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This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
ODC1 (Ornithine Decarboxylase 1) is a Protein Coding gene. Diseases associated with ODC1 include Global Developmental Delay-Alopecia-Macrocephaly-Facial Dysmorphism-Structural Brain Anomalies Syndrome and Colorectal Cancer. Among its related pathways are Validated targets of C-MYC transcriptional activation and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ornithine decarboxylase activity. An important paralog of this gene is AZIN2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0004586 | ornithine decarboxylase activity | TAS | 2317811 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0016829 | lyase activity | IEA | -- |
GO:0016831 | carboxy-lyase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO:0005737 | cytoplasm | IBA,ISS | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism |
.40
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2 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
3 | Urea cycle and metabolism of amino groups | ||
4 | Arginine and proline metabolism | ||
5 | Glutathione metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001822 | kidney development | IEA | -- |
GO:0006521 | regulation of cellular amino acid metabolic process | TAS | -- |
GO:0006595 | polyamine metabolic process | TAS | -- |
GO:0006596 | polyamine biosynthetic process | IEA | -- |
GO:0008284 | positive regulation of cell proliferation | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Eflornithine | Approved, Withdrawn | Pharma | Target, antagonist, blocker, inhibitor | 40 | ||
Pyridoxal Phosphate | Approved, Investigational | Nutra | Target, cofactor | 16 | ||
Carbon dioxide | Approved, Investigational, Vet_approved | Pharma | 0 | |||
Ornithine | Approved | Nutra | 84 | |||
Benserazide | Approved, Investigational | Pharma | Inhibitor, Inhibition | 26 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
DFMO |
|
Inhibitor, Inhibition | 68278-23-9 |
|
||
1,3-diaminopropane |
|
109-76-2 |
|
|||
N1-acetylspermine |
|
25593-72-0 |
|
|||
Norspermidine |
|
56-18-8 |
|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: |
ExUns: | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: | |||||||||
SP3: | |||||||||
SP4: | |||||||||
SP5: | |||||||||
SP6: | |||||||||
SP7: | |||||||||
SP8: | |||||||||
SP9: | |||||||||
SP10: | |||||||||
SP11: | |||||||||
SP12: | |||||||||
SP13: | |||||||||
SP14: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ODC1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | ODC1 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ODC1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ODC1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Odc1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Odc1 30 |
|
||
Chicken (Gallus gallus) |
Aves | ODC1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ODC1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | odc1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | odc1-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | odc1 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5110 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011805 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Odc1 30 31 32 |
|
ManyToMany | |
Odc2 31 32 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | odc-1 30 32 |
|
||
F53F10.2a 32 |
|
|
|||
F53F10.2 31 |
|
OneToMany | |||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B02673g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPE1 30 31 33 |
|
OneToMany | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER087C 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os09g0543400 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | spe1 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU01271 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10349 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2302615 | Protective: Colonic adenoma recurrence, reduced risk of | 10,448,012(-) | C/T | FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
global developmental delay-alopecia-macrocephaly-facial dysmorphism-structural brain anomalies syndrome |
|
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colorectal cancer |
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sleeping sickness |
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transient cerebral ischemia |
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esophagus carcinoma in situ |
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