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OASL Gene(Protein Coding)

2'-5'-Oligoadenylate Synthetase Like

GCID:
GC12M121020
GIFtS:
50
Genes Participants
UDN Logo

Aliases for OASL Gene

Aliases for OASL Gene

  • 2'-5'-Oligoadenylate Synthetase Like 2
  • 2-5-Oligoadenylate Synthetase Like 2 3 5
  • 59 KDa 2-5-Oligoadenylate Synthase-Like Protein 3 4
  • Thyroid Receptor-Interacting Protein 14 3 4
  • TR-Interacting Protein 14 3 4
  • 2-5-OAS-Related Protein 3 4
  • 2-5-OAS-RP 3 4
  • P59 OASL 3 4
  • TRIP-14 3 4
  • P59OASL 3 4
  • TRIP14 3 4
  • 59 KDa 2-5-Oligoadenylate Synthetase-Like Protein 3
  • 2-5-Oligoadenylate Synthase-Like Protein 3
  • 2-5-Oligoadenylate Synthetase-Like 2
  • P59-OASL 3
  • OASL1 3
  • OASLd 3

External Ids for OASL Gene

Previous GeneCards Identifiers for OASL Gene

  • GC12M120319
  • GC12M121055
  • GC12M121240
  • GC12M119870
  • GC12M119920
  • GC12M121459
  • GC12M118466

Summaries for OASL Gene

GeneCards Summary for OASL Gene

OASL (2'-5'-Oligoadenylate Synthetase Like) is a Protein Coding gene. Diseases associated with OASL include Microphthalmia With Limb Anomalies. Among its related pathways are Cytokine Signaling in Immune system and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is OAS1.

UniProtKB/Swiss-Prot for OASL Gene

  • Does not have 2-5-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.

Gene Wiki entry for OASL Gene

Additional gene information for OASL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OASL Gene

Genomics for OASL Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for OASL Gene

Promoters and enhancers for OASL Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12I121037 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 558.3 +0.4 378 1.8 PKNOX1 FOXA2 ATF1 RB1 SIN3A KLF5 IRF4 RAD21 YY1 ZNF207 OASL C12orf43 P2RX7
GH12I121059 Enhancer 1.3 FANTOM5 Ensembl ENCODE 50.6 -21.2 -21165 1.8 HDGF PKNOX1 ZBTB40 KLF5 RAD21 YY1 ZNF335 ZNF207 ZNF143 ATF7 OASL2P OASL P2RX4 P2RX7 C12orf43 SPPL3 ACADS ENSG00000256569 CAMKK2 LOC105378258
GH12I120580 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.7 +457.8 457849 1.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 E2F8 POP5 COQ5 GATC HNF1A-AS1 MLEC UNC119B C12orf43 ACADS ENSG00000256569 OASL
GH12I121095 Promoter/Enhancer 1.4 Ensembl ENCODE 12.2 -56.8 -56752 0.5 HDGF ARID4B SIN3A FEZF1 ZNF2 ZNF48 ZNF302 ZNF143 ZNF548 ATF7 ENSG00000279001 GC12P122141 PIR38074 PIR45701 PIR47477 GC12P122139 GCN1 SETD1B RPL29P24 ANAPC5
GH12I121276 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11 -239.1 -239050 3.8 BATF YY1 SCRT2 ATF7 FOS IKZF2 RUNX3 SMARCA5 USF2 JUNB P2RX4 CAMKK2 OASL P2RX7 LOC105370032
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OASL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OASL gene promoter:

Genomic Locations for OASL Gene

Genomic Locations for OASL Gene
chr12:121,019,111-121,039,242
(GRCh38/hg38)
Size:
20,132 bases
Orientation:
Minus strand
chr12:121,458,095-121,477,045
(GRCh37/hg19)

Genomic View for OASL Gene

Genes around OASL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OASL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OASL Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OASL Gene

Proteins for OASL Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for OASL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15646-OASL_HUMAN
    Recommended name:
    2-5-oligoadenylate synthase-like protein
    Protein Accession:
    Q15646
    Secondary Accessions:
    • B2RAZ2
    • I1YDD2
    • O75686
    • Q17R95
    • Q9Y6K6
    • Q9Y6K7

    Protein attributes for OASL Gene

    Size:
    514 amino acids
    Molecular mass:
    59226 Da
    Quaternary structure:
    • Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14 does not require the presence of thyroid hormone for its interaction. Binds MBD1.
    SequenceCaution:
    • Sequence=AAC41733.1; Type=Frameshift; Positions=386; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OASL Gene

    Alternative splice isoforms for OASL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OASL Gene

Protein Expression for OASL Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for OASL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OASL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OASL Gene

Domains & Families for OASL Gene

Gene Families for OASL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OASL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for OASL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15646

UniProtKB/Swiss-Prot:

OASL_HUMAN :
  • The ubiquitin-like domains are essential for its antiviral activity.
  • Belongs to the 2-5A synthase family.
Domain:
  • The ubiquitin-like domains are essential for its antiviral activity.
Family:
  • Belongs to the 2-5A synthase family.
genes like me logo Genes that share domains with OASL: view

Function for OASL Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for OASL Gene

GENATLAS Biochemistry:
2,5 oligoadenylate synthetase-like,interferon induced,cytoplasmic and nucleolar
UniProtKB/Swiss-Prot Function:
Does not have 2-5-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
UniProtKB/Swiss-Prot Induction:
By type I interferon (IFN) and viruses.

Phenotypes From GWAS Catalog for OASL Gene

Gene Ontology (GO) - Molecular Function for OASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001730 NOT 2-5-oligoadenylate synthetase activity IDA 9826176
GO:0003677 DNA binding IDA 9826176
GO:0003723 RNA binding HDA,IDA 22658674
GO:0003725 double-stranded RNA binding IDA 9826176
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with OASL: view
genes like me logo Genes that share phenotypes with OASL: view

Animal Models for OASL Gene

MGI Knock Outs for OASL:

Animal Model Products

miRNA for OASL Gene

miRTarBase miRNAs that target OASL

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OASL Gene

Localization for OASL Gene

Subcellular locations from UniProtKB/Swiss-Prot for OASL Gene

Isoform p56: Nucleus, nucleolus. Cytoplasm.
Isoform p30: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OASL gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA,IDA 9826176
GO:0005737 cytoplasm IDA,IEA 9826176
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with OASL: view

Pathways & Interactions for OASL Gene

genes like me logo Genes that share pathways with OASL: view

Gene Ontology (GO) - Biological Process for OASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0009615 response to virus IDA 18931074
GO:0045071 negative regulation of viral genome replication IDA 18931074
GO:0045087 innate immune response IEA --
GO:0051607 defense response to virus IDA 21478870
genes like me logo Genes that share ontologies with OASL: view

No data available for SIGNOR curated interactions for OASL Gene

Drugs & Compounds for OASL Gene

Products:

  1. Drug

(2) Drugs for OASL Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peginterferon alfa-2b Approved Pharma 309
Ribavirin Approved Pharma 1017

(1) Additional Compounds for OASL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OASL: view

Transcripts for OASL Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for OASL Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(75) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OASL Gene

2-5-oligoadenylate synthetase-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OASL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1:
SP2: -
SP3: - -

Relevant External Links for OASL Gene

GeneLoc Exon Structure for
OASL
ECgene alternative splicing isoforms for
OASL

Expression for OASL Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OASL Gene

mRNA expression in normal human tissues for OASL Gene
mRNA expression by BioGPS for OASL GenemRNA expression by GTEx for OASL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OASL Gene

This gene is overexpressed in Whole Blood (x18.0).

Protein differential expression in normal tissues from HIPED for OASL Gene

This gene is overexpressed in Lung (53.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OASL Gene



NURSA nuclear receptor signaling pathways regulating expression of OASL Gene:

OASL

SOURCE GeneReport for Unigene cluster for OASL Gene:

Hs.118633

mRNA Expression by UniProt/SwissProt for OASL Gene:

Q15646-OASL_HUMAN
Tissue specificity: Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.

Evidence on tissue expression from TISSUES for OASL Gene

  • Blood(4.3)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with OASL: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OASL Gene

Orthologs for OASL Gene

This gene was present in the common ancestor of chordates.

Orthologs for OASL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia OASL 33 34
  • 99.35 (n)
rat
(Rattus norvegicus)
 Mammalia Oasl 33
  • 78.33 (n)
mouse
(Mus musculus)
 Mammalia Oasl1 33 16 34
  • 77.52 (n)
dog
(Canis familiaris)
 Mammalia OASL1 34
  • 71 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia OASL 34
  • 64 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia OASL 34
  • 48 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves OAS*A 34
  • 36 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia OASL 34
  • 42 (a)
 OneToOne
Species where no ortholog for OASL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OASL Gene

ENSEMBL:
Gene Tree for OASL (if available)
TreeFam:
Gene Tree for OASL (if available)

Paralogs for OASL Gene

Paralogs for OASL Gene

(2) SIMAP similar genes for OASL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OASL: view

Variants for OASL Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for OASL Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000201669 -- 121,025,385(-) T/C intron_variant
rs1000308630 -- 121,021,509(-) C/T intron_variant
rs1000424759 -- 121,031,829(-) T/A intron_variant
rs1000480630 -- 121,026,839(-) A/G intron_variant
rs1000532486 -- 121,027,053(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OASL Gene

Variant ID Type Subtype PubMed ID
esv2759917 CNV loss 17122850
nsv1039216 CNV gain 25217958
nsv521928 CNV gain 19592680
nsv560454 CNV loss 21841781
nsv832531 CNV gain 17160897

Variation tolerance for OASL Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OASL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OASL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OASL Gene

Disorders for OASL Gene

MalaCards: The human disease database

(1) MalaCards diseases for OASL Gene - From: DISEASES

Disorder Aliases PubMed IDs
microphthalmia with limb anomalies
  • mla
- elite association - COSMIC cancer census association via MalaCards
Search OASL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OASL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OASL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OASL Gene

Publications for OASL Gene

  1. 2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro. (PMID: 20074559) Ishibashi M … Esumi M (Biochemical and biophysical research communications 2010) 3 4 22 58
  2. Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. (PMID: 14728690) Andersen JB … Justesen J (European journal of biochemistry 2004) 3 4 22 58
  3. The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. (PMID: 10087211) Hovnanian A … Hovanessian AG (Genomics 1999) 2 3 22 58
  4. p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. (PMID: 9722630) Hartmann R … Justesen J (Nucleic acids research 1998) 3 4 22 58
  5. Identification of OASL d, a splice variant of human OASL, with antiviral activity. (PMID: 22531715) Guo X … Li E (The international journal of biochemistry & cell biology 2012) 3 4 58

Products for OASL Gene

Sources for OASL Gene

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