OASL Gene (Protein Coding)

2'-5'-Oligoadenylate Synthetase Like

GC12M121319
GIFtS:
41
See more...

Aliases for OASL Gene

Aliases for OASL Gene

  • 2'-5'-Oligoadenylate Synthetase Like 2 3 5
  • P59OASL 2 3 4
  • TRIP14 2 3 4
  • 59 KDa 2'-5'-Oligoadenylate Synthase-Like Protein 3 4
  • 2'-5'-Oligoadenylate Synthase-Like Protein 3 4
  • Thyroid Receptor-Interacting Protein 14 3 4
  • 2'-5'-OAS-Related Protein 3 4
  • TR-Interacting Protein 14 3 4
  • 2'-5'-OAS-RP 3 4
  • P59 OASL 3 4
  • TRIP-14 3 4
  • OASL1 2 3
  • 59 KDa 2'-5'-Oligoadenylate Synthetase-Like Protein 3
  • 2'-5'-Oligoadenylate Synthetase-Like 2
  • P59-OASL 3
  • OASLd 3
  • OASL 5

External Ids for OASL Gene

Previous GeneCards Identifiers for OASL Gene

  • GC12M120319
  • GC12M121055
  • GC12M121240
  • GC12M119870
  • GC12M119920
  • GC12M121459
  • GC12M118466
  • GC12M121020
  • GC12M121026
  • GC12M121057

Summaries for OASL Gene

GeneCards Summary for OASL Gene

OASL (2'-5'-Oligoadenylate Synthetase Like) is a Protein Coding gene. Diseases associated with OASL include West Nile Fever and West Nile Virus Infection. Among its related pathways are Innate Immune System and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is OAS1.

UniProtKB/Swiss-Prot Summary for OASL Gene

  • Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.

Gene Wiki entry for OASL Gene

Additional gene information for OASL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OASL Gene

Genomics for OASL Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OASL Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J121036 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 258.2 +1.3 1254 3.6 SP1 FEZF1 MNT SIN3A IRF4 RXRA EBF1 KLF9 FOXA2 ZBTB33 OASL ENSG00000272849 LINC01089 GCN1 SETD1B RPL31P52 KDM2B SRSF9 ANAPC5 P2RX4
GH12J121059 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE 50.6 -21.2 -21165 1.8 NR2C1 IKZF1 IRF2 ZNF217 CTCF THAP11 ZNF395 REST VEZF1 TRIM22 OASL2P OASL P2RX4 P2RX7 C12orf43 SPPL3 ACADS ENSG00000256569 CAMKK2 piR-43099-125
GH12J120580 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.7 +457.6 457641 3.2 TBP SP1 MXD4 NR2C1 MNT DEK SMAD5 ZFP64 MBD2 ZNF217 POP5 lnc-COQ5-2 COQ5 GATC HNF1A-AS1 MLEC UNC119B C12orf43 ACADS ENSG00000256569
GH12J121095 Promoter/Enhancer 1.3 Ensembl ENCODE 12.2 -56.9 -56859 1.4 ZBTB10 SP1 FEZF1 MNT CTCF REST TRIM22 ZNF341 SMC3 GABPB1 ENSG00000279001 HSALNG0094563 piR-45075 piR-53478 piR-51702 piR-59152 GCN1 SETD1B ANAPC5 OASL
GH12J120958 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.2 +78.2 78168 5.5 BCL11A NFATC3 IRF4 MAFF SMAD4 EBF1 RARA KLF9 RBM22 JUND ACADS C12orf43 SPPL3 OASL ENSG00000256569 ENSG00000255946 UNC119B MLEC ENSG00000256364 P2RX4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OASL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OASL

Top Transcription factor binding sites by QIAGEN in the OASL gene promoter:
  • Elk-1
  • Ik-2
  • IRF-2
  • NRF-2
  • Olf-1
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1
  • STAT1alpha
  • STAT1beta

Genomic Locations for OASL Gene

Latest Assembly
chr12:121,017,763-121,039,242
(GRCh38/hg38)
Size:
21,480 bases
Orientation:
Minus strand

Previous Assembly
chr12:121,458,095-121,477,045
(GRCh37/hg19 by Entrez Gene)
Size:
18,951 bases
Orientation:
Minus strand

chr12:121,458,095-121,477,045
(GRCh37/hg19 by Ensembl)
Size:
18,951 bases
Orientation:
Minus strand

Genomic View for OASL Gene

Genes around OASL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OASL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OASL Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OASL Gene

Proteins for OASL Gene

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  • Protein details for OASL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15646-OASL_HUMAN
    Recommended name:
    2'-5'-oligoadenylate synthase-like protein
    Protein Accession:
    Q15646
    Secondary Accessions:
    • B2RAZ2
    • I1YDD2
    • O75686
    • Q17R95
    • Q9Y6K6
    • Q9Y6K7

    Protein attributes for OASL Gene

    Size:
    514 amino acids
    Molecular mass:
    59226 Da
    Quaternary structure:
    • Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14 does not require the presence of thyroid hormone for its interaction. Binds MBD1.
    SequenceCaution:
    • Sequence=AAC41733.1; Type=Frameshift; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: Has antiviral activity against RNA viruses.

    Three dimensional structures from OCA and Proteopedia for OASL Gene

    Alternative splice isoforms for OASL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OASL Gene

Protein Expression for OASL Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OASL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OASL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OASL Gene

Domains & Families for OASL Gene

Gene Families for OASL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OASL Gene

InterPro:
Blocks:
  • Ubiquitin domain
  • 2-5-oligoadenylate synthetase
ProtoNet:

Suggested Antigen Peptide Sequences for OASL Gene

GenScript: Design optimal peptide antigens:
  • p59 OASL (OASL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15646

UniProtKB/Swiss-Prot:

OASL_HUMAN :
  • The ubiquitin-like domains are essential for its antiviral activity.
  • Belongs to the 2-5A synthase family.
Domain:
  • The ubiquitin-like domains are essential for its antiviral activity.
Family:
  • Belongs to the 2-5A synthase family.
genes like me logo Genes that share domains with OASL: view

Function for OASL Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for OASL Gene

UniProtKB/Swiss-Prot Function:
Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
UniProtKB/Swiss-Prot Induction:
By type I interferon (IFN) and viruses.
GENATLAS Biochemistry:
2',5' oligoadenylate synthetase-like,interferon induced,cytoplasmic and nucleolar

Phenotypes From GWAS Catalog for OASL Gene

Gene Ontology (GO) - Molecular Function for OASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001730 NOT 2'-5'-oligoadenylate synthetase activity IEA,IDA 9826176
GO:0003677 DNA binding IDA 9826176
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003725 double-stranded RNA binding IEA,IDA 9826176
GO:0005515 protein binding IPI 30833792
genes like me logo Genes that share ontologies with OASL: view
genes like me logo Genes that share phenotypes with OASL: view

Animal Models for OASL Gene

MGI Knock Outs for OASL:
  • Oasl1 Oasl1<tm1Yjk>
  • Oasl1 Oasl1<tm1b(EUCOMM)Hmgu>

Animal Models for research

miRNA for OASL Gene

miRTarBase miRNAs that target OASL

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OASL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OASL Gene

Localization for OASL Gene

Subcellular locations from UniProtKB/Swiss-Prot for OASL Gene

[Isoform p56]: Nucleus, nucleolus. Cytoplasm.
[Isoform p30]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OASL gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
mitochondrion 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA,IDA --
GO:0005730 nucleolus IEA,IDA 9826176
GO:0005737 cytoplasm IEA,IDA 9826176
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with OASL: view

Pathways & Interactions for OASL Gene

genes like me logo Genes that share pathways with OASL: view

Gene Ontology (GO) - Biological Process for OASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0009615 response to virus IDA 18931074
GO:0045071 negative regulation of viral genome replication IBA,IDA 18931074
GO:0045087 innate immune response IEA --
GO:0051607 defense response to virus IEA,TAS --
genes like me logo Genes that share ontologies with OASL: view

No data available for SIGNOR curated interactions for OASL Gene

Drugs & Compounds for OASL Gene

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(2) Drugs for OASL Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peginterferon alfa-2b Approved Pharma 323
Ribavirin Approved Pharma 1081

(1) Additional Compounds for OASL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OASL: view

Transcripts for OASL Gene

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mRNA/cDNA for OASL Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OASL

Alternative Splicing Database (ASD) splice patterns (SP) for OASL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1:
SP2: -
SP3: - -

Relevant External Links for OASL Gene

GeneLoc Exon Structure for
OASL

Expression for OASL Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OASL Gene

mRNA expression in normal human tissues for OASL Gene
mRNA expression by GTEx for OASL GenemRNA expression by BioGPS for OASL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OASL Gene

This gene is overexpressed in Whole Blood (x18.0).

Protein differential expression in normal tissues from HIPED for OASL Gene

This gene is overexpressed in Lung (53.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OASL Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OASL

SOURCE GeneReport for Unigene cluster for OASL Gene:

Hs.118633

mRNA Expression by UniProt/SwissProt for OASL Gene:

Q15646-OASL_HUMAN
Tissue specificity: Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.

Evidence on tissue expression from TISSUES for OASL Gene

  • Blood(4.5)
  • Nervous system(4.3)
  • Lung(2.2)
  • Bone marrow(2.2)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with OASL: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OASL Gene

Orthologs for OASL Gene

This gene was present in the common ancestor of chordates.

Orthologs for OASL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia OASL 30 31
  • 99.35 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Oasl 30
  • 78.33 (n)
Mouse
(Mus musculus)
 Mammalia Oasl1 30 17 31
  • 77.52 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia OASL1 31
  • 71 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia OASL 31
  • 64 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia OASL 31
  • 48 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves OAS*A 31
  • 36 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia OASL 31
  • 42 (a)
 OneToOne
Species where no ortholog for OASL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OASL Gene

ENSEMBL:
Gene Tree for OASL (if available)
TreeFam:
Gene Tree for OASL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OASL: view image

Paralogs for OASL Gene

Paralogs for OASL Gene

(2) SIMAP similar genes for OASL Gene using alignment to 2 proteins:

  • OASL_HUMAN
  • H0YGP3_HUMAN
genes like me logo Genes that share paralogs with OASL: view

Variants for OASL Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OASL Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs35249920 - p.Asn341Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OASL Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OASL Gene

Variant ID Type Subtype PubMed ID
esv2759917 CNV loss 17122850
nsv1039216 CNV gain 25217958
nsv521928 CNV gain 19592680
nsv560454 CNV loss 21841781
nsv832531 CNV gain 17160897

Variation tolerance for OASL Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OASL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OASL

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OASL Gene

Disorders for OASL Gene

MalaCards: The human disease database

(7) MalaCards diseases for OASL Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search OASL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OASL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OASL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OASL Gene

Publications for OASL Gene

  1. 2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro. (PMID: 20074559) Ishibashi M … Esumi M (Biochemical and biophysical research communications 2010) 3 4 23
  2. Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. (PMID: 14728690) Andersen JB … Justesen J (European journal of biochemistry 2004) 3 4 23
  3. The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. (PMID: 10087211) Hovnanian A … Hovanessian AG (Genomics 1999) 2 3 23
  4. p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. (PMID: 9722630) Hartmann R … Justesen J (Nucleic acids research 1998) 3 4 23
  5. Identification of OASL d, a splice variant of human OASL, with antiviral activity. (PMID: 22531715) Guo X … Li E (The international journal of biochemistry & cell biology 2012) 3 4

ExternalLinks

View latest publications for OASL gene in Mastermind

Products for OASL Gene

  • Addgene plasmids for OASL

Sources for OASL Gene