External Ids for NXN Gene
Previous GeneCards Identifiers for NXN Gene
This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]
GeneCards Summary for NXN Gene
NXN (Nucleoredoxin) is a Protein Coding gene. Diseases associated with NXN include Robinow Syndrome, Autosomal Recessive 2 and Robinow Syndrome, Autosomal Recessive 1. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and thioredoxin-disulfide reductase activity. An important paralog of this gene is NXNL2.
UniProtKB/Swiss-Prot Summary for NXN Gene
Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).