Aliases for NUPR1 Gene

Aliases for NUPR1 Gene

  • Nuclear Protein 1, Transcriptional Regulator 2 3 5
  • Candidate Of Metastasis 1 2 3 4
  • Nuclear Protein 1 3 4
  • Protein P8 3 4
  • COM1 3 4
  • Nuclear Protein, Transcriptional Regulator, 1 3
  • Nuclear Transcriptional Regulator Protein 1 3
  • P8 3

External Ids for NUPR1 Gene

Previous GeneCards Identifiers for NUPR1 Gene

  • GC16M028457
  • GC16M026574

Summaries for NUPR1 Gene

GeneCards Summary for NUPR1 Gene

NUPR1 (Nuclear Protein 1, Transcriptional Regulator) is a Protein Coding gene. Diseases associated with NUPR1 include Pancreatic Cancer. Among its related pathways are Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is NUPR2.

UniProtKB/Swiss-Prot Summary for NUPR1 Gene

  • Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in regulation of many process namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:16478804, PubMed:19650074, PubMed:16300740, PubMed:19723804, PubMed:11056169, PubMed:22858377, PubMed:11940591, PubMed:18690848, PubMed:22565310, PubMed:20181828, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates to DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity).

Gene Wiki entry for NUPR1 Gene

Additional gene information for NUPR1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUPR1 Gene

Genomics for NUPR1 Gene

GeneHancer (GH) Regulatory Elements for NUPR1 Gene

Promoters and enhancers for NUPR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J028536 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 500.7 +0.9 948 3.7 POLR2G ZIC2 POLR2A ZBTB25 TOE1 TGIF2 CTBP1 SKI MYC HINFP SGF29 NUPR1 SULT1A2 TUFM ENSG00000260853 ENSG00000260367 SPNS1 NFATC2IP NPIPB12 ENSG00000198106
GH16J028542 Promoter/Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.7 -4.4 -4398 1.9 CREB1 USF1 SAP130 MEF2B SPI1 EBF1 RXRA POLR2A NFIL3 ELF3 SULT1A2 TUFM NPIPB7 APOBR CLN3 CD19 RABEP2 IL27 ENSG00000251417 SULT1A1
GH16J028531 Enhancer 1.1 FANTOM5 ENCODE 0.4 +5.5 5518 3.7 POLR2G ZBTB5 POLR2A ZBTB25 TGIF2 ZNF341 RBM25 NR2F2 CEBPG FOS lnc-SGF29-2 piR-49561 SULT1A2 TUFM APOBR SGF29 NPIPB7 CLN3 IL27 ENSG00000251417
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NUPR1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUPR1

Top Transcription factor binding sites by QIAGEN in the NUPR1 gene promoter:
  • AP-1
  • ATF6
  • Brachyury
  • HEN1
  • HSF1 (long)
  • HSF1short
  • NCX
  • NRSF form 1
  • NRSF form 2
  • Sox5

Genomic Locations for NUPR1 Gene

Genomic Locations for NUPR1 Gene
chr16:28,532,708-28,539,174
(GRCh38/hg38)
Size:
6,467 bases
Orientation:
Minus strand
chr16:28,548,606-28,550,495
(GRCh37/hg19)
Size:
1,890 bases
Orientation:
Minus strand

Genomic View for NUPR1 Gene

Genes around NUPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUPR1 Gene

Proteins for NUPR1 Gene

  • Protein details for NUPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60356-NUPR1_HUMAN
    Recommended name:
    Nuclear protein 1
    Protein Accession:
    O60356
    Secondary Accessions:
    • B2R5C4
    • O60357
    • Q6FGG3

    Protein attributes for NUPR1 Gene

    Size:
    82 amino acids
    Molecular mass:
    8873 Da
    Quaternary structure:
    • Monomer. Directly interacts with MSL1 and binds MORF4L1, two components of histone acetyltransferase complex; the interaction with MORF4L1 may be mediated by MSL1 (PubMed:19650074). Interacts with EP300; this interaction enhances the effect of EP300 on PAX2 transcription factor activity (PubMed:11940591). Interacts with PAXIP1; this interaction prevents PAXIP1 inhibition of PAX2 transcription factor activity (PubMed:11940591). Interacts with COPS5; this interaction allows COPS5-dependent CDKN1B nuclear to cytoplasm translocation (PubMed:16300740). Interacts with RNF2 (PubMed:28720707). Interacts with FOXO3; this interaction represses FOXO3 transactivation (PubMed:20181828). Interacts with PTMA; negatively regulates apoptotic process (PubMed:16478804). Interacts with MYOD1, EP300 and DDX5; this interaction coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter (PubMed:19723804) (By similarity). Interacts with TP53; interaction is stress-dependent (PubMed:18690848). Forms a complex with EP300 and TP53; this complex binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848).
    Miscellaneous:
    • Mediates resistance to anticancer drugs, namely taxol, doxorubicin, gemcitabine.
    SequenceCaution:
    • Sequence=AAC05335.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NUPR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUPR1 Gene

Post-translational modifications for NUPR1 Gene

Other Protein References for NUPR1 Gene

No data available for DME Specific Peptides for NUPR1 Gene

Domains & Families for NUPR1 Gene

Gene Families for NUPR1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUPR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUPR1 Gene

GenScript: Design optimal peptide antigens:
  • Protein p8 (NUPR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60356

UniProtKB/Swiss-Prot:

NUPR1_HUMAN :
  • Belongs to the NUPR family.
Family:
  • Belongs to the NUPR family.
genes like me logo Genes that share domains with NUPR1: view

Function for NUPR1 Gene

Molecular function for NUPR1 Gene

UniProtKB/Swiss-Prot Function:
Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in regulation of many process namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:16478804, PubMed:19650074, PubMed:16300740, PubMed:19723804, PubMed:11056169, PubMed:22858377, PubMed:11940591, PubMed:18690848, PubMed:22565310, PubMed:20181828, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates to DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by stress agents, such as nutrient deprivation (at protein level) (PubMed:22565310). Up-regulation by gamma-irradiation is eventually followed by down-regulation (PubMed:19650074). Expression increases with the tumor aggressiveness. up-regulated by DNA-damaging agent such as doxorubicin (PubMed:18690848).

Phenotypes From GWAS Catalog for NUPR1 Gene

Gene Ontology (GO) - Molecular Function for NUPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,IDA 11056169
GO:0003682 chromatin binding IEA --
GO:0003713 transcription coactivator activity IMP 11940591
GO:0005515 protein binding IPI 11940591
GO:0010698 acetyltransferase activator activity IEA,ISS --
genes like me logo Genes that share ontologies with NUPR1: view
genes like me logo Genes that share phenotypes with NUPR1: view

Animal Models for NUPR1 Gene

MGI Knock Outs for NUPR1:

Animal Model Products

CRISPR Products

miRNA for NUPR1 Gene

miRTarBase miRNAs that target NUPR1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUPR1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUPR1 Gene

Localization for NUPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUPR1 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUPR1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
plasma membrane 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NUPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 10092851
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 16300740
GO:0005829 cytosol IDA --
GO:0032993 protein-DNA complex IDA 11056169
genes like me logo Genes that share ontologies with NUPR1: view

Pathways & Interactions for NUPR1 Gene

PathCards logo

SuperPathways for NUPR1 Gene

genes like me logo Genes that share pathways with NUPR1: view

Pathways by source for NUPR1 Gene

1 KEGG pathway for NUPR1 Gene

SIGNOR curated interactions for NUPR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NUPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response IEA --
GO:0006473 protein acetylation IEA --
GO:0008283 cell proliferation IDA 10092851
GO:0008285 negative regulation of cell proliferation IBA 21873635
GO:0008584 male gonad development IEA --
genes like me logo Genes that share ontologies with NUPR1: view

Drugs & Compounds for NUPR1 Gene

No Compound Related Data Available

Transcripts for NUPR1 Gene

mRNA/cDNA for NUPR1 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUPR1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUPR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3: -

Relevant External Links for NUPR1 Gene

GeneLoc Exon Structure for
NUPR1

Expression for NUPR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUPR1 Gene

This gene is overexpressed in Pancreas (54.7) and Milk (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NUPR1 Gene



Protein tissue co-expression partners for NUPR1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUPR1

SOURCE GeneReport for Unigene cluster for NUPR1 Gene:

Hs.513463

mRNA Expression by UniProt/SwissProt for NUPR1 Gene:

O60356-NUPR1_HUMAN
Tissue specificity: Widely expressed, with high levels in liver, pancreas, prostate, ovary, colon, thyroid, spinal cord, trachea and adrenal gland, moderate levels in heart, placenta, lung, skeletal muscle, kidney, testis, small intestine, stomach and lymph node, and low levels in brain, spleen, thymus and bone marrow. Not detected in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for NUPR1 Gene

  • Pancreas(4.7)
  • Kidney(4.3)
  • Nervous system(4.2)
  • Lung(3.4)
  • Thyroid gland(2.7)
  • Liver(2.4)
genes like me logo Genes that share expression patterns with NUPR1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUPR1 Gene

Orthologs for NUPR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUPR1 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUPR1 31 30
  • 86.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NUPR1 31 30
  • 82.72 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nupr1 17 31 30
  • 79.65 (n)
rat
(Rattus norvegicus)
Mammalia P8 30
  • 79.22 (n)
oppossum
(Monodelphis domestica)
Mammalia NUPR1 31
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUPR1 31
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nupr1 31
  • 43 (a)
OneToOne
Species where no ortholog for NUPR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUPR1 Gene

ENSEMBL:
Gene Tree for NUPR1 (if available)
TreeFam:
Gene Tree for NUPR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NUPR1: view image

Paralogs for NUPR1 Gene

Paralogs for NUPR1 Gene

(1) SIMAP similar genes for NUPR1 Gene using alignment to 2 proteins:

  • NUPR1_HUMAN
  • H3BS92_HUMAN
genes like me logo Genes that share paralogs with NUPR1: view

Variants for NUPR1 Gene

Additional dbSNP identifiers (rs#s) for NUPR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NUPR1 Gene

Variant ID Type Subtype PubMed ID
esv2758640 CNV gain+loss 17122850
nsv1059555 CNV gain 25217958
nsv509608 CNV insertion 20534489
nsv833180 CNV loss 17160897
nsv833182 CNV gain 17160897

Variation tolerance for NUPR1 Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUPR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUPR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUPR1 Gene

Disorders for NUPR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUPR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatic cancer
  • pancreatic carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search NUPR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUPR1

genes like me logo Genes that share disorders with NUPR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUPR1 Gene

Publications for NUPR1 Gene

  1. Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation. (PMID: 16300740) Malicet C … Iovanna JL (Biochemical and biophysical research communications 2006) 3 4 23 54
  2. Expression of a novel factor in human breast cancer cells with metastatic potential. (PMID: 10493524) Ree AH … Fodstad O (Cancer research 1999) 2 3 4 54
  3. Cloning and expression of the human p8, a nuclear protein with mitogenic activity. (PMID: 10092851) Vasseur S … Iovanna JL (European journal of biochemistry 1999) 2 3 4 54
  4. Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis. (PMID: 30451898) Santofimia-Castaño P … Iovanna J (Scientific reports 2018) 3 4 54
  5. Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B. (PMID: 28720707) Santofimia-Castaño P … Neira JL (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 4 54

Products for NUPR1 Gene

Sources for NUPR1 Gene