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Aliases for NWD1 Gene

Aliases for NWD1 Gene

  • NACHT And WD Repeat Domain Containing 1 2 3 5
  • NACHT Domain- And WD Repeat-Containing Protein 1 3
  • NACHT And WD Repeat Domain-Containing Protein 1 3

External Ids for NWD1 Gene

Previous GeneCards Identifiers for NWD1 Gene

  • GC19P016692
  • GC19P016830
  • GC19P016399

Summaries for NWD1 Gene

Entrez Gene Summary for NWD1 Gene

  • The protein encoded by this gene is thought to be a cytosolic protein and predicted to contain a NACHT domain and multiple WD40 repeats. Increased expression of this gene was observed in some prostate cancer cell lines. Knocking down expression of this gene results in decreased androgen receptor protein levels, indicating that this gene may be important in modulating androgen receptor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

GeneCards Summary for NWD1 Gene

NWD1 (NACHT And WD Repeat Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is NWD2.

UniProtKB/Swiss-Prot for NWD1 Gene

  • May play a role in the control of androgen receptor (AR) protein steady-state levels.

Gene Wiki entry for NWD1 Gene

Additional gene information for NWD1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NWD1 Gene

Genomics for NWD1 Gene

GeneHancer (GH) Regulatory Elements for NWD1 Gene

Promoters and enhancers for NWD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J016717 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 666 -0.7 -694 3 HDGF PKNOX1 RFX5 RCOR1 ATF7 IKZF2 CREM SMARCA5 CEBPB ELF1 NWD1 GC19M016713
GH19J016733 Enhancer 0.9 Ensembl ENCODE 10.3 +14.4 14387 1.7 ZBTB6 SAP130 ARID4B FEZF1 YY1 ZNF335 POLR2A PATZ1 SCRT2 PRDM10 SIN3B CPAMD8 NWD1 GC19M016767
GH19J016341 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -377.3 -377338 2.6 HDGF PKNOX1 EBF1 BATF KLF5 IRF4 E4F1 ZNF664 ZNF157 EED KLF2 C19orf44 MED26 NWD1 ENSG00000277825 GC19M016221
GH19J016253 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.7 -466.1 -466060 0.9 HDAC1 HDGF CLOCK ARNT YBX1 SMARCA5 ZNF148 SP1 ARHGAP35 ZNF184 CHERP ENSG00000269578 AKAP8 C19orf44 SIN3B AP1M1 ENSG00000268743 BRD4 ENSG00000268189 AKAP8L
GH19J016282 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -435.0 -435049 5.4 BCOR TAF1 MAX ZMYM3 CEBPG NFXL1 ZNF2 ZNF366 POLR2A EGR1 AKAP8 KLF2 TPM4 HAUS8 BRD4 LINC01835 CHERP ENSG00000269578 NWD1 PIR54763
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NWD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NWD1 gene promoter:
  • NRSF form 1
  • NRSF form 2
  • LCR-F1
  • RORalpha1
  • MRF-2
  • C/EBPalpha

Genomic Locations for NWD1 Gene

Genomic Locations for NWD1 Gene
98,111 bases
Plus strand
97,988 bases
Plus strand

Genomic View for NWD1 Gene

Genes around NWD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NWD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NWD1 Gene

Proteins for NWD1 Gene

  • Protein details for NWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NACHT domain- and WD repeat-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • C9J021
    • Q68CT3

    Protein attributes for NWD1 Gene

    1564 amino acids
    Molecular mass:
    174552 Da
    Quaternary structure:
    • May interact with HSP90AA1, HSP90AB1 and BAG2.
    • Sequence=AAI17699.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for NWD1 Gene


neXtProt entry for NWD1 Gene

Post-translational modifications for NWD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NWD1 Gene

Domains & Families for NWD1 Gene

Gene Families for NWD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NWD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NWD1: view

No data available for UniProtKB/Swiss-Prot for NWD1 Gene

Function for NWD1 Gene

Molecular function for NWD1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the control of androgen receptor (AR) protein steady-state levels.
UniProtKB/Swiss-Prot Induction:
May be up-regulated by SOX9 and SRY.

Phenotypes From GWAS Catalog for NWD1 Gene

Gene Ontology (GO) - Molecular Function for NWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0005515 protein binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NWD1: view
genes like me logo Genes that share phenotypes with NWD1: view

Animal Model Products

CRISPR Products

miRNA for NWD1 Gene

miRTarBase miRNAs that target NWD1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NWD1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NWD1 Gene

Localization for NWD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NWD1 Gene

Cytoplasm, cytosol.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NWD1 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005682 U5 snRNP IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0071011 precatalytic spliceosome IBA --
GO:0071013 catalytic step 2 spliceosome IBA --
genes like me logo Genes that share ontologies with NWD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NWD1 Gene

Pathways & Interactions for NWD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008380 RNA splicing IBA --
genes like me logo Genes that share ontologies with NWD1: view

No data available for Pathways by source and SIGNOR curated interactions for NWD1 Gene

Drugs & Compounds for NWD1 Gene

No Compound Related Data Available

Transcripts for NWD1 Gene

Unigene Clusters for NWD1 Gene

NACHT and WD repeat domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NWD1

Alternative Splicing Database (ASD) splice patterns (SP) for NWD1 Gene

No ASD Table

Relevant External Links for NWD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NWD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NWD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NWD1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.0), Brain - Caudate (basal ganglia) (x5.7), Brain - Amygdala (x4.9), and Brain - Hippocampus (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of NWD1 Gene:


SOURCE GeneReport for Unigene cluster for NWD1 Gene:


mRNA Expression by UniProt/SwissProt for NWD1 Gene:

Tissue specificity: Expressed at highest levels in prostate, followed by testis, retina, trachea and optic nerve. Also detected in brain, epididymis, lung, vagina and pituitary. In the prostate, tends to be up-regulated during malignant progression compared to normal epithelium (at protein level).

Evidence on tissue expression from TISSUES for NWD1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with NWD1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NWD1 Gene

Orthologs for NWD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NWD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NWD1 34 33
  • 97.53 (n)
(Canis familiaris)
Mammalia NWD1 34 33
  • 84.84 (n)
(Bos Taurus)
Mammalia NWD1 34 33
  • 84.14 (n)
(Mus musculus)
Mammalia Nwd1 16 34 33
  • 78.61 (n)
(Rattus norvegicus)
Mammalia LOC100364350 33
  • 75.65 (n)
(Monodelphis domestica)
Mammalia NWD1 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia NWD1 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nwd1 33
  • 53.53 (n)
(Danio rerio)
Actinopterygii LOC100330908 33
  • 49.35 (n)
nwd1 34 34
  • 32 (a)
CR352328.3 34
  • 16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10185 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea T05C3.2 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
Species where no ortholog for NWD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NWD1 Gene

Gene Tree for NWD1 (if available)
Gene Tree for NWD1 (if available)
Evolutionary constrained regions (ECRs) for NWD1: view image

Paralogs for NWD1 Gene

Paralogs for NWD1 Gene

genes like me logo Genes that share paralogs with NWD1: view

Variants for NWD1 Gene

Sequence variations from dbSNP and Humsavar for NWD1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs193920843 uncertain-significance, Malignant tumor of prostate 16,800,094(+) A/G coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant
rs1000070671 -- 16,760,695(+) A/G intron_variant
rs1000100392 -- 16,780,219(+) A/C intron_variant
rs1000156594 -- 16,738,210(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000174586 -- 16,809,736(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NWD1 Gene

Variant ID Type Subtype PubMed ID
esv2660627 CNV deletion 23128226
esv3556107 CNV deletion 23714750
esv3643804 CNV loss 21293372
nsv1071512 CNV deletion 25765185
nsv1072335 CNV deletion 25765185
nsv1134761 CNV deletion 24896259
nsv1144868 CNV deletion 24896259
nsv475160 CNV novel sequence insertion 20440878

Variation tolerance for NWD1 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.67; 97.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NWD1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NWD1 Gene

Disorders for NWD1 Gene

Additional Disease Information for NWD1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NWD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NWD1 Gene

Publications for NWD1 Gene

  1. The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling. (PMID: 24681825) Correa RG … Reed JC (Oncotarget 2014) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Rare truncating variations and risk of schizophrenia: Whole-exome sequencing in three families with affected siblings and a three-stage follow-up study in a Japanese population. (PMID: 26706132) Watanabe Y … Someya T (Psychiatry research 2016) 3 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for NWD1 Gene

Sources for NWD1 Gene

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