenomeRNAi human phenotypes for ODF3B:
genes like me logo Genes that share phenotypes with ODF3B: view

miRNA for ODF3B Gene

miRTarBase miRNAs that target ODF3B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ODF3B Gene

Localization for ODF3B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ODF3B gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ODF3B Gene

Pathways & Interactions for ODF3B Gene

SuperPathways for ODF3B Gene

No Data Available

Interacting Proteins for ODF3B Gene

Gene Ontology (GO) - Biological Process for ODF3B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ODF3B Gene

Drugs & Compounds for ODF3B Gene

No Compound Related Data Available

Transcripts for ODF3B Gene

Unigene Clusters for ODF3B Gene

Outer dense fiber of sperm tails 3B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODF3B Gene

No ASD Table

Relevant External Links for ODF3B Gene

GeneLoc Exon Structure for
ODF3B
ECgene alternative splicing isoforms for
ODF3B

Expression for ODF3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ODF3B Gene

mRNA differential expression in normal tissues according to GTEx for ODF3B Gene

This gene is overexpressed in Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for ODF3B Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ODF3B Gene



Protein tissue co-expression partners for ODF3B Gene

NURSA nuclear receptor signaling pathways regulating expression of ODF3B Gene:

ODF3B

SOURCE GeneReport for Unigene cluster for ODF3B Gene:

Hs.531314
genes like me logo Genes that share expression patterns with ODF3B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ODF3B Gene

Orthologs for ODF3B Gene

This gene was present in the common ancestor of animals.

Orthologs for ODF3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODF3B 33 34
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia ODF3B 34
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Odf3b 33 16 34
  • 78.68 (n)
rat
(Rattus norvegicus)
Mammalia Odf3b 33
  • 77.44 (n)
oppossum
(Monodelphis domestica)
Mammalia ODF3B 34
  • 66 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC128071 34
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ODF3B 34
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii odf3b 34
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8086 34
  • 4 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToOne
Species where no ortholog for ODF3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ODF3B Gene

ENSEMBL:
Gene Tree for ODF3B (if available)
TreeFam:
Gene Tree for ODF3B (if available)

Paralogs for ODF3B Gene

Paralogs for ODF3B Gene

(4) SIMAP similar genes for ODF3B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ODF3B: view

Variants for ODF3B Gene

Sequence variations from dbSNP and Humsavar for ODF3B Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs560027665 uncertain-significance, Mitochondrial DNA depletion syndrome 1 (MNGIE type) 50,529,977(-) A/G downstream_transcript_variant
rs886057636 uncertain-significance, Mitochondrial DNA depletion syndrome 1 (MNGIE type) 50,529,985(-) G/A downstream_transcript_variant
rs886057637 uncertain-significance, Mitochondrial DNA depletion syndrome 1 (MNGIE type) 50,530,043(-) G/C downstream_transcript_variant
rs1000626842 -- 50,532,682(-) G/A upstream_transcript_variant
rs1001006901 -- 50,532,560(-) T/C 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ODF3B Gene

Variant ID Type Subtype PubMed ID
esv2758852 CNV loss 17122850
esv3568506 CNV loss 25503493
nsv1057656 CNV gain 25217958
nsv1160782 CNV deletion 26073780
nsv471224 CNV loss 18288195
nsv589222 CNV gain 21841781
nsv829340 CNV gain 20364138
nsv834238 CNV loss 17160897
nsv834239 CNV loss 17160897
nsv955201 CNV deletion 24416366

Variation tolerance for ODF3B Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.95; 59.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ODF3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ODF3B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF3B Gene

Disorders for ODF3B Gene

Additional Disease Information for ODF3B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ODF3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ODF3B Gene

Publications for ODF3B Gene

  1. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 44 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PMID: 19862010) Ganesh SK … Lin JP (Nature genetics 2009) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 58

Products for ODF3B Gene

Sources for ODF3B Gene

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