Free for academic non-profit institutions. Other users need a Commercial license
NXPE1 (Neurexophilin And PC-Esterase Domain Family Member 1) is a Protein Coding gene. An important paralog of this gene is NXPE2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J114559 | Promoter | 0.6 | EPDnew | 262.5 | +0.3 | 343 | 0.1 | FEZF1 ZNF843 PRDM6 ZSCAN5C | NXPE1 MN309174-090 HSALNG0087319 NXPE2 | |
GH11J114560 | Promoter | 0.4 | EPDnew | 250.7 | +0.0 | 31 | 0.1 | ZNF843 | NXPE1 MN309174-090 HSALNG0087319 NXPE2 | |
GH11J114561 | Enhancer | 0.3 | Ensembl | 262.3 | +0.8 | 843 | 0.4 | PRDM1 | NXPE1 MN309174-090 HSALNG0087319 NXPE2 | |
GH11J113872 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 10.8 | +685.5 | 685451 | 4.8 | TBP FEZF1 MNT SMAD5 IRF2 HES1 ZFP64 MBD2 POLR2A BHLHE40 | USP28 lnc-HTR3B-3 ENSG00000270179 RBM7 NXPE4 TTC12 ZW10 NXPE1 LRRC37A13P RF00066-041 | |
GH11J114214 | Enhancer | 1.8 | UCNEbase FANTOM5 Ensembl ENCODE dbSUPER | 10.9 | +342.3 | 342319 | 6.2 | TBP FEZF1 IKZF1 HES1 MBD2 ARNT ZNF395 NFATC3 VEZF1 NBN | RBM7 ZW10 NNMT NXPE4 NXPE1 TTC12 ENSG00000270179 ZBTB16 lnc-NNMT-3 piR-34504 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 32814053 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||
SP3: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NXPE1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | RGD1566243 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
Mouse (Mus musculus) |
Mammalia | Nxpe5 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-162k9.5 31 |
|
ManyToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs142774949 | Benign: not provided | 114,530,438(-) |
C/T NM_152315.5(NXPE1):c.144G>A (p.Ser48=) |
SYNONYMOUS | |
rs77697681 | Benign: not provided | 114,522,397(-) |
G/A NM_152315.5(NXPE1):c.789C>T (p.Phe263=) |
SYNONYMOUS | |
rs79538449 | Benign: not provided | 114,523,035(-) |
C/T NM_152315.5(NXPE1):c.526G>A (p.Gly176Ser) |
MISSENSE | |
rs10891692 | - |
p.Gly353Arg |
|||
rs34993124 | - |
p.Ile423Thr |
No disorders were found for NXPE1 Gene.