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Aliases for NUTM2A Gene

Aliases for NUTM2A Gene

  • NUT Family Member 2A 2 3 4 5
  • Family With Sequence Similarity 22, Member A 2 3
  • FAM22A 3 4
  • Protein FAM22A 3
  • KIAA2020 4

External Ids for NUTM2A Gene

Previous HGNC Symbols for NUTM2A Gene

  • FAM22A

Previous GeneCards Identifiers for NUTM2A Gene

  • GC10P088985

Summaries for NUTM2A Gene

GeneCards Summary for NUTM2A Gene

NUTM2A (NUT Family Member 2A) is a Protein Coding gene. Diseases associated with NUTM2A include Endometrial Stromal Sarcoma and Endometrial Stromal Nodule. An important paralog of this gene is NUTM2B.

Additional gene information for NUTM2A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUTM2A Gene

Genomics for NUTM2A Gene

GeneHancer (GH) Regulatory Elements for NUTM2A Gene

Promoters and enhancers for NUTM2A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J087222 Enhancer 0.2 Ensembl 600.7 -0.6 -640 0.4 NUTM2A ENSG00000285257 NUTM2A-AS1
GH10J087585 Enhancer 1.2 Ensembl ENCODE 22.9 +363.3 363339 2.6 ZNF473 NFIB ZSCAN21 MAFK TFE3 SP7 ZNF174 SP1 KLF14 PRDM1 ENSG00000272631 NUTM2A LINC00863 SHLD2 CFL1P1 BMPR1A BMS1P3 NUTM2A-AS1 ATAD1 GC10P087578
GH10J087341 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.5 +119.5 119460 5 MLLT1 ZNF121 ZSCAN21 YY1 SP7 PRDM1 IKZF1 GLIS2 GMEB1 CREB1 NUTM2A-AS1 NUTM2D GC10P087344 GC10P087345 LINC00863 WAPL NUTM2A
GH10J087840 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 10.5 +621.5 621499 8.1 ZNF121 ZSCAN21 MAFK ZBTB7A SP7 KLF14 PRDM1 ZNF644 MZF1 IKZF1 ATAD1 GC10P087845 GC10P087843 SHLD2 NUTM2A-AS1 RPL11P3 NUTM2A ENSG00000261011 ENSG00000224745 LIPJ
GH10J087090 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 7.5 -129.2 -129240 6.4 CC2D1A ZFX SP1 ELF3 MNT ZNF148 NKRF POLR2A ZNF121 CEBPG SHLD2 GLUD1 NUTM2A-AS1 ENSG00000272631 WAPL CFL1P1 ENSG00000227896 BMPR1A RPL11P3 ADIRF-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUTM2A on UCSC Golden Path with GeneCards custom track

Genomic Locations for NUTM2A Gene

Genomic Locations for NUTM2A Gene
13,868 bases
Plus strand
11,461 bases
Plus strand

Genomic View for NUTM2A Gene

Genes around NUTM2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUTM2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUTM2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTM2A Gene

Proteins for NUTM2A Gene

  • Protein details for NUTM2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NUT family member 2A
    Protein Accession:
    Secondary Accessions:
    • A6NMX5
    • C9JDI1
    • Q5VZW1

    Protein attributes for NUTM2A Gene

    878 amino acids
    Molecular mass:
    93890 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC23116.1; Type=Frameshift; Positions=83; Evidence={ECO:0000305};

    Alternative splice isoforms for NUTM2A Gene


neXtProt entry for NUTM2A Gene

Post-translational modifications for NUTM2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUTM2A Gene

No data available for DME Specific Peptides for NUTM2A Gene

Domains & Families for NUTM2A Gene

Gene Families for NUTM2A Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for NUTM2A Gene


Suggested Antigen Peptide Sequences for NUTM2A Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM22A (FA22A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NUT family.
  • Belongs to the NUT family.
genes like me logo Genes that share domains with NUTM2A: view

Function for NUTM2A Gene

Phenotypes From GWAS Catalog for NUTM2A Gene

Animal Model Products

CRISPR Products

miRNA for NUTM2A Gene

miRTarBase miRNAs that target NUTM2A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUTM2A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUTM2A Gene

Localization for NUTM2A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUTM2A gene
Compartment Confidence
nucleus 2
plasma membrane 1
mitochondrion 1
cytosol 1
extracellular 0
peroxisome 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NUTM2A Gene

Pathways & Interactions for NUTM2A Gene

PathCards logo

SuperPathways for NUTM2A Gene

No Data Available

Interacting Proteins for NUTM2A Gene

Gene Ontology (GO) - Biological Process for NUTM2A Gene


No data available for Pathways by source and SIGNOR curated interactions for NUTM2A Gene

Drugs & Compounds for NUTM2A Gene

No Compound Related Data Available

Transcripts for NUTM2A Gene

mRNA/cDNA for NUTM2A Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for NUTM2A Gene

NUT family member 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUTM2A

Alternative Splicing Database (ASD) splice patterns (SP) for NUTM2A Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
SP1: - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for NUTM2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUTM2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUTM2A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NUTM2A Gene

NURSA nuclear receptor signaling pathways regulating expression of NUTM2A Gene:


SOURCE GeneReport for Unigene cluster for NUTM2A Gene:

genes like me logo Genes that share expression patterns with NUTM2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUTM2A Gene

Orthologs for NUTM2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUTM2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC738010 34
  • 98.82 (n)
(Bos Taurus)
Mammalia NUTM2D 34
  • 70.57 (n)
-- 35
  • 46 (a)
(Canis familiaris)
Mammalia NUTM2G 34
  • 67.85 (n)
-- 35
  • 50 (a)
(Rattus norvegicus)
Mammalia Nutm2f 34
  • 58.32 (n)
(Mus musculus)
Mammalia Gm806 35 34
  • 58.11 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
Species where no ortholog for NUTM2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NUTM2A Gene

Gene Tree for NUTM2A (if available)
Gene Tree for NUTM2A (if available)

Paralogs for NUTM2A Gene

Paralogs for NUTM2A Gene

(7) SIMAP similar genes for NUTM2A Gene using alignment to 1 proteins:

  • NTM2A_HUMAN Pseudogenes for NUTM2A Gene

genes like me logo Genes that share paralogs with NUTM2A: view

Variants for NUTM2A Gene

Sequence variations from dbSNP and Humsavar for NUTM2A Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000446009 -- 87,235,813(+) C/A downstream_transcript_variant
rs1000887614 -- 87,222,180(+) C/A/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1001021590 -- 87,222,470(+) A/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1001219485 -- 87,223,268(+) G/T genic_upstream_transcript_variant, intron_variant
rs1002902706 -- 87,229,340(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUTM2A Gene

Variant ID Type Subtype PubMed ID
dgv1281n54 CNV loss 21841781
dgv1282n54 CNV loss 21841781
dgv949n100 CNV gain 25217958
esv1011149 CNV gain 20482838
esv2759774 CNV gain+loss 17122850
esv2764246 CNV gain+loss 21179565
esv27973 CNV gain+loss 19812545
esv3577594 CNV gain 25503493
esv3624105 CNV loss 21293372
nsv1040871 CNV gain 25217958
nsv1128645 CNV duplication 24896259
nsv1139532 CNV duplication 24896259
nsv1141879 OTHER inversion 24896259
nsv1150601 CNV duplication 26484159
nsv428236 CNV loss 18775914
nsv482147 CNV gain 20164927
nsv498736 CNV loss 21111241
nsv551603 CNV loss 21841781
nsv551812 CNV gain 21841781
nsv7483 CNV deletion 18451855
nsv8703 CNV loss 18304495
nsv8715 CNV gain+loss 18304495
nsv948120 CNV duplication 23825009
nsv950986 CNV deletion 24416366

Variation tolerance for NUTM2A Gene

Gene Damage Index Score: 6.86; 79.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUTM2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUTM2A Gene

Disorders for NUTM2A Gene

MalaCards: The human disease database

(3) MalaCards diseases for NUTM2A Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
endometrial stromal nodule
endometrial stromal tumor
  • endometrial stromal neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NUTM2A

genes like me logo Genes that share disorders with NUTM2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUTM2A Gene

Publications for NUTM2A Gene

  1. NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct variant of CIC-rearranged sarcoma. (PMID: 28188754) Sugita S … Hasegawa T (Human pathology 2017) 3 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for NUTM2A Gene

Sources for NUTM2A Gene

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