Aliases for NXPE4 Gene

Aliases for NXPE4 Gene

  • Neurexophilin And PC-Esterase Domain Family Member 4 2 3 5
  • Family With Sequence Similarity 55, Member D 2 3
  • NXPE Family Member 4 3 4
  • Protein FAM55D 3 4
  • C11orf33 3 4
  • FAM55D 3 4
  • Neurexophilin And PC-Esterase Domain Family, Member 4 2
  • Chromosome 11 Open Reading Frame 33 2
  • FLJ20127 2
  • NXPE4 5

External Ids for NXPE4 Gene

Previous HGNC Symbols for NXPE4 Gene

  • C11orf33
  • FAM55D

Previous GeneCards Identifiers for NXPE4 Gene

  • GC11M114442

Summaries for NXPE4 Gene

GeneCards Summary for NXPE4 Gene

NXPE4 (Neurexophilin And PC-Esterase Domain Family Member 4) is a Protein Coding gene. An important paralog of this gene is NXPE1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NXPE4 Gene

Genomics for NXPE4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NXPE4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J114651 Promoter 0.4 EPDnew 250.2 -55.3 -55349 0.1 NFATC3 LOC105369504 lnc-NXPE4-1 piR-59928-031 NXPE4 NXPE2 MN309411 CADM1
GH11J114595 Promoter 0.3 EPDnew 250.7 +0.4 433 0.1 NXPE4 piR-61177 NXPE1 NXPE2
GH11J113872 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 20.7 +721.4 721422 4.8 TBP FEZF1 MNT SMAD5 IRF2 HES1 ZFP64 MBD2 POLR2A BHLHE40 USP28 lnc-HTR3B-3 ENSG00000270179 RBM7 NXPE4 TTC12 ZW10 NXPE1 LRRC37A13P RF00066-041
GH11J115500 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 14.3 -907.2 -907238 5.5 ZBTB10 FEZF1 CEBPA POLR2A CTCF ZIC2 ZNF610 THAP11 SIN3A FOXA2 CADM1 HSALNG0087349 lnc-NXPE4-4 NXPE4 LOC105369507
GH11J114398 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +195.1 195114 5.4 ZSCAN16 CHD2 TBP ZBTB10 FEZF1 CEBPA NR2C1 MNT IKZF1 SMAD5 RBM7 C11orf71 ENSG00000255663 NONHSAG009665.2 ZW10 NXPE4 REXO2 ZBTB16 LOC101928940
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NXPE4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NXPE4

Genomic Locations for NXPE4 Gene

Latest Assembly
25,625 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
25,196 bases
Minus strand

(GRCh37/hg19 by Ensembl)
25,172 bases
Minus strand

Genomic View for NXPE4 Gene

Genes around NXPE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPE4 Gene

Proteins for NXPE4 Gene

  • Protein details for NXPE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NXPE family member 4
    Protein Accession:
    Secondary Accessions:
    • Q6QDB4
    • Q9NXP5

    Protein attributes for NXPE4 Gene

    544 amino acids
    Molecular mass:
    62263 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA90965.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for NXPE4 Gene


neXtProt entry for NXPE4 Gene

Post-translational modifications for NXPE4 Gene

  • Glycosylation at Asn29, Asn38, Asn47, Asn48, Asn92, Asn160, and Asn210
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPE4 Gene

No data available for DME Specific Peptides for NXPE4 Gene

Domains & Families for NXPE4 Gene

Gene Families for NXPE4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for NXPE4 Gene


Suggested Antigen Peptide Sequences for NXPE4 Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM55D (FA55D_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NXPE family.
  • Belongs to the NXPE family.
genes like me logo Genes that share domains with NXPE4: view

Function for NXPE4 Gene

Phenotypes From GWAS Catalog for NXPE4 Gene

Gene Ontology (GO) - Molecular Function for NXPE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NXPE4: view
genes like me logo Genes that share phenotypes with NXPE4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NXPE4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NXPE4 Gene

Localization for NXPE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPE4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NXPE4 gene
Compartment Confidence
extracellular 4
golgi apparatus 2
nucleus 1
mitochondrion 0
peroxisome 0
endoplasmic reticulum 0
lysosome 0

Gene Ontology (GO) - Cellular Components for NXPE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with NXPE4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NXPE4 Gene

Pathways & Interactions for NXPE4 Gene

PathCards logo

SuperPathways for NXPE4 Gene

No Data Available

Interacting Proteins for NXPE4 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000364627 Q6UWF7-NXPE4_HUMAN for NXPE4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NXPE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NXPE4: view

No data available for Pathways by source and SIGNOR curated interactions for NXPE4 Gene

Drugs & Compounds for NXPE4 Gene

No Compound Related Data Available

Transcripts for NXPE4 Gene

mRNA/cDNA for NXPE4 Gene

5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NXPE4

Alternative Splicing Database (ASD) splice patterns (SP) for NXPE4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: -

Relevant External Links for NXPE4 Gene

GeneLoc Exon Structure for

Expression for NXPE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NXPE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NXPE4 Gene

This gene is overexpressed in Colon - Transverse (x48.3).

Protein differential expression in normal tissues from HIPED for NXPE4 Gene

This gene is overexpressed in Salivary gland (42.3) and Testis (22.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NXPE4 Gene

Protein tissue co-expression partners for NXPE4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NXPE4

SOURCE GeneReport for Unigene cluster for NXPE4 Gene:


Evidence on tissue expression from TISSUES for NXPE4 Gene

  • Intestine(4.4)
genes like me logo Genes that share expression patterns with NXPE4: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NXPE4 Gene

Orthologs for NXPE4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPE4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NXPE4 30 31
  • 99.14 (n)
(Canis familiaris)
Mammalia NXPE4 30 31
  • 84.66 (n)
(Bos Taurus)
Mammalia NXPE4 30 31
  • 84.35 (n)
(Mus musculus)
Mammalia Nxpe4 30 17 31
  • 79.75 (n)
(Rattus norvegicus)
Mammalia Fam55b 30
  • 78.79 (n)
(Monodelphis domestica)
Mammalia NXPE4 31
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 59 (a)
-- 31
  • 55 (a)
-- 31
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 55 (a)
-- 31
  • 54 (a)
-- 31
  • 50 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100486856 30
  • 56.82 (n)
(Danio rerio)
Actinopterygii si:dkey-285b23.3 31
  • 27 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
-- 31
  • 24 (a)
-- 31
  • 23 (a)
-- 31
  • 22 (a)
-- 31
  • 22 (a)
-- 31
  • 22 (a)
-- 31
  • 22 (a)
-- 31
  • 21 (a)
-- 31
  • 20 (a)
Species where no ortholog for NXPE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NXPE4 Gene

Gene Tree for NXPE4 (if available)
Gene Tree for NXPE4 (if available)
Evolutionary constrained regions (ECRs) for NXPE4: view image

Paralogs for NXPE4 Gene

Paralogs for NXPE4 Gene

(3) SIMAP similar genes for NXPE4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NXPE4: view

Variants for NXPE4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NXPE4 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10891705 - p.Ala451Val
rs550897 - p.Tyr398His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NXPE4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NXPE4 Gene

Variant ID Type Subtype PubMed ID
esv2759865 CNV gain 17122850
esv3627794 CNV gain 21293372
nsv1053425 CNV loss 25217958
nsv472708 CNV novel sequence insertion 20440878
nsv832274 CNV gain 17160897
nsv975981 CNV duplication 23825009

Variation tolerance for NXPE4 Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.47; 85.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NXPE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPE4 Gene

Disorders for NXPE4 Gene

Additional Disease Information for NXPE4

No disorders were found for NXPE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPE4 Gene

Publications for NXPE4 Gene

  1. Novel eukaryotic enzymes modifying cell-surface biopolymers. (PMID: 20056006) Anantharaman V … Aravind L (Biology direct 2010) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Search for epithelial-specific mRNAs in peripheral blood of patients with colon cancer by RT-PCR. (PMID: 15375555) Solmi R … Strippoli P (International journal of oncology 2004) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. Neurexophilin and PC-esterase domain family member 4 (NXPE4) and prostate androgen-regulated mucin-like protein 1 (PARM1) as prognostic biomarkers for colorectal cancer. (PMID: 31297877) Liu YR … Wang G (Journal of cellular biochemistry 2019) 3

Products for NXPE4 Gene

Sources for NXPE4 Gene