NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009] See more...

Aliases for NUSAP1 Gene

Aliases for NUSAP1 Gene

  • Nucleolar And Spindle Associated Protein 1 2 3 5
  • ANKT 2 3 4
  • Nucleolar And Spindle-Associated Protein 1 3 4
  • PRO0310p1 2 3
  • BM037 2 3
  • Q0310 2 3
  • SAPL 2 3
  • LNP 2 3
  • Nucleolar Protein ANKT 3
  • FLJ13421 2
  • NUSAP1 5
  • NUSAP 3
  • NuSAP 4

External Ids for NUSAP1 Gene

Previous GeneCards Identifiers for NUSAP1 Gene

  • GC15P039341
  • GC15P039412
  • GC15P041624
  • GC15P018473
  • GC15P041332
  • GC15P041333
  • GC15P041342

Summaries for NUSAP1 Gene

Entrez Gene Summary for NUSAP1 Gene

  • NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]

GeneCards Summary for NUSAP1 Gene

NUSAP1 (Nucleolar And Spindle Associated Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is ENSG00000285920.

UniProtKB/Swiss-Prot Summary for NUSAP1 Gene

  • Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.

Additional gene information for NUSAP1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUSAP1 Gene

Genomics for NUSAP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NUSAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUSAP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUSAP1

Top Transcription factor binding sites by QIAGEN in the NUSAP1 gene promoter:
  • AREB6
  • Bach1
  • Bach2
  • CBF(2)
  • FOXO4
  • MyoD
  • NF-Y
  • Pax-5

Genomic Locations for NUSAP1 Gene

Genomic Locations for NUSAP1 Gene
chr15:41,320,794-41,381,050
(GRCh38/hg38)
Size:
60,257 bases
Orientation:
Plus strand
chr15:41,624,892-41,673,248
(GRCh37/hg19)
Size:
48,357 bases
Orientation:
Plus strand

Genomic View for NUSAP1 Gene

Genes around NUSAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUSAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUSAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUSAP1 Gene

Proteins for NUSAP1 Gene

  • Protein details for NUSAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXS6-NUSAP_HUMAN
    Recommended name:
    Nucleolar and spindle-associated protein 1
    Protein Accession:
    Q9BXS6
    Secondary Accessions:
    • B4DDF1
    • E7ERR5
    • J3KN21
    • Q53GW2
    • Q8TBT4
    • Q96E58
    • Q96FJ1
    • Q9GZM9
    • Q9NZ85
    • Q9UI70

    Protein attributes for NUSAP1 Gene

    Size:
    441 amino acids
    Molecular mass:
    49452 Da
    Quaternary structure:
    • Interacts with DNA and microtubules. Microtubule bundling is inhibited by IPO7, KPNA2 and KPNB1 while association with DNA is also inhibited by IPO7 and KPNA2 (By similarity).
    SequenceCaution:
    • Sequence=AAF24034.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF67624.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH12887.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUSAP1 Gene

neXtProt entry for NUSAP1 Gene

Post-translational modifications for NUSAP1 Gene

  • Ubiquitinated. Ubiquitination by FZR1 may lead to proteasome-dependent degradation of this protein.
  • Phosphorylation by ATM in G2/M-phase induces mitotic arrest.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUSAP1 Gene

Domains & Families for NUSAP1 Gene

Gene Families for NUSAP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUSAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUSAP1 Gene

GenScript: Design optimal peptide antigens:
  • Nucleolar and spindle-associated protein 1 (NUSAP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BXS6

UniProtKB/Swiss-Prot:

NUSAP_HUMAN :
  • The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination.
  • Belongs to the NUSAP family.
Domain:
  • The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination.
Family:
  • Belongs to the NUSAP family.
genes like me logo Genes that share domains with NUSAP1: view

Function for NUSAP1 Gene

Molecular function for NUSAP1 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.

Phenotypes From GWAS Catalog for NUSAP1 Gene

Gene Ontology (GO) - Molecular Function for NUSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IBA 21873635
genes like me logo Genes that share ontologies with NUSAP1: view
genes like me logo Genes that share phenotypes with NUSAP1: view

Animal Models for NUSAP1 Gene

MGI Knock Outs for NUSAP1:

Animal Model Products

CRISPR Products

miRNA for NUSAP1 Gene

miRTarBase miRNAs that target NUSAP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUSAP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUSAP1 Gene

Localization for NUSAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUSAP1 Gene

Cytoplasm. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Chromosome. Note=Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase (By similarity). Localizes to the mitotic spindle during anaphase and telophase then disappears from around the chromosomes during cytokinesis (By similarity). Localizes to multiple distinct regions of chromosomes throughout mitosis. {ECO:0000250, ECO:0000269 PubMed:17276916, ECO:0000269 PubMed:17618083}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUSAP1 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NUSAP1: view

Pathways & Interactions for NUSAP1 Gene

PathCards logo

SuperPathways for NUSAP1 Gene

No Data Available

SIGNOR curated interactions for NUSAP1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NUSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IDA 12963707
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0000281 mitotic cytokinesis IEA,IDA 12963707
GO:0007049 cell cycle IEA --
GO:0007076 mitotic chromosome condensation IDA 12963707
genes like me logo Genes that share ontologies with NUSAP1: view

No data available for Pathways by source for NUSAP1 Gene

Drugs & Compounds for NUSAP1 Gene

No Compound Related Data Available

Transcripts for NUSAP1 Gene

mRNA/cDNA for NUSAP1 Gene

7 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUSAP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUSAP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - -
SP7: - -
SP8: - - -
SP9: -
SP10:
SP11: - - -
SP12:

Relevant External Links for NUSAP1 Gene

GeneLoc Exon Structure for
NUSAP1

Expression for NUSAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUSAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUSAP1 Gene

This gene is overexpressed in Amniocyte (42.2) and Lung (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUSAP1 Gene



Protein tissue co-expression partners for NUSAP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUSAP1

SOURCE GeneReport for Unigene cluster for NUSAP1 Gene:

Hs.615092

Evidence on tissue expression from TISSUES for NUSAP1 Gene

  • Liver(4.8)
  • Lung(4.6)
  • Bone marrow(4.5)
  • Blood(4.5)
  • Nervous system(3.8)
  • Kidney(3.3)
  • Intestine(2.6)
  • Lymph node(2.4)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with NUSAP1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUSAP1 Gene

Orthologs for NUSAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUSAP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NUSAP1 30 31
  • 99.24 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NUSAP1 30 31
  • 85.2 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NUSAP1 30 31
  • 84.06 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Nusap1 30 17 31
  • 77.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nusap1 30
  • 76.32 (n)
Oppossum
(Monodelphis domestica)
Mammalia NUSAP1 31
  • 52 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NUSAP1 31
  • 45 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NUSAP1 30 31
  • 57.08 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NUSAP1 31
  • 37 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nusap1 30
  • 55.99 (n)
Str.367 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.24026 30
Zebrafish
(Danio rerio)
Actinopterygii nusap1 30 31
  • 49.92 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 24 (a)
OneToOne
Species where no ortholog for NUSAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NUSAP1 Gene

ENSEMBL:
Gene Tree for NUSAP1 (if available)
TreeFam:
Gene Tree for NUSAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUSAP1: view image

Paralogs for NUSAP1 Gene

Paralogs for NUSAP1 Gene

(11) SIMAP similar genes for NUSAP1 Gene using alignment to 5 proteins:

  • NUSAP_HUMAN
  • E9PB35_HUMAN
  • H0YKA7_HUMAN
  • H0YM18_HUMAN
  • H0YMD2_HUMAN
genes like me logo Genes that share paralogs with NUSAP1: view

Variants for NUSAP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUSAP1 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs7178634 - p.Thr33Ala
rs7178777 - p.Thr33Asn

Additional dbSNP identifiers (rs#s) for NUSAP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUSAP1 Gene

Variant ID Type Subtype PubMed ID
dgv2580n100 CNV gain 25217958
esv2671704 CNV deletion 23128226
nsv1039283 CNV gain 25217958
nsv1134434 CNV deletion 24896259

Variation tolerance for NUSAP1 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.84; 96.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUSAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUSAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUSAP1 Gene

Disorders for NUSAP1 Gene

No disorders were found for NUSAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUSAP1 Gene

Publications for NUSAP1 Gene

  1. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. (PMID: 12963707) Raemaekers T … Carmeliet G (The Journal of cell biology 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Overexpression of NuSAP1 is predictive of an unfavourable prognosis and promotes proliferation and invasion of triple-negative breast cancer cells via the Wnt/β-catenin/EMT signalling axis. (PMID: 32298762) Sun L … Zhao Y (Gene 2020) 3
  4. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3
  5. The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer. (PMID: 30737378) Tang W … Wang J (Nature communications 2019) 3

Products for NUSAP1 Gene

Sources for NUSAP1 Gene