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Aliases for OCLM Gene

Aliases for OCLM Gene

  • Oculomedin 2 3 3 5
  • TISR 3 4
  • Trabecular Meshwork Inducible Stretch Response Protein 3
  • Trabecular Meshwork-Inducible Stretch Response Protein 4

External Ids for OCLM Gene

Previous GeneCards Identifiers for OCLM Gene

  • GC01P183895
  • GC01P181797
  • GC01P182889
  • GC01U900851
  • GC01P183608
  • GC01P183101
  • GC01P184636
  • GC01P186369

Summaries for OCLM Gene

Entrez Gene Summary for OCLM Gene

  • The protein encoded by this gene is induced by cyclic mechanical stretching in trabecular cells of the eye and it is also expressed in retina. This protein may play a role in trabecular meshwork function and the development of glaucoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for OCLM Gene

OCLM (Oculomedin) is a Protein Coding gene. Diseases associated with OCLM include Glaucoma, Primary Open Angle.

Additional gene information for OCLM Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OCLM Gene

Genomics for OCLM Gene

GeneHancer (GH) Regulatory Elements for OCLM Gene

Promoters and enhancers for OCLM Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I186373 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 48.5 -25.2 -25223 3.7 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 TPR ODR4 OCLM ENSG00000228238 GC01P186372 GC01M186369
GH01I186828 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 13.2 +429.0 429042 2.6 ZSCAN4 MZF1 SIN3A FEZF1 RFX5 GTF3C2 ZNF335 ZNF213 ZNF366 ZSCAN5C PLA2G4A TPR OCLM PTGS2 GC01P187071
GH01I186081 Enhancer 1.4 FANTOM5 Ensembl ENCODE 14.1 -317.8 -317805 2 PKNOX1 FOXA2 SMAD1 ARNT FEZF1 IRF4 ZNF766 CBX5 E2F8 SP3 OCLM TPR ODR4 HMCN1 PDC ENSG00000224691 GC01M185927
GH01I187041 Enhancer 0.6 dbSUPER 25 +642.2 642190 3.5 CTCF ARHGAP35 MAFF NONO ZNF512B ZNF316 GATA3 ZNF274 ZNF512 ZNF207 TPR OCLM GC01P187071 PLA2G4A
GH01I186212 Enhancer 1.1 Ensembl ENCODE 11.9 -187.8 -187833 0.3 HDGF PKNOX1 FOXA2 RB1 NFIB ARNT SIN3A RAD21 RFX5 ZNF213 TPR OCLM PACERR LOC105371654 ENSG00000224691
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OCLM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OCLM gene promoter:

Genomic Locations for OCLM Gene

Genomic Locations for OCLM Gene
884 bases
Plus strand

Genomic View for OCLM Gene

Genes around OCLM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OCLM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OCLM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OCLM Gene

Proteins for OCLM Gene

  • Protein details for OCLM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q4G0F9

    Protein attributes for OCLM Gene

    44 amino acids
    Molecular mass:
    5321 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OCLM Gene

Post-translational modifications for OCLM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OCLM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OCLM Gene

Domains & Families for OCLM Gene

Gene Families for OCLM Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for OCLM Gene


Suggested Antigen Peptide Sequences for OCLM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OCLM: view

No data available for UniProtKB/Swiss-Prot for OCLM Gene

Function for OCLM Gene

Phenotypes From GWAS Catalog for OCLM Gene

Phenotypes for OCLM Gene

GenomeRNAi human phenotypes for OCLM:
genes like me logo Genes that share phenotypes with OCLM: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OCLM Gene

Localization for OCLM Gene

Gene Ontology (GO) - Cellular Components for OCLM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OCLM: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OCLM Gene

Pathways & Interactions for OCLM Gene

No Data Available

Interacting Proteins for OCLM Gene

Selected Interacting proteins: Q9Y5M6-TISR_HUMAN for OCLM Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for OCLM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception TAS 10362512
genes like me logo Genes that share ontologies with OCLM: view

No data available for Pathways by source and SIGNOR curated interactions for OCLM Gene

Drugs & Compounds for OCLM Gene

No Compound Related Data Available

Transcripts for OCLM Gene

mRNA/cDNA for OCLM Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OCLM Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OCLM Gene

No ASD Table

Relevant External Links for OCLM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OCLM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OCLM Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OCLM Gene

Protein tissue co-expression partners for OCLM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OCLM Gene:


SOURCE GeneReport for Unigene cluster for OCLM Gene:


mRNA Expression by UniProt/SwissProt for OCLM Gene:

Tissue specificity: Expressed in eye trabeculum; also expressed in retina.

Evidence on tissue expression from TISSUES for OCLM Gene

  • Eye(4.2)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with OCLM: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OCLM Gene

Orthologs for OCLM Gene

Evolution for OCLM Gene

Gene Tree for OCLM (if available)
Gene Tree for OCLM (if available)

No data available for Orthologs for OCLM Gene

Paralogs for OCLM Gene

No data available for Paralogs for OCLM Gene

Variants for OCLM Gene

Sequence variations from dbSNP and Humsavar for OCLM Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000113607 -- 186,400,913(+) C/T 5_prime_UTR_variant
rs1000464904 -- 186,399,558(+) T/G upstream_transcript_variant
rs1002588304 -- 186,399,542(+) G/A upstream_transcript_variant
rs1002974962 -- 186,399,261(+) G/A upstream_transcript_variant
rs1005640460 -- 186,400,137(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OCLM Gene

Variant ID Type Subtype PubMed ID
esv2762201 CNV gain 21179565
esv3575361 CNV gain 25503493
esv3890826 CNV gain 25118596
nsv1012164 CNV gain 25217958

Variation tolerance for OCLM Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OCLM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OCLM Gene

Disorders for OCLM Gene

MalaCards: The human disease database

(1) MalaCards diseases for OCLM Gene - From: DISEASES

Disorder Aliases PubMed IDs
glaucoma, primary open angle
  • poag
- elite association - COSMIC cancer census association via MalaCards
Search OCLM in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OCLM

genes like me logo Genes that share disorders with OCLM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OCLM Gene

Publications for OCLM Gene

  1. A novel gene (oculomedin) induced by mechanical stretching in human trabecular cells of the eye. (PMID: 10362512) Sato Y … Ohtsuki H (Biochemical and biophysical research communications 1999) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Protein expression, genomic structure, and polymorphisms of oculomedin. (PMID: 12868032) Fujiwara N … Ohtsuki H (Ophthalmic genetics 2003) 3 22 58
  4. Absence of trabecular meshwork-inducible stretch response (TISR)/oculomedin gene and proximal promoter mutation in primary open angle glaucoma patients. (PMID: 11129344) Leung YF … Pang CP (Human genetics 2000) 3 22 58
  5. Evaluation of the Oculomedin gene in the etiology of primary open angle and exfoliative glaucoma. (PMID: 12655282) Jansson M … Wadelius C (Molecular vision 2003) 3 58

Products for OCLM Gene

Sources for OCLM Gene

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