Aliases for NXPE2 Gene
Aliases for NXPE2 Gene
External Ids for NXPE2 Gene
- HGNC: 26331
- Entrez Gene: 120406
- Ensembl: ENSG00000204361
- UniProtKB: Q96DL1
Previous HGNC Symbols for NXPE2 Gene
- FAM55B
Previous GeneCards Identifiers for NXPE2 Gene
- GC11P114550
Summaries for NXPE2 Gene
GeneCards Summary for NXPE2 Gene
NXPE2 (Neurexophilin And PC-Esterase Domain Family Member 2) is a Protein Coding gene. An important paralog of this gene is NXPE4.
Additional gene information for NXPE2 Gene
- Monarch Initiative
- Search for NXPE2 at DataMed
- Search for NXPE2 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPE2 Gene
Genomics for NXPE2 Gene
GeneHancer (GH) Regulatory Elements for NXPE2 Gene
Promoters and enhancers for NXPE2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J114651 | Promoter | 0.6 | EPDnew | 0.7 | +3.1 | 3074 | 0.1 | NFATC3 | LOC105369504 NXPE4 NXPE2 GC11P114707 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around NXPE2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for NXPE2 Gene
Genomic Locations for NXPE2 Gene
- chr11:114,648,490-114,707,117
- (GRCh38/hg38)
- Size:
- 58,628 bases
- Orientation:
- Plus strand
- chr11:114,549,108-114,579,362
- (GRCh37/hg19)
- Size:
- 30,255 bases
- Orientation:
- Plus strand
Genomic View for NXPE2 Gene
Genes around NXPE2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.2-q23.3 by Entrez Gene
- 11q23.2 by HGNC
- 11q23.3 by Ensembl
NXPE2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NXPE2 Gene
Proteins for NXPE2 Gene
-
Protein details for NXPE2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96DL1-NXPE2_HUMAN
- Recommended name:
- NXPE family member 2
- Protein Accession:
- Q96DL1
- Q2NKI8
Protein attributes for NXPE2 Gene
- Size:
- 559 amino acids
- Molecular mass:
- 64901 Da
- Quaternary structure:
- No Data Available
Protein Expression for NXPE2 Gene
Post-translational modifications for NXPE2 Gene
Other Protein References for NXPE2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for NXPE2
- Invitrogen Antibodies for NXPE2
- Search GeneTex for Antibodies for NXPE2
Protein Products
-
OriGene Purified Proteins for NXPE2
- Search Origene for MassSpec and Protein Over-expression Lysates for NXPE2
- Origene Custom Protein Services for NXPE2
- Novus Biologicals proteins for NXPE2
- Search GeneTex for Proteins for NXPE2
Assay Products
No data available for DME Specific Peptides for NXPE2 Gene
Domains & Families for NXPE2 Gene
Gene Families for NXPE2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for NXPE2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NXPE2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96DL1- Family:
-
- Belongs to the NXPE family.
Function for NXPE2 Gene
Phenotypes From GWAS Catalog for NXPE2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 24550280 |
Phenotypes for NXPE2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for NXPE2
- Cyagen custom Knockout/knockin (KOKI) mouse models for NXPE2
-
CRISPR Products
-
OriGene CRISPR knockouts for NXPE2
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- genomics-online: gRNA clones - Search results for 69 available NXPE2 gene related products
- Overview of 69 available NXPE2 gene related products
- Applied Biological Materials CRISPR for NXPE2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NXPE2
- GenScript: Design CRISPR guide RNA sequences for NXPE2
miRNA for NXPE2 Gene
- miRTarBase miRNAs that target NXPE2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NXPE2
- Browse OriGene Inhibitory RNA Products For NXPE2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NXPE2
- genomics-online: shRNA clones - Search results for 69 available NXPE2 gene related products
- Overview of 69 available NXPE2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for NXPE2
- VectorBuilder custom plasmid, inducible vectors for NXPE2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NXPE2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NXPE2
- Applied Biological Materials Clones for NXPE2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NXPE2
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NXPE2 Gene
Localization for NXPE2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NXPE2 Gene
- Membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NXPE2 Gene
Pathways & Interactions for NXPE2 Gene
No Data Available
Interacting Proteins for NXPE2 Gene
No data available for Pathways by source and SIGNOR curated interactions for NXPE2 Gene
Transcripts for NXPE2 Gene
mRNA/cDNA for NXPE2 Gene
- (8) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000389586 1873 bps (uc009yyy.3)
Unigene Clusters for NXPE2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NXPE2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NXPE2
- genomics-online: gRNA clones - Search results for 69 available NXPE2 gene related products
- Overview of 69 available NXPE2 gene related products
- Applied Biological Materials CRISPR for NXPE2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NXPE2
- GenScript: Design CRISPR guide RNA sequences for NXPE2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NXPE2
- Browse OriGene Inhibitory RNA Products For NXPE2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NXPE2
- genomics-online: shRNA clones - Search results for 69 available NXPE2 gene related products
- Overview of 69 available NXPE2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for NXPE2
- VectorBuilder custom plasmid, inducible vectors for NXPE2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NXPE2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NXPE2
- Applied Biological Materials Clones for NXPE2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NXPE2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
-
Lung (Respiratory System)
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for NXPE2 Gene
This gene is overexpressed in Colon - Transverse (x22.4) and Minor Salivary Gland (x9.5).
This gene is overexpressed in Blymphocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NXPE2 Gene
NURSA nuclear receptor signaling pathways regulating expression of NXPE2 Gene:
NXPE2SOURCE GeneReport for Unigene cluster for NXPE2 Gene:
Hs.446760Evidence on tissue expression from TISSUES for NXPE2 Gene
- Stomach(4)
Primer Products
-
OriGene qPCR primer pairs for NXPE2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NXPE2 Gene
Orthologs for NXPE2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NXPE2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NXPE2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Nxpe2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Nxpe2 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100495331 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-105h11.2 34 |
|
ManyToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany |
- Species where no ortholog for NXPE2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for NXPE2 Gene
- ENSEMBL:
- Gene Tree for NXPE2 (if available)
- TreeFam:
- Gene Tree for NXPE2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NXPE2: view image
Paralogs for NXPE2 Gene
Variants for NXPE2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000009320 | -- | 114,613,093(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000013203 | -- | 114,487,352(+) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000063196 | -- | 114,804,189(+) | A/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000070174 | -- | 114,515,176(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000070672 | -- | 114,488,506(+) | G/C | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3627797 | CNV | gain | 21293372 |
| nsv1053425 | CNV | loss | 25217958 |
| nsv832274 | CNV | gain | 17160897 |
| nsv832275 | CNV | gain | 17160897 |
| nsv975982 | CNV | duplication | 23825009 |
Gene Damage Index Score:
4.73;
66.33% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NXPE2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NXPE2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPE2 Gene
Disorders for NXPE2 Gene
Additional Disease Information for NXPE2
No disorders were found for NXPE2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPE2 Gene
Publications for NXPE2 Gene
- Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes. (PMID: 24550280) Ivarsson Y … Kim PM (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 58
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
Products for NXPE2 Gene
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- Taconic Biosciences Mouse Models for NXPE2
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- Humanized Mice
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- VectorBuilder custom plasmid, inducible vectors for NXPE2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available NXPE2 related products ranked by validation data
- antibodies-online: Search results for available NXPE2 related products ranked by validation data
- antibodies-online: Search results for available NXPE2 related products ranked by validation data
- Search GeneTex for Antibodies for NXPE2
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- Horizon Cell Lines for NXPE2
- genomics-online: cdna clones - Search results for 69 available NXPE2 gene related products
- Overview of 69 available NXPE2 gene related products
- orf clones - Search results for 69 available NXPE2 gene related products
- Overview of 69 available NXPE2 gene related products
- genomics-online: gRNA clones - Search results for 69 available NXPE2 gene related products
- Overview of 69 available NXPE2 gene related products
- genomics-online: primer clones - Search results for 69 available NXPE2 gene related products
- Overview of 69 available NXPE2 gene related products
- genomics-online: shRNA clones - Search results for 69 available NXPE2 gene related products
- Overview of 69 available NXPE2 gene related products
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Sources for NXPE2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
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- (125) NCBI Bookshelf
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- (128) ViGene Biosciences
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt