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Aliases for NUTM2A Gene

Aliases for NUTM2A Gene

  • NUT Family Member 2A 2 3 5
  • Family With Sequence Similarity 22, Member A 2 3
  • FAM22A 3 4
  • Protein FAM22A 3
  • KIAA2020 4

External Ids for NUTM2A Gene

Previous HGNC Symbols for NUTM2A Gene

  • FAM22A

Previous GeneCards Identifiers for NUTM2A Gene

  • GC10P088985

Summaries for NUTM2A Gene

GeneCards Summary for NUTM2A Gene

NUTM2A (NUT Family Member 2A) is a Protein Coding gene. Diseases associated with NUTM2A include Endometrial Stromal Sarcoma and Endometrial Stromal Nodule. An important paralog of this gene is NUTM2B.

Additional gene information for NUTM2A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUTM2A Gene

Genomics for NUTM2A Gene

GeneHancer (GH) Regulatory Elements for NUTM2A Gene

Promoters and enhancers for NUTM2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I087585 Enhancer 1 ENCODE 22.9 +363.3 363339 2.6 PKNOX1 SMAD1 FEZF1 YY1 FOS ZNF214 KLF13 YY2 REST ZNF662 ENSG00000272631 CFL1P1 NUTM2A LINC00863 FAM35A ATAD1 BMPR1A BMS1P3 NUTM2A-AS1 GC10P087578
GH10I087090 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 7.5 -129.1 -129145 6.2 MLX ZFP64 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC SSRP1 ZNF610 FAM35A GLUD1 NUTM2A-AS1 ENSG00000272631 WAPL BMPR1A CFL1P1 RPL11P3 ENSG00000227896 BMS1P3
GH10I087840 Enhancer 1.5 FANTOM5 Ensembl ENCODE 10.5 +620.9 620861 6.8 FOXA2 ARNT SIN3A FEZF1 ZNF2 ZNF213 FOS KLF13 SP3 JUNB GC10P087843 FAM35A NUTM2A-AS1 RPL11P3 NUTM2A ENSG00000261011 ENSG00000224745 LIPJ ATAD1 GC10P087845
GH10I087341 Promoter/Enhancer 1.4 Ensembl ENCODE 8.7 +119.5 119460 3 ATF1 SIN3A ZNF2 ZNF121 POLR2B GLIS2 ZNF213 ZNF143 ATF7 SP3 NUTM2A-AS1 GC10P087344 GC10P087345 LINC00863 WAPL NUTM2D NUTM2A
GH10I087203 Enhancer 1.1 Ensembl ENCODE 10.5 -18.6 -18609 2.7 HDGF ARID4B SIN3A ZNF2 ZNF48 GLIS2 ZNF207 ZNF143 RUNX3 YY2 GC10M087204 NUTM2A FAM35A MINPP1 LOC105378410 NUTM2A-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUTM2A on UCSC Golden Path with GeneCards custom track

Genomic Locations for NUTM2A Gene

Genomic Locations for NUTM2A Gene
chr10:87,223,041-87,236,908
(GRCh38/hg38)
Size:
13,868 bases
Orientation:
Plus strand
chr10:88,985,205-88,996,665
(GRCh37/hg19)

Genomic View for NUTM2A Gene

Genes around NUTM2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUTM2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUTM2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTM2A Gene

Proteins for NUTM2A Gene

  • Protein details for NUTM2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVF1-NTM2A_HUMAN
    Recommended name:
    NUT family member 2A
    Protein Accession:
    Q8IVF1
    Secondary Accessions:
    • A6NMX5
    • C9JDI1
    • Q5VZW1

    Protein attributes for NUTM2A Gene

    Size:
    878 amino acids
    Molecular mass:
    93890 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC23116.1; Type=Frameshift; Positions=83; Evidence={ECO:0000305}; Sequence=CAH72466.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NUTM2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUTM2A Gene

Post-translational modifications for NUTM2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUTM2A Gene

No data available for DME Specific Peptides for NUTM2A Gene

Domains & Families for NUTM2A Gene

Gene Families for NUTM2A Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for NUTM2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUTM2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVF1

UniProtKB/Swiss-Prot:

NTM2A_HUMAN :
  • Belongs to the NUT family.
Family:
  • Belongs to the NUT family.
genes like me logo Genes that share domains with NUTM2A: view

Function for NUTM2A Gene

Phenotypes From GWAS Catalog for NUTM2A Gene

Animal Model Products

CRISPR Products

miRNA for NUTM2A Gene

miRTarBase miRNAs that target NUTM2A

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUTM2A Gene

Localization for NUTM2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUTM2A gene
Compartment Confidence
nucleus 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NUTM2A Gene

Pathways & Interactions for NUTM2A Gene

SuperPathways for NUTM2A Gene

No Data Available

Interacting Proteins for NUTM2A Gene

Gene Ontology (GO) - Biological Process for NUTM2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUTM2A Gene

Drugs & Compounds for NUTM2A Gene

No Compound Related Data Available

Transcripts for NUTM2A Gene

mRNA/cDNA for NUTM2A Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUTM2A Gene

NUT family member 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUTM2A Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for NUTM2A Gene

GeneLoc Exon Structure for
NUTM2A
ECgene alternative splicing isoforms for
NUTM2A

Expression for NUTM2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUTM2A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NUTM2A Gene



NURSA nuclear receptor signaling pathways regulating expression of NUTM2A Gene:

NUTM2A

SOURCE GeneReport for Unigene cluster for NUTM2A Gene:

Hs.710565
genes like me logo Genes that share expression patterns with NUTM2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUTM2A Gene

Orthologs for NUTM2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUTM2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC738010 33
  • 98.82 (n)
cow
(Bos Taurus)
Mammalia NUTM2D 33
  • 70.57 (n)
-- 34
  • 46 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NUTM2G 33
  • 67.85 (n)
-- 34
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nutm2f 33
  • 58.32 (n)
mouse
(Mus musculus)
Mammalia Gm806 33 34
  • 58.11 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 39 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
OneToMany
Species where no ortholog for NUTM2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NUTM2A Gene

ENSEMBL:
Gene Tree for NUTM2A (if available)
TreeFam:
Gene Tree for NUTM2A (if available)

Paralogs for NUTM2A Gene

Paralogs for NUTM2A Gene

(7) SIMAP similar genes for NUTM2A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NUTM2A Gene

genes like me logo Genes that share paralogs with NUTM2A: view

Variants for NUTM2A Gene

Sequence variations from dbSNP and Humsavar for NUTM2A Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000446009 -- 87,235,813(+) C/A downstream_transcript_variant
rs1000887614 -- 87,222,180(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1001021590 -- 87,222,470(+) A/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1001219485 -- 87,223,268(+) G/T genic_upstream_transcript_variant, intron_variant
rs1002902706 -- 87,229,340(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUTM2A Gene

Variant ID Type Subtype PubMed ID
dgv1281n54 CNV loss 21841781
dgv1282n54 CNV loss 21841781
dgv949n100 CNV gain 25217958
esv1011149 CNV gain 20482838
esv2759774 CNV gain+loss 17122850
esv2764246 CNV gain+loss 21179565
esv27973 CNV gain+loss 19812545
esv3577594 CNV gain 25503493
esv3624105 CNV loss 21293372
nsv1040871 CNV gain 25217958
nsv1128645 CNV duplication 24896259
nsv1139532 CNV duplication 24896259
nsv1141879 OTHER inversion 24896259
nsv1150601 CNV duplication 26484159
nsv428236 CNV loss 18775914
nsv482147 CNV gain 20164927
nsv498736 CNV loss 21111241
nsv551603 CNV loss 21841781
nsv551812 CNV gain 21841781
nsv7483 CNV deletion 18451855
nsv8703 CNV loss 18304495
nsv8715 CNV gain+loss 18304495
nsv948120 CNV duplication 23825009
nsv950986 CNV deletion 24416366

Variation tolerance for NUTM2A Gene

Gene Damage Index Score: 6.86; 79.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUTM2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUTM2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUTM2A Gene

Disorders for NUTM2A Gene

MalaCards: The human disease database

(2) MalaCards diseases for NUTM2A Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
endometrial stromal nodule
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NUTM2A

genes like me logo Genes that share disorders with NUTM2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUTM2A Gene

Publications for NUTM2A Gene

  1. NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct variant of CIC-rearranged sarcoma. (PMID: 28188754) Sugita S … Hasegawa T (Human pathology 2017) 3 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for NUTM2A Gene

Sources for NUTM2A Gene

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