Aliases for NXPH3 Gene

Aliases for NXPH3 Gene

  • Neurexophilin 3 2 3 5
  • NPH3 2 3 4
  • Neurexophilin-3 3 4
  • KIAA1159 4
  • NXPH3 5

External Ids for NXPH3 Gene

Previous GeneCards Identifiers for NXPH3 Gene

  • GC17P047364
  • GC17P050133
  • GC17P047995
  • GC17P048127
  • GC17P045008
  • GC17P047653
  • GC17P043018

Summaries for NXPH3 Gene

GeneCards Summary for NXPH3 Gene

NXPH3 (Neurexophilin 3) is a Protein Coding gene. Diseases associated with NXPH3 include Cone-Rod Dystrophy 2. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is NXPH1.

UniProtKB/Swiss-Prot Summary for NXPH3 Gene

  • May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).

Gene Wiki entry for NXPH3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NXPH3 Gene

Genomics for NXPH3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NXPH3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NXPH3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NXPH3

Top Transcription factor binding sites by QIAGEN in the NXPH3 gene promoter:
  • CP2
  • GATA-2
  • GCNF
  • GCNF-1
  • GCNF-2
  • HOXA5
  • MAZR
  • POU2F1
  • POU2F1a

Genomic Locations for NXPH3 Gene

Latest Assembly
7,957 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
7,957 bases
Plus strand

(GRCh37/hg19 by Ensembl)
7,970 bases
Plus strand

Genomic View for NXPH3 Gene

Genes around NXPH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPH3 Gene

Proteins for NXPH3 Gene

  • Protein details for NXPH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8NDC3
    • Q8TBF6
    • Q9ULR1

    Protein attributes for NXPH3 Gene

    252 amino acids
    Molecular mass:
    28127 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXPH3 Gene

Post-translational modifications for NXPH3 Gene

  • May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
  • Glycosylation at Asn62, Asn127, Asn137, and Asn143
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXPH3 Gene

Domains & Families for NXPH3 Gene

Gene Families for NXPH3 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NXPH3 Gene

  • Neurexophilin

Suggested Antigen Peptide Sequences for NXPH3 Gene

GenScript: Design optimal peptide antigens:
  • Neurexophilin-3 (NXPH3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the neurexophilin family.
  • Belongs to the neurexophilin family.
genes like me logo Genes that share domains with NXPH3: view

Function for NXPH3 Gene

Molecular function for NXPH3 Gene

UniProtKB/Swiss-Prot Function:
May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).

Phenotypes From GWAS Catalog for NXPH3 Gene

Gene Ontology (GO) - Molecular Function for NXPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005102 signaling receptor binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with NXPH3: view
genes like me logo Genes that share phenotypes with NXPH3: view

Animal Models for NXPH3 Gene

MGI Knock Outs for NXPH3:

Animal Models for research

  • Taconic Biosciences Mouse Models for NXPH3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NXPH3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NXPH3 Gene

Localization for NXPH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPH3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NXPH3 gene
Compartment Confidence
extracellular 4
cytoskeleton 1
nucleus 1
plasma membrane 0
mitochondrion 0
endoplasmic reticulum 0
cytosol 0
lysosome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitotic spindle (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NXPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NXPH3: view

Pathways & Interactions for NXPH3 Gene

PathCards logo

SuperPathways for NXPH3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NXPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway NAS 9570794
genes like me logo Genes that share ontologies with NXPH3: view

No data available for Pathways by source and SIGNOR curated interactions for NXPH3 Gene

Drugs & Compounds for NXPH3 Gene

No Compound Related Data Available

Transcripts for NXPH3 Gene

mRNA/cDNA for NXPH3 Gene

7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NXPH3

Alternative Splicing Database (ASD) splice patterns (SP) for NXPH3 Gene

No ASD Table

Relevant External Links for NXPH3 Gene

GeneLoc Exon Structure for

Expression for NXPH3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NXPH3 Gene

mRNA differential expression in normal tissues according to GTEx for NXPH3 Gene

This gene is overexpressed in Artery - Aorta (x7.9), Artery - Tibial (x4.8), Brain - Cerebellar Hemisphere (x4.7), and Brain - Cerebellum (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NXPH3

SOURCE GeneReport for Unigene cluster for NXPH3 Gene:


mRNA Expression by UniProt/SwissProt for NXPH3 Gene:

Tissue specificity: Highest level in brain.

Evidence on tissue expression from TISSUES for NXPH3 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with NXPH3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NXPH3 Gene

Orthologs for NXPH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPH3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia NXPH3 29 30
  • 94.05 (n)
(Bos Taurus)
Mammalia NXPH3 29 30
  • 91.53 (n)
(Rattus norvegicus)
Mammalia Nxph3 29
  • 89.95 (n)
(Mus musculus)
Mammalia Nxph3 29 16 30
  • 89.55 (n)
(Monodelphis domestica)
Mammalia NXPH3 30
  • 87 (a)
(Gallus gallus)
Aves NXPH3 29
  • 69.51 (n)
(Anolis carolinensis)
Reptilia NXPH3 30
  • 57 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nxph3 29
  • 60.71 (n)
(Danio rerio)
Actinopterygii nxph2b 30
  • 45 (a)
Species where no ortholog for NXPH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NXPH3 Gene

Gene Tree for NXPH3 (if available)
Gene Tree for NXPH3 (if available)
Evolutionary constrained regions (ECRs) for NXPH3: view image
Alliance of Genome Resources:
Additional Orthologs for NXPH3

Paralogs for NXPH3 Gene

Paralogs for NXPH3 Gene

(3) SIMAP similar genes for NXPH3 Gene using alignment to 3 proteins:

  • L8E9I1_HUMAN
genes like me logo Genes that share paralogs with NXPH3: view

Variants for NXPH3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NXPH3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NXPH3 Gene

Variant ID Type Subtype PubMed ID
nsv2078 CNV deletion 18451855

Variation tolerance for NXPH3 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NXPH3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NXPH3 Gene

Disorders for NXPH3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NXPH3 Gene - From: COP

Disorder Aliases PubMed IDs
cone-rod dystrophy 2
  • cord2
- elite association - COSMIC cancer census association via MalaCards
Search NXPH3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NXPH3

genes like me logo Genes that share disorders with NXPH3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NXPH3 Gene

Publications for NXPH3 Gene

  1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PMID: 9570794) Missler M … Südhof TC (The Journal of neuroscience : the official journal of the Society for Neuroscience 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4

Products for NXPH3 Gene

Sources for NXPH3 Gene