Aliases for OAF Gene

Aliases for OAF Gene

  • Out At First Homolog 2 3 5
  • HCV NS5A-Transactivated Protein 13 Target Protein 2 3 4
  • Out At First Protein Homolog 3 4
  • NS5ATP13TP2 3 4
  • OAF Homolog (Drosophila) 2
  • OAF Homolog 3
  • MGC52117 2
  • OAF 5

External Ids for OAF Gene

Previous GeneCards Identifiers for OAF Gene

  • GC11P119587
  • GC11P120081
  • GC11P116021

Summaries for OAF Gene

GeneCards Summary for OAF Gene

OAF (Out At First Homolog) is a Protein Coding gene. Diseases associated with OAF include Acute Maxillary Sinusitis and Alveolar Periostitis.

Additional gene information for OAF Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OAF Gene

Genomics for OAF Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OAF Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J120207 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 610.9 +0.2 220 7.1 HNRNPL GATAD2A PRDM10 NFKBIZ RCOR2 BACH1 JUND LARP7 PRDM1 RBFOX2 OAF POU2F3 TRIM29 LOC107984399 ARHGEF12 GRIK4 lnc-POU2F3-2
GH11J120181 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 18.1 -23.1 -23100 12.2 HNRNPL GATAD2A CTCF REST TFE3 ZNF512 SOX13 IKZF1 RCOR2 BACH1 LOC105369530 RNF26 OAF POU2F3 TBCEL TRIM29 LOC107984399
GH11J120168 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.9 -41.7 -41685 1.7 HNRNPL CTCF TEAD4 POLR2A REST EZH2 GTF2F1 NONO MGA ZFX LOC107984399 OAF RNF26 TRIM29 NECTIN1
GH11J120195 Enhancer 1.2 ENCODE CraniofacialAtlas dbSUPER 15.5 -12.1 -12131 7.6 HNRNPL GATAD2A ZIC2 RBFOX2 POLR2A RXRB IRF2 SP1 CEBPA SCRT2 OAF LOC107984399 TLCD5 TRIM29 LOC105369530
GH11J120172 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 14.7 -38.2 -38227 1.4 CTCF TFE3 KDM1A LARP7 ZNF143 RXRB REST RAD21 IRF2 TRIM22 OAF TRIM29 LOC107984399 NECTIN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OAF on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OAF

Top Transcription factor binding sites by QIAGEN in the OAF gene promoter:
  • AML1a
  • AREB6
  • FOXO1
  • FOXO1a
  • HNF-3beta
  • Ik-3
  • POU2F1
  • POU2F1a
  • PPAR-alpha
  • RORalpha2

Genomic Locations for OAF Gene

Genomic Locations for OAF Gene
19,303 bases
Plus strand
19,567 bases
Plus strand

Genomic View for OAF Gene

Genes around OAF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OAF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OAF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAF Gene

Proteins for OAF Gene

  • Protein details for OAF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Out at first protein homolog
    Protein Accession:

    Protein attributes for OAF Gene

    273 amino acids
    Molecular mass:
    30688 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OAF Gene

Post-translational modifications for OAF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OAF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OAF Gene

Domains & Families for OAF Gene

Gene Families for OAF Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for OAF Gene


Suggested Antigen Peptide Sequences for OAF Gene

GenScript: Design optimal peptide antigens:
  • HCV NS5A-transactivated protein 13 target protein 2 (OAF_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the OAF family.
  • Belongs to the OAF family.
genes like me logo Genes that share domains with OAF: view

Function for OAF Gene

Phenotypes From GWAS Catalog for OAF Gene

genes like me logo Genes that share phenotypes with OAF: view

Animal Models for OAF Gene

MGI Knock Outs for OAF:
  • Oaf Oaf<tm1a(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for OAF

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OAF

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OAF Gene

Localization for OAF Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OAF gene
Compartment Confidence
extracellular 4
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OAF Gene

Pathways & Interactions for OAF Gene

PathCards logo

SuperPathways for OAF Gene

No Data Available

Gene Ontology (GO) - Biological Process for OAF Gene


No data available for Pathways by source and SIGNOR curated interactions for OAF Gene

Drugs & Compounds for OAF Gene

No Compound Related Data Available

Transcripts for OAF Gene

mRNA/cDNA for OAF Gene

6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OAF

Alternative Splicing Database (ASD) splice patterns (SP) for OAF Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: - - -

Relevant External Links for OAF Gene

GeneLoc Exon Structure for

Expression for OAF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OAF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OAF Gene

This gene is overexpressed in Liver (x9.4).

Protein differential expression in normal tissues from HIPED for OAF Gene

This gene is overexpressed in Serum (35.6) and Vitreous humor (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OAF Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OAF

SOURCE GeneReport for Unigene cluster for OAF Gene:


Evidence on tissue expression from TISSUES for OAF Gene

  • Liver(3.3)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with OAF: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OAF Gene

Orthologs for OAF Gene

This gene was present in the common ancestor of animals.

Orthologs for OAF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OAF 30 31
  • 99.15 (n)
(Bos Taurus)
Mammalia OAF 30 31
  • 91.74 (n)
(Canis familiaris)
Mammalia OAF 30 31
  • 89.39 (n)
(Rattus norvegicus)
Mammalia Oaf 30
  • 86.26 (n)
(Mus musculus)
Mammalia Oaf 30 17 31
  • 86.04 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 81 (a)
-- 31
  • 73 (a)
(Monodelphis domestica)
Mammalia OAF 31
  • 75 (a)
(Gallus gallus)
Aves OAF 30 31
  • 78.64 (n)
(Anolis carolinensis)
Reptilia OAF 31
  • 67 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia oaf 30
  • 68.06 (n)
Str.2508 30
(Danio rerio)
Actinopterygii oafa 30 31
  • 68.32 (n)
OAF (2 of 2) 31
  • 50 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta oaf 30 31
  • 57.26 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008944 30
  • 52.63 (n)
Species where no ortholog for OAF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OAF Gene

Gene Tree for OAF (if available)
Gene Tree for OAF (if available)
Evolutionary constrained regions (ECRs) for OAF: view image

Paralogs for OAF Gene

No data available for Paralogs for OAF Gene

Variants for OAF Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OAF Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
735074 Benign: not provided 120,228,962(+) C/T SYNONYMOUS_VARIANT
rs2508489 - p.His210Arg
rs2508490 - p.Arg217His

Additional dbSNP identifiers (rs#s) for OAF Gene

Structural Variations from Database of Genomic Variants (DGV) for OAF Gene

Variant ID Type Subtype PubMed ID
esv2745144 CNV deletion 23290073
esv2745145 CNV deletion 23290073
nsv518 CNV insertion 18451855
nsv518464 CNV loss 19592680

Variation tolerance for OAF Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.43; 88.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OAF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OAF Gene

Disorders for OAF Gene

MalaCards: The human disease database

(13) MalaCards diseases for OAF Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute maxillary sinusitis
  • acute antritis
alveolar periostitis
  • alveolitis of jaw
ethmoid sinusitis
  • ethmoidal sinusitis
chronic maxillary sinusitis
  • chronic antritis
maxillary sinusitis
- elite association - COSMIC cancer census association via MalaCards
Search OAF in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with OAF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OAF Gene

Publications for OAF Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate. (PMID: 27576135) Kawahara R … Paes Leme AF (Journal of proteomics 2017) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3

Products for OAF Gene

Sources for OAF Gene