Aliases for ODF2L Gene

Aliases for ODF2L Gene

  • Outer Dense Fiber Of Sperm Tails 2 Like 2 3 5
  • Basal Body Centriole-Associated Protein 3 4
  • Protein BCAP 3 4
  • KIAA1229 2 4
  • Outer Dense Fiber Of Sperm Tails 2-Like 2
  • Outer Dense Fiber Protein 2-Like 4
  • ODF2L 5
  • BCAP 4

External Ids for ODF2L Gene

Previous GeneCards Identifiers for ODF2L Gene

  • GC01M086527
  • GC01M086808
  • GC01M084923

Summaries for ODF2L Gene

GeneCards Summary for ODF2L Gene

ODF2L (Outer Dense Fiber Of Sperm Tails 2 Like) is a Protein Coding gene. Diseases associated with ODF2L include Peroxisome Biogenesis Disorder 2A and Borderline Leprosy. Gene Ontology (GO) annotations related to this gene include nucleotide binding. An important paralog of this gene is ODF2.

UniProtKB/Swiss-Prot Summary for ODF2L Gene

  • Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis.

Additional gene information for ODF2L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ODF2L Gene

Genomics for ODF2L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ODF2L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J086393 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 623.1 +0.7 724 4.4 CREB1 TEAD4 PRDM10 ZNF629 RFX1 ZNF692 POLR2A ZHX2 FOXA1 ZNF143 ODF2L CLCA2 piR-50852-003 COL24A1
GH01J085575 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 27.9 +815.5 815541 11.4 CEBPG CREB1 GATAD2A CTCF HNRNPL TEAD4 PRDM10 ZNF629 IKZF1 ZNF692 DDAH1 CCN1 MN308959 ODF2L ZNHIT6 C1orf52 BCL10 ENSG00000272691 ENSG00000282057 lnc-WDR63-5
GH01J086154 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 20.4 +240.3 240270 2.9 PRDM10 ZNF629 ZNF692 ZIC2 PATZ1 ZNF501 EZH2 ZNF600 ZNF341 ZNF140 COL24A1 lnc-ODF2L-3 ODF2L ZNHIT6 BCL10 C1orf52 piR-61514-010
GH01J087327 Promoter/Enhancer 3.3 VISTA UCNEbase EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.2 -935.8 -935759 10.2 SP1 HNRNPL CREB1 CTCF TEAD4 PRDM10 ZNF629 IKZF1 KDM1A ZNF692 LMO4 ODF2L lnc-SELENOF-12 lnc-HS2ST1-1
GH01J086428 Enhancer 1 Ensembl ENCODE 32.6 -33.8 -33758 3 CEBPG JUND FOXA1 GABPA ETV6 CEBPA EP300 SCRT2 CEBPB NFE2 ODF2L CLCA2 CLCA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ODF2L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ODF2L

Top Transcription factor binding sites by QIAGEN in the ODF2L gene promoter:
  • AML1a
  • AP-4
  • FOXD3
  • FOXI1
  • HFH-3
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Pbx1a

Genomic Locations for ODF2L Gene

Genomic Locations for ODF2L Gene
chr1:86,346,824-86,396,342
(GRCh38/hg38)
Size:
49,519 bases
Orientation:
Minus strand
chr1:86,812,507-86,862,025
(GRCh37/hg19)
Size:
49,519 bases
Orientation:
Minus strand

Genomic View for ODF2L Gene

Genes around ODF2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODF2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODF2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF2L Gene

Proteins for ODF2L Gene

  • Protein details for ODF2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULJ1-ODF2L_HUMAN
    Recommended name:
    Protein BCAP
    Protein Accession:
    Q9ULJ1
    Secondary Accessions:
    • A8MU56
    • B4E037
    • Q05C40
    • Q5BJG5
    • Q5TBX3
    • Q5TBX4
    • Q86X31

    Protein attributes for ODF2L Gene

    Size:
    636 amino acids
    Molecular mass:
    73728 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH29420.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH47368.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=AK308351; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA86543.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ODF2L Gene

neXtProt entry for ODF2L Gene

Post-translational modifications for ODF2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ODF2L Gene

Domains & Families for ODF2L Gene

Gene Families for ODF2L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ODF2L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ODF2L Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59792, highly similar to Homo sapiens outer dense fiber of sperm tails 2-like (ODF2L), transcript variant 1, mRNA (B4DZ83_HUMAN)
  • cDNA FLJ60202, highly similar to Homo sapiens outer dense fiber of sperm tails 2-like (ODF2L), transcript variant 1, mRNA (B4E037_HUMAN)
  • Outer dense fiber protein 2-like (ODF2L_HUMAN)
  • ODF2L protein (Q96GC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULJ1

UniProtKB/Swiss-Prot:

ODF2L_HUMAN :
  • Belongs to the ODF2 family.
Family:
  • Belongs to the ODF2 family.
genes like me logo Genes that share domains with ODF2L: view

Function for ODF2L Gene

Molecular function for ODF2L Gene

UniProtKB/Swiss-Prot Function:
Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis.

Phenotypes From GWAS Catalog for ODF2L Gene

genes like me logo Genes that share phenotypes with ODF2L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ODF2L

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ODF2L Gene

Localization for ODF2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ODF2L Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to centrioles in proliferative cells and basal bodies in ciliated cells (PubMed:17485331). Disappears during ciliogenesis but reappears, albeit at a lower levels once ciliogenesis has completed (PubMed:28775150). {ECO:0000269 PubMed:17485331, ECO:0000269 PubMed:28775150}.
[Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Not present in the centrioles in cycling cells. Disappears during ciliogenesis. {ECO:0000269 PubMed:28775150}.
[Isoform 6]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Disappears during ciliogenesis but reappears, albeit at a lower levels once ciliogenesis has completed. {ECO:0000269 PubMed:28775150}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ODF2L gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ODF2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 17485331
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ODF2L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ODF2L Gene

Pathways & Interactions for ODF2L Gene

PathCards logo

SuperPathways for ODF2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for ODF2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:1902018 negative regulation of cilium assembly IDA 28775150
genes like me logo Genes that share ontologies with ODF2L: view

No data available for Pathways by source and SIGNOR curated interactions for ODF2L Gene

Drugs & Compounds for ODF2L Gene

No Compound Related Data Available

Transcripts for ODF2L Gene

mRNA/cDNA for ODF2L Gene

9 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ODF2L

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ODF2L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: -
SP3:
SP4: - - -
SP5: - -
SP6: -
SP7:

Relevant External Links for ODF2L Gene

GeneLoc Exon Structure for
ODF2L

Expression for ODF2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ODF2L Gene

Protein differential expression in normal tissues from HIPED for ODF2L Gene

This gene is overexpressed in Milk (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ODF2L Gene



Protein tissue co-expression partners for ODF2L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ODF2L

SOURCE GeneReport for Unigene cluster for ODF2L Gene:

Hs.149360

mRNA Expression by UniProt/SwissProt for ODF2L Gene:

Q9ULJ1-ODF2L_HUMAN
Tissue specificity: Mainly expressed in trachea and testis. Not detected in bone marrow, bladder, leukocytes. Only weakly detected in tongue, stomach, brain and ovaries.

Evidence on tissue expression from TISSUES for ODF2L Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ODF2L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ODF2L Gene

Orthologs for ODF2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for ODF2L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ODF2L 30 31
  • 99.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ODF2L 30 31
  • 90.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ODF2L 30 31
  • 90.19 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Odf2l 30 17 31
  • 79.84 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Odf2l 30
  • 79.44 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 51 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia ODF2L 31
  • 45 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ODF2L 30 31
  • 60.64 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ODF2L 31
  • 41 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia odf2l 30
  • 54.59 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 14 (a)
OneToMany
Species where no ortholog for ODF2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ODF2L Gene

ENSEMBL:
Gene Tree for ODF2L (if available)
TreeFam:
Gene Tree for ODF2L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ODF2L: view image

Paralogs for ODF2L Gene

Paralogs for ODF2L Gene

(1) SIMAP similar genes for ODF2L Gene using alignment to 10 proteins:

  • ODF2L_HUMAN
  • B5ME44_HUMAN
  • E9PJZ1_HUMAN
  • E9PMV9_HUMAN
  • E9PNP0_HUMAN
  • G5E956_HUMAN
  • H0YCM1_HUMAN
  • H0YD68_HUMAN
  • H0YF19_HUMAN
  • Q96GC1_HUMAN
genes like me logo Genes that share paralogs with ODF2L: view

Variants for ODF2L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ODF2L Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
728845 Benign: not provided 86,356,562(-) C/T MISSENSE_VARIANT,INTRON_VARIANT
735673 Likely Benign: not provided 86,372,469(-) T/A MISSENSE_VARIANT
788940 Benign: not provided 86,356,543(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
791082 Benign: not provided 86,358,813(-) T/C MISSENSE_VARIANT
rs12032435 - p.Arg177His

Additional dbSNP identifiers (rs#s) for ODF2L Gene

Structural Variations from Database of Genomic Variants (DGV) for ODF2L Gene

Variant ID Type Subtype PubMed ID
esv2657167 CNV deletion 23128226
esv2714363 CNV deletion 23290073
esv2714374 CNV deletion 23290073
nsv1002541 CNV gain 25217958
nsv1161035 CNV duplication 26073780
nsv546722 CNV loss 21841781

Variation tolerance for ODF2L Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.33; 70.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ODF2L Gene

Human Gene Mutation Database (HGMD)
ODF2L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ODF2L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF2L Gene

Disorders for ODF2L Gene

MalaCards: The human disease database

(2) MalaCards diseases for ODF2L Gene - From: DISEASES

Disorder Aliases PubMed IDs
peroxisome biogenesis disorder 2a
  • pbd2a
borderline leprosy
  • borderline or dimorphous leprosy
- elite association - COSMIC cancer census association via MalaCards
Search ODF2L in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ODF2L

genes like me logo Genes that share disorders with ODF2L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ODF2L Gene

Publications for ODF2L Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  2. BCAP is a centriolar satellite protein and inhibitor of ciliogenesis. (PMID: 28775150) de Saram P … Wilkinson CJ (Journal of cell science 2017) 3 4
  3. Identification of BCAP, a new protein associated with basal bodies and centrioles. (PMID: 17485331) Ponsard C … Middendorp S (Frontiers in bioscience : a journal and virtual library 2007) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3

Products for ODF2L Gene

Sources for ODF2L Gene