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Aliases for NUTM2B Gene

Aliases for NUTM2B Gene

  • NUT Family Member 2B 2 3 4 5
  • Family With Sequence Similarity 22, Member B 2 3
  • FAM22B 3 4
  • Protein FAM22B 3
  • BA119F19.1 3

External Ids for NUTM2B Gene

Previous HGNC Symbols for NUTM2B Gene

  • FAM22B

Previous GeneCards Identifiers for NUTM2B Gene

  • GC10P081479
  • GC10P081573
  • GC10P080039
  • GC10P080065
  • GC10P081987
  • GC10P080089
  • GC10P080111
  • GC10P080136
  • GC10P080158
  • GC10P080359
  • GC10P080380
  • GC10P081539
  • GC10P081879

Summaries for NUTM2B Gene

GeneCards Summary for NUTM2B Gene

NUTM2B (NUT Family Member 2B) is a Protein Coding gene. Diseases associated with NUTM2B include Kidney Clear Cell Sarcoma and Endometrial Stromal Sarcoma. An important paralog of this gene is NUTM2E.

Additional gene information for NUTM2B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUTM2B Gene

Genomics for NUTM2B Gene

GeneHancer (GH) Regulatory Elements for NUTM2B Gene

Promoters and enhancers for NUTM2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J079700 Enhancer 0.2 Ensembl 610.8 +0.7 701 0.4 NUTM2B GC10M079856 GC10P082186 GC10P082221 GC10P082464 GC10P082486 PIR44259 PIR44753 PIR52725 PIR35971
GH10J079825 Promoter/Enhancer 1.4 Ensembl ENCODE 9 +127.3 127301 5.2 SIX5 CBFA2T2 MLLT1 SP7 POLR2A PRDM1 EGR1 IKZF1 ZBTB8A RFX1 GC10P082156 LOC642361 NUTM2B-AS1 MBL1P NUTM2E ZMIZ1-AS1 ENSG00000272489 NUTM2B PIR60133
GH10J079110 Enhancer 1.2 ENCODE dbSUPER 9.7 -585.4 -585396 6.6 ZNF473 CC2D1A CBFA2T2 MLLT1 GTF2F1 ZSCAN21 CDC5L TRIM24 SP7 SP1 ENSG00000272489 NUTM2B ZMIZ1 GC10M079169
GH10J079936 Enhancer 1.2 FANTOM5 Ensembl ENCODE 6 +239.4 239401 8.2 PRDM1 EGR1 IKZF1 IKZF2 ZNF341 ETV6 DPF2 EED CTBP1 RUNX3 SFTPD MBL1P ANXA11 SFTPA2 CTSLP6 LINC00857 SFTPD-AS1 NUTM2B ENSG00000283913
GH10J079684 Promoter 0.8 Ensembl 9.1 -14.8 -14799 0.6 CREB1 CTCF RFX5 MNT ENSG00000224886 GC10M079853 PIR33043 PIR44537 PIR44580 PIR50385 PIR40093 PIR40335 PIR40158 PIR32913
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUTM2B on UCSC Golden Path with GeneCards custom track

Genomic Locations for NUTM2B Gene

Genomic Locations for NUTM2B Gene
chr10:79,699,700-79,715,486
(GRCh38/hg38)
Size:
15,787 bases
Orientation:
Plus strand
chr10:81,462,983-81,474,437
(GRCh37/hg19)
Size:
11,455 bases
Orientation:
Plus strand

Genomic View for NUTM2B Gene

Genes around NUTM2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUTM2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUTM2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTM2B Gene

Proteins for NUTM2B Gene

  • Protein details for NUTM2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNL0-NTM2B_HUMAN
    Recommended name:
    NUT family member 2B
    Protein Accession:
    A6NNL0
    Secondary Accessions:
    • A6NM73

    Protein attributes for NUTM2B Gene

    Size:
    878 amino acids
    Molecular mass:
    93984 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NUTM2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUTM2B Gene

Post-translational modifications for NUTM2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUTM2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUTM2B Gene

Domains & Families for NUTM2B Gene

Gene Families for NUTM2B Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for NUTM2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUTM2B Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM22B (FA22B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NNL0

UniProtKB/Swiss-Prot:

NTM2B_HUMAN :
  • Belongs to the NUT family.
Family:
  • Belongs to the NUT family.
genes like me logo Genes that share domains with NUTM2B: view

Function for NUTM2B Gene

Phenotypes From GWAS Catalog for NUTM2B Gene

Phenotypes for NUTM2B Gene

MGI mutant phenotypes for NUTM2B:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NUTM2B: view

Animal Models for NUTM2B Gene

MGI Knock Outs for NUTM2B:
  • Nutm2 Nutm2<tm2b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for NUTM2B Gene

miRTarBase miRNAs that target NUTM2B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUTM2B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUTM2B Gene

Localization for NUTM2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUTM2B gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NUTM2B Gene

Pathways & Interactions for NUTM2B Gene

PathCards logo

SuperPathways for NUTM2B Gene

No Data Available

Interacting Proteins for NUTM2B Gene

Selected Interacting proteins: A6NNL0-NTM2B_HUMAN for NUTM2B Gene via IID

Symbol External ID(s) Details
ATXN1

Gene Ontology (GO) - Biological Process for NUTM2B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUTM2B Gene

Drugs & Compounds for NUTM2B Gene

No Compound Related Data Available

Transcripts for NUTM2B Gene

mRNA/cDNA for NUTM2B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUTM2B

Alternative Splicing Database (ASD) splice patterns (SP) for NUTM2B Gene

No ASD Table

Relevant External Links for NUTM2B Gene

GeneLoc Exon Structure for
NUTM2B
ECgene alternative splicing isoforms for
NUTM2B

Expression for NUTM2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUTM2B Gene

NURSA nuclear receptor signaling pathways regulating expression of NUTM2B Gene:

NUTM2B
genes like me logo Genes that share expression patterns with NUTM2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUTM2B Gene

Orthologs for NUTM2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUTM2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC738010 34
  • 98.79 (n)
-- 35
  • 98 (a)
ManyToMany
-- 35
  • 97 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia NUTM2D 34
  • 70.33 (n)
-- 35
  • 46 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NUTM2G 34
  • 67.74 (n)
-- 35
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm806 35 34
  • 58.5 (n)
OneToMany
Nutm2 17
rat
(Rattus norvegicus)
Mammalia Nutm2f 34
  • 58.45 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 39 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
OneToMany
Species where no ortholog for NUTM2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NUTM2B Gene

ENSEMBL:
Gene Tree for NUTM2B (if available)
TreeFam:
Gene Tree for NUTM2B (if available)

Paralogs for NUTM2B Gene

Paralogs for NUTM2B Gene

(7) SIMAP similar genes for NUTM2B Gene using alignment to 1 proteins:

  • NTM2B_HUMAN
genes like me logo Genes that share paralogs with NUTM2B: view

Variants for NUTM2B Gene

Sequence variations from dbSNP and Humsavar for NUTM2B Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000713405 -- 79,709,491(+) G/T intron_variant
rs1002415764 -- 79,704,928(+) T/C intron_variant
rs1006861341 -- 79,707,586(+) T/C intron_variant
rs1008513746 -- 79,701,433(+) A/C/T upstream_transcript_variant
rs1009235261 -- 79,703,720(+) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for NUTM2B Gene

Variant ID Type Subtype PubMed ID
esv1005705 CNV gain 20482838
esv24649 CNV gain+loss 19812545
esv3546549 CNV deletion 23714750
esv3623921 CNV loss 21293372
nsv1110179 CNV duplication 24896259
nsv1141879 OTHER inversion 24896259
nsv1147914 CNV duplication 26484159
nsv436110 CNV deletion 17901297
nsv8697 CNV loss 18304495
nsv948085 CNV duplication 23825009
nsv950982 CNV deletion 24416366

Variation tolerance for NUTM2B Gene

Gene Damage Index Score: 4.28; 62.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUTM2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUTM2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUTM2B Gene

Disorders for NUTM2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for NUTM2B Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
kidney clear cell sarcoma
  • childhood kidney clear cell sarcoma
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NUTM2B

genes like me logo Genes that share disorders with NUTM2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUTM2B Gene

Publications for NUTM2B Gene

  1. The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney. (PMID: 26542179) Gooskens SL … O'Sullivan MJ (Genes, chromosomes & cancer 2016) 3 58
  2. Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney. (PMID: 26945340) Kao YC … Antonescu CR (The American journal of surgical pathology 2016) 3 58
  3. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J … Zoghbi HY (Cell 2006) 3 58
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58

Products for NUTM2B Gene

Sources for NUTM2B Gene

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