Aliases for NYAP2 Gene

Aliases for NYAP2 Gene

  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 2 2 3 5
  • KIAA1486 2 3 4
  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adapter 2 3 4
  • NYAP2 5

External Ids for NYAP2 Gene

Previous HGNC Symbols for NYAP2 Gene

  • KIAA1486

Previous GeneCards Identifiers for NYAP2 Gene

  • GC02P226265

Summaries for NYAP2 Gene

GeneCards Summary for NYAP2 Gene

NYAP2 (Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 2) is a Protein Coding gene. An important paralog of this gene is NYAP1.

UniProtKB/Swiss-Prot Summary for NYAP2 Gene

  • Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NYAP2 Gene

Genomics for NYAP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NYAP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J225400 Promoter/Enhancer 0.9 Ensembl ENCODE 250.7 +1.7 1690 2.8 SIN3A REST MAFF EHMT2 MIER2 GATA2 MAFK ZNF143 POLR2A RAD21 NYAP2 lnc-NYAP2-1 ENSG00000273301 piR-48759-178
GH02J224943 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8 -453.2 -453220 7 NR2C1 POLR2A SIN3A GABPA IRF4 TRIM22 CBFB SPI1 BHLHE40 JUND DOCK10 NYAP2 CUL3 HSALNG0022654 lnc-NYAP2-10 CCDC195
GH02J225037 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.5 -359.1 -359131 6 ZBTB10 BCL11A POLR2A SIN3A REST EBF1 SMARCA5 MAX CBFB TAF1 DOCK10 NYAP2 CUL3 MIR4439 lnc-NYAP2-10 CCDC195
GH02J224908 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 8 -489.5 -489520 2.7 FEZF1 ZNF217 CEBPB RXRA EBF1 RFX5 PRDM6 NFE2 BHLHE40 HNF4A DOCK10 NYAP2 CUL3 HSALNG0022653 lnc-CCDC195-2 CCDC195
GH02J224921 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 8.2 -474.4 -474389 8.1 BCL11A TRIM22 IRF4 SMC3 SMARCA5 ZNF585B CBFB SPI1 BATF ZNF24 DOCK10 NYAP2 CUL3 HSALNG0022653 piR-44984-007 CCDC195
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NYAP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NYAP2

Genomic Locations for NYAP2 Gene

Latest Assembly
303,945 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
303,945 bases
Plus strand

(GRCh37/hg19 by Ensembl)
253,371 bases
Plus strand

Genomic View for NYAP2 Gene

Genes around NYAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NYAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NYAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NYAP2 Gene

Proteins for NYAP2 Gene

  • Protein details for NYAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
    Protein Accession:
    Secondary Accessions:
    • A2RRN4
    • Q96NL2

    Protein attributes for NYAP2 Gene

    653 amino acids
    Molecular mass:
    70548 Da
    Quaternary structure:
    • Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).
    • Sequence=BAA96010.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for NYAP2 Gene


neXtProt entry for NYAP2 Gene

Post-translational modifications for NYAP2 Gene

  • Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NYAP2 Gene

No data available for DME Specific Peptides for NYAP2 Gene

Domains & Families for NYAP2 Gene

Gene Families for NYAP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NYAP2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NYAP family.
  • Belongs to the NYAP family.
genes like me logo Genes that share domains with NYAP2: view

No data available for Suggested Antigen Peptide Sequences for NYAP2 Gene

Function for NYAP2 Gene

Molecular function for NYAP2 Gene

UniProtKB/Swiss-Prot Function:
Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

Phenotypes From GWAS Catalog for NYAP2 Gene

Gene Ontology (GO) - Molecular Function for NYAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NYAP2: view

Phenotypes for NYAP2 Gene

genes like me logo Genes that share phenotypes with NYAP2: view

Animal Models for NYAP2 Gene

MGI Knock Outs for NYAP2:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NYAP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NYAP2 Gene

Localization for NYAP2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NYAP2 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NYAP2 Gene

Pathways & Interactions for NYAP2 Gene

PathCards logo

SuperPathways for NYAP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NYAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014065 phosphatidylinositol 3-kinase signaling ISS --
GO:0048812 neuron projection morphogenesis ISS --
genes like me logo Genes that share ontologies with NYAP2: view

No data available for Pathways by source and SIGNOR curated interactions for NYAP2 Gene

Drugs & Compounds for NYAP2 Gene

No Compound Related Data Available

Transcripts for NYAP2 Gene

mRNA/cDNA for NYAP2 Gene

4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NYAP2

Alternative Splicing Database (ASD) splice patterns (SP) for NYAP2 Gene

No ASD Table

Relevant External Links for NYAP2 Gene

GeneLoc Exon Structure for

Expression for NYAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NYAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NYAP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for NYAP2 Gene

This gene is overexpressed in Fetal Brain (38.9), Frontal cortex (16.6), and Heart (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NYAP2 Gene

Protein tissue co-expression partners for NYAP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NYAP2

SOURCE GeneReport for Unigene cluster for NYAP2 Gene:


Evidence on tissue expression from TISSUES for NYAP2 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with NYAP2: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NYAP2 Gene

Orthologs for NYAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NYAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NYAP2 30 31
  • 99.18 (n)
(Bos Taurus)
Mammalia NYAP2 30 31
  • 86.65 (n)
(Canis familiaris)
Mammalia NYAP2 30 31
  • 85.25 (n)
(Rattus norvegicus)
Mammalia Nyap2 30
  • 84.84 (n)
(Mus musculus)
Mammalia Nyap2 30 17 31
  • 83.99 (n)
(Monodelphis domestica)
Mammalia NYAP2 31
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia NYAP2 31
  • 77 (a)
(Gallus gallus)
Aves NYAP2 30 31
  • 78.86 (n)
(Anolis carolinensis)
Reptilia NYAP2 31
  • 69 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nyap2 30
  • 70.68 (n)
(Danio rerio)
Actinopterygii LOC100000797 30
  • 59.99 (n)
NYAP2 (1 of 2) 31
  • 49 (a)
NYAP2 (2 of 2) 31
  • 28 (a)
Species where no ortholog for NYAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NYAP2 Gene

Gene Tree for NYAP2 (if available)
Gene Tree for NYAP2 (if available)
Evolutionary constrained regions (ECRs) for NYAP2: view image

Paralogs for NYAP2 Gene

Paralogs for NYAP2 Gene

(1) SIMAP similar genes for NYAP2 Gene using alignment to 2 proteins:

  • F8W6E8_HUMAN
genes like me logo Genes that share paralogs with NYAP2: view

Variants for NYAP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NYAP2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs61753536 Benign: not provided 225,651,472(+) G/C
NM_020864.1(NYAP2):c.1869G>C (p.Thr623=)
rs3748993 - p.Thr586Pro
rs7422680 - p.Thr205Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NYAP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NYAP2 Gene

Variant ID Type Subtype PubMed ID
esv1558776 CNV insertion 17803354
esv25689 CNV loss 19812545
esv2665271 CNV deletion 23128226
esv3427876 CNV insertion 20981092
esv3594490 CNV loss 21293372
esv3594493 CNV loss 21293372
nsv1131555 CNV deletion 24896259
nsv1138894 CNV deletion 24896259
nsv475737 CNV novel sequence insertion 20440878
nsv834556 CNV loss 17160897

Variation tolerance for NYAP2 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NYAP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NYAP2 Gene

Disorders for NYAP2 Gene

Additional Disease Information for NYAP2

No disorders were found for NYAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NYAP2 Gene

Publications for NYAP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  2. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. (PMID: 21946561) Yokoyama K … Yamamoto T (The EMBO journal 2011) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3

Products for NYAP2 Gene

Sources for NYAP2 Gene