This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Jun 2015] See more...

Aliases for NXF2B Gene

Aliases for NXF2B Gene

  • Nuclear RNA Export Factor 2B 2 3 5
  • Nuclear RNA Export Factor 2 3 4
  • Cancer/Testis Antigen 39 3 4
  • TAP-Like Protein 2 3 4
  • BA353J17.1 2 3
  • T-Complex Protein 11 X-Linked Protein 2 3
  • TCP11X2 3
  • TAPL-2 4
  • NXF2B 5
  • TAPL2 4
  • CT39 4

External Ids for NXF2B Gene

Previous GeneCards Identifiers for NXF2B Gene

  • GC0XM101503
  • GC0XM101615

Summaries for NXF2B Gene

Entrez Gene Summary for NXF2B Gene

  • This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Jun 2015]

GeneCards Summary for NXF2B Gene

NXF2B (Nuclear RNA Export Factor 2B) is a Protein Coding gene. Diseases associated with NXF2B include Progesterone-Receptor Negative Breast Cancer. Among its related pathways are Transport of Mature Transcript to Cytoplasm and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is NXF2.

UniProtKB/Swiss-Prot Summary for NXF2B Gene

  • Involved in the export of mRNA from the nucleus to the cytoplasm.

Additional gene information for NXF2B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NXF2B Gene

Genomics for NXF2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NXF2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ102439 Promoter 0.3 EPDnew 600.7 +0.0 47 0.1 NXF2B ENSG00000231590 ENSG00000284800 NXF2
GH0XJ102426 Promoter 0.3 EPDnew 600.4 +13.5 13477 0.1 ENSG00000231590 lnc-TCP11X2-2 NXF2B MF281437-053 ENSG00000284800 NXF2
GH0XJ102154 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 12.6 +284.5 284508 2.2 CREB1 CTCF YY1 SP2 POLR2A CREM ATF1 MTA1 RAD21 HDGF BEX5 lnc-TCEAL6-1 NXF2 NXF2B HSALNG0139246 TCEAL6
GH0XJ102260 Promoter 0.3 EPDnew 0.1 +179.4 179418 0.1 LOC100499471 lnc-TCP11X1-4 NXF2 MF281437-053 NXF2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NXF2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NXF2B

Top Transcription factor binding sites by QIAGEN in the NXF2B gene promoter:
  • AML1a
  • CP2
  • GATA-1
  • GCNF
  • GCNF-1
  • GCNF-2
  • HSF2
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for NXF2B Gene

Genomic Locations for NXF2B Gene
chrX:102,360,395-102,440,008
(GRCh38/hg38)
Size:
79,614 bases
Orientation:
Minus strand
chrX:101,615,316-101,726,732
(GRCh37/hg19)
Size:
111,417 bases
Orientation:
Minus strand

Genomic View for NXF2B Gene

Genes around NXF2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXF2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXF2B Gene

Proteins for NXF2B Gene

  • Protein details for NXF2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZY0-NXF2_HUMAN
    Recommended name:
    Nuclear RNA export factor 2
    Protein Accession:
    Q9GZY0
    Secondary Accessions:
    • Q9BXU4
    • Q9NSS1
    • Q9NX66

    Protein attributes for NXF2B Gene

    Size:
    626 amino acids
    Molecular mass:
    71627 Da
    Quaternary structure:
    • Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214. Interacts with LUZP4.
    SequenceCaution:
    • Sequence=AAK31975.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91154.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB75659.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due to either intron retention or a splicing event.; Evidence={ECO:0000305};

neXtProt entry for NXF2B Gene

Post-translational modifications for NXF2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NXF2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXF2B Gene

Domains & Families for NXF2B Gene

Gene Families for NXF2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NXF2B Gene

Suggested Antigen Peptide Sequences for NXF2B Gene

GenScript: Design optimal peptide antigens:
  • TAP-like protein 2 (NXF2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZY0

UniProtKB/Swiss-Prot:

NXF2_HUMAN :
  • The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required for NXF2-mediated nuclear mRNA export.
  • Belongs to the NXF family.
Domain:
  • The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required for NXF2-mediated nuclear mRNA export.
  • The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus.
  • The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF2 to the nuclear rim.
  • The RNA-binding domain is a non-canonical RNP-type domain.
Family:
  • Belongs to the NXF family.
genes like me logo Genes that share domains with NXF2B: view

Function for NXF2B Gene

Molecular function for NXF2B Gene

UniProtKB/Swiss-Prot Function:
Involved in the export of mRNA from the nucleus to the cytoplasm.

Phenotypes From GWAS Catalog for NXF2B Gene

Gene Ontology (GO) - Molecular Function for NXF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA,NAS 11073998
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with NXF2B: view
genes like me logo Genes that share phenotypes with NXF2B: view

Animal Models for NXF2B Gene

MGI Knock Outs for NXF2B:
  • Nxf2 Nxf2<tm1.2Jw>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NXF2B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NXF2B Gene

Localization for NXF2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXF2B Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Localized in the nucleoplasm and at the nuclear envelope. Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NXF2B gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NXF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0042025 host cell nucleus IEA --
genes like me logo Genes that share ontologies with NXF2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NXF2B Gene

Pathways & Interactions for NXF2B Gene

genes like me logo Genes that share pathways with NXF2B: view

Interacting Proteins for NXF2B Gene

Gene Ontology (GO) - Biological Process for NXF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus TAS --
GO:0007275 multicellular organism development ISS --
GO:0016973 poly(A)+ mRNA export from nucleus IBA 21873635
GO:0050658 RNA transport ISS --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with NXF2B: view

No data available for SIGNOR curated interactions for NXF2B Gene

Drugs & Compounds for NXF2B Gene

No Compound Related Data Available

Transcripts for NXF2B Gene

mRNA/cDNA for NXF2B Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NXF2B

Alternative Splicing Database (ASD) splice patterns (SP) for NXF2B Gene

No ASD Table

Relevant External Links for NXF2B Gene

GeneLoc Exon Structure for
NXF2B

Expression for NXF2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NXF2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for NXF2B Gene

This gene is overexpressed in Testis (x27.3) and Pituitary (x11.6).

Protein differential expression in normal tissues from HIPED for NXF2B Gene

This gene is overexpressed in Testis (29.6), Urinary Bladder (27.1), and Ovary (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NXF2B Gene



Protein tissue co-expression partners for NXF2B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NXF2B

SOURCE GeneReport for Unigene cluster for NXF2B Gene:

Hs.648337

mRNA Expression by UniProt/SwissProt for NXF2B Gene:

Q9GZY0-NXF2_HUMAN
Tissue specificity: Expressed almost exclusively in testis. Also expressed in several cancers.

Evidence on tissue expression from TISSUES for NXF2B Gene

  • Nervous system(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with NXF2B: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NXF2B Gene

Orthologs for NXF2B Gene

This gene was present in the common ancestor of mammals.

Orthologs for NXF2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NXF2B 30
  • 98.87 (n)
Dog
(Canis familiaris)
Mammalia NXF2 30
  • 82.37 (n)
Rat
(Rattus norvegicus)
Mammalia Nxf2 30
  • 71.49 (n)
Mouse
(Mus musculus)
Mammalia Nxf2 30 17
  • 70.93 (n)
Species where no ortholog for NXF2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NXF2B Gene

ENSEMBL:
Gene Tree for NXF2B (if available)
TreeFam:
Gene Tree for NXF2B (if available)

Paralogs for NXF2B Gene

Paralogs for NXF2B Gene

(5) SIMAP similar genes for NXF2B Gene using alignment to 3 proteins:

  • NXF2_HUMAN
  • L8E7H1_HUMAN
  • Q5JRM6_HUMAN

Pseudogenes.org Pseudogenes for NXF2B Gene

genes like me logo Genes that share paralogs with NXF2B: view

Variants for NXF2B Gene

Additional dbSNP identifiers (rs#s) for NXF2B Gene

Structural Variations from Database of Genomic Variants (DGV) for NXF2B Gene

Variant ID Type Subtype PubMed ID
dgv2351e212 CNV loss 25503493
dgv2352e212 CNV loss 25503493
dgv2353e212 CNV loss 25503493
esv3574272 CNV loss 25503493
nsv1115881 CNV duplication 24896259
nsv1115882 CNV duplication 24896259
nsv1115883 CNV duplication 24896259
nsv1145979 CNV duplication 26484159
nsv473823 CNV novel sequence insertion 20440878

Additional Variant Information for NXF2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NXF2B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for NXF2B Gene

Disorders for NXF2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for NXF2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
progesterone-receptor negative breast cancer
- elite association - COSMIC cancer census association via MalaCards
Search NXF2B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NXF2B

genes like me logo Genes that share disorders with NXF2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NXF2B Gene

Publications for NXF2B Gene

  1. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N … Wilson SA (Nucleic acids research 2015) 3 4
  2. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PMID: 16382448) Chen YT … Jongeneel CV (Genes, chromosomes & cancer 2006) 2 3
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for NXF2B Gene

Sources for NXF2B Gene