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Aliases for NUTF2 Gene

Aliases for NUTF2 Gene

  • Nuclear Transport Factor 2 2 3 5
  • Placental Protein 15 3 4
  • NTF-2 3 4
  • NTF2 3 4
  • PP15 3 4

External Ids for NUTF2 Gene

Previous GeneCards Identifiers for NUTF2 Gene

  • GC16P058575
  • GC16P068258
  • GC16P067616
  • GC16P067657
  • GC16P066438
  • GC16P067880
  • GC16P053772

Summaries for NUTF2 Gene

Entrez Gene Summary for NUTF2 Gene

  • This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]

GeneCards Summary for NUTF2 Gene

NUTF2 (Nuclear Transport Factor 2) is a Protein Coding gene. Diseases associated with NUTF2 include Retinitis Pigmentosa 7. Among its related pathways are Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include transporter activity and Ran GTPase binding.

UniProtKB/Swiss-Prot for NUTF2 Gene

  • Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.

Gene Wiki entry for NUTF2 Gene

Additional gene information for NUTF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUTF2 Gene

Genomics for NUTF2 Gene

GeneHancer (GH) Regulatory Elements for NUTF2 Gene

Promoters and enhancers for NUTF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I067841 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -1.7 -1743 7.5 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 THAP11 NUTF2 ZDHHC1 ENKD1 NAE1 EDC4 RANBP10 ZFP90 CTCF ENSG00000262514
GH16I067560 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.8 -283.6 -283557 5.8 HDGF SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CTCF ENSG00000261386 ENSG00000259804 GC16M067560 ZFP90 NFATC3 ATP6V0D1 EDC4 ZDHHC1 ENSG00000262514
GH16I067909 Enhancer 0.7 ENCODE dbSUPER 10.8 +63.4 63446 1.1 SCRT1 SCRT2 ZIC2 PRDM1 NRN1L EDC4 NUTF2 THAP11 DUS2 ACD PARD6A DDX28 TPPP3 PSKH1
GH16I067908 Enhancer 0.2 dbSUPER 10.8 +62.0 62031 0.5 NRN1L EDC4 NUTF2 THAP11 DUS2 ACD PARD6A DDX28 PSKH1 CTRL
GH16I067871 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 0.3 +26.4 26429 3.5 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B EDC4 GC16M067866 ACD ZFP90 ENSG00000263276 PRMT7 ENSG00000270165 E2F4 CTCF RANBP10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUTF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUTF2 gene promoter:

Genomic Locations for NUTF2 Gene

Genomic Locations for NUTF2 Gene
chr16:67,846,732-67,872,567
(GRCh38/hg38)
Size:
25,836 bases
Orientation:
Plus strand
chr16:67,880,635-67,906,470
(GRCh37/hg19)

Genomic View for NUTF2 Gene

Genes around NUTF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUTF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTF2 Gene

Proteins for NUTF2 Gene

  • Protein details for NUTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61970-NTF2_HUMAN
    Recommended name:
    Nuclear transport factor 2
    Protein Accession:
    P61970
    Secondary Accessions:
    • B2R4G7
    • P13662
    • Q6IB67

    Protein attributes for NUTF2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14478 Da
    Quaternary structure:
    • Homodimer (PubMed:7744965). Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import (PubMed:10679025). Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import (PubMed:7744965). Interacts with CAPG; mediates its nuclear import (PubMed:18266911).

    Three dimensional structures from OCA and Proteopedia for NUTF2 Gene

neXtProt entry for NUTF2 Gene

Post-translational modifications for NUTF2 Gene

Other Protein References for NUTF2 Gene

No data available for DME Specific Peptides for NUTF2 Gene

Domains & Families for NUTF2 Gene

Gene Families for NUTF2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NUTF2 Gene

Suggested Antigen Peptide Sequences for NUTF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUTF2: view

No data available for UniProtKB/Swiss-Prot for NUTF2 Gene

Function for NUTF2 Gene

Molecular function for NUTF2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.

Phenotypes From GWAS Catalog for NUTF2 Gene

Gene Ontology (GO) - Molecular Function for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005487 nuclear pore activity IDA 7744965
GO:0005515 protein binding IPI 7744965
GO:0008536 Ran GTPase binding IPI 18266911
GO:0008565 protein transporter activity IEA --
GO:0042802 identical protein binding IPI 19098896
genes like me logo Genes that share ontologies with NUTF2: view
genes like me logo Genes that share phenotypes with NUTF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUTF2 Gene

Localization for NUTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUTF2 Gene

Cytoplasm, cytosol. Nucleus outer membrane. Nucleus, nuclear pore complex. Nucleus inner membrane. Nucleus, nucleoplasm. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. {ECO:0000269 PubMed:10679025}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUTF2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0005640 nuclear outer membrane IEA --
GO:0005643 nuclear pore IEA --
GO:0005654 nucleoplasm IEA,IDA 10679025
genes like me logo Genes that share ontologies with NUTF2: view

Pathways & Interactions for NUTF2 Gene

SuperPathways for NUTF2 Gene

SuperPathway Contained pathways
1 Cytoskeletal Signaling
genes like me logo Genes that share pathways with NUTF2: view

Pathways by source for NUTF2 Gene

1 Cell Signaling Technology pathway for NUTF2 Gene

Gene Ontology (GO) - Biological Process for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IMP 18266911
GO:0006606 protein import into nucleus IDA 7744965
GO:0006611 protein export from nucleus IDA 16449645
GO:0006810 transport IEA --
GO:0006913 nucleocytoplasmic transport IEA --
genes like me logo Genes that share ontologies with NUTF2: view

No data available for SIGNOR curated interactions for NUTF2 Gene

Drugs & Compounds for NUTF2 Gene

(2) Additional Compounds for NUTF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NUTF2: view

Transcripts for NUTF2 Gene

Unigene Clusters for NUTF2 Gene

Nuclear transport factor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUTF2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - - - - - -

Relevant External Links for NUTF2 Gene

GeneLoc Exon Structure for
NUTF2
ECgene alternative splicing isoforms for
NUTF2

Expression for NUTF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUTF2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUTF2 Gene



Protein tissue co-expression partners for NUTF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUTF2 Gene:

NUTF2

SOURCE GeneReport for Unigene cluster for NUTF2 Gene:

Hs.356630

Evidence on tissue expression from TISSUES for NUTF2 Gene

  • Lung(4.3)
  • Nervous system(3.5)
  • Muscle(2)
genes like me logo Genes that share expression patterns with NUTF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUTF2 Gene

Orthologs for NUTF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUTF2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Nutf2-ps1 34
  • 100 (a)
OneToMany
Nutf2 33 34
  • 94.23 (n)
Nutf2-ps2 16
chimpanzee
(Pan troglodytes)
Mammalia NUTF2 33 34
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 96 (a)
OneToMany
-- 34
  • 74 (a)
OneToMany
-- 34
  • 69 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NUTF2 33 34
  • 95.8 (n)
dog
(Canis familiaris)
Mammalia NUTF2 33 34
  • 95.54 (n)
rat
(Rattus norvegicus)
Mammalia Nutf2 33
  • 93.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NUTF2 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUTF2 33 34
  • 76.12 (n)
lizard
(Anolis carolinensis)
Reptilia NUTF2 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nutf2 33
  • 81.1 (n)
Str.10710 33
African clawed frog
(Xenopus laevis)
Amphibia nutf2-prov 33
zebrafish
(Danio rerio)
Actinopterygii nutf2 33 34
  • 78.22 (n)
wufb40a01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9725 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007024 33
  • 53.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ntf-2r 33 34
  • 51.82 (n)
Ntf-2 34
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ran-4 33 34
  • 54.4 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR013W 33
  • 51.01 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTF2 33 34 36
  • 48.99 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13508g 33
  • 48.99 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NTF2B 33
  • 49.42 (n)
rice
(Oryza sativa)
Liliopsida Os08g0532300 33
  • 51.44 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nxt2 33
  • 54.8 (n)
Species where no ortholog for NUTF2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUTF2 Gene

ENSEMBL:
Gene Tree for NUTF2 (if available)
TreeFam:
Gene Tree for NUTF2 (if available)

Paralogs for NUTF2 Gene

No data available for Paralogs for NUTF2 Gene

Variants for NUTF2 Gene

Sequence variations from dbSNP and Humsavar for NUTF2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000000842 -- 67,853,556(+) T/C intron_variant
rs1000082581 -- 67,845,853(+) C/T upstream_transcript_variant
rs1000108866 -- 67,856,514(+) G/T intron_variant
rs1000112117 -- 67,860,436(+) G/A/T intron_variant
rs1000150548 -- 67,863,380(+) GCTGGCT/GCT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUTF2 Gene

Variant ID Type Subtype PubMed ID
nsv984342 CNV duplication 23825009
nsv977988 CNV duplication 23825009
nsv524363 CNV loss 19592680
nsv522852 CNV gain 19592680
nsv478420 CNV novel sequence insertion 20440878
nsv1844 CNV deletion 18451855
nsv1131269 CNV deletion 24896259

Variation tolerance for NUTF2 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUTF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUTF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUTF2 Gene

Disorders for NUTF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUTF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 7
  • rp7
- elite association - COSMIC cancer census association via MalaCards
Search NUTF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUTF2

genes like me logo Genes that share disorders with NUTF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUTF2 Gene

Publications for NUTF2 Gene

  1. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. (PMID: 7744965) Paschal BM … Gerace L (The Journal of cell biology 1995) 2 3 4 22 58
  2. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. (PMID: 18266911) Van Impe K … Gettemans J (Traffic (Copenhagen, Denmark) 2008) 3 4 22 58
  3. Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran. (PMID: 10679025) Steggerda SM … Paschal BM (Molecular biology of the cell 2000) 3 4 22 58
  4. Isolation of cDNA coding for the placental protein 15 (PP15). (PMID: 3380696) Grundmann U … Küpper HA (Nucleic acids research 1988) 2 3 4 58
  5. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S … Cupples LA (Nature genetics 2009) 3 44 58

Products for NUTF2 Gene

Sources for NUTF2 Gene

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