This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016] See more...

Aliases for NUTF2 Gene

Aliases for NUTF2 Gene

  • Nuclear Transport Factor 2 2 3 4 5
  • Placental Protein 15 3 4
  • NTF-2 3 4
  • NTF2 3 4
  • PP15 3 4

External Ids for NUTF2 Gene

Previous GeneCards Identifiers for NUTF2 Gene

  • GC16P058575
  • GC16P068258
  • GC16P067616
  • GC16P067657
  • GC16P066438
  • GC16P067880
  • GC16P053772

Summaries for NUTF2 Gene

Entrez Gene Summary for NUTF2 Gene

  • This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]

GeneCards Summary for NUTF2 Gene

NUTF2 (Nuclear Transport Factor 2) is a Protein Coding gene. Diseases associated with NUTF2 include Retinitis Pigmentosa 7. Among its related pathways are Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include transporter activity and Ran GTPase binding. An important paralog of this gene is NXT2.

UniProtKB/Swiss-Prot Summary for NUTF2 Gene

  • Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.

Gene Wiki entry for NUTF2 Gene

Additional gene information for NUTF2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUTF2 Gene

Genomics for NUTF2 Gene

GeneHancer (GH) Regulatory Elements for NUTF2 Gene

Promoters and enhancers for NUTF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J067841 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -2.0 -1959 7.5 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A TCF12 NRF1 ZNF300 USF1 NUTF2 ZDHHC1 EDC4 ENKD1 NAE1 CENPT RANBP10 ACD CTCF ZFP90
GH16J067560 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.8 -283.7 -283741 5.8 HNRNPK EP300 CTCF SIN3A NRF1 ZNF300 POLR2G USF1 SP1 NCOR1 CTCF ENSG00000261386 LOC107984813 ZFP90 E2F4 NFATC3 ATP6V0D1 ENSG00000263276 ZDHHC1 ENSG00000260465
GH16J067479 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.6 -365.2 -365150 5.5 RXRA FOXK2 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 MYC ZNF300 ATP6V0D1 LOC101927837 lnc-AGRP-6 ZDHHC1 ENKD1 NAE1 RIPOR1 ACD CARMIL2 C16orf86
GH16J067909 Enhancer 0.8 Ensembl ENCODE dbSUPER 10.8 +63.3 63262 1.1 ZIC2 MXI1 STAT3 SCRT1 CTCF RAD21 PRDM1 SCRT2 NRN1L EDC4 NUTF2 THAP11 DUS2 ACD PARD6A DDX28 TPPP3 PSKH1
GH16J067908 Enhancer 0.3 dbSUPER 10.8 +61.8 61847 0.5 MXD3 NRN1L EDC4 NUTF2 THAP11 DUS2 ACD PARD6A DDX28 PSKH1 lnc-CTRL-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUTF2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUTF2

Top Transcription factor binding sites by QIAGEN in the NUTF2 gene promoter:
  • ATF-2
  • CRE-BP1
  • GATA-2
  • MyoD
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • RFX1

Genomic Locations for NUTF2 Gene

Genomic Locations for NUTF2 Gene
chr16:67,846,916-67,872,567
(GRCh38/hg38)
Size:
25,652 bases
Orientation:
Plus strand
chr16:67,880,635-67,906,470
(GRCh37/hg19)
Size:
25,836 bases
Orientation:
Plus strand

Genomic View for NUTF2 Gene

Genes around NUTF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUTF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTF2 Gene

Proteins for NUTF2 Gene

  • Protein details for NUTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61970-NTF2_HUMAN
    Recommended name:
    Nuclear transport factor 2
    Protein Accession:
    P61970
    Secondary Accessions:
    • B2R4G7
    • P13662
    • Q6IB67

    Protein attributes for NUTF2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14478 Da
    Quaternary structure:
    • Homodimer (PubMed:7744965). Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import (PubMed:10679025). Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import (PubMed:7744965). Interacts with CAPG; mediates its nuclear import (PubMed:18266911).

    Three dimensional structures from OCA and Proteopedia for NUTF2 Gene

neXtProt entry for NUTF2 Gene

Post-translational modifications for NUTF2 Gene

  • Ubiquitination at Lys55
  • Modification sites at PhosphoSitePlus

Other Protein References for NUTF2 Gene

No data available for DME Specific Peptides for NUTF2 Gene

Domains & Families for NUTF2 Gene

Gene Families for NUTF2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NUTF2 Gene

Suggested Antigen Peptide Sequences for NUTF2 Gene

GenScript: Design optimal peptide antigens:
  • Placental protein 15 (NTF2_HUMAN)
genes like me logo Genes that share domains with NUTF2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NUTF2 Gene

Function for NUTF2 Gene

Molecular function for NUTF2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.

Phenotypes From GWAS Catalog for NUTF2 Gene

Gene Ontology (GO) - Molecular Function for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7744965
GO:0008536 Ran GTPase binding IPI 18266911
GO:0017056 structural constituent of nuclear pore IDA 7744965
GO:0042802 identical protein binding IPI 19098896
GO:0061608 nuclear import signal receptor activity IEA --
genes like me logo Genes that share ontologies with NUTF2: view
genes like me logo Genes that share phenotypes with NUTF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUTF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUTF2 Gene

Localization for NUTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUTF2 Gene

Cytoplasm, cytosol. Nucleus outer membrane. Nucleus, nuclear pore complex. Nucleus inner membrane. Nucleus, nucleoplasm. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. {ECO:0000269 PubMed:10679025}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUTF2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
extracellular 2
mitochondrion 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0005640 nuclear outer membrane IEA --
GO:0005643 nuclear pore IEA --
GO:0005654 nucleoplasm IEA,IDA 10679025
genes like me logo Genes that share ontologies with NUTF2: view

Pathways & Interactions for NUTF2 Gene

PathCards logo

SuperPathways for NUTF2 Gene

SuperPathway Contained pathways
1 Cytoskeletal Signaling
genes like me logo Genes that share pathways with NUTF2: view

Pathways by source for NUTF2 Gene

1 Cell Signaling Technology pathway for NUTF2 Gene

Gene Ontology (GO) - Biological Process for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IDA 7744965
GO:0006611 protein export from nucleus IDA 16449645
GO:0006913 nucleocytoplasmic transport IBA 21873635
GO:0015031 protein transport IEA --
GO:0042307 positive regulation of protein import into nucleus IEA --
genes like me logo Genes that share ontologies with NUTF2: view

No data available for SIGNOR curated interactions for NUTF2 Gene

Drugs & Compounds for NUTF2 Gene

(2) Additional Compounds for NUTF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NUTF2: view

Transcripts for NUTF2 Gene

mRNA/cDNA for NUTF2 Gene

5 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUTF2

Alternative Splicing Database (ASD) splice patterns (SP) for NUTF2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - - - - - -

Relevant External Links for NUTF2 Gene

GeneLoc Exon Structure for
NUTF2

Expression for NUTF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUTF2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUTF2 Gene



Protein tissue co-expression partners for NUTF2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUTF2

SOURCE GeneReport for Unigene cluster for NUTF2 Gene:

Hs.356630

Evidence on tissue expression from TISSUES for NUTF2 Gene

  • Lung(4.3)
  • Nervous system(3.5)
  • Muscle(2)
genes like me logo Genes that share expression patterns with NUTF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUTF2 Gene

Orthologs for NUTF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUTF2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Nutf2-ps1 31
  • 100 (a)
OneToMany
Nutf2 31 30
  • 94.23 (n)
OneToMany
Nutf2-ps2 17
chimpanzee
(Pan troglodytes)
Mammalia NUTF2 31 30
  • 99.74 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 96 (a)
OneToMany
-- 31
  • 74 (a)
OneToMany
-- 31
  • 69 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NUTF2 31 30
  • 95.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NUTF2 31 30
  • 95.54 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nutf2 30
  • 93.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NUTF2 31
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUTF2 31 30
  • 76.12 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUTF2 31
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nutf2 30
  • 81.1 (n)
Str.10710 30
African clawed frog
(Xenopus laevis)
Amphibia nutf2-prov 30
zebrafish
(Danio rerio)
Actinopterygii nutf2 31 30
  • 78.22 (n)
OneToOne
wufb40a01 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9725 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007024 30
  • 53.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ntf-2r 31 30
  • 51.82 (n)
OneToMany
Ntf-2 31
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ran-4 31 30
  • 54.4 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR013W 30
  • 51.01 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTF2 33 31 30
  • 48.99 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13508g 30
  • 48.99 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NTF2B 30
  • 49.42 (n)
rice
(Oryza sativa)
Liliopsida Os08g0532300 30
  • 51.44 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nxt2 30
  • 54.8 (n)
Species where no ortholog for NUTF2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUTF2 Gene

ENSEMBL:
Gene Tree for NUTF2 (if available)
TreeFam:
Gene Tree for NUTF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUTF2: view image

Paralogs for NUTF2 Gene

Paralogs for NUTF2 Gene

genes like me logo Genes that share paralogs with NUTF2: view

Variants for NUTF2 Gene

Additional dbSNP identifiers (rs#s) for NUTF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUTF2 Gene

Variant ID Type Subtype PubMed ID
nsv1131269 CNV deletion 24896259
nsv1844 CNV deletion 18451855
nsv478420 CNV novel sequence insertion 20440878
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv977988 CNV duplication 23825009
nsv984342 CNV duplication 23825009

Variation tolerance for NUTF2 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUTF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUTF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUTF2 Gene

Disorders for NUTF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUTF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 7
  • rp7
- elite association - COSMIC cancer census association via MalaCards
Search NUTF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUTF2

genes like me logo Genes that share disorders with NUTF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUTF2 Gene

Publications for NUTF2 Gene

  1. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. (PMID: 7744965) Paschal BM … Gerace L (The Journal of cell biology 1995) 2 3 4 23 54
  2. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. (PMID: 18266911) Van Impe K … Gettemans J (Traffic (Copenhagen, Denmark) 2008) 3 4 23 54
  3. Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran. (PMID: 10679025) Steggerda SM … Paschal BM (Molecular biology of the cell 2000) 3 4 23 54
  4. Isolation of cDNA coding for the placental protein 15 (PP15). (PMID: 3380696) Grundmann U … Küpper HA (Nucleic acids research 1988) 2 3 4 54
  5. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PMID: 19060911) Aulchenko YS … ENGAGE Consortium (Nature genetics 2009) 3 41 54

Products for NUTF2 Gene

Sources for NUTF2 Gene