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This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
NXF1 (Nuclear RNA Export Factor 1) is a Protein Coding gene. Diseases associated with NXF1 include Influenza and Lethal Congenital Contracture Syndrome 1. Among its related pathways are mRNA Splicing - Major Pathway and mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include nucleotide binding. An important paralog of this gene is NXF2B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IEA,IBA | 21873635 |
GO:0003729 | mRNA binding | IEA | -- |
GO:0005515 | protein binding | IEA,IPI | 9175835 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000346 | colocalizes_with transcription export complex | IDA | 23299939 |
GO:0005634 | nucleus | IEA,IDA | 19864460 |
GO:0005635 | nuclear envelope | IEA | -- |
GO:0005643 | nuclear pore | IEA | -- |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport of the SLBP independent Mature mRNA | ||
2 | mRNA Splicing - Major Pathway |
.41
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3 | Transport of Mature Transcript to Cytoplasm | ||
4 | Translational Control | ||
5 | Pathways of neurodegeneration - multiple diseases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006405 | RNA export from nucleus | IEA,TAS | -- |
GO:0006406 | mRNA export from nucleus | IEA,TAS | -- |
GO:0015031 | protein transport | IEA | -- |
GO:0016032 | viral process | IEA | -- |
GO:0016973 | poly(A)+ mRNA export from nucleus | IEA,IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP12: |
ExUns: | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||
SP2: | - | ||||||||||||||||||||
SP3: | - | ||||||||||||||||||||
SP4: | |||||||||||||||||||||
SP5: | |||||||||||||||||||||
SP6: | |||||||||||||||||||||
SP7: | |||||||||||||||||||||
SP8: | |||||||||||||||||||||
SP9: | |||||||||||||||||||||
SP10: | |||||||||||||||||||||
SP11: | |||||||||||||||||||||
SP12: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NXF1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NXF1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NXF1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nxf1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nxf1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | NXF1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NXF1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nxf1 30 |
|
||
Str.6094 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | nxf1 30 31 |
|
OneToMany | |
NXF1 (4 of 4) 31 |
|
OneToMany | |||
NXF1 (2 of 4) 31 |
|
OneToMany | |||
NXF1 (3 of 4) 31 |
|
OneToMany | |||
mgab03e05 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2787 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002193 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | sbr 30 31 32 |
|
ManyToMany | |
Nxf3 31 |
|
ManyToMany | |||
nxf2 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | nxf-2 30 31 |
|
ManyToMany | |
nxf-1 31 32 |
|
ManyToMany | |||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AAL104C 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C09801g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MEX67 30 33 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mex67 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs191516295 | Likely Benign: not provided | 62,801,631(-) |
G/C NM_006362.5(NXF1):c.640C>G (p.Leu214Val) |
MISSENSE | |
rs369105346 | Likely Benign: not provided | 62,792,705(-) |
G/T NM_006362.5(NXF1):c.1761-4C>A |
NON_CODING_TRANSCRIPT_VARIANT,INTRON |
Disorder | Aliases | PubMed IDs |
---|---|---|
influenza |
|
|
lethal congenital contracture syndrome 1 |
|
|
genital herpes |
|
|
lethal congenital contracture syndrome |
|
|