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Aliases for ODF1 Gene

Aliases for ODF1 Gene

  • Outer Dense Fiber Of Sperm Tails 1 2 3 5
  • Heat Shock Protein Beta-10 3 4
  • Cancer/Testis Antigen 133 2 3
  • HSPB10 3 4
  • ODFP 3 4
  • Outer Dense Fiber Of Sperm Tails, 27-KD 3
  • Outer Dense Fibre Of Sperm Tails 1 2
  • Outer Dense Fiber Protein 1 3
  • ODFPGA 3
  • ODFPGB 3
  • CT133 3
  • ODF27 3
  • ODFPG 3
  • ODF2 3
  • SODF 3
  • ODF 3
  • RT7 3

External Ids for ODF1 Gene

Previous GeneCards Identifiers for ODF1 Gene

  • GC08P103632
  • GC08P103232
  • GC08P103520
  • GC08P103633
  • GC08P098764

Summaries for ODF1 Gene

Entrez Gene Summary for ODF1 Gene

  • The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ODF1 Gene

ODF1 (Outer Dense Fiber Of Sperm Tails 1) is a Protein Coding gene. Among its related pathways are Transcription_CREM signaling in testis. Gene Ontology (GO) annotations related to this gene include protein domain specific binding.

UniProtKB/Swiss-Prot for ODF1 Gene

  • Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

Gene Wiki entry for ODF1 Gene

Additional gene information for ODF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODF1 Gene

Genomics for ODF1 Gene

GeneHancer (GH) Regulatory Elements for ODF1 Gene

Promoters and enhancers for ODF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I102551 Promoter 0.8 EPDnew 550.8 +0.0 48 0.1 RFX1 ZNF629 CREB1 ATF7 EBF1 ATF2 LOC105375684 ODF1 LOC107986898 GC08M102622
GH08I102582 Enhancer 1.5 FANTOM5 Ensembl ENCODE 10.8 +33.0 33000 4 HDGF FOXA2 SIN3A ZBTB7B IRF4 YY1 ZNF766 ZNF143 DEK JUNB LOC107986898 RNU6-1224P RNU6ATAC8P ODF1 UBR5-AS1 CTHRC1 KLF10 UBR5 LOC105375684 GC08M102622
GH08I102647 Enhancer 0.8 ENCODE 10.3 +96.0 96011 0.7 NEUROD1 SIN3A RFX5 POLR2B E2F8 SCRT2 FOS RUNX3 PAF1 SMARCA5 UBR5 ODF1 LOC101927245 POU5F1P2
GH08I102649 Enhancer 0.5 dbSUPER 10.3 +98.6 98599 0.6 CTCF SSRP1 PKNOX1 POLR2A ZNF189 CHD1 RNU6-1224P LOC107986898 ODF1 LOC101927245 KLF10 POU5F1P2
GH08I102505 Enhancer 0.4 ENCODE 10.4 -46.0 -45993 0.9 TEAD1 REST RPS12P15 LOC107986898 RNU6-1224P RNU6ATAC8P UBR5 LOC105375683 ODF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ODF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ODF1 gene promoter:

Genomic Locations for ODF1 Gene

Genomic Locations for ODF1 Gene
chr8:102,551,572-102,561,017
(GRCh38/hg38)
Size:
9,446 bases
Orientation:
Plus strand
chr8:103,563,800-103,573,245
(GRCh37/hg19)

Genomic View for ODF1 Gene

Genes around ODF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ODF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ODF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ODF1 Gene

Proteins for ODF1 Gene

  • Protein details for ODF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14990-ODFP1_HUMAN
    Recommended name:
    Outer dense fiber protein 1
    Protein Accession:
    Q14990
    Secondary Accessions:
    • Q3SX72

    Protein attributes for ODF1 Gene

    Size:
    250 amino acids
    Molecular mass:
    28366 Da
    Quaternary structure:
    • Interact (via leucine zipper motif) with TCP11 isoform 2 and isoform 3 (PubMed:21597245). Interacts with SPAG4 (By similarity). Interacts with KLC3 (By similarity).

neXtProt entry for ODF1 Gene

Post-translational modifications for ODF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ODF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ODF1 Gene

Domains & Families for ODF1 Gene

Gene Families for ODF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ODF1 Gene

Suggested Antigen Peptide Sequences for ODF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14990

UniProtKB/Swiss-Prot:

ODFP1_HUMAN :
  • The C-terminal contains many C-X-P repeats.
Domain:
  • The C-terminal contains many C-X-P repeats.
genes like me logo Genes that share domains with ODF1: view

Function for ODF1 Gene

Molecular function for ODF1 Gene

GENATLAS Biochemistry:
outer dense fiber protein 1,component of the filamentous structures of the sperm tail
UniProtKB/Swiss-Prot Function:
Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

Phenotypes From GWAS Catalog for ODF1 Gene

Gene Ontology (GO) - Molecular Function for ODF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21597245
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with ODF1: view

Phenotypes for ODF1 Gene

MGI mutant phenotypes for ODF1:
inferred from 1 alleles
GenomeRNAi human phenotypes for ODF1:
genes like me logo Genes that share phenotypes with ODF1: view

Animal Models for ODF1 Gene

MGI Knock Outs for ODF1:

miRNA for ODF1 Gene

miRTarBase miRNAs that target ODF1

Clone Products

  • Addgene plasmids for ODF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ODF1 Gene

Localization for ODF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ODF1 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
extracellular 3
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ODF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001520 outer dense fiber IBA --
GO:0005634 nucleus HDA,IDA 21630459
genes like me logo Genes that share ontologies with ODF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ODF1 Gene

Pathways & Interactions for ODF1 Gene

genes like me logo Genes that share pathways with ODF1: view

Pathways by source for ODF1 Gene

1 GeneGo (Thomson Reuters) pathway for ODF1 Gene

Gene Ontology (GO) - Biological Process for ODF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ODF1: view

No data available for SIGNOR curated interactions for ODF1 Gene

Drugs & Compounds for ODF1 Gene

(1) Drugs for ODF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ODF1: view

Transcripts for ODF1 Gene

mRNA/cDNA for ODF1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ODF1 Gene

Outer dense fiber of sperm tails 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for ODF1

Alternative Splicing Database (ASD) splice patterns (SP) for ODF1 Gene

No ASD Table

Relevant External Links for ODF1 Gene

GeneLoc Exon Structure for
ODF1
ECgene alternative splicing isoforms for
ODF1

Expression for ODF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ODF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ODF1 Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for ODF1 Gene

This gene is overexpressed in Testis (46.9) and Ovary (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ODF1 Gene



Protein tissue co-expression partners for ODF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ODF1 Gene:

ODF1

SOURCE GeneReport for Unigene cluster for ODF1 Gene:

Hs.159274

mRNA Expression by UniProt/SwissProt for ODF1 Gene:

Q14990-ODFP1_HUMAN
Tissue specificity: Testis.
genes like me logo Genes that share expression patterns with ODF1: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ODF1 Gene

Orthologs for ODF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ODF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ODF1 33 34
  • 98.13 (n)
cow
(Bos Taurus)
Mammalia ODF1 33 34
  • 88.13 (n)
dog
(Canis familiaris)
Mammalia ODF1 33 34
  • 87.82 (n)
rat
(Rattus norvegicus)
Mammalia Odf1 33
  • 86.1 (n)
mouse
(Mus musculus)
Mammalia Odf1 33 16 34
  • 85.11 (n)
oppossum
(Monodelphis domestica)
Mammalia ODF1 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ODF1 34
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ODF1 34
  • 44 (a)
OneToOne
Species where no ortholog for ODF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ODF1 Gene

ENSEMBL:
Gene Tree for ODF1 (if available)
TreeFam:
Gene Tree for ODF1 (if available)

Paralogs for ODF1 Gene

No data available for Paralogs for ODF1 Gene

Variants for ODF1 Gene

Sequence variations from dbSNP and Humsavar for ODF1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000129823 -- 102,559,626(+) C/G intron_variant
rs1000193711 -- 102,551,201(+) T/C upstream_transcript_variant
rs1000421436 -- 102,557,987(+) C/G intron_variant
rs1000487219 -- 102,555,114(+) C/T intron_variant
rs1000896792 -- 102,558,221(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ODF1 Gene

Variant ID Type Subtype PubMed ID
esv22177 CNV loss 19812545
esv2669040 CNV deletion 23128226
esv2762761 CNV gain 21179565
esv33118 CNV loss 17666407
esv3576598 CNV gain 25503493
esv3618224 CNV gain 21293372
esv3618226 CNV loss 21293372
nsv1024876 CNV gain 25217958

Variation tolerance for ODF1 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.61; 94.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ODF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ODF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODF1 Gene

Disorders for ODF1 Gene

Additional Disease Information for ODF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ODF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ODF1 Gene

Publications for ODF1 Gene

  1. Sequence, expression, and chromosomal assignment of a human sperm outer dense fiber gene. (PMID: 8305202) Gastmann O … Hoyer-Fender S (Molecular reproduction and development 1993) 2 3 4 22 58
  2. Human t-complex protein 11 (TCP11), a testis-specific gene product, is a potential determinant of the sperm morphology. (PMID: 21597245) Liu Y … Ma Y (The Tohoku journal of experimental medicine 2011) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Keratins: unraveling the coordinated construction of scaffolds in spermatogenic cells. (PMID: 11774369) Kierszenbaum AL (Molecular reproduction and development 2002) 3 22 58

Products for ODF1 Gene

  • Addgene plasmids for ODF1

Sources for ODF1 Gene

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