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Aliases for NXPH3 Gene

Aliases for NXPH3 Gene

  • Neurexophilin 3 2 3 5
  • NPH3 3 4
  • Neurexophilin-3 3
  • KIAA1159 4

External Ids for NXPH3 Gene

Previous GeneCards Identifiers for NXPH3 Gene

  • GC17P047364
  • GC17P050133
  • GC17P047995
  • GC17P048127
  • GC17P045008
  • GC17P047653
  • GC17P043018

Summaries for NXPH3 Gene

GeneCards Summary for NXPH3 Gene

NXPH3 (Neurexophilin 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include receptor binding. An important paralog of this gene is NXPH1.

UniProtKB/Swiss-Prot for NXPH3 Gene

  • May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).

Gene Wiki entry for NXPH3 Gene

Additional gene information for NXPH3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPH3 Gene

Genomics for NXPH3 Gene

GeneHancer (GH) Regulatory Elements for NXPH3 Gene

Promoters and enhancers for NXPH3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I049575 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.6 582 1.7 ARNT ARID4B SIN3A ZNF2 ZNF121 GLIS2 CBX5 ELK1 ZNF416 ZNF207 NXPH3 ENSG00000250310 KAT7 ENSG00000262837 SUMO2P17 ENSG00000230532 UBE2Z EME1 CACNA1G-AS1 LOC105371824
GH17I049735 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 20.2 +167.4 167359 15.6 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT SIN3A FEZF1 IRF4 YY1 ZNF766 LUC7L3 ENSG00000262837 FAM117A UBE2Z FLJ45513 NXPH3 ZNF652 KAT7 ENSG00000230532 SLC35B1
GH17I049190 Enhancer 1.7 FANTOM5 Ensembl ENCODE 18.1 -383.1 -383119 4 CLOCK MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 TRQ-TTG1-1 ENSG00000262837 UBE2Z FAM117A FLJ45513 ENSG00000230532 KAT7 TAC4 PICART1 CALCOCO2
GH17I049569 Enhancer 1.5 Ensembl ENCODE dbSUPER 18.5 -5.7 -5718 1.5 MLX DMAP1 YY1 ZNF213 ZNF143 ZNF548 SP3 MEF2D SSRP1 ZNF610 ENSG00000262837 ENSG00000230532 NXPH3 SUMO2P17 LOC105371824 UBE2Z EME1 CACNA1G-AS1 PICART1 LOC100288866
GH17I048994 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 9.8 -576.4 -576410 10.8 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 IGF2BP1 ENSG00000250838 ENSG00000262837 UBE2Z FAM117A FLJ45513 ENSG00000238804 PRAC1 PRAC2 HOXB13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NXPH3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NXPH3 gene promoter:

Genomic Locations for NXPH3 Gene

Genomic Locations for NXPH3 Gene
chr17:49,575,858-49,583,827
(GRCh38/hg38)
Size:
7,970 bases
Orientation:
Plus strand
chr17:47,653,220-47,661,189
(GRCh37/hg19)

Genomic View for NXPH3 Gene

Genes around NXPH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPH3 Gene

Proteins for NXPH3 Gene

  • Protein details for NXPH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95157-NXPH3_HUMAN
    Recommended name:
    Neurexophilin-3
    Protein Accession:
    O95157
    Secondary Accessions:
    • Q8NDC3
    • Q8TBF6
    • Q9ULR1

    Protein attributes for NXPH3 Gene

    Size:
    252 amino acids
    Molecular mass:
    28127 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXPH3 Gene

Post-translational modifications for NXPH3 Gene

  • May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
  • Glycosylation at Asn62, Asn127, isoforms=137, and isoforms=143

Other Protein References for NXPH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXPH3 Gene

Domains & Families for NXPH3 Gene

Gene Families for NXPH3 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NXPH3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NXPH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95157

UniProtKB/Swiss-Prot:

NXPH3_HUMAN :
  • Belongs to the neurexophilin family.
Family:
  • Belongs to the neurexophilin family.
genes like me logo Genes that share domains with NXPH3: view

Function for NXPH3 Gene

Molecular function for NXPH3 Gene

UniProtKB/Swiss-Prot Function:
May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).

Phenotypes From GWAS Catalog for NXPH3 Gene

Gene Ontology (GO) - Molecular Function for NXPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005102 receptor binding IBA,IEA --
genes like me logo Genes that share ontologies with NXPH3: view
genes like me logo Genes that share phenotypes with NXPH3: view

Animal Models for NXPH3 Gene

MGI Knock Outs for NXPH3:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NXPH3 Gene

Localization for NXPH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPH3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NXPH3 gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NXPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NXPH3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NXPH3 Gene

Pathways & Interactions for NXPH3 Gene

SuperPathways for NXPH3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NXPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway NAS 9570794
genes like me logo Genes that share ontologies with NXPH3: view

No data available for Pathways by source and SIGNOR curated interactions for NXPH3 Gene

Drugs & Compounds for NXPH3 Gene

No Compound Related Data Available

Transcripts for NXPH3 Gene

mRNA/cDNA for NXPH3 Gene

Unigene Clusters for NXPH3 Gene

Neurexophilin 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXPH3 Gene

No ASD Table

Relevant External Links for NXPH3 Gene

GeneLoc Exon Structure for
NXPH3
ECgene alternative splicing isoforms for
NXPH3

Expression for NXPH3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NXPH3 Gene

mRNA differential expression in normal tissues according to GTEx for NXPH3 Gene

This gene is overexpressed in Artery - Aorta (x7.9), Artery - Tibial (x4.8), Brain - Cerebellar Hemisphere (x4.7), and Brain - Cerebellum (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of NXPH3 Gene:

NXPH3

SOURCE GeneReport for Unigene cluster for NXPH3 Gene:

Hs.55069

mRNA Expression by UniProt/SwissProt for NXPH3 Gene:

O95157-NXPH3_HUMAN
Tissue specificity: Highest level in brain.

Evidence on tissue expression from TISSUES for NXPH3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with NXPH3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NXPH3 Gene

Orthologs for NXPH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPH3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NXPH3 33 34
  • 94.05 (n)
cow
(Bos Taurus)
Mammalia NXPH3 33 34
  • 91.53 (n)
rat
(Rattus norvegicus)
Mammalia Nxph3 33
  • 89.95 (n)
mouse
(Mus musculus)
Mammalia Nxph3 33 16 34
  • 89.55 (n)
oppossum
(Monodelphis domestica)
Mammalia NXPH3 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves NXPH3 33
  • 69.51 (n)
lizard
(Anolis carolinensis)
Reptilia NXPH3 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nxph3 33
  • 60.71 (n)
zebrafish
(Danio rerio)
Actinopterygii nxph2b 34
  • 45 (a)
ManyToMany
Species where no ortholog for NXPH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPH3 Gene

ENSEMBL:
Gene Tree for NXPH3 (if available)
TreeFam:
Gene Tree for NXPH3 (if available)

Paralogs for NXPH3 Gene

Paralogs for NXPH3 Gene

(3) SIMAP similar genes for NXPH3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NXPH3: view

Variants for NXPH3 Gene

Sequence variations from dbSNP and Humsavar for NXPH3 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000060935 -- 49,582,385(+) C/T 3_prime_UTR_variant
rs1000068528 -- 49,577,004(+) G/C intron_variant
rs1000222754 -- 49,581,233(+) G/T 3_prime_UTR_variant
rs1000349968 -- 49,575,384(+) G/T upstream_transcript_variant
rs1000568411 -- 49,580,081(+) C/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for NXPH3 Gene

Variant ID Type Subtype PubMed ID
nsv2078 CNV deletion 18451855

Variation tolerance for NXPH3 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NXPH3 Gene

Human Gene Mutation Database (HGMD)
NXPH3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NXPH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPH3 Gene

Disorders for NXPH3 Gene

Additional Disease Information for NXPH3

No disorders were found for NXPH3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPH3 Gene

Publications for NXPH3 Gene

  1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PMID: 9570794) Missler M … Südhof TC (The Journal of neuroscience : the official journal of the Society for Neuroscience 1998) 2 3 4 58
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58

Products for NXPH3 Gene

Sources for NXPH3 Gene

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