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OASL (2'-5'-Oligoadenylate Synthetase Like) is a Protein Coding gene. Diseases associated with OASL include West Nile Fever and Microphthalmia With Limb Anomalies. Among its related pathways are Interferon gamma signaling and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is OAS1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001730 | NOT 2'-5'-oligoadenylate synthetase activity | IDA | 9826176 |
GO:0003677 | DNA binding | IDA | 9826176 |
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0003725 | double-stranded RNA binding | IBA,IDA | 9826176 |
GO:0005515 | protein binding | IPI | 30833792 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | IBA,IDA | -- |
GO:0005730 | nucleolus | IEA,IDA | 9826176 |
GO:0005737 | cytoplasm | IEA,IDA | 9826176 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Interferon gamma signaling | ||
2 | PI3K-Akt signaling pathway | ||
3 | Cytokine Signaling in Immune system | ||
4 | Innate Immune System |
.61
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5 | Immune response IFN alpha/beta signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0006955 | immune response | IEA | -- |
GO:0009615 | response to virus | IDA | 18931074 |
GO:0045071 | negative regulation of viral genome replication | IBA,IDA | 18931074 |
GO:0045087 | innate immune response | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||
SP2: | - | ||||||||||||||||||
SP3: | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | OASL 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Oasl 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Oasl1 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | OASL1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OASL 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | OASL 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | OAS*A 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | OASL 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs35249920 | - | p.Asn341Ile |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759917 | CNV | loss | 17122850 |
nsv1039216 | CNV | gain | 25217958 |
nsv521928 | CNV | gain | 19592680 |
nsv560454 | CNV | loss | 21841781 |
nsv832531 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
west nile fever |
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microphthalmia with limb anomalies |
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breast large cell neuroendocrine carcinoma |
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west nile encephalitis |
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