Aliases for OBP2B Gene

Aliases for OBP2B Gene

  • Odorant Binding Protein 2B 2 3 5
  • Odorant-Binding Protein IIb 3 4
  • Odorant-Binding Protein 2b 3 4
  • OBPIIb 3 4
  • LCN14 2 3
  • HOBPIIb 2
  • OBP2B 5

External Ids for OBP2B Gene

Previous GeneCards Identifiers for OBP2B Gene

  • GC09P127182
  • GC09M127637
  • GC09M129434
  • GC09M131356
  • GC09M133110
  • GC09M135070
  • GC09M136080
  • GC09M105573

Summaries for OBP2B Gene

GeneCards Summary for OBP2B Gene

OBP2B (Odorant Binding Protein 2B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include odorant binding. An important paralog of this gene is OBP2A.

UniProtKB/Swiss-Prot Summary for OBP2B Gene

Additional gene information for OBP2B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OBP2B Gene

Genomics for OBP2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OBP2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J133223 Enhancer 0.4 Ensembl 616.3 -0.3 -256 1 ZBTB48 SMARCA4 KLF1 OBP2B ABO LCN1P1 RF00017-8038
GH09J133209 Promoter 0.3 EPDnew 600.4 +14.0 13981 0.1 OBP2B piR-42491-238 LOC101928193 RF00017-8038
GH09J133236 Promoter/Enhancer 1.6 ENCODE CraniofacialAtlas dbSUPER 13.5 -15.0 -15004 3.3 HNRNPL CTCF TEAD4 PRDM10 RFX1 IKZF1 KDM1A ZNF692 RCOR2 PRDM1 ABO SETX BRD3OS OBP2B MED22 RPL7A EEF1A1P5 LCN1P1 RF00017-8040 lnc-ABO-33
GH09J133233 Enhancer 0.4 Ensembl 18.8 -10.9 -10946 1.6 MNT ZNF146 JUN MAX ABO OBP2B LCN1P1 RF00017-8040 lnc-ABO-33 RF00017-8038
GH09J133199 Promoter/Enhancer 0.9 ENCODE CraniofacialAtlas 6.5 +23.3 23281 1.5 CTCF GABPA MNT POLR2A GABPB1 SPI1 ZC3H11A MAX ZBTB33 OBP2B LOC101928193 piR-42491-238 RF00017-8038
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OBP2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OBP2B

Top Transcription factor binding sites by QIAGEN in the OBP2B gene promoter:
  • c-Myc
  • GATA-1
  • GATA-3
  • Max1
  • MyoD
  • POU2F1
  • POU2F1a
  • TGIF

Genomic Locations for OBP2B Gene

Genomic Locations for OBP2B Gene
chr9:133,205,277-133,223,255
(GRCh38/hg38)
Size:
17,979 bases
Orientation:
Minus strand
chr9:136,080,664-136,084,630
(GRCh37/hg19)
Size:
3,967 bases
Orientation:
Minus strand

Genomic View for OBP2B Gene

Genes around OBP2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OBP2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OBP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OBP2B Gene

Proteins for OBP2B Gene

  • Protein details for OBP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPH6-OBP2B_HUMAN
    Recommended name:
    Odorant-binding protein 2b
    Protein Accession:
    Q9NPH6
    Secondary Accessions:
    • Q5VSP6
    • Q9NY51
    • Q9NY52

    Protein attributes for OBP2B Gene

    Size:
    170 amino acids
    Molecular mass:
    19457 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OBP2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OBP2B Gene

Post-translational modifications for OBP2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OBP2B Gene

No data available for DME Specific Peptides for OBP2B Gene

Domains & Families for OBP2B Gene

Gene Families for OBP2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for OBP2B Gene

InterPro:
Blocks:
  • Lipocalin signature
  • Von Ebner's gland protein signature
ProtoNet:

Suggested Antigen Peptide Sequences for OBP2B Gene

GenScript: Design optimal peptide antigens:
  • Odorant-binding protein IIb (OBP2B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPH6

UniProtKB/Swiss-Prot:

OBP2B_HUMAN :
  • Belongs to the calycin superfamily. Lipocalin family.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with OBP2B: view

Function for OBP2B Gene

Molecular function for OBP2B Gene

UniProtKB/Swiss-Prot Function:
Probably binds and transports small hydrophobic volatile molecules.
GENATLAS Biochemistry:
odorant binding protein 2B,expressed in genital sphere organs (prostate,mammary glands,deferents ducts) and placenta member of the lipocalin family,of small extracellular proteins outlier group

Phenotypes From GWAS Catalog for OBP2B Gene

Gene Ontology (GO) - Molecular Function for OBP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding NAS 10607840
GO:0036094 small molecule binding IEA --
genes like me logo Genes that share ontologies with OBP2B: view
genes like me logo Genes that share phenotypes with OBP2B: view

Animal Models for OBP2B Gene

MGI Knock Outs for OBP2B:
  • Obp2a Obp2a<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OBP2B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OBP2B Gene

Localization for OBP2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for OBP2B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OBP2B gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for OBP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OBP2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OBP2B Gene

Pathways & Interactions for OBP2B Gene

PathCards logo

SuperPathways for OBP2B Gene

No Data Available

Interacting Proteins for OBP2B Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000484615 Q9NPH6-OBP2B_HUMAN for OBP2B Gene via STRING IID

Gene Ontology (GO) - Biological Process for OBP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007608 sensory perception of smell NAS 10607840
GO:0007635 chemosensory behavior TAS 10607840
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OBP2B: view

No data available for Pathways by source and SIGNOR curated interactions for OBP2B Gene

Drugs & Compounds for OBP2B Gene

No Compound Related Data Available

Transcripts for OBP2B Gene

mRNA/cDNA for OBP2B Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OBP2B

Alternative Splicing Database (ASD) splice patterns (SP) for OBP2B Gene

No ASD Table

Relevant External Links for OBP2B Gene

GeneLoc Exon Structure for
OBP2B

Expression for OBP2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OBP2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OBP2B Gene

This gene is overexpressed in Testis (x20.4), Skin - Not Sun Exposed (Suprapubic) (x10.2), Skin - Sun Exposed (Lower leg) (x7.5), and Breast - Mammary Tissue (x7.0).

Protein differential expression in normal tissues from HIPED for OBP2B Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OBP2B Gene



Protein tissue co-expression partners for OBP2B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OBP2B

SOURCE GeneReport for Unigene cluster for OBP2B Gene:

Hs.449629

mRNA Expression by UniProt/SwissProt for OBP2B Gene:

Q9NPH6-OBP2B_HUMAN
Tissue specificity: Strongly expressed in genital sphere organs such as the prostate and mammary glands.
genes like me logo Genes that share expression patterns with OBP2B: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OBP2B Gene

Orthologs for OBP2B Gene

This gene was present in the common ancestor of mammals.

Orthologs for OBP2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OBP2B 30
  • 96.27 (n)
Cow
(Bos Taurus)
Mammalia LOC618559 30
  • 73.64 (n)
-- 31
  • 58 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Obp2a 30
  • 62.33 (n)
Mouse
(Mus musculus)
Mammalia Obp2a 30 17 31
  • 59.88 (n)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 31 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 27 (a)
OneToMany
Species where no ortholog for OBP2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OBP2B Gene

ENSEMBL:
Gene Tree for OBP2B (if available)
TreeFam:
Gene Tree for OBP2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OBP2B: view image

Paralogs for OBP2B Gene

(4) SIMAP similar genes for OBP2B Gene using alignment to 2 proteins:

  • OBP2B_HUMAN
  • C9J395_HUMAN
genes like me logo Genes that share paralogs with OBP2B: view

Variants for OBP2B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OBP2B Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs11244035 - p.Val167Ile

Additional dbSNP identifiers (rs#s) for OBP2B Gene

Structural Variations from Database of Genomic Variants (DGV) for OBP2B Gene

Variant ID Type Subtype PubMed ID
dgv12930n54 CNV gain 21841781
dgv951n27 CNV gain 19166990
esv2739138 CNV deletion 23290073
esv2739155 CNV deletion 23290073
nsv469905 CNV gain 18288195
nsv6748 CNV insertion 18451855

Variation tolerance for OBP2B Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OBP2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OBP2B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OBP2B Gene

Disorders for OBP2B Gene

Additional Disease Information for OBP2B

No disorders were found for OBP2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OBP2B Gene

Publications for OBP2B Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  4. A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres. (PMID: 10607840) Lacazette E … Pitiot G (Human molecular genetics 2000) 3 4
  5. ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. (PMID: 30232004) Abraham CG … Espinosa JM (Cell reports 2018) 3

Products for OBP2B Gene

Sources for OBP2B Gene