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Aliases for OBP2A Gene

Aliases for OBP2A Gene

  • Odorant Binding Protein 2A 2 3 5
  • Odorant-Binding Protein IIa 3 4
  • OBPIIa 3 4
  • Putative Odorant-Binding Protein 2c 3
  • Odorant-Binding Protein 2a 3
  • HOBPIIa 3
  • LCN13 3
  • OBP2C 3
  • OBP 3

External Ids for OBP2A Gene

Previous GeneCards Identifiers for OBP2A Gene

  • GC09P129587
  • GC09P130209
  • GC09P131961
  • GC09P133877
  • GC09P135663
  • GC09P137577
  • GC09P138437
  • GC09P107899

Summaries for OBP2A Gene

Entrez Gene Summary for OBP2A Gene

  • This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for OBP2A Gene

OBP2A (Odorant Binding Protein 2A) is a Protein Coding gene. Diseases associated with OBP2A include Spinal Cord Disease. Gene Ontology (GO) annotations related to this gene include odorant binding. An important paralog of this gene is OBP2B.

UniProtKB/Swiss-Prot for OBP2A Gene

  • Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids.

Gene Wiki entry for OBP2A Gene

Additional gene information for OBP2A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OBP2A Gene

Genomics for OBP2A Gene

GeneHancer (GH) Regulatory Elements for OBP2A Gene

Promoters and enhancers for OBP2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J135546 Promoter 0.5 EPDnew 650.7 0.0 -32 0.1 OBP2A LCN1 GC09M135517
GH09J136224 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.9 +679.6 679586 3.1 HDGF RB1 ZSCAN4 ARID4B SIN3A ZNF2 IRF4 RAD21 RFX5 SCRT2 LHX3 NACC2 ENTR1 PMPCA QSOX2 OBP2A PIR36610 GC09M136222
GH09J135561 Promoter 0.8 EPDnew 0.4 +15.6 15598 0.1 FOSL1 ZFHX2 EGR1 JUN FOS EGR2 PAEP OBP2A GC09M135517
GH09J135521 Promoter 0.5 EPDnew 0.3 -24.7 -24718 0.1 LCN1 OBP2A GC09M135517
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OBP2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OBP2A gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • COUP-TF1
  • COUP
  • Max1
  • c-Myc

Genomic Locations for OBP2A Gene

Genomic Locations for OBP2A Gene
chr9:135,546,139-135,549,969
(GRCh38/hg38)
Size:
3,831 bases
Orientation:
Plus strand
chr9:138,437,985-138,441,815
(GRCh37/hg19)
Size:
3,831 bases
Orientation:
Plus strand

Genomic View for OBP2A Gene

Genes around OBP2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OBP2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OBP2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OBP2A Gene

Proteins for OBP2A Gene

  • Protein details for OBP2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY56-OBP2A_HUMAN
    Recommended name:
    Odorant-binding protein 2a
    Protein Accession:
    Q9NY56
    Secondary Accessions:
    • Q5T8A3
    • Q9NY50
    • Q9NY53
    • Q9NY54
    • Q9NY55

    Protein attributes for OBP2A Gene

    Size:
    170 amino acids
    Molecular mass:
    19318 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for OBP2A Gene

    Alternative splice isoforms for OBP2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OBP2A Gene

Post-translational modifications for OBP2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OBP2A Gene

Domains & Families for OBP2A Gene

Gene Families for OBP2A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for OBP2A Gene

Graphical View of Domain Structure for InterPro Entry

Q9NY56

UniProtKB/Swiss-Prot:

OBP2A_HUMAN :
  • Belongs to the calycin superfamily. Lipocalin family.
Family:
  • Belongs to the calycin superfamily. Lipocalin family.
genes like me logo Genes that share domains with OBP2A: view

Function for OBP2A Gene

Molecular function for OBP2A Gene

UniProtKB/Swiss-Prot Function:
Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids.
GENATLAS Biochemistry:
odorant binding protein 2A,expressed in the nasal structure,salivary and lacrymal glands,lung,lipocalin family of outlier group

Phenotypes From GWAS Catalog for OBP2A Gene

Gene Ontology (GO) - Molecular Function for OBP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding NAS 10607840
GO:0036094 small molecule binding IEA --
genes like me logo Genes that share ontologies with OBP2A: view
genes like me logo Genes that share phenotypes with OBP2A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OBP2A Gene

Localization for OBP2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for OBP2A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OBP2A gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for OBP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OBP2A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OBP2A Gene

Pathways & Interactions for OBP2A Gene

SuperPathways for OBP2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for OBP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007606 sensory perception of chemical stimulus TAS 10607840
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OBP2A: view

No data available for Pathways by source and SIGNOR curated interactions for OBP2A Gene

Drugs & Compounds for OBP2A Gene

(1) Drugs for OBP2A Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, Antagonist, Target 242
genes like me logo Genes that share compounds with OBP2A: view

Transcripts for OBP2A Gene

mRNA/cDNA for OBP2A Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OBP2A Gene

Odorant binding protein 2A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OBP2A Gene

No ASD Table

Relevant External Links for OBP2A Gene

GeneLoc Exon Structure for
OBP2A
ECgene alternative splicing isoforms for
OBP2A

Expression for OBP2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OBP2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OBP2A Gene

This gene is overexpressed in Testis (x22.9), Skin - Sun Exposed (Lower leg) (x10.7), and Skin - Not Sun Exposed (Suprapubic) (x7.0).

Protein differential expression in normal tissues from HIPED for OBP2A Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OBP2A Gene



Protein tissue co-expression partners for OBP2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OBP2A Gene:

OBP2A

SOURCE GeneReport for Unigene cluster for OBP2A Gene:

Hs.567489

mRNA Expression by UniProt/SwissProt for OBP2A Gene:

Q9NY56-OBP2A_HUMAN
Tissue specificity: Strongly expressed in the nasal structures, salivary and lachrymal glands, and lung.
genes like me logo Genes that share expression patterns with OBP2A: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OBP2A Gene

Orthologs for OBP2A Gene

This gene was present in the common ancestor of mammals.

Orthologs for OBP2A Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Obp2b 16 34 33
  • 62.08 (n)
Lcn4 34
  • 34 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Obp2b 33
  • 60.08 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 54 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 31 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 26 (a)
OneToMany
Species where no ortholog for OBP2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OBP2A Gene

ENSEMBL:
Gene Tree for OBP2A (if available)
TreeFam:
Gene Tree for OBP2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OBP2A: view image

Paralogs for OBP2A Gene

Paralogs for OBP2A Gene

(4) SIMAP similar genes for OBP2A Gene using alignment to 5 proteins:

  • OBP2A_HUMAN
  • F2Z2D7_HUMAN
  • F5H159_HUMAN
  • Q5T8A4_HUMAN
  • Q5T8A5_HUMAN
genes like me logo Genes that share paralogs with OBP2A: view

Variants for OBP2A Gene

Sequence variations from dbSNP and Humsavar for OBP2A Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001032053 -- 135,550,236(+) G/A downstream_transcript_variant
rs1001338849 -- 135,545,920(+) G/A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001441799 -- 135,550,118(+) G/C downstream_transcript_variant
rs1002618305 -- 135,549,831(+) G/A intron_variant
rs1003789746 -- 135,544,777(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OBP2A Gene

Variant ID Type Subtype PubMed ID
esv1004958 CNV insertion 20482838
esv1483790 CNV insertion 17803354
esv29917 CNV gain+loss 19812545
nsv416052 CNV insertion 16902084
nsv466656 CNV gain 19166990
nsv615842 CNV gain 21841781
nsv615882 CNV gain 21841781
nsv615883 CNV loss 21841781
nsv615884 CNV loss 21841781
nsv615885 CNV loss 21841781
nsv951822 CNV deletion 24416366

Variation tolerance for OBP2A Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.95; 98.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OBP2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OBP2A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OBP2A Gene

Disorders for OBP2A Gene

MalaCards: The human disease database

(1) MalaCards diseases for OBP2A Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinal cord disease
  • myelopathy
- elite association - COSMIC cancer census association via MalaCards
Search OBP2A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OBP2A

genes like me logo Genes that share disorders with OBP2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OBP2A Gene

Publications for OBP2A Gene

  1. Crystal structure of the human odorant binding protein, OBPIIa. (PMID: 25810031) Schiefner A … Skerra A (Proteins 2015) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Porcine odorant-binding protein selectively binds to a human olfactory receptor. (PMID: 12379593) Matarazzo V … Ronin C (Chemical senses 2002) 3 22 58
  4. Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties. (PMID: 12044155) Briand L … Pernollet JC (Biochemistry 2002) 3 4 58
  5. A novel human odorant-binding protein gene family resulting from genomic duplicons at 9q34: differential expression in the oral and genital spheres. (PMID: 10607840) Lacazette E … Pitiot G (Human molecular genetics 2000) 3 4 58

Products for OBP2A Gene

Sources for OBP2A Gene

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