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OAZ1 Gene(Protein Coding)

Ornithine Decarboxylase Antizyme 1

GCID:
GC19P002269
GIFtS:
46
Genes Participants
UDN Logo

Aliases for OAZ1 Gene

Aliases for OAZ1 Gene

  • Ornithine Decarboxylase Antizyme 1 2 3 5
  • Antizyme 1 2 3
  • ODC-Az 3 4
  • AZ1 3 4
  • OAZ 3 4
  • AZI 3

External Ids for OAZ1 Gene

Previous HGNC Symbols for OAZ1 Gene

  • OAZ

Previous GeneCards Identifiers for OAZ1 Gene

  • GC19P002332
  • GC19P002209
  • GC19P002220
  • GC19P002040

Summaries for OAZ1 Gene

Entrez Gene Summary for OAZ1 Gene

  • The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for OAZ1 Gene

OAZ1 (Ornithine Decarboxylase Antizyme 1) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include enzyme inhibitor activity and ornithine decarboxylase inhibitor activity. An important paralog of this gene is OAZ2.

UniProtKB/Swiss-Prot for OAZ1 Gene

  • Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147).

Gene Wiki entry for OAZ1 Gene

Additional gene information for OAZ1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OAZ1 Gene

Genomics for OAZ1 Gene

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GeneHancer (GH) Regulatory Elements for OAZ1 Gene

Promoters and enhancers for OAZ1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I002268 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.7 2729 7.4 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 NFYC OAZ1 GC19M002271 GC19P002271 SF3A2 ZNF77 LINGO3 TCF3 MIR1227 DAZAP1 MUM1
GH19I001939 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.1 -327.5 -327469 5.4 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF207 ZNF143 CSNK1G2 LOC105372238 KLF16 ZNF555 SF3A2 BTBD2 CSNK1G2-AS1 PEAK3 ENSG00000267283 REXO1
GH19I002615 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.4 +355.2 355215 17.8 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF77 GADD45B SF3A2 RNU6-993P GNA11 SLC39A3 PEAK3 CACTIN-AS1 TLE2 DOT1L
GH19I001901 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.9 -365.5 -365514 5 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A YBX1 DMAP1 IRF4 SCAMP4 GC19P001907 ADAT3 CIRBP TMEM259 SF3A2 DAZAP1 CSNK1G2 DOT1L OAZ1
GH19I002160 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.1 -101.7 -101746 13.7 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 DOT1L CIRBP ZNF77 AP3D1 GADD45B LOC100288123 TCF3 DAZAP1 SF3A2 ENSG00000267317
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OAZ1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OAZ1 gene promoter:

Genomic Locations for OAZ1 Gene

Genomic Locations for OAZ1 Gene
chr19:2,269,486-2,273,490
(GRCh38/hg38)
Size:
4,005 bases
Orientation:
Plus strand
chr19:2,269,485-2,273,487
(GRCh37/hg19)

Genomic View for OAZ1 Gene

Genes around OAZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OAZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OAZ1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OAZ1 Gene

Proteins for OAZ1 Gene

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  • Protein details for OAZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54368-OAZ1_HUMAN
    Recommended name:
    Ornithine decarboxylase antizyme 1
    Protein Accession:
    P54368
    Secondary Accessions:
    • O43382
    • Q14989
    • Q92595
    • Q9UPL9

    Protein attributes for OAZ1 Gene

    Size:
    228 amino acids
    Molecular mass:
    25406 Da
    Quaternary structure:
    • Interacts with ODC1 and thereby sterically blocks ODC homodimerization (PubMed:26305948, PubMed:26443277). Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome (PubMed:12097147). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:17900240).
    SequenceCaution:
    • Sequence=BAA11374.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OAZ1 Gene

    Alternative splice isoforms for OAZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OAZ1 Gene

Post-translational modifications for OAZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OAZ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OAZ1 Gene

Domains & Families for OAZ1 Gene

Gene Families for OAZ1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for OAZ1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OAZ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54368

UniProtKB/Swiss-Prot:

OAZ1_HUMAN :
  • Belongs to the ODC antizyme family.
Family:
  • Belongs to the ODC antizyme family.
genes like me logo Genes that share domains with OAZ1: view

Function for OAZ1 Gene

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Molecular function for OAZ1 Gene

GENATLAS Biochemistry:
ornithine decarboxylase antizyme 1,expressed in the liver,programming ribosomal frameshifting,modulating the rate of ODC degradation
UniProtKB/Swiss-Prot Function:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147).
UniProtKB/Swiss-Prot Induction:
Induced by a ribosomal frameshifting mechanism in response to increased levels of intracellular polyamines.

Phenotypes From GWAS Catalog for OAZ1 Gene

Gene Ontology (GO) - Molecular Function for OAZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17900240
GO:0008073 ornithine decarboxylase inhibitor activity IEA,ISS --
genes like me logo Genes that share ontologies with OAZ1: view
genes like me logo Genes that share phenotypes with OAZ1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OAZ1 Gene

Localization for OAZ1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OAZ1 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 2
mitochondrion 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OAZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS,IEA --
genes like me logo Genes that share ontologies with OAZ1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OAZ1 Gene

Pathways & Interactions for OAZ1 Gene

genes like me logo Genes that share pathways with OAZ1: view

Pathways by source for OAZ1 Gene

2 BioSystems pathways for OAZ1 Gene
1 Qiagen pathway for OAZ1 Gene

Interacting Proteins for OAZ1 Gene

Selected Interacting proteins: P54368-OAZ1_HUMAN for OAZ1 Gene via IID

Gene Ontology (GO) - Biological Process for OAZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006521 regulation of cellular amino acid metabolic process TAS --
GO:0006595 polyamine metabolic process IBA,IEA --
GO:0006596 polyamine biosynthetic process TAS,IEA --
GO:0006810 transport IEA --
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with OAZ1: view

No data available for SIGNOR curated interactions for OAZ1 Gene

Drugs & Compounds for OAZ1 Gene

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(4) Drugs for OAZ1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ornithine Approved Nutra Target 70
spermine Approved Nutra Full agonist, Agonist 0
putrescine Experimental Pharma Antagonist, Pore Blocker 0
spermidine Experimental Pharma Antagonist, Pore Blocker 0

(3) Additional Compounds for OAZ1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-Acetylspermine
  • N'-Monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-Acetamide
  • N-Acetylspermine
 25593-72-0
Norspermidine
  • -1,3-propanediamine
  • 1,7-Diamino-4-azaheptane
  • 3, 3'-Diaminodipropylamine
  • 3, {3'-Iminobis[propylamine]}
  • 3,3'-Diamino-Dipropylamine
 56-18-8
genes like me logo Genes that share compounds with OAZ1: view

Transcripts for OAZ1 Gene

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mRNA/cDNA for OAZ1 Gene

(2) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(2012) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OAZ1 Gene

Ornithine decarboxylase antizyme 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OAZ1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - -
SP6: - -
SP7: - - - -
SP8: -
SP9: - -

Relevant External Links for OAZ1 Gene

GeneLoc Exon Structure for
OAZ1
ECgene alternative splicing isoforms for
OAZ1

Expression for OAZ1 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OAZ1 Gene

mRNA expression in normal human tissues for OAZ1 Gene
mRNA expression by BioGPS for OAZ1 GenemRNA expression by GTEx for OAZ1 Gene

mRNA differential expression in normal tissues according to GTEx for OAZ1 Gene

This gene is overexpressed in Whole Blood (x7.8).

NURSA nuclear receptor signaling pathways regulating expression of OAZ1 Gene:

OAZ1

SOURCE GeneReport for Unigene cluster for OAZ1 Gene:

Hs.446427

Evidence on tissue expression from TISSUES for OAZ1 Gene

  • Nervous system(5)
  • Lung(4.8)
  • Pancreas(4.7)
  • Skin(4.5)
  • Eye(4.3)
  • Intestine(4.1)
  • Liver(3.6)
  • Kidney(3.4)
  • Stomach(3.2)
  • Muscle(2.8)
  • Bone(2.7)
  • Bone marrow(2.7)
  • Lymph node(2.7)
  • Heart(2.6)
  • Adrenal gland(2.5)
  • Blood(2.5)
  • Gall bladder(2.5)
  • Spleen(2.5)
  • Thyroid gland(2.4)
genes like me logo Genes that share expression patterns with OAZ1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OAZ1 Gene

Orthologs for OAZ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OAZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia OAZ1 33 34
  • 100 (n)
dog
(Canis familiaris)
 Mammalia OAZ1 33 34
  • 92.66 (n)
cow
(Bos Taurus)
 Mammalia OAZ1 33 34
  • 91.92 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 87 (a)
 OneToMany
-- 34
  • 81 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Oaz1 33 16 34
  • 85.93 (n)
rat
(Rattus norvegicus)
 Mammalia Oaz1 33
  • 85.93 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia OAZ1 34
  • 64 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves OAZ 34
  • 86 (a)
 OneToOne
OAZ1 33
  • 84.06 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia oaz1 33
  • 78.63 (n)
zebrafish
(Danio rerio)
 Actinopterygii oaz1a 33 34
  • 67.98 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Oda 34
  • 21 (a)
 OneToMany
Species where no ortholog for OAZ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OAZ1 Gene

ENSEMBL:
Gene Tree for OAZ1 (if available)
TreeFam:
Gene Tree for OAZ1 (if available)

Paralogs for OAZ1 Gene

Paralogs for OAZ1 Gene

(2) SIMAP similar genes for OAZ1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for OAZ1 Gene

genes like me logo Genes that share paralogs with OAZ1: view

Variants for OAZ1 Gene

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Sequence variations from dbSNP and Humsavar for OAZ1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000125788 -- 2,268,579(+) C/T upstream_transcript_variant
rs1000702754 -- 2,273,984(+) G/A downstream_transcript_variant
rs1000753675 -- 2,273,850(+) C/T downstream_transcript_variant
rs1000788561 -- 2,271,214(+) G/C intron_variant
rs1001379209 -- 2,272,608(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OAZ1 Gene

Variant ID Type Subtype PubMed ID
dgv6218n54 CNV loss 21841781
nsv578383 CNV loss 21841781
nsv833707 CNV loss 17160897

Variation tolerance for OAZ1 Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.28; 92.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OAZ1 Gene

Human Gene Mutation Database (HGMD)
OAZ1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OAZ1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OAZ1 Gene

Disorders for OAZ1 Gene

Additional Disease Information for OAZ1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OAZ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OAZ1 Gene

Publications for OAZ1 Gene

  1. Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme. (PMID: 7811704) Tewari DS … Tewari M (Biochimica et biophysica acta 1994) 2 3 4 22 58
  2. Association of OAZ1 gene polymorphisms with subclinical and clinical vascular events. (PMID: 17761941) Dumont J … Brousseau T (Arteriosclerosis, thrombosis, and vascular biology 2007) 3 22 44 58
  3. Assignment of the human antizyme gene (OAZ) to chromosome 19p13.3 by fluorescence in situ hybridization. (PMID: 8954789) Matsufuji S … Hayashi S (Genomics 1996) 2 3 22 58
  4. Molcecular cloning of human antizyme cDNA. (PMID: 9132164) Yang D … Onozaki K (Biochemistry and molecular biology international 1996) 3 4 22 58
  5. Structural basis of antizyme-mediated regulation of polyamine homeostasis. (PMID: 26305948) Wu HY … Chan NL (Proceedings of the National Academy of Sciences of the United States of America 2015) 3 4 58

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