Aliases for NUTF2 Gene
External Ids for NUTF2 Gene
Previous GeneCards Identifiers for NUTF2 Gene
This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]
GeneCards Summary for NUTF2 Gene
NUTF2 (Nuclear Transport Factor 2) is a Protein Coding gene. Diseases associated with NUTF2 include Retinitis Pigmentosa 7. Among its related pathways are Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include transporter activity and Ran GTPase binding. An important paralog of this gene is NXT2.
UniProtKB/Swiss-Prot Summary for NUTF2 Gene
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.