The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and... See more...

Aliases for NXT1 Gene

Aliases for NXT1 Gene

  • Nuclear Transport Factor 2 Like Export Factor 1 2 3 5
  • NTF2-Related Export Protein 1 3 4
  • NTF2-Like Export Factor 1 2 3
  • NTX2-Like Export Factor1 2 3
  • Protein P15 3 4
  • Nuclear Transport Factor 2-Like Export Factor 1 2
  • NUTF-Like Export Factor 1 3
  • MTR2 3
  • P15 3

External Ids for NXT1 Gene

Previous GeneCards Identifiers for NXT1 Gene

  • GC20P023319
  • GC20P023326
  • GC20P023279
  • GC20P023331

Summaries for NXT1 Gene

Entrez Gene Summary for NXT1 Gene

  • The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NXT1 Gene

NXT1 (Nuclear Transport Factor 2 Like Export Factor 1) is a Protein Coding gene. Diseases associated with NXT1 include St. Louis Encephalitis. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. Gene Ontology (GO) annotations related to this gene include Ran GTPase binding. An important paralog of this gene is NXT2.

UniProtKB/Swiss-Prot Summary for NXT1 Gene

  • Stimulator of protein export for NES-containing proteins (PubMed:10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602).

Gene Wiki entry for NXT1 Gene

Additional gene information for NXT1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NXT1 Gene

Genomics for NXT1 Gene

GeneHancer (GH) Regulatory Elements for NXT1 Gene

Promoters and enhancers for NXT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J023348 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 535.8 +0.0 43 4.4 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G SP1 NCOR1 NXT1 ENSG00000234832 NXT1-AS1 piR-54193 NAPB CSTL1
GH20J022581 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 29.5 -767.1 -767056 4.2 TCF12 POLR2G NCOR1 PHF8 ZNF263 TCF7 ZBTB26 ZBTB25 TGIF2 ZBTB7A FOXA2 NXT1 LNCNEF LINC00261
GH20J023356 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 21.3 +9.5 9465 8.4 EP300 FOXK2 ZNF217 SIN3A TCF12 NRF1 MYC POLR2G USF1 SP1 GZF1 LINC01431 lnc-NAPB-6 NXT1 NAPB CSTL1
GH20J023635 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 16.6 +286.1 286149 3.8 HNRNPK NRF1 POLR2G NCOR1 PHF8 ZFX ZIC2 POLR2A ZBTB11 ZBTB26 CST3 NXT1 ENSG00000270001
GH20J022574 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.6 -773.1 -773062 6.1 FOXK2 TCF12 POLR2G NCOR1 PHF8 ZIC2 TCF7 TRIM28 TGIF2 ZBTB7A LINC00261 NXT1 FOXA2 LNCNEF lnc-FOXA2-9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NXT1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NXT1

Top Transcription factor binding sites by QIAGEN in the NXT1 gene promoter:
  • c-Myc
  • Cdc5
  • E2F
  • E2F-1
  • Elk-1
  • Max
  • p53
  • POU3F2
  • ZIC2
  • Zic3

Genomic Locations for NXT1 Gene

Genomic Locations for NXT1 Gene
chr20:23,350,736-23,354,771
(GRCh38/hg38)
Size:
4,036 bases
Orientation:
Plus strand
chr20:23,331,373-23,335,414
(GRCh37/hg19)
Size:
4,042 bases
Orientation:
Plus strand

Genomic View for NXT1 Gene

Genes around NXT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXT1 Gene

Proteins for NXT1 Gene

  • Protein details for NXT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKK6-NXT1_HUMAN
    Recommended name:
    NTF2-related export protein 1
    Protein Accession:
    Q9UKK6

    Protein attributes for NXT1 Gene

    Size:
    140 amino acids
    Molecular mass:
    15847 Da
    Quaternary structure:
    • Heterodimer with NXF1 (PubMed:11583626). Forms a complex with RANGAP1, RANBP2/NUP358 and NXF1 (PubMed:14729961). Interacts (via NTF2 domain) with NXF1 (PubMed:11583626). Stabilizes the NTF2 domain of NXF1 by heterodimerization (PubMed:11583626). The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export (PubMed:11583626). Preferentially binds Ran-GTP (PubMed:10567585). Associates with NXF2, NXF3 and NXF5. Does not bind nucleoporins (NPC) directly, its association to NPC is mediated by NXF1 (PubMed:11583626).

    Three dimensional structures from OCA and Proteopedia for NXT1 Gene

neXtProt entry for NXT1 Gene

Post-translational modifications for NXT1 Gene

  • Ubiquitination at Lys7 and Lys30
  • Modification sites at PhosphoSitePlus

Other Protein References for NXT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXT1 Gene

Domains & Families for NXT1 Gene

Gene Families for NXT1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NXT1 Gene

Blocks:
  • Nuclear transport factor 2 (NTF2)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NXT1 Gene

GenScript: Design optimal peptide antigens:
  • Protein p15 (NXT1_HUMAN)
genes like me logo Genes that share domains with NXT1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NXT1 Gene

Function for NXT1 Gene

Molecular function for NXT1 Gene

UniProtKB/Swiss-Prot Function:
Stimulator of protein export for NES-containing proteins (PubMed:10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602).

Phenotypes From GWAS Catalog for NXT1 Gene

Gene Ontology (GO) - Molecular Function for NXT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11566096
GO:0008536 Ran GTPase binding IEA --
genes like me logo Genes that share ontologies with NXT1: view
genes like me logo Genes that share phenotypes with NXT1: view

Animal Model Products

CRISPR Products

miRNA for NXT1 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NXT1 Gene

Localization for NXT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXT1 Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NXT1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NXT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IEA,TAS 10567585
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 10567585
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NXT1: view

Pathways & Interactions for NXT1 Gene

genes like me logo Genes that share pathways with NXT1: view

Gene Ontology (GO) - Biological Process for NXT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006405 RNA export from nucleus IEA --
GO:0006406 mRNA export from nucleus TAS --
GO:0006606 protein import into nucleus IBA 21873635
GO:0006611 protein export from nucleus IEA --
GO:0006913 nucleocytoplasmic transport IBA 21873635
genes like me logo Genes that share ontologies with NXT1: view

No data available for SIGNOR curated interactions for NXT1 Gene

Drugs & Compounds for NXT1 Gene

(1) Drugs for NXT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for NXT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NXT1: view

Transcripts for NXT1 Gene

mRNA/cDNA for NXT1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXT1 Gene

No ASD Table

Relevant External Links for NXT1 Gene

GeneLoc Exon Structure for
NXT1

Expression for NXT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NXT1 Gene

Protein differential expression in normal tissues from HIPED for NXT1 Gene

This gene is overexpressed in Liver (59.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NXT1 Gene



Protein tissue co-expression partners for NXT1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NXT1

SOURCE GeneReport for Unigene cluster for NXT1 Gene:

Hs.516933

Evidence on tissue expression from TISSUES for NXT1 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with NXT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NXT1 Gene

Orthologs for NXT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NXT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NXT1 31 30
  • 99.29 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nxt1 17 31 30
  • 91.43 (n)
rat
(Rattus norvegicus)
Mammalia Nxt1 30
  • 91.43 (n)
dog
(Canis familiaris)
Mammalia NXT1 30
  • 91.19 (n)
cow
(Bos Taurus)
Mammalia NXT1 31 30
  • 89.21 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1856 30
zebrafish
(Danio rerio)
Actinopterygii nxt2 31
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008234 30
  • 54.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta Nxt1 31 30
  • 52.2 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nxt-1 31
  • 29 (a)
OneToMany
Species where no ortholog for NXT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NXT1 Gene

ENSEMBL:
Gene Tree for NXT1 (if available)
TreeFam:
Gene Tree for NXT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NXT1: view image

Paralogs for NXT1 Gene

Paralogs for NXT1 Gene

(1) SIMAP similar genes for NXT1 Gene using alignment to 1 proteins:

  • NXT1_HUMAN

Pseudogenes.org Pseudogenes for NXT1 Gene

genes like me logo Genes that share paralogs with NXT1: view

Variants for NXT1 Gene

Additional dbSNP identifiers (rs#s) for NXT1 Gene

Variation tolerance for NXT1 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NXT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NXT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for NXT1 Gene

Disorders for NXT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NXT1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
st. louis encephalitis
  • neuroinvasive st. louis encephalitis virus infection
- elite association - COSMIC cancer census association via MalaCards
Search NXT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NXT1

genes like me logo Genes that share disorders with NXT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NXT1 Gene

Publications for NXT1 Gene

  1. NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells. (PMID: 11259602) Guzik BW … Hammarskjöld ML (Molecular and cellular biology 2001) 2 3 4 23 54
  2. Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export. (PMID: 10567585) Black BE … Paschal BM (Molecular and cellular biology 1999) 2 3 4 23 54
  3. Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. (PMID: 11583626) Fribourg S … Conti E (Molecular cell 2001) 3 4 23 54
  4. RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro. (PMID: 10848583) Ossareh-Nazari B … Dargemont C (Molecular and cellular biology 2000) 3 4 23 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for NXT1 Gene

Sources for NXT1 Gene