Aliases for OBI1 Gene

Aliases for OBI1 Gene

  • ORC Ubiquitin Ligase 1 2 3 4 5
  • Ring Finger Protein 219 2 3
  • C13orf7 3 4
  • RNF219 3 4
  • Chromosome 13 Open Reading Frame 7 2
  • RING Finger Protein 219 4
  • EC 2.3.2.27 4

External Ids for OBI1 Gene

Previous HGNC Symbols for OBI1 Gene

  • C13orf7
  • RNF219

Summaries for OBI1 Gene

GeneCards Summary for OBI1 Gene

OBI1 (ORC Ubiquitin Ligase 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for OBI1 Gene

  • E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578).

Additional gene information for OBI1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OBI1 Gene

Genomics for OBI1 Gene

GeneHancer (GH) Regulatory Elements for OBI1 Gene

Promoters and enhancers for OBI1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J078657 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.2 179 3.6 ZBTB40 NRF1 POLR2G USF1 PHF8 TEAD4 ZFX POLR2A ZNF423 ZBTB26 OBI1 POU4F1 LOC780529 piR-30350-018
GH13J078625 Enhancer 0.5 Ensembl 12.2 +33.3 33278 0.6 NFE2 MAFG DPF2 GATA1 DACH1 ARID1B CBFA2T3 POU4F1 OBI1 LOC780529 lnc-POU4F1-2 piR-34822-081
GH13J078664 Enhancer 0.5 Ensembl 7.7 -5.4 -5422 1.2 NCOR1 TAL1 HDAC2 TCF12 KDM1A ARID1B CBFA2T2 RFX1 CBFA2T3 HDAC1 LOC780529 POU4F1 OBI1 RF00017-1459
GH13J078383 Enhancer 0.7 UCNEbase Ensembl 4.4 +275.6 275567 2.4 EP300 POLR2A RPL31P54 OBI1 RF00019-041 RNY3P3 lnc-SLAIN1-8 OBI1-AS1
GH13J078680 Enhancer 0.5 Ensembl 5.1 -21.4 -21422 0.4 EP300 ZSCAN5C OSR2 WT1 FEZF1 ZNF501 POLR2A ZBTB44 POU4F1 OBI1 RF00017-1459 piR-38580-080
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OBI1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OBI1

Genomic Locations for OBI1 Gene

Genomic Locations for OBI1 Gene
chr13:78,614,286-78,659,179
(GRCh38/hg38)
Size:
44,894 bases
Orientation:
Minus strand
chr13:79,188,421-79,233,314
(GRCh37/hg19)
Size:
44,894 bases
Orientation:
Minus strand

Genomic View for OBI1 Gene

Genes around OBI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OBI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OBI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OBI1 Gene

Proteins for OBI1 Gene

  • Protein details for OBI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W0B1-OBI1_HUMAN
    Recommended name:
    ORC ubiquitin ligase 1
    Protein Accession:
    Q5W0B1
    Secondary Accessions:
    • B2RN99
    • Q8TBY2
    • Q9H0T2
    • Q9H8M0

    Protein attributes for OBI1 Gene

    Size:
    726 amino acids
    Molecular mass:
    81116 Da
    Quaternary structure:
    • Associates with ORC complex (PubMed:31160578). Binds to chromatin; association is cell cycle-regulated, absent from mitotic chromosomes, is associated with chromatin from G1 and partially released from chromatin from mid S-phase (PubMed:31160578).
    SequenceCaution:
    • Sequence=BAB14594.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BC028586; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAB66586.3; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for OBI1 Gene

Post-translational modifications for OBI1 Gene

Other Protein References for OBI1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OBI1 Gene

Domains & Families for OBI1 Gene

Gene Families for OBI1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OBI1 Gene

Suggested Antigen Peptide Sequences for OBI1 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 219 (RN219_HUMAN)
genes like me logo Genes that share domains with OBI1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for OBI1 Gene

Function for OBI1 Gene

Molecular function for OBI1 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase essential for DNA replication origin activation during S phase (PubMed:31160578). Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase (PubMed:31160578).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=. ;.

Enzyme Numbers (IUBMB) for OBI1 Gene

Phenotypes From GWAS Catalog for OBI1 Gene

Gene Ontology (GO) - Molecular Function for OBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 31160578
GO:0004842 ubiquitin-protein transferase activity IDA 31160578
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OBI1: view
genes like me logo Genes that share phenotypes with OBI1: view

miRNA for OBI1 Gene

miRTarBase miRNAs that target OBI1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OBI1 Gene

Localization for OBI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OBI1 Gene

Chromosome. Note=Association to chromatin is cell cycle-regulated, absent from mitotic chromosomes, is associated with chromatin from G1 and partially released from chromatin from mid S-phase. {ECO:0000269 PubMed:31160578}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OBI1 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
mitochondrion 2
cytosol 2
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 31160578
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with OBI1: view

Pathways & Interactions for OBI1 Gene

PathCards logo

SuperPathways for OBI1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OBI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006275 regulation of DNA replication IDA 31160578
GO:0006513 protein monoubiquitination IDA 31160578
GO:0051865 protein autoubiquitination IDA 31160578
genes like me logo Genes that share ontologies with OBI1: view

No data available for Pathways by source and SIGNOR curated interactions for OBI1 Gene

Drugs & Compounds for OBI1 Gene

No Compound Related Data Available

Transcripts for OBI1 Gene

mRNA/cDNA for OBI1 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OBI1 Gene

No ASD Table

Relevant External Links for OBI1 Gene

GeneLoc Exon Structure for
OBI1

Expression for OBI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OBI1

SOURCE GeneReport for Unigene cluster for OBI1 Gene:

Hs.567576

Evidence on tissue expression from TISSUES for OBI1 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with OBI1: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OBI1 Gene

Orthologs for OBI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OBI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF219 31 30
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RNF219 31 30
  • 92.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RNF219 31 30
  • 90.19 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf219 17 31 30
  • 83.1 (n)
rat
(Rattus norvegicus)
Mammalia Rnf219 30
  • 81.24 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF219 31
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF219 31
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF219 31 30
  • 68.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF219 31
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf219 30
  • 57.32 (n)
zebrafish
(Danio rerio)
Actinopterygii RNF219 31
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4956 31
  • 36 (a)
OneToOne
Species where no ortholog for OBI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OBI1 Gene

ENSEMBL:
Gene Tree for OBI1 (if available)
TreeFam:
Gene Tree for OBI1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OBI1: view image

Paralogs for OBI1 Gene

No data available for Paralogs for OBI1 Gene

Variants for OBI1 Gene

Additional dbSNP identifiers (rs#s) for OBI1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OBI1 Gene

Variant ID Type Subtype PubMed ID
dgv234n27 CNV loss 19166990
dgv3268n54 CNV loss 21841781
dgv339n67 CNV gain 20364138
dgv340n67 CNV loss 20364138
esv2421781 CNV deletion 20811451
esv2667717 CNV deletion 23128226
esv2747700 CNV deletion 23290073
esv3580774 CNV loss 25503493
esv3580775 CNV loss 25503493
esv3632802 CNV loss 21293372
nsv1098 CNV insertion 18451855
nsv1142153 CNV tandem duplication 24896259
nsv1160140 CNV deletion 26073780
nsv442321 CNV loss 18776908
nsv514712 CNV loss 21397061
nsv517259 CNV loss 19592680

Variation tolerance for OBI1 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OBI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OBI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OBI1 Gene

Disorders for OBI1 Gene

No disorders were found for OBI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for OBI1 Gene

Publications for OBI1 Gene

  1. The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing. (PMID: 31160578) Coulombe P … Méchali M (Nature communications 2019) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 54
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 54

Products for OBI1 Gene

Sources for OBI1 Gene