The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in pol... See more...

Aliases for OAZ2 Gene

Aliases for OAZ2 Gene

  • Ornithine Decarboxylase Antizyme 2 2 3 4 5
  • ODC-Az 2 3 4
  • AZ2 3 4

External Ids for OAZ2 Gene

Previous GeneCards Identifiers for OAZ2 Gene

  • GC15P060699
  • GC15M9D0083
  • GC15M062558
  • GC15M062766
  • GC15M064979
  • GC15M041805

Summaries for OAZ2 Gene

Entrez Gene Summary for OAZ2 Gene

  • The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for OAZ2 Gene

OAZ2 (Ornithine Decarboxylase Antizyme 2) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include enzyme inhibitor activity and ornithine decarboxylase inhibitor activity. An important paralog of this gene is OAZ1.

UniProtKB/Swiss-Prot Summary for OAZ2 Gene

  • Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity).

Gene Wiki entry for OAZ2 Gene

Additional gene information for OAZ2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OAZ2 Gene

Genomics for OAZ2 Gene

GeneHancer (GH) Regulatory Elements for OAZ2 Gene

Promoters and enhancers for OAZ2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OAZ2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OAZ2

Top Transcription factor binding sites by QIAGEN in the OAZ2 gene promoter:
  • Ik-1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4

Genomic Locations for OAZ2 Gene

Genomic Locations for OAZ2 Gene
chr15:64,687,573-64,703,281
(GRCh38/hg38)
Size:
15,709 bases
Orientation:
Minus strand
chr15:64,979,772-64,995,480
(GRCh37/hg19)
Size:
15,709 bases
Orientation:
Minus strand

Genomic View for OAZ2 Gene

Genes around OAZ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OAZ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OAZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAZ2 Gene

Proteins for OAZ2 Gene

  • Protein details for OAZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95190-OAZ2_HUMAN
    Recommended name:
    Ornithine decarboxylase antizyme 2
    Protein Accession:
    O95190

    Protein attributes for OAZ2 Gene

    Size:
    189 amino acids
    Molecular mass:
    21011 Da
    Quaternary structure:
    • Interacts with ODC1 and thereby sterically blocks ODC homodimerization (By similarity). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:17900240).

    Alternative splice isoforms for OAZ2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OAZ2 Gene

Post-translational modifications for OAZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OAZ2 Gene

No data available for DME Specific Peptides for OAZ2 Gene

Domains & Families for OAZ2 Gene

Gene Families for OAZ2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OAZ2 Gene

Blocks:
  • Ornithine decarboxylase antizyme
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OAZ2 Gene

GenScript: Design optimal peptide antigens:
  • Ornithine decarboxylase antizyme 2 (OAZ2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95190

UniProtKB/Swiss-Prot:

OAZ2_HUMAN :
  • Belongs to the ODC antizyme family.
Family:
  • Belongs to the ODC antizyme family.
genes like me logo Genes that share domains with OAZ2: view

Function for OAZ2 Gene

Molecular function for OAZ2 Gene

UniProtKB/Swiss-Prot Function:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity).
GENATLAS Biochemistry:
ornithine decarboxylase antizyme 2,negative regulator of polyamine level

Phenotypes From GWAS Catalog for OAZ2 Gene

Gene Ontology (GO) - Molecular Function for OAZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17900240
GO:0008073 ornithine decarboxylase inhibitor activity IEA,IDA 17900240
genes like me logo Genes that share ontologies with OAZ2: view
genes like me logo Genes that share phenotypes with OAZ2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OAZ2

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OAZ2 Gene

Localization for OAZ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OAZ2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OAZ2 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 2
golgi apparatus 2
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OAZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with OAZ2: view

Pathways & Interactions for OAZ2 Gene

genes like me logo Genes that share pathways with OAZ2: view

Gene Ontology (GO) - Biological Process for OAZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006521 regulation of cellular amino acid metabolic process TAS --
GO:0006595 polyamine metabolic process IEA,TAS 9428668
GO:0006596 polyamine biosynthetic process IEA --
GO:0043086 negative regulation of catalytic activity IEA --
GO:0045732 positive regulation of protein catabolic process IEA,ISS --
genes like me logo Genes that share ontologies with OAZ2: view

No data available for SIGNOR curated interactions for OAZ2 Gene

Drugs & Compounds for OAZ2 Gene

(1) Drugs for OAZ2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ornithine Approved Nutra Target 78
genes like me logo Genes that share compounds with OAZ2: view

Transcripts for OAZ2 Gene

mRNA/cDNA for OAZ2 Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OAZ2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^ 11
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP6: - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: - - - - -

Relevant External Links for OAZ2 Gene

GeneLoc Exon Structure for
OAZ2

Expression for OAZ2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OAZ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OAZ2 Gene

This gene is overexpressed in Tlymphocyte (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OAZ2 Gene



Protein tissue co-expression partners for OAZ2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OAZ2

SOURCE GeneReport for Unigene cluster for OAZ2 Gene:

Hs.744924

Evidence on tissue expression from TISSUES for OAZ2 Gene

  • Nervous system(4.8)
  • Lung(3.2)
  • Skin(3.1)
  • Eye(3)
  • Kidney(2.4)
  • Intestine(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with OAZ2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OAZ2 Gene

Orthologs for OAZ2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OAZ2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia OAZ2 31 30
  • 98.54 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OAZ2 31 30
  • 98.41 (n)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OAZ2 31 30
  • 98.4 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Oaz2 17 31 30
  • 97.35 (n)
oppossum
(Monodelphis domestica)
Mammalia OAZ2 31
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oaz2 30
  • 96.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OAZ2 31
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves OAZ2 31 30
  • 86.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OAZ2 31
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oaz2 30
  • 79.89 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68610 30
zebrafish
(Danio rerio)
Actinopterygii oaz1b 31
  • 44 (a)
ManyToMany
oaz1 30
fruit fly
(Drosophila melanogaster)
Insecta Oda 31
  • 18 (a)
OneToMany
Species where no ortholog for OAZ2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OAZ2 Gene

ENSEMBL:
Gene Tree for OAZ2 (if available)
TreeFam:
Gene Tree for OAZ2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OAZ2: view image

Paralogs for OAZ2 Gene

Paralogs for OAZ2 Gene

(2) SIMAP similar genes for OAZ2 Gene using alignment to 4 proteins:

  • OAZ2_HUMAN
  • J3KRW5_HUMAN
  • J3KS80_HUMAN
  • J3QLV9_HUMAN
genes like me logo Genes that share paralogs with OAZ2: view

Variants for OAZ2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OAZ2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs3751534 - p.Pro70Leu

Additional dbSNP identifiers (rs#s) for OAZ2 Gene

Structural Variations from Database of Genomic Variants (DGV) for OAZ2 Gene

Variant ID Type Subtype PubMed ID
esv22620 CNV loss 19812545
nsv569701 CNV loss 21841781
nsv569702 CNV loss 21841781
nsv833038 CNV loss 17160897

Variation tolerance for OAZ2 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OAZ2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OAZ2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OAZ2 Gene

Disorders for OAZ2 Gene

Additional Disease Information for OAZ2

No disorders were found for OAZ2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OAZ2 Gene

Publications for OAZ2 Gene

  1. Structure of human ornithine decarboxylase antizyme 2 gene. (PMID: 10352227) Zhou J … Gesteland RF (Gene 1999) 2 3 4 23 54
  2. A second mammalian antizyme: conservation of programmed ribosomal frameshifting. (PMID: 9782076) Ivanov IP … Atkins JF (Genomics 1998) 2 3 4 54
  3. The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification. (PMID: 19960435) Geerts D … Bachmann AS (International journal of cancer 2010) 3 23 54
  4. Subcellular localization and phosphorylation of antizyme 2. (PMID: 19725046) Murai N … Matsufuji S (Journal of cellular biochemistry 2009) 3 23 54
  5. Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. (PMID: 17900240) Kanerva K … Andersson LC (The Biochemical journal 2008) 3 4 54

Products for OAZ2 Gene

Sources for OAZ2 Gene