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Aliases for OAS2 Gene

Aliases for OAS2 Gene

  • 2'-5'-Oligoadenylate Synthetase 2 2 3
  • 2-5-Oligoadenylate Synthetase 2, 69/71kDa 2 3
  • P69 OAS / P71 OAS 3 4
  • 2-5A Synthase 2 3 4
  • 2-5-Oligoadenylate Synthetase 2 (69-71 KD) 2
  • 2-5-Oligoadenylate Synthetase 2 5
  • 2-5-Oligoadenylate Synthase 2 3
  • (2-5)Oligo(A) Synthetase 2 3
  • (2-5)Oligo(A) Synthase 2 4
  • P69OAS / P71OAS 4
  • EC 2.7.7.84 4

External Ids for OAS2 Gene

Previous GeneCards Identifiers for OAS2 Gene

  • GC12P112311
  • GC12P112935
  • GC12P113199
  • GC12P111828
  • GC12P111879
  • GC12P113416
  • GC12P110428

Summaries for OAS2 Gene

Entrez Gene Summary for OAS2 Gene

  • This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for OAS2 Gene

OAS2 (2'-5'-Oligoadenylate Synthetase 2) is a Protein Coding gene. Diseases associated with OAS2 include Microphthalmia With Limb Anomalies. Among its related pathways are Hepatitis C and Innate Immune System. Gene Ontology (GO) annotations related to this gene include RNA binding and transferase activity. An important paralog of this gene is OAS3.

UniProtKB/Swiss-Prot for OAS2 Gene

  • Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:9880569, PubMed:11682059). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity).

Gene Wiki entry for OAS2 Gene

Additional gene information for OAS2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OAS2 Gene

Genomics for OAS2 Gene

GeneHancer (GH) Regulatory Elements for OAS2 Gene

Promoters and enhancers for OAS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J112976 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 666.9 +8.3 8262 5.1 HDGF PKNOX1 PTBP1 FOXA2 RB1 STAT5A RAD21 RFX5 YY1 ZNF143 OAS2 GC12M112972 OAS3 DTX1 OAS1 SLC8B1 SDSL GC12M112984 ENSG00000257452
GH12J112599 Enhancer 1.2 FANTOM5 ENCODE 8.6 -370.7 -370739 0.4 FOXA2 ZFP64 ARID4B YY1 SLC30A9 RXRA SP5 MIER2 REST PPARG GC12M112589 RPH3A OAS2 OAS3 OAS1 GC12P112610
GH12J113270 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 3.6 +301.2 301219 2.3 ELF3 ARID4B SIN3A DMAP1 ZNF48 ZSCAN9 RAD21 EGR1 EGR2 RXRA GC12M113256 SDSL RASAL1 RITA1 SLC8B1 RBM19 OAS2 OAS3 OAS1 PLBD2
GH12J112597 Enhancer 0.5 FANTOM5 8.7 -372.7 -372744 0.4 NFE2 NFE2L2 GC12M112589 RPH3A OAS2 OAS3 OAS1 TRAFD1 GC12P112594 PIR44714
GH12J113141 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 3.7 +171.7 171688 2.1 ZNF121 POLR2A ZMYM3 MNT SDSL RASAL1 SLC8B1 CFAP73 OAS2 OAS3 OAS1 SDS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OAS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OAS2 gene promoter:
  • Elk-1
  • En-1

Genomic Locations for OAS2 Gene

Genomic Locations for OAS2 Gene
chr12:112,970,819-113,011,723
(GRCh38/hg38)
Size:
40,905 bases
Orientation:
Plus strand
chr12:113,416,200-113,449,528
(GRCh37/hg19)
Size:
33,329 bases
Orientation:
Plus strand

Genomic View for OAS2 Gene

Genes around OAS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OAS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAS2 Gene

Proteins for OAS2 Gene

  • Protein details for OAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29728-OAS2_HUMAN
    Recommended name:
    2-5-oligoadenylate synthase 2
    Protein Accession:
    P29728
    Secondary Accessions:
    • A8K9T1
    • Q6PJ33
    • Q86XX8

    Protein attributes for OAS2 Gene

    Size:
    719 amino acids
    Molecular mass:
    82431 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for OAS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OAS2 Gene

Post-translational modifications for OAS2 Gene

Other Protein References for OAS2 Gene

No data available for DME Specific Peptides for OAS2 Gene

Domains & Families for OAS2 Gene

Gene Families for OAS2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for OAS2 Gene

Graphical View of Domain Structure for InterPro Entry

P29728

UniProtKB/Swiss-Prot:

OAS2_HUMAN :
  • Belongs to the 2-5A synthase family.
Family:
  • Belongs to the 2-5A synthase family.
genes like me logo Genes that share domains with OAS2: view

Function for OAS2 Gene

Molecular function for OAS2 Gene

UniProtKB/Swiss-Prot Function:
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569). Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:9880569, PubMed:11682059). Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569). Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819). May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity). Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
3 ATP = pppA2p5A2p5A + 2 diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Produced as a latent enzyme which is activated by double stranded RNA (dsRNA) generated during the course of viral infection(PubMed:9880569). The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2-hydroxyl group is tolerated (PubMed:9880569). ssRNA or dsDNA do not act as activators (PubMed:9880569). Strongly inhibited by copper, iron and zinc ions (PubMed:11682059). Partially inhibited by cobalt and nickel ions (PubMed:11682059).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.1 mM for ATP {ECO:0000269 PubMed:10464285, ECO:0000269 PubMed:11986302, ECO:0000269 PubMed:9880569};
UniProtKB/Swiss-Prot Induction:
By type I interferon (IFN) and viruses.
GENATLAS Biochemistry:
2,5-oligoadenylate synthetase 2,with two alternatively spliced isoforms 69kDa,71kDa,interferon induced

Enzyme Numbers (IUBMB) for OAS2 Gene

Phenotypes From GWAS Catalog for OAS2 Gene

Gene Ontology (GO) - Molecular Function for OAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001730 2-5-oligoadenylate synthetase activity IMP 10464285
GO:0003723 RNA binding IEA --
GO:0003725 double-stranded RNA binding IEA,IMP 10464285
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IMP,IEA 10464285
genes like me logo Genes that share ontologies with OAS2: view
genes like me logo Genes that share phenotypes with OAS2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OAS2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OAS2 Gene

Localization for OAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OAS2 Gene

Cytoplasm. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OAS2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with OAS2: view

Pathways & Interactions for OAS2 Gene

genes like me logo Genes that share pathways with OAS2: view

Gene Ontology (GO) - Biological Process for OAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 2440675
GO:0006401 RNA catabolic process IEA --
GO:0006955 immune response IEA --
GO:0009615 response to virus TAS 21142819
genes like me logo Genes that share ontologies with OAS2: view

No data available for SIGNOR curated interactions for OAS2 Gene

Drugs & Compounds for OAS2 Gene

(1) Additional Compounds for OAS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OAS2: view

Transcripts for OAS2 Gene

mRNA/cDNA for OAS2 Gene

Unigene Clusters for OAS2 Gene

2-5-oligoadenylate synthetase 2, 69/71kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OAS2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OAS2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11
SP1:
SP2: -
SP3: -
SP4:
SP5: - - -
SP6:
SP7:
SP8:

Relevant External Links for OAS2 Gene

GeneLoc Exon Structure for
OAS2
ECgene alternative splicing isoforms for
OAS2

Expression for OAS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OAS2 Gene

Protein differential expression in normal tissues from HIPED for OAS2 Gene

This gene is overexpressed in Lymph node (21.3), Esophagus (7.4), and Blymphocyte (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OAS2 Gene



Protein tissue co-expression partners for OAS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OAS2 Gene:

OAS2

SOURCE GeneReport for Unigene cluster for OAS2 Gene:

Hs.414332

Evidence on tissue expression from TISSUES for OAS2 Gene

  • Blood(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with OAS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OAS2 Gene

Orthologs for OAS2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OAS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OAS2 34 33
  • 99.35 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OAS2 34 33
  • 79.05 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OAS2 34 33
  • 78.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Oas2 16 34 33
  • 71.83 (n)
rat
(Rattus norvegicus)
Mammalia Oas2 33
  • 70.24 (n)
oppossum
(Monodelphis domestica)
Mammalia OAS2 34
  • 60 (a)
OneToOne
Species where no ortholog for OAS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OAS2 Gene

ENSEMBL:
Gene Tree for OAS2 (if available)
TreeFam:
Gene Tree for OAS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OAS2: view image

Paralogs for OAS2 Gene

Paralogs for OAS2 Gene

(2) SIMAP similar genes for OAS2 Gene using alignment to 4 proteins:

  • OAS2_HUMAN
  • F8VPI5_HUMAN
  • F8W1C5_HUMAN
  • Q7Z6D0_HUMAN
genes like me logo Genes that share paralogs with OAS2: view

Variants for OAS2 Gene

Sequence variations from dbSNP and Humsavar for OAS2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000005248 -- 113,010,488(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000109097 -- 112,979,123(+) C/G intron_variant
rs1000232251 -- 113,004,283(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000246033 -- 112,986,597(+) C/T intron_variant
rs1000525694 -- 113,000,095(+) A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OAS2 Gene

Variant ID Type Subtype PubMed ID
esv3630792 CNV gain 21293372
nsv1042636 CNV gain 25217958
nsv1047747 CNV gain 25217958
nsv507676 OTHER sequence alteration 20534489
nsv832516 CNV gain 17160897
nsv890 CNV insertion 18451855
nsv952480 CNV duplication 24416366

Variation tolerance for OAS2 Gene

Residual Variation Intolerance Score: 19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OAS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OAS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OAS2 Gene

Disorders for OAS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OAS2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
microphthalmia with limb anomalies
  • mla
- elite association - COSMIC cancer census association via MalaCards
Search OAS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OAS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OAS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OAS2 Gene

Publications for OAS2 Gene

  1. Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. (PMID: 19923450) Lin RJ … Lin YL (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 4 22 58
  2. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PMID: 16014697) Tessier MC … Polychronakos C (Journal of medical genetics 2006) 3 22 44 58
  3. The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. (PMID: 21142819) Kristiansen H … Hartmann R (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2011) 3 4 58
  4. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 44 58
  5. Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease. (PMID: 21050126) Barkhash AV … Brinton MA (The Journal of infectious diseases 2010) 3 44 58

Products for OAS2 Gene

Sources for OAS2 Gene

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