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Aliases for NUSAP1 Gene

Aliases for NUSAP1 Gene

  • Nucleolar And Spindle Associated Protein 1 2 3 5
  • NUSAP 3 4
  • ANKT 3 4
  • Nucleolar And Spindle-Associated Protein 1 3
  • Nucleolar Protein ANKT 3
  • PRO0310p1 3
  • BM037 3
  • Q0310 3
  • SAPL 3
  • LNP 3

External Ids for NUSAP1 Gene

Previous GeneCards Identifiers for NUSAP1 Gene

  • GC15P039341
  • GC15P039412
  • GC15P041624
  • GC15P018473

Summaries for NUSAP1 Gene

Entrez Gene Summary for NUSAP1 Gene

  • NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]

GeneCards Summary for NUSAP1 Gene

NUSAP1 (Nucleolar And Spindle Associated Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for NUSAP1 Gene

  • Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.

Additional gene information for NUSAP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUSAP1 Gene

Genomics for NUSAP1 Gene

GeneHancer (GH) Regulatory Elements for NUSAP1 Gene

Promoters and enhancers for NUSAP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I041330 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.3 301 4.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NUSAP1 OIP5 NDUFAF1 DNAJC17 ENSG00000259211 INO80 GANC LOC105370795 VPS39 MAPKBP1
GH15I041282 Promoter/Enhancer 1.6 Ensembl ENCODE 12.1 -47.9 -47897 3.7 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B OIP5-AS1 NDUFAF1 INO80 MGA GANC BAHD1 ENSG00000259211 RPAP1 DNAJC17 LOC105370795
GH15I041259 Enhancer 1.1 Ensembl ENCODE 10.5 -73.3 -73292 2 PKNOX1 FOXA2 MLX ARID4B DMAP1 BRCA1 ZNF48 YY1 RXRA SP5 GC15M041261 GC15M041262 GC15M041263 GC15M041264 GC15M041265 GC15M041266 GC15M041267 PIR32693 GC15M041269 EXD1
GH15I041290 Enhancer 0.9 Ensembl ENCODE 12.1 -41.0 -41041 1.9 PKNOX1 EBF1 IRF4 ZNF121 ATF7 IKZF2 BCLAF1 RUNX3 SMARCA5 ZNF687 NDUFAF1 NUSAP1 OIP5 CHP1 EXD1 RNU6-1169P RTF1 ZFYVE19 OIP5-AS1 PIR39466
GH15I041255 Enhancer 0.8 ENCODE 10.5 -76.3 -76317 1.6 FOXA2 SIN3A RARA YY1 THAP11 MIXL1 HMG20B RXRA CEBPB ELF1 NDUFAF1 EXD1 CHP1 NUSAP1 OIP5 RTF1 RPAP1 GC15M041261 GC15M041262 GC15M041263
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUSAP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUSAP1 gene promoter:

Genomic Locations for NUSAP1 Gene

Genomic Locations for NUSAP1 Gene
48,357 bases
Plus strand

Genomic View for NUSAP1 Gene

Genes around NUSAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUSAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUSAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUSAP1 Gene

Proteins for NUSAP1 Gene

  • Protein details for NUSAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolar and spindle-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DDF1
    • E7ERR5
    • J3KN21
    • Q53GW2
    • Q8TBT4
    • Q96E58
    • Q96FJ1
    • Q9GZM9
    • Q9NZ85
    • Q9UI70

    Protein attributes for NUSAP1 Gene

    441 amino acids
    Molecular mass:
    49452 Da
    Quaternary structure:
    • Interacts with DNA and microtubules. Microtubule bundling is inhibited by IPO7, KPNA2 and KPNB1 while association with DNA is also inhibited by IPO7 and KPNA2 (By similarity).
    • Sequence=AAF24034.1; Type=Frameshift; Positions=205; Evidence={ECO:0000305}; Sequence=AAF67624.1; Type=Frameshift; Positions=175, 205; Evidence={ECO:0000305}; Sequence=AAH12887.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUSAP1 Gene

neXtProt entry for NUSAP1 Gene

Post-translational modifications for NUSAP1 Gene

  • Phosphorylation by ATM in G2/M-phase induces mitotic arrest.
  • Ubiquitinated. Ubiquitination by FZR1 may lead to proteasome-dependent degradation of this protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUSAP1 Gene

Domains & Families for NUSAP1 Gene

Gene Families for NUSAP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUSAP1 Gene


Suggested Antigen Peptide Sequences for NUSAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination.
  • Belongs to the NUSAP family.
  • The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination.
  • Belongs to the NUSAP family.
genes like me logo Genes that share domains with NUSAP1: view

Function for NUSAP1 Gene

Molecular function for NUSAP1 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.

Gene Ontology (GO) - Molecular Function for NUSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IDA,HDA 22658674
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with NUSAP1: view
genes like me logo Genes that share phenotypes with NUSAP1: view

Animal Models for NUSAP1 Gene

MGI Knock Outs for NUSAP1:

Animal Model Products

miRNA for NUSAP1 Gene

miRTarBase miRNAs that target NUSAP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUSAP1 Gene

Localization for NUSAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUSAP1 Gene

Cytoplasm. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Chromosome. Note=Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase (By similarity). Localizes to the mitotic spindle during anaphase and telophase then disappears from around the chromosomes during cytokinesis (By similarity). Localizes to multiple distinct regions of chromosomes throughout mitosis. {ECO:0000250, ECO:0000269 PubMed:17276916, ECO:0000269 PubMed:17618083}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUSAP1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (4)
  • Nucleoli fibrillar center (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with NUSAP1: view

Pathways & Interactions for NUSAP1 Gene

SuperPathways for NUSAP1 Gene

No Data Available

SIGNOR curated interactions for NUSAP1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NUSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IDA 12963707
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0000281 mitotic cytokinesis IDA,IEA 12963707
GO:0007049 cell cycle IEA --
GO:0007076 mitotic chromosome condensation IDA 12963707
genes like me logo Genes that share ontologies with NUSAP1: view

No data available for Pathways by source for NUSAP1 Gene

Drugs & Compounds for NUSAP1 Gene

No Compound Related Data Available

Transcripts for NUSAP1 Gene

Unigene Clusters for NUSAP1 Gene

Nucleolar and spindle associated protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUSAP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - -
SP7: - -
SP8: - - -
SP9: -
SP11: - - -

Relevant External Links for NUSAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUSAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUSAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUSAP1 Gene

This gene is overexpressed in Amniocyte (42.2) and Lung (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUSAP1 Gene

Protein tissue co-expression partners for NUSAP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUSAP1 Gene:


SOURCE GeneReport for Unigene cluster for NUSAP1 Gene:


Evidence on tissue expression from TISSUES for NUSAP1 Gene

  • Liver(4.8)
  • Lung(4.5)
  • Bone marrow(4.3)
  • Blood(4.2)
  • Nervous system(3.3)
  • Kidney(2.8)
genes like me logo Genes that share expression patterns with NUSAP1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUSAP1 Gene

Orthologs for NUSAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUSAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUSAP1 33 34
  • 99.24 (n)
(Bos Taurus)
Mammalia NUSAP1 33 34
  • 85.2 (n)
(Canis familiaris)
Mammalia NUSAP1 33 34
  • 84.06 (n)
(Mus musculus)
Mammalia Nusap1 33 16 34
  • 77.29 (n)
(Rattus norvegicus)
Mammalia Nusap1 33
  • 76.32 (n)
(Monodelphis domestica)
Mammalia NUSAP1 34
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia NUSAP1 34
  • 45 (a)
(Gallus gallus)
Aves NUSAP1 33 34
  • 57.08 (n)
(Anolis carolinensis)
Reptilia NUSAP1 34
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nusap1 33
  • 55.99 (n)
Str.367 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24026 33
(Danio rerio)
Actinopterygii nusap1 33 34
  • 49.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
Species where no ortholog for NUSAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUSAP1 Gene

Gene Tree for NUSAP1 (if available)
Gene Tree for NUSAP1 (if available)

Paralogs for NUSAP1 Gene

(11) SIMAP similar genes for NUSAP1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NUSAP1: view

No data available for Paralogs for NUSAP1 Gene

Variants for NUSAP1 Gene

Sequence variations from dbSNP and Humsavar for NUSAP1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000030820 -- 41,332,748(+) T/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000054809 -- 41,370,925(+) AAAAAA/AAAAAAA intron_variant
rs1000065734 -- 41,330,863(+) A/G upstream_transcript_variant
rs1000080188 -- 41,336,210(+) G/A intron_variant
rs1000135132 -- 41,377,102(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUSAP1 Gene

Variant ID Type Subtype PubMed ID
dgv2580n100 CNV gain 25217958
esv2671704 CNV deletion 23128226
nsv1039283 CNV gain 25217958
nsv1134434 CNV deletion 24896259

Variation tolerance for NUSAP1 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.84; 96.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUSAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUSAP1 Gene

Disorders for NUSAP1 Gene

Additional Disease Information for NUSAP1

No disorders were found for NUSAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUSAP1 Gene

Publications for NUSAP1 Gene

  1. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. (PMID: 12963707) Raemaekers T … Carmeliet G (The Journal of cell biology 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Nucleolar and spindle-associated protein 1 (NUSAP1) interacts with a SUMO E3 ligase complex during chromosome segregation. (PMID: 28900032) Mills CA … Emanuele MJ (The Journal of biological chemistry 2017) 3 58
  5. NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity. (PMID: 26733216) Li C … Liou YC (Scientific reports 2016) 3 58

Products for NUSAP1 Gene

Sources for NUSAP1 Gene

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