Aliases for OAF Gene

Aliases for OAF Gene

  • Out At First Homolog 2 3 5
  • HCV NS5A-Transactivated Protein 13 Target Protein 2 3 4
  • Out At First Protein Homolog 3 4
  • NS5ATP13TP2 3 4
  • OAF Homolog (Drosophila) 2
  • OAF Homolog 3

External Ids for OAF Gene

Previous GeneCards Identifiers for OAF Gene

  • GC11P119587
  • GC11P120081
  • GC11P116021

Summaries for OAF Gene

GeneCards Summary for OAF Gene

OAF (Out At First Homolog) is a Protein Coding gene. Diseases associated with OAF include Chronic Maxillary Sinusitis.

Additional gene information for OAF Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OAF Gene

Genomics for OAF Gene

GeneHancer (GH) Regulatory Elements for OAF Gene

Promoters and enhancers for OAF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J120207 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 760.9 +0.2 220 7.1 CTCF RBPJ POLR2A NR2F6 MYC HLF L3MBTL2 MAX NKRF ZFX OAF POU2F3 TRIM29 ENSG00000176984 ARHGEF12 GRIK4 lnc-POU2F3-2
GH11J120181 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 18.1 -23.1 -23100 12.2 FOXA1 MLX RBPJ NR2F1 NR2F6 MIXL1 RELA RAD21 ZNF652 CTCF LOC105369530 RNF26 OAF POU2F3 TRIM29 ENSG00000176984
GH11J120168 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.9 -41.7 -41685 1.7 CTCF RBPJ L3MBTL2 EGR1 REST ZBTB8A ATF1 POLR2A GTF2F1 ZFX ENSG00000176984 OAF RNF26 TRIM29
GH11J120195 Enhancer 1.2 ENCODE CraniofacialAtlas dbSUPER 15.5 -12.1 -12131 7.6 RBPJ CTBP1 NR2F6 HLF ELF3 SP1 ZNF384 CEBPG SP7 PPARG OAF ENSG00000176984 TLCD5 TRIM29 LOC105369530
GH11J120172 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 14.7 -38.2 -38227 1.4 CTCF MIXL1 MYC CC2D1A HLF MAX RAD21 TFE3 ARID2 REST OAF TRIM29 ENSG00000176984
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OAF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OAF gene promoter:
  • AML1a
  • AREB6
  • FOXO1
  • FOXO1a
  • HNF-3beta
  • Ik-3
  • POU2F1
  • POU2F1a
  • PPAR-alpha
  • RORalpha2

Genomic Locations for OAF Gene

Genomic Locations for OAF Gene
chr11:120,211,032-120,230,334
(GRCh38/hg38)
Size:
19,303 bases
Orientation:
Plus strand
chr11:120,081,475-120,101,041
(GRCh37/hg19)
Size:
19,567 bases
Orientation:
Plus strand

Genomic View for OAF Gene

Genes around OAF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OAF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OAF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAF Gene

Proteins for OAF Gene

  • Protein details for OAF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UD1-OAF_HUMAN
    Recommended name:
    Out at first protein homolog
    Protein Accession:
    Q86UD1

    Protein attributes for OAF Gene

    Size:
    273 amino acids
    Molecular mass:
    30688 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OAF Gene

Post-translational modifications for OAF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OAF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OAF Gene

Domains & Families for OAF Gene

Gene Families for OAF Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for OAF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OAF Gene

GenScript: Design optimal peptide antigens:
  • HCV NS5A-transactivated protein 13 target protein 2 (OAF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86UD1

UniProtKB/Swiss-Prot:

OAF_HUMAN :
  • Belongs to the OAF family.
Family:
  • Belongs to the OAF family.
genes like me logo Genes that share domains with OAF: view

Function for OAF Gene

Phenotypes From GWAS Catalog for OAF Gene

genes like me logo Genes that share phenotypes with OAF: view

Animal Models for OAF Gene

MGI Knock Outs for OAF:
  • Oaf Oaf<tm1a(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for OAF

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OAF

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OAF Gene

Localization for OAF Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OAF gene
Compartment Confidence
extracellular 3
nucleus 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OAF Gene

Pathways & Interactions for OAF Gene

PathCards logo

SuperPathways for OAF Gene

No Data Available

Gene Ontology (GO) - Biological Process for OAF Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OAF Gene

Drugs & Compounds for OAF Gene

No Compound Related Data Available

Transcripts for OAF Gene

mRNA/cDNA for OAF Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(172) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OAF

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OAF Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: - - -
SP3:

Relevant External Links for OAF Gene

GeneLoc Exon Structure for
OAF
ECgene alternative splicing isoforms for
OAF

Expression for OAF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OAF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OAF Gene

This gene is overexpressed in Liver (x9.4).

Protein differential expression in normal tissues from HIPED for OAF Gene

This gene is overexpressed in Serum (35.6) and Vitreous humor (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OAF Gene



NURSA nuclear receptor signaling pathways regulating expression of OAF Gene:

OAF

SOURCE GeneReport for Unigene cluster for OAF Gene:

Hs.445081

Evidence on tissue expression from TISSUES for OAF Gene

  • Liver(3)
genes like me logo Genes that share expression patterns with OAF: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OAF Gene

Orthologs for OAF Gene

This gene was present in the common ancestor of animals.

Orthologs for OAF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OAF 33 32
  • 99.15 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OAF 33 32
  • 91.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OAF 33 32
  • 89.39 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oaf 32
  • 86.26 (n)
mouse
(Mus musculus)
Mammalia Oaf 17 33 32
  • 86.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 81 (a)
OneToMany
-- 33
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia OAF 33
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves OAF 33 32
  • 78.64 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OAF 33
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oaf 32
  • 68.06 (n)
Str.2508 32
zebrafish
(Danio rerio)
Actinopterygii oafa 33 32
  • 68.32 (n)
OneToMany
OAF (2 of 2) 33
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta oaf 33 32
  • 57.26 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008944 32
  • 52.63 (n)
Species where no ortholog for OAF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OAF Gene

ENSEMBL:
Gene Tree for OAF (if available)
TreeFam:
Gene Tree for OAF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OAF: view image

Paralogs for OAF Gene

No data available for Paralogs for OAF Gene

Variants for OAF Gene

Sequence variations from dbSNP and Humsavar for OAF Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000037371 -- 120,224,241(+) A/C intron_variant
rs1000128362 -- 120,216,379(+) C/T intron_variant
rs1000299677 -- 120,221,733(+) C/T intron_variant
rs1000428950 -- 120,209,889(+) G/A upstream_transcript_variant
rs1000533475 -- 120,215,205(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OAF Gene

Variant ID Type Subtype PubMed ID
esv2745144 CNV deletion 23290073
esv2745145 CNV deletion 23290073
nsv518 CNV insertion 18451855
nsv518464 CNV loss 19592680

Variation tolerance for OAF Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.43; 88.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OAF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OAF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OAF Gene

Disorders for OAF Gene

MalaCards: The human disease database

(1) MalaCards diseases for OAF Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic maxillary sinusitis
  • chronic antritis
- elite association - COSMIC cancer census association via MalaCards
Search OAF in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with OAF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OAF Gene

Publications for OAF Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 56
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  3. Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate. (PMID: 27576135) Kawahara R … Paes Leme AF (Journal of proteomics 2017) 3 56
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 56

Products for OAF Gene

Sources for OAF Gene