ODC1 Gene (Protein Coding)

Ornithine Decarboxylase 1

GCID:: GC02M010432

GIFtS:: 48

Genes Participants

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined ... See more...

Aliases for ODC1 Gene

Ornithine Decarboxylase 1 ² ³ ⁵
Ornithine Decarboxylase ³ ⁴
EC 4.1.1.17 ⁴ ⁵⁴
ODC ³ ⁴

External Ids for ODC1 Gene

HGNC: 8109
Entrez Gene: 4953
Ensembl: ENSG00000115758
OMIM: 165640
UniProtKB: P11926

Previous GeneCards Identifiers for ODC1 Gene

GC02M010365
GC02M010631
GC02M010602
GC02M010531
GC02M010497
GC02M010580

Search aliases for ODC1 gene in PubMed and other databases

Summaries for ODC1 Gene

Entrez Gene Summary for ODC1 Gene

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]

GeneCards Summary for ODC1 Gene

ODC1 (Ornithine Decarboxylase 1) is a Protein Coding gene. Diseases associated with ODC1 include Colorectal Cancer and Sleeping Sickness. Among its related pathways are Urea cycle and metabolism of amino groups and Glutathione metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ornithine decarboxylase activity. An important paralog of this gene is AZIN2.

UniProtKB/Swiss-Prot Summary for ODC1 Gene

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
- DCOR_HUMAN,P11926

Gene Wiki entry for ODC1 Gene

Additional gene information for ODC1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ODC1 Gene

Genomics for ODC1 Gene

GeneHancer (GH) Regulatory Elements for ODC1 Gene

Promoters and enhancers for ODC1 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH02J010445	Promoter/Enhancer	2.4	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	750.6	+0.4	382	6.1	SIN3A SP1 ZBTB40 MLX RBPJ POLR2A USF2 HDAC2 CREB1 MIXL1	ODC1-DT ODC1 SNORA80B lnc-NOL10-3 RRM2 ENSG00000206898 HPCAL1 RF02535-001
GH02J010493	Enhancer	1.3	FANTOM5 Ensembl ENCODE	10.7	-45.3	-45347	2.2	SIN3A RBPJ POLR2A CREB1 MYC HLF MAX MNT ZBTB33 ELF3	SNORA80B ODC1 NOL10 HSALNG0012982 HSALNG0012985
GH02J010487	Enhancer	1.1	Ensembl ENCODE	11.4	-38.5	-38547	1.4	GATA3 LCORL MLX TCF7L2 NR2F1 ATF1 NR2F6 ZNF217 CREB1 HLF	HSALNG0012983 PDIA6 KLF11 SLC66A3 ENSG00000272275 ODC1 SNORA80B NOL10 ENSG00000260077 HSALNG0012982
GH02J010490	Enhancer	0.9	Ensembl ENCODE	10.7	-42.2	-42218	1.5	SMARCE1 ELF1 ELF3 MAFK SMARCA4 IKZF1 CREB1 CEBPA CTBP1 HDAC1	HSALNG0012982 SNORA80B ODC1 HSALNG0012985
GH02J010477	Enhancer	0.7	Ensembl ENCODE	12.2	-29.2	-29247	1.6	ZNF24 MAX ZIC2 TCF7L2 SAP130 DRAP1 ZFP91 GLIS1 RARA TEAD3	piR-43164-036 ODC1 SNORA80B HSALNG0012983

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ODC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ODC1 gene promoter:

AML1a
En-1
FOXO4
Ik-3
Lmo2
Nkx3-1 v1
PPAR-gamma1
PPAR-gamma2
RORalpha2
STAT3

Genomic Locations for ODC1 Gene

chr2:10,439,968-10,448,554: (GRCh38/hg38)

Size:: 8,587 bases
Orientation:: Minus strand

chr2:10,580,094-10,588,630: (GRCh37/hg19)

Size:: 8,537 bases
Orientation:: Minus strand

Genomic View for ODC1 Gene

Genes around ODC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

2p25.1 by HGNC
2p25.1 by Entrez Gene
2p25.1 by Ensembl

ODC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for ODC1 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ODC1 Gene

NC_000002.12

Proteins for ODC1 Gene

Protein details for ODC1 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P11926-DCOR_HUMAN

Recommended name:

Ornithine decarboxylase

Protein Accession:

P11926

Secondary Accessions:
- Q53TU3
- Q6LDS9
Protein attributes for ODC1 Gene
Size:

461 amino acids

Molecular mass:

51148 Da

Cofactor:

Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Quaternary structure:
Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers (Probable). Does not form a heterodimer with AZIN2 (By similarity).
Three dimensional structures from OCA and Proteopedia for ODC1 Gene
- 1D7K (3D)
- 2ON3 (3D)
- 2OO0 (3D)
- 4ZGY (3D)
- 5BWA (3D)

neXtProt entry for ODC1 Gene

Protein Expression for ODC1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ODC1 Gene

P11926:

DCASKTEIQLVQ
AASTFNGF
GVSFHVGSG
GSDDEDES
SQIKYAA
LDEGFTAKDILDQKINEVS
IWGPTCD
AEPGRYYVASAFTLAVN
LKKHLRWLKALP
KLKFEEIT
LDIGGGF
SDDKDAFYVAD
SDARCVFDM
ELMKVAR
RLSVKFGA
GAYTVAAAS
DGVYGSFN
VLRIATDDSK

Post-translational modifications for ODC1 Gene

S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.
- P11926-DCOR_HUMAN
Modification sites at PhosphoSitePlus
- P11926
Modification sites at neXtProt
- NX_P11926

Other Protein References for ODC1 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

G Biosciences Immunotag™ ODC1 Antibody

NSJ Bioreagents ODC Antibody (Mouse Monoclonal)

Creative Diagnostics

Creative Biolabs

GeneTex Anti-ODC antibody [N3C3] and Anti-ODC antibody [ODC1/485]

OriGene Antibodies for ODC1
- AM20652PU-N
- AM50149PU-S
- AM50149PU-T
- AM50303PU-S
- AM50303PU-T
- CF501286
- CF501546
- EUD2551
- TA308547
- TA321500
- TA332473
- TA501286
- TA501286S
- TA501546
Custom Antibody Services

Novus Biologicals Antibodies for ODC1

Invitrogen Antibodies for ODC1 (AFLGC-ODC1)

antibodies-online: Show 64 available ODC1 Antibodies ranked by validation data
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Biorbyt antibodies for ODC1
- orb11186
- orb381927
- orb388533
- orb388535
- orb388536
- orb240041
- orb555961

Boster Bio Antibodies for ODC1
- M03138

Santa Cruz Biotechnology (SCBT) Antibodies for ODC1
- ODC (G-10)
- ODC (E-6)

Browse Sino Biological Antibodies

Protein Products

G Biosciences Human Ornithine decarboxylase/ODC1, Liquid

Creative Biomart

OriGene Purified Proteins for ODC1
- NM_002539
- NM_002539
- NM_002539
- NM_002539
- NM_002539
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Origene Custom Protein Services for ODC1

Novus Biologicals proteins and lysates for ODC1

ProSpec Recombinant Proteins for ODC1

antibodies-online: Show 29 available ODC1 Proteins ranked by validation data
Compare Top ODC1 Proteins
Quality Products:

ProSci Proteins for ODC1
- ornithine decarboxylase 1

Abcam proteins for ODC1
- Ornithine Decarboxylase

Assay Products

G Biosciences Immunotag™ Human ODC1 (Ornithine decarboxylase) ELISA and Immunotag™ Ornithine decarboxylase ELISA Kit

Creative Diagnostics Human ODC1 ELISA Matched Antibody Pair (ABPR-0645) and Human ODC1 ELISA Matched Antibody Pair (ABPR-0646)

Aviva Systems Biology ODC1 ELISA Kit (Human) (OKEH00954) and ODC1 ELISA Kit (Human) (OKCD07326)

antibodies-online: Show 64 available ODC1 Elisa Kits ranked by validation data
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Browse Boster Bio ELISA Kits

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Domains & Families for ODC1 Gene

Gene Families for ODC1 Gene

HGNC:

Small nucleolar RNA protein coding host genes

IUPHAR :

Decarboxylases

Human Protein Atlas (HPA):

Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Protein Domains for ODC1 Gene

Blocks:

InterPro:

ProtoNet:

P11926

Suggested Antigen Peptide Sequences for ODC1 Gene

GenScript: Design optimal peptide antigens:

Ornithine decarboxylase (DCOR_HUMAN)
cDNA, FLJ93177, Homo sapiens ornithine decarboxylase 1 (ODC1), mRNA (Q53TU3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P11926

UniProtKB/Swiss-Prot:

DCOR_HUMAN :

Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Family:

Belongs to the Orn/Lys/Arg decarboxylase class-II family.

Function for ODC1 Gene

Molecular function for ODC1 Gene

UniProtKB/Swiss-Prot Function:

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.

DCOR_HUMAN,P11926

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=H(+) + L-ornithine = CO2 + putrescine; Xref=Rhea:RHEA:22964, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:46911, ChEBI:CHEBI:326268; EC=4.1.1.17; Evidence=. ;.

DCOR_HUMAN,P11926

UniProtKB/Swiss-Prot EnzymeRegulation:

Inhibited by S-nitrosylation (PubMed:10462479, PubMed:11461922). Inhibited by antizymes (AZs) OAZ1, OAZ2 and OAZ3 in response to polyamine levels. AZs inhibit the assembly of the functional homodimer by binding to ODC monomers. Additionally, OAZ1 targets ODC monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240). Inhibited by 1-amino-oxy-3-aminopropane (APA, an isosteric analog of putrescine) (PubMed:17407445). Irreversibly inhibited by alpha-difluoromethylornithine (DFMO) (PubMed:17407445).

DCOR_HUMAN,P11926

UniProtKB/Swiss-Prot BiophysicochemicalProperties:

Kinetic parameters: KM=0.08 mM for L-ornithine {ECO:0000269 PubMed:17407445}; Note=kcat is 3.3 sec(-1) with L-ornithine as substrate. {ECO:0000269 PubMed:17407445};

DCOR_HUMAN,P11926

UniProtKB/Swiss-Prot Induction:

Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).

DCOR_HUMAN,P11926

GENATLAS Biochemistry:

ornithine decarboxylase 1,ornithine metabolism,mitochondrial matrix

ODC1

Enzyme Numbers (IUBMB) for ODC1 Gene

EC 4.1.1.17 ⁵⁴ ⁴

Gene Ontology (GO) - Molecular Function for ODC1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	IEA	--
GO:0004586	ornithine decarboxylase activity	TAS	2317811
GO:0005515	protein binding	IPI	25416956
GO:0016829	lyase activity	IEA	--
GO:0016831	carboxy-lyase activity	IEA	--

Phenotypes for ODC1 Gene

MGI mutant phenotypes for ODC1:

inferred from 2 alleles

GenomeRNAi human phenotypes for ODC1:

Animal Models for ODC1 Gene

MGI Knock Outs for ODC1:

Odc1 ^{Odc1<tm1b(EUCOMM)Hmgu>}
Odc1 ^Odc1<tm1Jlc>

Animal Model Products

Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study

CRISPR Products

OriGene CRISPR knockouts for ODC1
- KN406858
- KN511436

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ODC1

genomics-online: gRNA clones - Search results for available ODC1 gene related products

Applied Biological Materials (abm): CRISPR Clones for ODC1 - Select products 50% OFF >
* ODC1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
* ODC1 CRISPR applications: KO, Activation, Repression, and more - Browse All

Santa Cruz Biotechnology (SCBT) CRISPR for ODC1

miRNA for ODC1 Gene

miRTarBase miRNAs that target ODC1

miRNA Products

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Browse OriGene miRNA Products For ODC1

Inhibitory RNA Products

Origene sirna, shrna, and RNAi products in human, mouse, rat for ODC1
Browse OriGene Inhibitory RNA Products For ODC1

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ODC1

genomics-online: shRNA clones - Search results for available ODC1 gene related products

Search Santa Cruz Biotechnology (SCBT) for ODC1 siRNA/shRNA

Clone Products

OriGene clones in human,mouse,rat for ODC1
- MC203159
- RN205687
- RN216718
- SC204567
- SC321469
- SC335394
- SC336252
- SC336253
OriGene ORF clones in human,mouse,rat for ODC1
- MG207353
- MG207359
- MR207353
- MR207353L3
- MR207353L3V
- MR207353L4
- MR207353L4V
- MR207359
- MR207359L3
- MR207359L3V
- MR207359L4
- MR207359L4V
- RC206858
- RC206858L1
- RC206858L1V
- RC206858L2
- RC206858L2V
- RC206858L3
- RC206858L3V
- RC206858L4
- RC206858L4V
- RC237500
- RC238358
- RC238359
- RG206858
- RR205687
- RR205687L3
- RR205687L3V
- RR205687L4
- RR205687L4V
- RR216718
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for ODC1

Search Addgene for plasmids for ODC1

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ODC1

genomics-online: cdna clones - Search results for available ODC1 gene related products
orf clones - Search results for available ODC1 gene related products

Applied Biological Materials (abm): Clones for ODC1 - Select products 50% OFF >
* ODC1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for ODC1

Browse GeneCopoeia Cell Lines

Search Horizon for Cell Lines for ODC1

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ODC1 Gene

Localization for ODC1 Gene

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
cytosol	5
nucleus	3
plasma membrane	2
extracellular	2
cytoskeleton	1
mitochondrion	1
peroxisome	1
endoplasmic reticulum	1
lysosome	1

Subcellular locations from the

Human Protein Atlas (HPA)

Cytosol (2)
Plasma membrane (2)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for ODC1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005737	cytoplasm	IBA,ISS	--
GO:0005829	cytosol	TAS	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ODC1 Gene

Pathways & Interactions for ODC1 Gene

SuperPathways for ODC1 Gene

	SuperPathway	Contained pathways
1	Metabolism	Metabolic pathways .40	Metabolism .40
2	CDK-mediated phosphorylation and removal of Cdc6	Regulation of ornithine decarboxylase (ODC) .81	Metabolism of polyamines .60
3	Urea cycle and metabolism of amino groups	putrescine biosynthesis I .01	Urea cycle and metabolism of amino groups -
4	Arginine and proline metabolism	Arginine and proline metabolism -
5	Glutathione metabolism	Glutathione metabolism .61

Pathways by source for ODC1 Gene

5 BioSystems pathways for ODC1 Gene

4 Reactome pathways for ODC1 Gene

3 KEGG pathways for ODC1 Gene

UniProtKB/Swiss-Prot P11926-DCOR_HUMAN

Pathway: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.

Interacting Proteins for ODC1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: P11926-DCOR_HUMAN ENSP00000234111 for ODC1 Gene via UniProtKB MINT STRING IID

Symbol	External ID(s)	Details
OAZ3	Q9UMX2 ⁴ ¹²⁹ Q9UMX2-2 ⁴ ENSP00000313922 ²¹	EBI-1044287, EBI-10281601 EBI-1044287, EBI-12049527 STRING: ENSP00000313922 IID: # exp=3
KAT5	Q92993 ⁴ ¹²⁹ ENSP00000340330 ²¹	EBI-1044287, EBI-399080 STRING: ENSP00000340330 IID: # exp=1
TK1	P04183 ²⁰ ¹²⁹ ENSP00000301634 ²¹	MINT-8273840 STRING: ENSP00000301634 IID: # exp=1
AGMAT	ENSP00000364986 ²¹ Q9BSE5 ¹²⁹	STRING: ENSP00000364986 IID: # pred=2
AMD1	ENSP00000357880 ²¹ P17707 ¹²⁹	STRING: ENSP00000357880 IID: # pred=1

GPS-Prot Interaction Network for ODC1

SIGNOR curated interactions for ODC1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ODC1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001822	kidney development	IEA	--
GO:0006521	regulation of cellular amino acid metabolic process	TAS	--
GO:0006595	polyamine metabolic process	TAS	--
GO:0006596	polyamine biosynthetic process	IEA	--
GO:0008284	positive regulation of cell proliferation	IEA	--

Drugs & Compounds for ODC1 Gene

(90) Drugs for ODC1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name	Status	Disease Links	Group	Role	Clinical Trials
Eflornithine	Approved, Withdrawn	MalaCards Medline Plus	Pharma	Target, antagonist, blocker, inhibitor	37
Pyridoxal Phosphate	Approved, Investigational	MalaCards Medline Plus	Nutra	Target, cofactor	22
Carbon dioxide	Approved, Investigational, Vet_approved	MalaCards Medline Plus	Pharma		0
Ornithine	Approved	MalaCards Medline Plus	Nutra		79
Benserazide	Approved, Investigational	MalaCards Medline Plus	Pharma	Inhibition, Inhibitor	25

(83) Additional Compounds for ODC1 Gene - From: Novoseek, HMDB, and IUPHAR

Name	Synonyms	Role	CAS Number	PubChem IDs	PubMed IDs
DFMO		Inhibition, Inhibitor	MalaCards Medline Plus	68278-23-9		11698350 7493642 20051371 11688517 9009157
L-alpha-methyldopa		Inhibition, Inhibitor	MalaCards Medline Plus
1,3-diaminopropane	1,3-Propanediamine 1,3-Propylenediamine Propane-1,3-diamine tn 1,3-diamino-N-Propane		MalaCards Medline Plus	109-76-2	428
N1-acetylspermine	N'-acetylspermine N'-monoacetylspermine N(1)-Acetylspermine N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-acetamide N-Acetylspermine		MalaCards Medline Plus	25593-72-0	916
Norspermidine	1,7-diamino-4-Azaheptane 3,3'-Iminobis(propylamine) 3,3'-Iminobispropylamine 3,3'-Iminodi(propylamine) 3,3-Diaminodipropylamine		MalaCards Medline Plus	56-18-8	5942

Drug Products

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Browse compounds at ApexBio

Transcripts for ODC1 Gene

mRNA/cDNA for ODC1 Gene

(4) REFSEQ mRNAs :

(15) Additional mRNA sequences :

(834) Selected AceView cDNA sequences:

(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

ENST00000234111 2476 bps (ENST00000234111.8)
ENST00000405333 1943 bps (ENST00000405333.5)
ENST00000446285 665 bps (ENST00000446285.5)
ENST00000443218 494 bps (ENST00000443218.1)

CRISPR Products

OriGene CRISPR knockouts for ODC1
- KN406858
- KN511436

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ODC1

genomics-online: gRNA clones - Search results for available ODC1 gene related products

Applied Biological Materials (abm): CRISPR Clones for ODC1 - Select products 50% OFF >
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* ODC1 CRISPR applications: KO, Activation, Repression, and more - Browse All

Santa Cruz Biotechnology (SCBT) CRISPR for ODC1

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for ODC1

Browse OriGene miRNA Products For ODC1

Inhibitory RNA Products

Origene sirna, shrna, and RNAi products in human, mouse, rat for ODC1
Browse OriGene Inhibitory RNA Products For ODC1

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ODC1

genomics-online: shRNA clones - Search results for available ODC1 gene related products

Search Santa Cruz Biotechnology (SCBT) for ODC1 siRNA/shRNA

Clone Products

OriGene clones in human,mouse,rat for ODC1
- MC203159
- RN205687
- RN216718
- SC204567
- SC321469
- SC335394
- SC336252
- SC336253
OriGene ORF clones in human,mouse,rat for ODC1
- MG207353
- MG207359
- MR207353
- MR207353L3
- MR207353L3V
- MR207353L4
- MR207353L4V
- MR207359
- MR207359L3
- MR207359L3V
- MR207359L4
- MR207359L4V
- RC206858
- RC206858L1
- RC206858L1V
- RC206858L2
- RC206858L2V
- RC206858L3
- RC206858L3V
- RC206858L4
- RC206858L4V
- RC237500
- RC238358
- RC238359
- RG206858
- RR205687
- RR205687L3
- RR205687L3V
- RR205687L4
- RR205687L4V
- RR216718
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for ODC1

Search Addgene for plasmids for ODC1

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ODC1

genomics-online: cdna clones - Search results for available ODC1 gene related products
orf clones - Search results for available ODC1 gene related products

Applied Biological Materials (abm): Clones for ODC1 - Select products 50% OFF >
* ODC1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* ODC1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ODC1 Gene

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15a	·
SP1:													-		-		-		-																														-		-
SP2:					-		-		-		-		-		-		-		-
SP3:									-		-		-		-		-		-
SP4:																	-		-
SP5:													-		-		-		-		-		-
SP6:													-		-		-		-		-
SP7:
SP8:
SP9:																													-
SP10:
SP11:			-		-		-		-		-		-		-		-		-
SP12:							-		-		-		-		-		-		-
SP13:																			-
SP14:

ExUns:	15b	^	16	^	17a	·	17b	^	18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ODC1 Gene

GeneLoc Exon Structure for: ODC1
ECgene alternative splicing isoforms for: ODC1

Expression for ODC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ODC1 Gene

mRNA expression in normal human tissues for ODC1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ODC1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MaxQB, and MOPED for ODC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ODC1 Gene:

ODC1

SOURCE GeneReport for Unigene cluster for ODC1 Gene:

Hs.467701

Evidence on tissue expression from TISSUES for ODC1 Gene

Nervous system(4.6)
Intestine(4.2)
Lung(4.2)
Skin(4.1)
Liver(3.4)
Pancreas(3.4)
Eye(3.3)
Stomach(3.1)
Kidney(3)
Muscle(2.6)
Blood(2.5)
Heart(2.5)
Spleen(2.4)
Adrenal gland(2.3)
Thyroid gland(2.3)

Primer Products

OriGene qPCR primer pairs for ODC1
- HP206203
- MP210450
OriGene qPCR primer pairs and template standards for ODC1
- HK205289
- MK202593

genomics-online: primer clones - Search results for available ODC1 gene related products

Gene Expression Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for ODC1

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ODC1 Gene

Orthologs for ODC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ODC1 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
chimpanzee (Pan troglodytes)	Mammalia	ODC1 ³³ ³²	99.57 (n)	OneToOne	2A:10536487-10544545 459027 XM_001157520.2 XP_001157520.1
oppossum (Monodelphis domestica)	Mammalia	-- ³³	91 (a)	OneToMany	3:478411627-478413101
oppossum (Monodelphis domestica)	Mammalia	-- ³³	91 (a)	OneToMany	1:528427872-528432556
cow (Bos Taurus)	Mammalia	ODC1 ³³ ³²	89.01 (n)	OneToMany	11:87178098-87182503 281365 NM_174130.2 NP_776555.1
cow (Bos Taurus)	Mammalia	-- ³³	77 (a)	OneToMany	21:50322855-50324578
platypus (Ornithorhynchus anatinus)	Mammalia	ODC1 ³³	89 (a)	OneToOne	Contig8737:3292-11211
dog (Canis familiaris)	Mammalia	ODC1 ³³ ³²	88.94 (n)	OneToOne	17:7366484-7377498 475666 XM_851618.3 XP_856711.1
mouse (Mus musculus)	Mammalia	Odc1 ¹⁷ ³³ ³²	86.62 (n)		17544867 12:17544873-17551502 18263 NM_013614.2 NP_038642.2
rat (Rattus norvegicus)	Mammalia	Odc1 ³²	86.62 (n)		24609 NM_012615.2 NP_036747.1
chicken (Gallus gallus)	Aves	ODC1 ³³ ³²	78.19 (n)	OneToOne	3:96350213-96356450 421937 NM_001167766.1 NP_001161238.1
lizard (Anolis carolinensis)	Reptilia	ODC1 ³³	82 (a)	OneToOne	1:147521088-147561049
tropical clawed frog (Silurana tropicalis)	Amphibia	odc1 ³²	74.73 (n)		448028 NM_001005441.1 NP_001005441.1
African clawed frog (Xenopus laevis)	Amphibia	odc1-prov ³²			BC044004.1
zebrafish (Danio rerio)	Actinopterygii	odc1 ³³ ³² ³²	67.25 (n)	OneToOne	17:52270218-52283861 114426 NM_131801.2 NP_571876.1
rainbow trout (Oncorhynchus mykiss)	Actinopterygii	Omy.5110 ³²			BX860964.1
African malaria mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP011805 ³²	52.63 (n)		1280843 XM_320710.4 XP_320710.4
fruit fly (Drosophila melanogaster)	Insecta	Odc1 ³³ ³⁴ ³²	51.63 (n)	ManyToMany	2R:3892308-3894177 35766 NM_057704.4 NP_477052.2
fruit fly (Drosophila melanogaster)	Insecta	Odc2 ³³ ³⁴	41 (a)	ManyToMany	2R:3894769-3896567
worm (Caenorhabditis elegans)	Secernentea	odc-1 ³⁴ ³²	53.91 (n)		179079 NM_072351.6 NP_504752.1
		F53F10.2a ³⁴	28 (a)
		F53F10.2 ³³	24 (a)	OneToMany	I:3831117-3834124
K. lactis yeast (Kluyveromyces lactis)	Saccharomycetes	KLLA0B02673g ³²	54.12 (n)		2897080 XM_451651.1 XP_451651.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SPE1 ³⁵ ³³ ³²	52.38 (n)		XI:96757-98157 853651 NP_012737.1
A. gosspyii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_AER087C ³²	51.52 (n)		4621151 NM_210301.2 NP_984947.2
rice (Oryza sativa)	Liliopsida	Os09g0543400 ³²	49.54 (n)		4347746 NM_001070362.2 NP_001063827.2
fission yeast (Schizosaccharomyces pombe)	Schizosaccharomycetes	spe1 ³²	55.18 (n)		2542855 NP_594665.1
bread mold (Neurospora crassa)	Ascomycetes	NCU01271 ³²	53.09 (n)		3876899 XM_955656.2 XP_960749.1
sea squirt (Ciona savignyi)	Ascidiacea	CSA.10349 ³³	43 (a)	OneToMany	reftig_14:654859-661950

Species where no ortholog for ODC1 was found in the sources mined by GeneCards:

Actinobacteria (Mycobacterium tuberculosis)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
thale cress (Arabidopsis thaliana)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
wheat (Triticum aestivum)

Evolution for ODC1 Gene

ENSEMBL:: Gene Tree for ODC1 (if available)
TreeFam:: Gene Tree for ODC1 (if available)
Aminode:: Evolutionary constrained regions (ECRs) for ODC1: view image

Paralogs for ODC1 Gene

AZIN2 ⁵
AZIN1 ⁵

(2) SIMAP similar genes for ODC1 Gene using alignment to 3 proteins:

DCOR_HUMAN
C9JG30_HUMAN
L8EA08_HUMAN

ADC
AZIN1

Pseudogenes.org Pseudogenes for ODC1 Gene

Variants for ODC1 Gene

Sequence variations from dbSNP and Humsavar for ODC1 Gene

SNP ID	Clin	Chr 02 pos	Variation	Type
rs2302615	protective, Colonic adenoma recurrence, reduced risk of	10,448,012(-)	C/T	5_prime_UTR_variant, intron_variant
rs1000101367	--	10,447,155(-)	T/C	intron_variant
rs1000614261	--	10,446,692(-)	C/G	intron_variant
rs1000665289	--	10,446,949(-)	C/T	intron_variant
rs1000979644	--	10,442,798(-)	C/A/T	intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ODC1 Gene

Variant ID	Type	Subtype	PubMed ID
esv23515	CNV	loss	19812545
nsv1007185	CNV	gain	25217958
nsv1072922	CNV	deletion	25765185
nsv580963	CNV	gain	21841781
nsv580964	CNV	gain+loss	21841781
nsv580965	CNV	gain	21841781
nsv580966	CNV	loss	21841781
nsv580967	CNV	loss	21841781

Variation tolerance for ODC1 Gene

Residual Variation Intolerance Score: 6.02% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 1.40; 27.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ODC1 Gene

Human Gene Mutation Database (HGMD): ODC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for: ODC1

SNP Genotyping and Copy Number Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for ODC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODC1 Gene

Disorders for ODC1 Gene

(26) MalaCards diseases for ODC1 Gene - From: HGMD, OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder	Aliases	PubMed IDs
colorectal cancer	crc	12810952
sleeping sickness	african sleeping sickness	7598507
transient cerebral ischemia	tia	1499693
esophagus carcinoma in situ	carcinoma in situ of esophagus
cerebral artery occlusion

- elite association - COSMIC cancer census association via MalaCards

Search ODC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ODC1

Genetic Association Database: (GAD)
Human Genome Epidemiology Navigator: (HuGE)
: ATLAS of Genetics and Cytogenetics in Oncology and Haematology

Search disorders for ODC1 gene in PubMed and other databases

No data available for UniProtKB/Swiss-Prot and Genatlas for ODC1 Gene

Publications for ODC1 Gene

Genetic polymorphism in ornithine decarboxylase and risk of breast cancer. (PMID: 19225907) Brown I … Schofield AC (Familial cancer 2009) ³ ²³ ⁴³ ⁵⁶
Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. (PMID: 17900240) Kanerva K … Andersson LC (The Biochemical journal 2008) ³ ⁴ ²³ ⁵⁶
Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention. (PMID: 17047198) Barry EL … O'Brien TG (Journal of the National Cancer Institute 2006) ³ ²³ ⁴³ ⁵⁶
Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. (PMID: 12810952) Martinez ME … Gerner EW (Proceedings of the National Academy of Sciences of the United States of America 2003) ³ ²³ ⁴³ ⁵⁶
Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. (PMID: 11461922) Bauer PM … Ignarro LJ (The Journal of biological chemistry 2001) ³ ⁴ ²³ ⁵⁶