Aliases for NUTM2E Gene

Aliases for NUTM2E Gene

  • NUT Family Member 2E 2 3 3 4 5
  • Family With Sequence Similarity 22, Member E 2 3
  • FAM22E 3 4
  • NUTM2E 5

External Ids for NUTM2E Gene

Previous HGNC Symbols for NUTM2E Gene

  • FAM22E

Previous GeneCards Identifiers for NUTM2E Gene

  • GC10P081602
  • GC10P081711
  • GC10P080040
  • GC10P080067
  • GC10P081988
  • GC10P082150
  • GC10P082432
  • GC10P083271
  • GC10P080091
  • GC10P080114
  • GC10P080138
  • GC10P080160
  • GC10P080361
  • GC10P080382
  • GC10P081540
  • GC10P081880

Summaries for NUTM2E Gene

GeneCards Summary for NUTM2E Gene

NUTM2E (NUT Family Member 2E) is a Protein Coding gene. Diseases associated with NUTM2E include Kidney Clear Cell Sarcoma and Kidney Sarcoma. An important paralog of this gene is NUTM2B.

Additional gene information for NUTM2E Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUTM2E Gene

Genomics for NUTM2E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NUTM2E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J079825 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 613.8 -0.5 -472 5.2 PRDM10 ZNF512 RFX1 SIX5 IKZF1 LARP7 PRDM1 ZNF143 PKNOX1 PATZ1 NUTM2E NUTM2B-AS1 piR-34693-001 MBL1P ZMIZ1-AS1 ENSG00000272489 NUTM2B LOC642361
GH10J079684 Promoter 0.7 Ensembl 8.8 -142.4 -142372 1 RFX1 CTCF ZNF444 SIN3A KLF9 RFX5 RAD21 MNT CREB1 ENSG00000224886 BEND3P3 ENSG00000280355 lnc-NUTM2B-2 piR-31914 piR-38261-002 piR-40044-002 piR-48881-002 piR-56386-002 piR-47094
GH10J079669 Enhancer 0.3 Ensembl 16.7 -158.2 -158172 1.4 PKNOX1 NUTM2E MBL1P LOC101929506 ENSG00000244733 BEND3P3 lnc-NUTM2B-2 NUTM2B SFTPA1 NUTM2B-AS1
GH10J079744 Enhancer 0.7 Ensembl 7 -82.1 -82078 0.8 IKZF1 ZNF24 DPF2 HDAC1 SOX6 TCF12 TRIM24 NCOR1 NFIC FOXM1 piR-39868 NUTM2E piR-54002-001 NUTM2B NUTM2B-AS1
GH10J079726 Enhancer 0.7 Ensembl 6.8 -100.3 -100326 0.9 CREB1 PRDM10 ATF7 CTBP1 CEBPB FOXA2 ZNF217 GATAD2B CUX1 DPF2 NUTM2E MN296989 piR-37785-001 NUTM2B NUTM2B-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUTM2E on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUTM2E

Genomic Locations for NUTM2E Gene

Genomic Locations for NUTM2E Gene
chr10:79,827,273-79,851,338
(GRCh38/hg38)
Size:
24,066 bases
Orientation:
Plus strand
chr10:81,601,114-81,610,632
(GRCh37/hg19)
Size:
9,519 bases
Orientation:
Plus strand

Genomic View for NUTM2E Gene

Genes around NUTM2E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUTM2E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUTM2E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTM2E Gene

Proteins for NUTM2E Gene

  • Protein details for NUTM2E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B1AL46-NTM2E_HUMAN
    Recommended name:
    NUT family member 2E
    Protein Accession:
    B1AL46
    Secondary Accessions:
    • A6NHL0

    Protein attributes for NUTM2E Gene

    Size:
    878 amino acids
    Molecular mass:
    93979 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NUTM2E Gene

Post-translational modifications for NUTM2E Gene

No Post-translational modifications

Other Protein References for NUTM2E Gene

No data available for DME Specific Peptides for NUTM2E Gene

Domains & Families for NUTM2E Gene

Gene Families for NUTM2E Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUTM2E Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUTM2E Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM22E (FA22E_HUMAN)

Graphical View of Domain Structure for InterPro Entry

B1AL46

UniProtKB/Swiss-Prot:

NTM2E_HUMAN :
  • Belongs to the NUT family.
Family:
  • Belongs to the NUT family.
genes like me logo Genes that share domains with NUTM2E: view

Function for NUTM2E Gene

miRNA for NUTM2E Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUTM2E Gene

Localization for NUTM2E Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUTM2E gene
Compartment Confidence
plasma membrane 1
mitochondrion 1
nucleus 1
cytosol 1
extracellular 0
cytoskeleton 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NUTM2E Gene

Pathways & Interactions for NUTM2E Gene

PathCards logo

SuperPathways for NUTM2E Gene

No Data Available

Interacting Proteins for NUTM2E Gene

Gene Ontology (GO) - Biological Process for NUTM2E Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUTM2E Gene

Drugs & Compounds for NUTM2E Gene

No Compound Related Data Available

Transcripts for NUTM2E Gene

mRNA/cDNA for NUTM2E Gene

1 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NUTM2E Gene

No ASD Table

Relevant External Links for NUTM2E Gene

GeneLoc Exon Structure for
NUTM2E

Expression for NUTM2E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUTM2E Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUTM2E

genes like me logo Genes that share expression patterns with NUTM2E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUTM2E Gene

Orthologs for NUTM2E Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUTM2E Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 97 (a)
ManyToMany
-- 31
  • 97 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 50 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 45 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 39 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Gm806 31
  • 38 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 36 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 48 (a)
OneToMany
Species where no ortholog for NUTM2E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NUTM2E Gene

ENSEMBL:
Gene Tree for NUTM2E (if available)
TreeFam:
Gene Tree for NUTM2E (if available)

Paralogs for NUTM2E Gene

Paralogs for NUTM2E Gene

(9) SIMAP similar genes for NUTM2E Gene using alignment to 2 proteins:

  • NTM2E_HUMAN
  • R4GNA6_HUMAN
genes like me logo Genes that share paralogs with NUTM2E: view

Variants for NUTM2E Gene

Additional dbSNP identifiers (rs#s) for NUTM2E Gene

Variation tolerance for NUTM2E Gene

Gene Damage Index Score: 2.55; 44.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUTM2E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUTM2E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for NUTM2E Gene

Disorders for NUTM2E Gene

MalaCards: The human disease database

(4) MalaCards diseases for NUTM2E Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
kidney clear cell sarcoma
  • childhood kidney clear cell sarcoma
kidney sarcoma
  • renal sarcoma
central nervous system mesenchymal non-meningothelial tumor
  • central nervous system mesenchymal non-meningothelial tumour
clear cell sarcoma
  • adult soft part clear cell sarcoma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with NUTM2E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUTM2E Gene

Publications for NUTM2E Gene

  1. The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney. (PMID: 26542179) Gooskens SL … O'Sullivan MJ (Genes, chromosomes & cancer 2016) 3
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for NUTM2E Gene

Sources for NUTM2E Gene