Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
OAZ1 (Ornithine Decarboxylase Antizyme 1) is a Protein Coding gene. Diseases associated with OAZ1 include Geographic Tongue. Among its related pathways are Viral mRNA Translation and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include enzyme inhibitor activity and ornithine decarboxylase inhibitor activity. An important paralog of this gene is OAZ2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 28298427 |
GO:0008073 | ornithine decarboxylase inhibitor activity | IEA,ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | IEA,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
2 | nNOS Signaling in Skeletal Muscle |
BMP Pathway
.44
|
|
3 | Metabolism |
.40
|
|
4 | Viral mRNA Translation | ||
5 | Aurora A signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006521 | regulation of cellular amino acid metabolic process | TAS | -- |
GO:0006595 | polyamine metabolic process | IEA | -- |
GO:0006596 | polyamine biosynthetic process | TAS,IEA | -- |
GO:0043086 | negative regulation of catalytic activity | IEA | -- |
GO:0045732 | positive regulation of protein catabolic process | IEA,ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ornithine | Approved | Nutra | Target | 84 | ||
putrescine | Experimental | Pharma | Pore Blocker, Antagonist | 0 | ||
spermidine | Experimental | Pharma | Pore Blocker, Antagonist | 0 | ||
spermine | Experimental | Nutra | Agonist, Full agonist, Pore Blocker, Antagonist, Channel blocker | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
N1-acetylspermine |
|
25593-72-0 |
|
|||
Norspermidine |
|
56-18-8 |
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | · | 7d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||
SP7: | - | - | - | - | |||||||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||||||||||
SP9: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | OAZ1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | OAZ1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OAZ1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Oaz1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Oaz1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | OAZ1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | OAZ 31 |
|
OneToOne | |
OAZ1 30 |
|
||||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | oaz1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | oaz1a 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Oda 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2230749 | - | p.Ser53Phe | |||
rs28359762 | - | p.Gly44Asp | |||
rs28384673 | - | p.Ser50Phe | |||
rs28384677 | - | p.Ala147Val | |||
rs4667 | - | p.Arg32Leu |
Disorder | Aliases | PubMed IDs |
---|---|---|
geographic tongue |
|
|