Aliases for ODC1 Gene
Aliases for ODC1 Gene
External Ids for ODC1 Gene
- HGNC: 8109
- Entrez Gene: 4953
- Ensembl: ENSG00000115758
- OMIM: 165640
- UniProtKB: P11926
Previous GeneCards Identifiers for ODC1 Gene
- GC02M010365
- GC02M010631
- GC02M010602
- GC02M010531
- GC02M010497
- GC02M010580
Summaries for ODC1 Gene
-
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
GeneCards Summary for ODC1 Gene
ODC1 (Ornithine Decarboxylase 1) is a Protein Coding gene. Diseases associated with ODC1 include Colorectal Cancer and Sleeping Sickness. Among its related pathways are Integrated Breast Cancer Pathway and Validated targets of C-MYC transcriptional activation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ornithine decarboxylase activity. An important paralog of this gene is AZIN2.
UniProtKB/Swiss-Prot for ODC1 Gene
-
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Additional gene information for ODC1 Gene
- Monarch Initiative
- Search for ODC1 at DataMed
- Search for ODC1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ODC1 Gene
Genomics for ODC1 Gene
GeneHancer (GH) Regulatory Elements for ODC1 Gene
Promoters and enhancers for ODC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ODC1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ODC1 gene promoter:
-
- STAT3
- RORalpha2
- Ik-3
- AML1a
- FOXO4
- En-1
- PPAR-gamma1
- PPAR-gamma2
- Lmo2
- Nkx3-1 v1
Regulatory Element Products
Genomic Locations for ODC1 Gene
Genomic Locations for ODC1 Gene
- chr2:10,439,968-10,448,554
- (GRCh38/hg38)
- Size:
- 8,587 bases
- Orientation:
- Minus strand
- chr2:10,580,094-10,588,630
- (GRCh37/hg19)
- Size:
- 8,537 bases
- Orientation:
- Minus strand
Genomic View for ODC1 Gene
Genes around ODC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p25.1 by Entrez Gene
- 2p25.1 by HGNC
- 2p25.1 by Ensembl
ODC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ODC1 Gene
Proteins for ODC1 Gene
-
Protein details for ODC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P11926-DCOR_HUMAN
- Recommended name:
- Ornithine decarboxylase
- Protein Accession:
- P11926
- Q53TU3
- Q6LDS9
Protein attributes for ODC1 Gene
- Size:
- 461 amino acids
- Molecular mass:
- 51148 Da
- Cofactor:
- Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
- Quaternary structure:
-
- Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers (Probable). Does not form a heterodimer with AZIN2 (By similarity).
Protein Expression for ODC1 Gene
Post-translational modifications for ODC1 Gene
- S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ODC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ODC1
-
Abcam antibodies for ODC1
- Invitrogen Antibodies for ODC1
- GeneTex ODC1 Antibody for ODC1
-
Boster Bio Antibodies for ODC1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ODC1
Protein Products
-
OriGene Purified Proteins for ODC1
- Search Origene for MassSpec and Protein Over-expression Lysates for ODC1
- Origene Custom Protein Services for ODC1
- ProSpec Recombinant Proteins for ODC1
- Search GeneTex for Proteins for ODC1
-
ProSci Proteins for ODC1
-
Abcam proteins for ODC1
Assay Products
No data available for DME Specific Peptides for ODC1 Gene
Domains & Families for ODC1 Gene
Gene Families for ODC1 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ODC1 Gene
Suggested Antigen Peptide Sequences for ODC1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P11926- Family:
-
- Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Function for ODC1 Gene
Molecular function for ODC1 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
- UniProtKB/Swiss-Prot CatalyticActivity:
- L-ornithine = putrescine + CO(2).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by S-nitrosylation (PubMed:10462479, PubMed:11461922). Inhibited by antizymes (AZs) OAZ1, OAZ2 and OAZ3 in response to polyamine levels. AZs inhibit the assembly of the functional homodimer by binding to ODC monomers. Additionally, OAZ1 targets ODC monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240). Inhibited by 1-amino-oxy-3-aminopropane (APA, an isosteric analog of putrescine) (PubMed:17407445). Irreversibly inhibited by alpha-difluoromethylornithine (DFMO) (PubMed:17407445).
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=0.08 mM for L-ornithine {ECO:0000269 PubMed:17407445}; Note=kcat is 3.3 sec(-1) with L-ornithine as substrate. {ECO:0000269 PubMed:17407445};
- UniProtKB/Swiss-Prot Induction:
- Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).
- GENATLAS Biochemistry:
- ornithine decarboxylase 1,ornithine metabolism,mitochondrial matrix
Enzyme Numbers (IUBMB) for ODC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004586 | ornithine decarboxylase activity | TAS | 2317811 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0016829 | lyase activity | IEA | -- |
| GO:0016831 | carboxy-lyase activity | IEA | -- |
Phenotypes for ODC1 Gene
- MGI mutant phenotypes for ODC1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ODC1:
-
- Decreased ionizing radiation sensitivity
- Increased shRNA abundance (Z-score > 2)
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella enterica Typhimurium binding
- Decreased Salmonella-containing vacuole maturation
- Decreased Salmonella enterica Typhimurium ruffling
- Decreased Salmonella enterica Typhimurium effector injection
- Decreased Salmonella enterica Typhimurium membrane closure
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Synthetic lethal with Ras
- Decreased shRNA abundance (Z-score < -2)
- Increased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ODC1
-
CRISPR Products
-
OriGene CRISPR knockouts for ODC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ODC1
- genomics-online: gRNA clones - Search results for available ODC1 gene related products
- Applied Biological Materials CRISPR for ODC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ODC1
- GenScript: Design CRISPR guide RNA sequences for ODC1
miRNA for ODC1 Gene
- miRTarBase miRNAs that target ODC1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ODC1
- Browse OriGene Inhibitory RNA Products For ODC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ODC1
- genomics-online: shRNA clones - Search results for available ODC1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ODC1
- VectorBuilder custom plasmid, inducible vectors for ODC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ODC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ODC1
- genomics-online: cdna clones - Search results for available ODC1 gene related products
- orf clones - Search results for available ODC1 gene related products
- Applied Biological Materials Clones for ODC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ODC1 Gene
Localization for ODC1 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| plasma membrane | 3 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| lysosome | 1 |
- Cytosol (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005737 | cytoplasm | IBA,ISS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ODC1 Gene
Pathways & Interactions for ODC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 3 | Urea cycle and metabolism of amino groups | ||
| 4 | Arginine and proline metabolism | ||
| 5 | Glutathione metabolism | ||
Pathways by source for ODC1 Gene
5 BioSystems pathways for ODC1 Gene
4 Reactome pathways for ODC1 Gene
3 KEGG pathways for ODC1 Gene
UniProtKB/Swiss-Prot P11926-DCOR_HUMAN
- Pathway: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Interacting Proteins for ODC1 Gene
Selected Interacting proteins:
ENSP00000234111
P11926-DCOR_HUMAN
for ODC1 Gene via
STRING
MINT
UniProtKB
IID
GPS-Prot Interaction Network for ODC1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001822 | kidney development | IEA | -- |
| GO:0006521 | regulation of cellular amino acid metabolic process | TAS | -- |
| GO:0006595 | polyamine metabolic process | TAS | -- |
| GO:0006596 | polyamine biosynthetic process | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
No data available for SIGNOR curated interactions for ODC1 Gene
Drugs & Compounds for ODC1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| spermine | Approved | Nutra | Full agonist, Agonist, Antagonist, Pore Blocker, Channel blocker, Target, product of | 0 | ||
| Pyridoxal Phosphate | Approved, Investigational | Nutra | Target, cofactor | 17 | ||
| Eflornithine | Approved, Withdrawn | Pharma | inhibitor, Target, antagonist, blocker | 34 | ||
| Carbon dioxide | Approved, Investigational, Vet_approved | Pharma | 0 | |||
| Ornithine | Approved | Nutra | 70 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| DFMO |
|
Inhibition, Inhibitor | 68278-23-9 |
|
||
| L-alpha-methyldopa |
|
Inhibition, Inhibitor |
|
|
||
| 1,3-diaminopropane |
|
109-76-2 |
|
|||
| N1-acetylspermine |
|
25593-72-0 |
|
|||
| Norspermidine |
|
56-18-8 |
|
Drug Products
Transcripts for ODC1 Gene
mRNA/cDNA for ODC1 Gene
- (4) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (834) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000234111 2653 bps (uc002rao.3)
- ENST00000405333 1943 bps (uc010exg.3)
- ENST00000446285 665 bps (uc061gqm.1)
- ENST00000443218 494 bps (uc061gqn.1)
Unigene Clusters for ODC1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ODC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ODC1
- genomics-online: gRNA clones - Search results for available ODC1 gene related products
- Applied Biological Materials CRISPR for ODC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ODC1
- GenScript: Design CRISPR guide RNA sequences for ODC1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ODC1
- Browse OriGene Inhibitory RNA Products For ODC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ODC1
- genomics-online: shRNA clones - Search results for available ODC1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ODC1
- VectorBuilder custom plasmid, inducible vectors for ODC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ODC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ODC1
- genomics-online: cdna clones - Search results for available ODC1 gene related products
- orf clones - Search results for available ODC1 gene related products
- Applied Biological Materials Clones for ODC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | |||||||||
| SP10: | |||||||||
| SP11: | |||||||||
| SP12: | |||||||||
| SP13: | |||||||||
| SP14: |
Expression for ODC1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ODC1 Gene
NURSA nuclear receptor signaling pathways regulating expression of ODC1 Gene:
ODC1SOURCE GeneReport for Unigene cluster for ODC1 Gene:
Hs.467701Evidence on tissue expression from TISSUES for ODC1 Gene
- Nervous system(4.6)
- Intestine(4.2)
- Lung(4.2)
- Skin(4.1)
- Liver(3.4)
- Pancreas(3.4)
- Eye(3.3)
- Stomach(3.1)
- Kidney(3)
- Muscle(2.6)
- Blood(2.5)
- Heart(2.5)
- Spleen(2.4)
- Adrenal gland(2.3)
- Thyroid gland(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for ODC1
-
OriGene qPCR primer pairs for ODC1
- genomics-online: primer clones - Search results for available ODC1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ODC1 Gene
Orthologs for ODC1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ODC1 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | ODC1 34 33 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ODC1 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ODC1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Odc1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Odc1 33 |
|
||
| chicken (Gallus gallus) |
Aves | ODC1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ODC1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | odc1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | odc1-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | odc1 34 33 33 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5110 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011805 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Odc1 34 35 33 |
|
ManyToMany | |
| Odc2 34 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | odc-1 35 33 |
|
||
| F53F10.2a 35 |
|
|
|||
| F53F10.2 34 |
|
OneToMany | |||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B02673g 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPE1 36 34 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER087C 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os09g0543400 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | spe1 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU01271 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10349 34 |
|
OneToMany |
- Species where no ortholog for ODC1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ODC1 Gene
- ENSEMBL:
- Gene Tree for ODC1 (if available)
- TreeFam:
- Gene Tree for ODC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ODC1: view image
Paralogs for ODC1 Gene
(2) SIMAP similar genes for ODC1 Gene using alignment to 3 proteins:
- DCOR_HUMAN
- C9JG30_HUMAN
- L8EA08_HUMAN
Pseudogenes.org Pseudogenes for ODC1 Gene
Variants for ODC1 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2302615 | protective, Colonic adenoma recurrence, reduced risk of | 10,448,012(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000101367 | -- | 10,447,155(-) | T/C | intron_variant | |
| rs1000614261 | -- | 10,446,692(-) | C/G | intron_variant | |
| rs1000665289 | -- | 10,446,949(-) | C/T | intron_variant | |
| rs1000979644 | -- | 10,442,798(-) | C/A/T | intron_variant |
Residual Variation Intolerance Score:
6.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.40;
27.49% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ODC1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ODC1 Gene
Disorders for ODC1 Gene
(24) MalaCards diseases for ODC1 Gene - From: HGMD, OMIM, ClinVar, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| colorectal cancer |
|
|
| sleeping sickness |
|
|
| transient cerebral ischemia |
|
|
| esophagus carcinoma in situ |
|
|
| kidney hypertrophy |
|
|
Search ODC1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ODC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ODC1 Gene
Publications for ODC1 Gene
- Genetic polymorphism in ornithine decarboxylase and risk of breast cancer. (PMID: 19225907) Brown I … Schofield AC (Familial cancer 2009) 3 22 44 58
- Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. (PMID: 17900240) Kanerva K … Andersson LC (The Biochemical journal 2008) 3 4 22 58
- Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention. (PMID: 17047198) Barry EL … O'Brien TG (Journal of the National Cancer Institute 2006) 3 22 44 58
- Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. (PMID: 12810952) Martinez ME … Gerner EW (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 22 44 58
- Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. (PMID: 11461922) Bauer PM … Ignarro LJ (The Journal of biological chemistry 2001) 3 4 22 58
Products for ODC1 Gene
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- antibodies-online: Search results for 213 available ODC1 Antibodies ranked by validation data
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- GeneTex ODC1 Antibody for ODC1
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- Boster Bio Antibodies for ODC1
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Sources for ODC1 Gene
- (1) GeneCards
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- (68) Cloud-Clone Corp.
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