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Aliases for ODF2L Gene

Aliases for ODF2L Gene

  • Outer Dense Fiber Of Sperm Tails 2 Like 2 3 5
  • Outer Dense Fiber Of Sperm Tails 2-Like 2
  • Outer Dense Fiber Protein 2-Like 3
  • DJ977L11.1 3
  • KIAA1229 4

External Ids for ODF2L Gene

Previous GeneCards Identifiers for ODF2L Gene

  • GC01M086527
  • GC01M086808
  • GC01M084923

Summaries for ODF2L Gene

GeneCards Summary for ODF2L Gene

ODF2L (Outer Dense Fiber Of Sperm Tails 2 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleotide binding. An important paralog of this gene is ODF2.

Additional gene information for ODF2L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODF2L Gene

Genomics for ODF2L Gene

GeneHancer (GH) Regulatory Elements for ODF2L Gene

Promoters and enhancers for ODF2L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I086393 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 573.2 +0.5 487 4 HDGF ATF1 SIN3A FEZF1 ZNF2 YY1 GLIS2 ZNF207 ZNF143 ATF7 ODF2L CLCA2 GC01P086383
GH01I085575 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.9 +815.5 815541 11.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CYR61 DDAH1 ODF2L ZNHIT6 C1orf52 BCL10 ENSG00000272691 ENSG00000282057 GC01P085583
GH01I086154 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 20.4 +240.3 240270 2.9 MZF1 SIN3A ZNF335 GLIS2 ZNF366 EGR2 ZNF202 YY2 ZBTB11 MCM5 COL24A1 ODF2L ZNHIT6 BCL10 C1orf52 GC01M086135
GH01I086428 Enhancer 1 Ensembl ENCODE 32.6 -33.6 -33603 2.3 RFX5 SCRT2 ETV6 ATF7 CEBPB ZNF398 ELF1 ATF4 MAFF SMARCA4 ODF2L CLCA2 CLCA1
GH01I087327 Promoter/Enhancer 2.6 VISTA EPDnew Ensembl ENCODE dbSUPER 10.2 -933.7 -933669 5.6 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 LMO4 ODF2L GC01P087340
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ODF2L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ODF2L gene promoter:

Genomic Locations for ODF2L Gene

Genomic Locations for ODF2L Gene
49,519 bases
Minus strand

Genomic View for ODF2L Gene

Genes around ODF2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODF2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODF2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF2L Gene

Proteins for ODF2L Gene

  • Protein details for ODF2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Outer dense fiber protein 2-like
    Protein Accession:
    Secondary Accessions:
    • A8MU56
    • B4E037
    • Q05C40
    • Q5BJG5
    • Q5TBX3
    • Q5TBX4
    • Q86X31

    Protein attributes for ODF2L Gene

    636 amino acids
    Molecular mass:
    73728 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH29420.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH47368.1; Type=Erroneous termination; Positions=397; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=AK308351; Type=Frameshift; Positions=296; Evidence={ECO:0000305}; Sequence=BAA86543.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ODF2L Gene

neXtProt entry for ODF2L Gene

Post-translational modifications for ODF2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ODF2L Gene

Domains & Families for ODF2L Gene

Gene Families for ODF2L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ODF2L Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ODF2 family.
  • Belongs to the ODF2 family.
genes like me logo Genes that share domains with ODF2L: view

Function for ODF2L Gene

genes like me logo Genes that share phenotypes with ODF2L: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ODF2L Gene

Localization for ODF2L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ODF2L gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ODF2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with ODF2L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ODF2L Gene

Pathways & Interactions for ODF2L Gene

SuperPathways for ODF2L Gene

No Data Available

Interacting Proteins for ODF2L Gene

Gene Ontology (GO) - Biological Process for ODF2L Gene


No data available for Pathways by source and SIGNOR curated interactions for ODF2L Gene

Drugs & Compounds for ODF2L Gene

No Compound Related Data Available

Transcripts for ODF2L Gene

Unigene Clusters for ODF2L Gene

Outer dense fiber of sperm tails 2-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODF2L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: -
SP4: - - -
SP5: - -
SP6: -

Relevant External Links for ODF2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ODF2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ODF2L Gene

Protein differential expression in normal tissues from HIPED for ODF2L Gene

This gene is overexpressed in Milk (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ODF2L Gene

Protein tissue co-expression partners for ODF2L Gene

NURSA nuclear receptor signaling pathways regulating expression of ODF2L Gene:


SOURCE GeneReport for Unigene cluster for ODF2L Gene:


Evidence on tissue expression from TISSUES for ODF2L Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ODF2L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ODF2L Gene

Orthologs for ODF2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for ODF2L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ODF2L 33 34
  • 99.35 (n)
(Canis familiaris)
Mammalia ODF2L 33 34
  • 90.28 (n)
(Bos Taurus)
Mammalia ODF2L 33 34
  • 90.19 (n)
(Mus musculus)
Mammalia Odf2l 33 16 34
  • 79.84 (n)
(Rattus norvegicus)
Mammalia Odf2l 33
  • 79.44 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 51 (a)
-- 34
  • 46 (a)
(Monodelphis domestica)
Mammalia ODF2L 34
  • 45 (a)
(Gallus gallus)
Aves ODF2L 33 34
  • 60.64 (n)
(Anolis carolinensis)
Reptilia ODF2L 34
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia odf2l 33
  • 54.59 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 14 (a)
Species where no ortholog for ODF2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ODF2L Gene

Gene Tree for ODF2L (if available)
Gene Tree for ODF2L (if available)

Paralogs for ODF2L Gene

Paralogs for ODF2L Gene

(1) SIMAP similar genes for ODF2L Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ODF2L: view

Variants for ODF2L Gene

Sequence variations from dbSNP and Humsavar for ODF2L Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000017063 -- 86,349,039(-) TTAAAATTAA/TTAA downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000043815 -- 86,372,860(-) C/T intron_variant
rs1000278189 -- 86,394,658(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000306890 -- 86,348,979(-) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000416816 -- 86,349,488(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ODF2L Gene

Variant ID Type Subtype PubMed ID
esv2657167 CNV deletion 23128226
esv2714363 CNV deletion 23290073
esv2714374 CNV deletion 23290073
nsv1002541 CNV gain 25217958
nsv1161035 CNV duplication 26073780
nsv546722 CNV loss 21841781

Variation tolerance for ODF2L Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ODF2L Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF2L Gene

Disorders for ODF2L Gene

Additional Disease Information for ODF2L

No disorders were found for ODF2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ODF2L Gene

Publications for ODF2L Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58

Products for ODF2L Gene

Sources for ODF2L Gene

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