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Aliases for OCM Gene

Aliases for OCM Gene

  • Oncomodulin 2 3 5
  • Parvalbumin Beta 3 4
  • Beta Parvalbumin 2 3
  • Oncomodulin-1 3 4
  • OCM1 3 4
  • OM 3 4
  • Oncomodulin 1 2
  • HCG18255 3
  • ONCM 3
  • OCMN 4

External Ids for OCM Gene

Previous GeneCards Identifiers for OCM Gene

  • GC07M096148
  • GC07M097211
  • GC07M097225
  • GC07M097258
  • GC07M097452

Summaries for OCM Gene

Entrez Gene Summary for OCM Gene

  • Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. Oncomodulin is an oncodevelopmental protein found in early embryonic cells in the placenta and also in tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for OCM Gene

OCM (Oncomodulin) is a Protein Coding gene. Diseases associated with OCM include Melanoma, Uveal. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is OCM2.

UniProtKB/Swiss-Prot for OCM Gene

  • Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.

Additional gene information for OCM Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OCM Gene

Genomics for OCM Gene

GeneHancer (GH) Regulatory Elements for OCM Gene

Promoters and enhancers for OCM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J005822 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 600.3 -36.4 -36398 2.5 SP1 ZFX CC2D1A ELF3 MNT SIX5 CBFA2T2 NKRF MLLT1 GTF2F1 ZNF815P OCM ZNF316 C7orf26 ZNF12 ANKRD61 USP42 RNF216 ENSG00000230733 GC07P005828
GH07J005856 Enhancer 0.8 Ensembl ENCODE 600.7 -1.8 -1823 3.2 CC2D1A CTCF RAD21 PRDM10 REST TRIM22 SMARCA5 SMC3 SKIL ZNF654 OCM ZNF890P ZNF815P GC07P005828
GH07J005661 Enhancer 0.9 Ensembl ENCODE dbSUPER 5.6 -197.0 -197020 2.8 NR2F2 RAD21 JUN MAX ZBTB33 NFATC1 ACTB FSCN1 FBXL18 OCM RNF216 EIF2AK1 RNF216-IT1
GH07J005708 Enhancer 0.2 dbSUPER 5.7 -150.7 -150711 0.5 OCM MIR6874 GC07P005695 RNF216
GH07J005833 Enhancer 0.8 Ensembl ENCODE 0.3 -24.5 -24503 5.4 ZNF121 TRIM24 IKZF1 EGR1 OSR2 TRIM28 ZFHX2 BCOR NFIB GLIS1 ZNF890P ZNF815P CCZ1B GC07P005828 OCM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OCM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OCM gene promoter:
  • ATF6
  • IRF-1
  • p53
  • RORalpha1
  • RP58
  • STAT3
  • TBP
  • TFIID

Genomic Locations for OCM Gene

Genomic Locations for OCM Gene
chr7:5,859,804-5,886,363
(GRCh38/hg38)
Size:
26,560 bases
Orientation:
Plus strand
chr7:5,919,458-5,925,994
(GRCh37/hg19)
Size:
6,537 bases
Orientation:
Plus strand

Genomic View for OCM Gene

Genes around OCM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OCM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OCM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OCM Gene

Proteins for OCM Gene

  • Protein details for OCM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CE72-ONCO_HUMAN
    Recommended name:
    Oncomodulin-1
    Protein Accession:
    P0CE72
    Secondary Accessions:
    • B9EJH7
    • P32930
    • Q6ISI5
    • Q75MW0

    Protein attributes for OCM Gene

    Size:
    109 amino acids
    Molecular mass:
    12184 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OCM Gene

neXtProt entry for OCM Gene

Post-translational modifications for OCM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OCM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OCM Gene

Domains & Families for OCM Gene

Gene Families for OCM Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OCM Gene

Suggested Antigen Peptide Sequences for OCM Gene

GenScript: Design optimal peptide antigens:
  • Parvalbumin beta (ONCO_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0CE72

UniProtKB/Swiss-Prot:

ONCO_HUMAN :
  • Belongs to the parvalbumin family.
Family:
  • Belongs to the parvalbumin family.
genes like me logo Genes that share domains with OCM: view

Function for OCM Gene

Molecular function for OCM Gene

UniProtKB/Swiss-Prot Function:
Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.
GENATLAS Biochemistry:
oncomodulin,expressed in embryonal cells,placenta,tumors

Gene Ontology (GO) - Molecular Function for OCM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 8354278
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OCM: view
genes like me logo Genes that share phenotypes with OCM: view

Animal Models for OCM Gene

MGI Knock Outs for OCM:
  • Ocm Ocm<tm1e(EUCOMM)Wtsi>
  • Ocm Ocm<tm1.1Ddsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OCM

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OCM Gene

Localization for OCM Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OCM gene
Compartment Confidence
nucleus 4
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for OCM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with OCM: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for OCM Gene

Pathways & Interactions for OCM Gene

PathCards logo

SuperPathways for OCM Gene

No Data Available

Gene Ontology (GO) - Biological Process for OCM Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OCM Gene

Drugs & Compounds for OCM Gene

No Compound Related Data Available

Transcripts for OCM Gene

mRNA/cDNA for OCM Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for OCM Gene

Oncomodulin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OCM

Alternative Splicing Database (ASD) splice patterns (SP) for OCM Gene

No ASD Table

Relevant External Links for OCM Gene

GeneLoc Exon Structure for
OCM
ECgene alternative splicing isoforms for
OCM

Expression for OCM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OCM Gene

mRNA differential expression in normal tissues according to GTEx for OCM Gene

This gene is overexpressed in Brain - Amygdala (x11.3).

NURSA nuclear receptor signaling pathways regulating expression of OCM Gene:

OCM

SOURCE GeneReport for Unigene cluster for OCM Gene:

Hs.571315
genes like me logo Genes that share expression patterns with OCM: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OCM Gene

Orthologs for OCM Gene

This gene was present in the common ancestor of chordates.

Orthologs for OCM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OCM 35 34
  • 99.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 97 (a)
OneToMany
LOC489870 34
  • 90.21 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 95 (a)
OneToMany
LOC100301381 34
  • 90.74 (n)
mouse
(Mus musculus)
Mammalia Ocm 17 35 34
  • 86.85 (n)
rat
(Rattus norvegicus)
Mammalia Ocm2 34
  • 86.85 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves OCM 35 34
  • 69.72 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485867 34
  • 67.58 (n)
zebrafish
(Danio rerio)
Actinopterygii pvalb8 35 34
  • 62.39 (n)
ManyToMany
pvalb9 35
  • 54 (a)
ManyToMany
Species where no ortholog for OCM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OCM Gene

ENSEMBL:
Gene Tree for OCM (if available)
TreeFam:
Gene Tree for OCM (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OCM: view image

Paralogs for OCM Gene

Paralogs for OCM Gene

(8) SIMAP similar genes for OCM Gene using alignment to 1 proteins:

  • ONCO_HUMAN
genes like me logo Genes that share paralogs with OCM: view

Variants for OCM Gene

Sequence variations from dbSNP and Humsavar for OCM Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000016704 -- 5,864,313(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000147379 -- 5,880,655(+) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000242653 -- 5,880,546(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000246806 -- 5,860,180(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000490188 -- 5,885,253(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OCM Gene

Variant ID Type Subtype PubMed ID
dgv402n21 CNV loss 19592680
dgv6241n100 CNV gain 25217958
dgv6242n100 CNV loss 25217958
dgv6243n100 CNV loss 25217958
esv3576285 CNV gain 25503493
esv3612004 CNV loss 21293372
esv3612005 CNV gain 21293372
esv3891030 CNV loss 25118596
nsv1017061 CNV loss 25217958
nsv1017079 CNV gain 25217958
nsv436904 CNV insertion 17901297
nsv830892 CNV loss 17160897
nsv830894 CNV loss 17160897
nsv981428 CNV duplication 23825009

Variation tolerance for OCM Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OCM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OCM

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OCM Gene

Disorders for OCM Gene

MalaCards: The human disease database

(1) MalaCards diseases for OCM Gene - From: DISEASES

Disorder Aliases PubMed IDs
melanoma, uveal
  • uveal melanoma
- elite association - COSMIC cancer census association via MalaCards
Search OCM in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with OCM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OCM Gene

Publications for OCM Gene

  1. Human alpha and beta parvalbumins. Structure and tissue-specific expression. (PMID: 8354278) Föhr UG … Heizmann CW (European journal of biochemistry 1993) 2 3 4 58
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  3. The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome. (PMID: 1559707) Ritzler JM … Berchtold MW (Genomics 1992) 2 3 58
  4. Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage. (PMID: 28031328) An H … Sun FL (Molecular and cellular biology 2017) 3 58
  5. Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice. (PMID: 26843644) Tong B … Simmons DD (The Journal of neuroscience : the official journal of the Society for Neuroscience 2016) 3 58

Products for OCM Gene

Sources for OCM Gene

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