Aliases for NUP98 Gene
Aliases for NUP98 Gene
External Ids for NUP98 Gene
- HGNC: 8068
- Entrez Gene: 4928
- Ensembl: ENSG00000110713
- OMIM: 601021
- UniProtKB: P52948
Previous GeneCards Identifiers for NUP98 Gene
- GC11M004267
- GC11M003962
- GC11M003655
- GC11M003660
- GC11M003652
- GC11M003696
- GC11M003430
- GC11M003697
Summaries for NUP98 Gene
-
Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]
GeneCards Summary for NUP98 Gene
NUP98 (Nucleoporin 98) is a Protein Coding gene. Diseases associated with NUP98 include Myeloid Leukemia and Myelodysplastic Syndrome. Among its related pathways are Cell Cycle, Mitotic and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include transporter activity and structural constituent of nuclear pore.
UniProtKB/Swiss-Prot for NUP98 Gene
-
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134).
Additional gene information for NUP98 Gene
- Monarch Initiative
- Search for NUP98 at DataMed
- Search for NUP98 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP98 Gene
Genomics for NUP98 Gene
GeneHancer (GH) Regulatory Elements for NUP98 Gene
Promoters and enhancers for NUP98 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around NUP98 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NUP98 gene promoter:
-
- Pax-4a
- Nkx3-1 v4
- aMEF-2
- MEF-2A
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Egr-1
- Tal-1
Regulatory Element Products
Genomic Locations for NUP98 Gene
Genomic Locations for NUP98 Gene
- chr11:3,671,083-3,797,792
- (GRCh38/hg38)
- Size:
- 126,710 bases
- Orientation:
- Minus strand
- chr11:3,692,313-3,819,022
- (GRCh37/hg19)
- Size:
- 126,710 bases
- Orientation:
- Minus strand
Genomic View for NUP98 Gene
Genes around NUP98 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.4 by Entrez Gene
- 11p15.4 by HGNC
- 11p15.4 by Ensembl
NUP98 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NUP98 Gene
Proteins for NUP98 Gene
-
Protein details for NUP98 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P52948-NUP98_HUMAN
- Recommended name:
- Nuclear pore complex protein Nup98-Nup96
- Protein Accession:
- P52948
- Q8IUT2
- Q8WYB0
- Q96E54
- Q9H3Q4
- Q9NT02
- Q9UF57
- Q9UHX0
- Q9Y6J4
- Q9Y6J5
Protein attributes for NUP98 Gene
- Size:
- 1817 amino acids
- Molecular mass:
- 197579 Da
- Quaternary structure:
-
- Part of the nuclear pore complex (NPC) (PubMed:15229283, PubMed:18287282). Interacts directly with NUP96 (PubMed:12191480). Part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and NUP96; this complex plays a role in RNA export and in tethering NUP98 and NUP153 to the nucleus (PubMed:11684705). Interacts with RAE1 (PubMed:10209021, PubMed:20498086). Does not interact with TPR (PubMed:11684705). Interacts directly with NUP88 and NUP214, subunits of the cytoplasmic filaments of the NPC (By similarity). Interacts (via N-terminus) with DHX9 (via DRBM, OB-fold and RGG domains); this interaction occurs in a RNA-dependent manner and stimulates DHX9-mediated ATPase activity (PubMed:28221134).
- (Microbial infection) Interacts with vesicular stomatitis virus protein M (PubMed:11106761).
- SequenceCaution:
-
- Sequence=AAD22395.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=AAD22396.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=AAF19342.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF19342.1; Type=Frameshift; Positions=1551; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for NUP98 Gene
Protein Expression for NUP98 Gene
Post-translational modifications for NUP98 Gene
- Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively (PubMed:10087256, PubMed:20407419, PubMed:12191480, PubMed:18287282). Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96 (PubMed:20407419, PubMed:12191480).
- Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation.
- Ubiquitination at Lys1092, Lys1739, Lys1722, Lys1668, Lys1608, Lys1601, isoforms=2, 5, 61405, Lys1341, Lys1222, Lys1052, Lys1040, isoforms=2, 3, 4, 5, 6757, isoforms=2, 3, 4, 5, 6639, Lys603, Lys572, Lys534, and isoforms=2, 3, 4, 5, 6193
- Modification sites at PhosphoSitePlus
Other Protein References for NUP98 Gene
Antibody Products
- Novus Biologicals Antibodies for NUP98
-
Abcam antibodies for NUP98
- Invitrogen Antibodies for NUP98 (AFLGC-NUP98)
- GeneTex NUP98 Antibody for NUP98
-
Santa Cruz Biotechnology (SCBT) Antibodies for NUP98
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NUP98
- Origene Custom Protein Services for NUP98
- Search GeneTex for Proteins for NUP98
-
Abcam proteins for NUP98
Assay Products
No data available for DME Specific Peptides for NUP98 Gene
Domains & Families for NUP98 Gene
Gene Families for NUP98 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for NUP98 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NUP98 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P52948UniProtKB/Swiss-Prot:
NUP98_HUMAN :- Contains G-L-F-G repeats. The FG repeat domains in Nup98 have a direct role in the transport.
- Belongs to the nucleoporin GLFG family.
- Domain:
-
- Contains G-L-F-G repeats. The FG repeat domains in Nup98 have a direct role in the transport.
- Family:
-
- Belongs to the nucleoporin GLFG family.
Function for NUP98 Gene
Molecular function for NUP98 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134).
- GENATLAS Biochemistry:
- nucleoporin,essential component of multiple RNA export pathway,unlikely involved in the nuclear import of protein,fused with HOX9D in acute myeloid leukemia with translocation t(7;11) (p15;p15),and with DDX10 in de novo or therapy related myeloid malignancies with HOXD13 in translocation t(2;11) (q35;p15) with inv11(p15-q22) and with PMX1 in translocation t(1;11) (q23;p15),with RAP1GDS1 in t(4;11)(q21;p15) in T cell acute lymphocitic leukemia,fused with TOP1 in t(11;20)(p15;q11) in therapy related myelodysplastic syndrome
Enzyme Numbers (IUBMB) for NUP98 Gene
Phenotypes From GWAS Catalog for NUP98 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IBA | -- |
| GO:0003729 | mRNA binding | IMP | 28221134 |
| GO:0005215 | transporter activity | TAS | 7736573 |
| GO:0005515 | protein binding | IPI | 9348540 |
| GO:0008139 | nuclear localization sequence binding | IBA | -- |
Phenotypes for NUP98 Gene
- MGI mutant phenotypes for NUP98:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for NUP98:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased HIV-1 infection
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability
- no effect
- Decreased cell number
- Decreased influenza A virus infection
- Increased vaccinia virus (VACV) infection
- Nucleoplasmic pre-40S maturation defects
- Nuclear 40S maturation defects
- Nuclear 60S biogenesis defects
- Decreased NF-kappaB reporter expression
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
- Decreased influenza A/WSN/33 replication
- shRNA abundance <= 50%
- Increased viability
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NUP98
-
CRISPR Products
-
OriGene CRISPR knockouts for NUP98
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NUP98
- genomics-online: gRNA clones - Search results for available NUP98 gene related products
- Applied Biological Materials CRISPR for NUP98
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUP98
- GenScript: Design CRISPR guide RNA sequences for NUP98
miRNA for NUP98 Gene
- miRTarBase miRNAs that target NUP98
-
- hsa-mir-34a-5p (MIRT025511)
- hsa-mir-98-5p (MIRT027735)
- hsa-mir-652-3p (MIRT039534)
- hsa-mir-18a-3p (MIRT040801)
- hsa-mir-149-5p (MIRT045389)
- hsa-mir-30a-3p (MIRT049913)
- hsa-mir-16-5p (MIRT051267)
- hsa-mir-4726-3p (MIRT059110)
- hsa-mir-6827-5p (MIRT059114)
- hsa-mir-20a-5p (MIRT440068)
- hsa-mir-106b-5p (MIRT440069)
- hsa-mir-7108-5p (MIRT687343)
- hsa-mir-3187-3p (MIRT687344)
- hsa-mir-6514-3p (MIRT687345)
- hsa-mir-6894-3p (MIRT687346)
- hsa-mir-644a (MIRT687347)
- hsa-mir-663b (MIRT687348)
- hsa-mir-4529-5p (MIRT687349)
- hsa-mir-18b-3p (MIRT687350)
- hsa-mir-4324 (MIRT687351)
- hsa-mir-1279 (MIRT687352)
- hsa-mir-3934-5p (MIRT687353)
- hsa-mir-1226-3p (MIRT687354)
- hsa-mir-3651 (MIRT687355)
- hsa-mir-129-2-3p (MIRT687356)
- hsa-mir-129-1-3p (MIRT687357)
- hsa-mir-6779-3p (MIRT687358)
- hsa-mir-4687-5p (MIRT687359)
- hsa-mir-3591-3p (MIRT687360)
- hsa-mir-21-3p (MIRT687361)
- hsa-mir-4314 (MIRT713818)
- hsa-mir-3156-3p (MIRT713819)
- hsa-mir-1260b (MIRT713820)
- hsa-mir-1260a (MIRT713821)
- hsa-mir-188-3p (MIRT713822)
- hsa-mir-920 (MIRT713823)
- hsa-mir-6726-5p (MIRT713824)
- hsa-mir-5591-5p (MIRT713825)
- hsa-mir-4300 (MIRT713826)
- hsa-mir-6090 (MIRT713827)
- hsa-mir-6506-5p (MIRT713828)
- hsa-mir-619-5p (MIRT713829)
- hsa-mir-3192-5p (MIRT713830)
- hsa-mir-4646-5p (MIRT713831)
- hsa-mir-204-3p (MIRT713832)
- hsa-mir-330-5p (MIRT713833)
- hsa-mir-326 (MIRT713834)
- hsa-mir-3607-5p (MIRT713835)
- hsa-mir-4717-3p (MIRT713836)
- hsa-mir-514a-5p (MIRT713837)
- hsa-mir-93-5p (MIRT727048)
- hsa-mir-519d-3p (MIRT727049)
- hsa-mir-20b-5p (MIRT727050)
- hsa-mir-17-5p (MIRT727051)
- hsa-mir-1184 (MIRT735897)
- hsa-mir-1205 (MIRT735985)
- hsa-mir-153-5p (MIRT737885)
- hsa-mir-17-3p (MIRT738003)
- hsa-mir-216b-5p (MIRT739034)
- hsa-mir-3158-5p (MIRT740476)
- hsa-mir-4722-3p (MIRT747568)
- hsa-mir-4769-3p (MIRT748647)
- hsa-mir-5591-3p (MIRT751062)
- hsa-mir-6511b-5p (MIRT753206)
- hsa-mir-6727-3p (MIRT753934)
- hsa-mir-6811-5p (MIRT756693)
- hsa-mir-6817-5p (MIRT756833)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NUP98
- Browse OriGene Inhibitory RNA Products For NUP98
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUP98
- genomics-online: shRNA clones - Search results for available NUP98 gene related products
Clone Products
- Sino Biological Human cDNA Clone for NUP98
- Addgene plasmids for NUP98
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NUP98
- genomics-online: cdna clones - Search results for available NUP98 gene related products
- orf clones - Search results for available NUP98 gene related products
- Applied Biological Materials Clones for NUP98
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUP98 Gene
Localization for NUP98 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NUP98 Gene
- Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nuclear pore complex. Nucleus, nucleoplasm. Note=Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:11839768). Dissociates from the dissasembled NPC structure early during prophase of mitosis (PubMed:12802065). Colocalized with NUP153 and TPR to the nuclear basket of NPC (PubMed:11839768). Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body) (PubMed:11839768, PubMed:28221134). Remains localized to the nuclear membrane after poliovirus (PV) infection (PubMed:11106761). {ECO:0000269 PubMed:11106761, ECO:0000269 PubMed:11839768, ECO:0000269 PubMed:12802065, ECO:0000269 PubMed:28221134}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
- Nucleoplasm (3)
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | colocalizes_with kinetochore | IDA | 15146057 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005635 | nuclear envelope | TAS | -- |
| GO:0005643 | nuclear pore | NAS | 10087256 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for NUP98 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of the SLBP independent Mature mRNA |
.55
|
|
| 2 | HIV Life Cycle |
.91
.64
|
.45
|
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | Mitotic Prophase |
.57
|
|
| 5 | Influenza Viral RNA Transcription and Replication | ||
Pathways by source for NUP98 Gene
71 Reactome pathways for NUP98 Gene
2 KEGG pathways for NUP98 Gene
1 Cell Signaling Technology pathway for NUP98 Gene
Interacting Proteins for NUP98 Gene
Selected Interacting proteins:
P52948-NUP98_HUMAN
ENSP00000316032
for NUP98 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NUP98
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000973 | posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery | IBA | -- |
| GO:0006110 | regulation of glycolytic process | TAS | -- |
| GO:0006260 | DNA replication | IMP | 9348540 |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
| GO:0006405 | RNA export from nucleus | IBA | -- |
Transcripts for NUP98 Gene
mRNA/cDNA for NUP98 Gene
- (4) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (347) Selected AceView cDNA sequences:
- (20) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000533346 580 bps (uc057ycp.1)
- ENST00000324932 6973 bps (uc001lyh.3)
- ENST00000355260 5628 bps (uc001lyi.4)
- ENST00000429801 2541 bps (uc057ycr.1)
- ENST00000469881 687 bps (uc057ycs.1)
CRISPR Products
-
OriGene CRISPR knockouts for NUP98
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NUP98
- genomics-online: gRNA clones - Search results for available NUP98 gene related products
- Applied Biological Materials CRISPR for NUP98
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUP98
- GenScript: Design CRISPR guide RNA sequences for NUP98
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NUP98
- Browse OriGene Inhibitory RNA Products For NUP98
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUP98
- genomics-online: shRNA clones - Search results for available NUP98 gene related products
Clone Products
- Sino Biological Human cDNA Clone for NUP98
- Addgene plasmids for NUP98
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NUP98
- genomics-online: cdna clones - Search results for available NUP98 gene related products
- orf clones - Search results for available NUP98 gene related products
- Applied Biological Materials Clones for NUP98
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29a | · | 29b | ^ | 30a | · | 30b | ^ | 31 | ^ | 32a | · | 32b | ^ | 33a | · | 33b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 34a | · | 34b | · | 34c | · | 34d |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: | |||||||
| SP10: | |||||||
| SP11: | |||||||
| SP12: | |||||||
| SP13: |
Expression for NUP98 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Serum (29.5) and Peripheral blood mononuclear cells (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUP98 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NUP98 Gene:
NUP98SOURCE GeneReport for Unigene cluster for NUP98 Gene:
Hs.524750Evidence on tissue expression from TISSUES for NUP98 Gene
- Blood(4.5)
- Liver(4.3)
- Bone marrow(3.1)
- Nervous system(3.1)
Primer Products
-
OriGene qPCR primer pairs for NUP98
-
OriGene qPCR primer pairs and template standards for NUP98
- genomics-online: primer clones - Search results for available NUP98 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP98 Gene
Orthologs for NUP98 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NUP98 34 |
|
OneToOne | |
| LOC100609884 33 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | NUP98 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NUP98 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Nup98 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nup98 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NUP98 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| NUP98 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | NUP98 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nup98 33 |
|
||
| Str.6622 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2522 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nup98 34 33 |
|
OneToOne | |
| zgc63593 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11018 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002351 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Nup98-96 34 33 |
|
OneToOne | |
| CG10198 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | npp-10 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NUP145 34 |
|
OneToOne | |
| NUP100 36 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | SAR3 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0172000 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for NUP98 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for NUP98 Gene
- ENSEMBL:
- Gene Tree for NUP98 (if available)
- TreeFam:
- Gene Tree for NUP98 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NUP98: view image
Paralogs for NUP98 Gene
(1) SIMAP similar genes for NUP98 Gene using alignment to 11 proteins:
- NUP98_HUMAN
- E9PNN0_HUMAN
- H0YCR0_HUMAN
- H0YCT1_HUMAN
- H0YDA1_HUMAN
- H0YDF4_HUMAN
- H0YEN4_HUMAN
- H7BYP8_HUMAN
- H7C3P6_HUMAN
- J3KP29_HUMAN
- Q9HDC8_HUMAN
No data available for Paralogs for NUP98 Gene
Variants for NUP98 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057519323 | likely-pathogenic, Hirschsprung disease 1 | 3,676,355(-) | T/C | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| VAR_035859 | A breast cancer sample | p.Gly1669Val | |||
| rs1000064885 | -- | 3,799,778(-) | GGG/GGGGGG | upstream_transcript_variant | |
| rs1000068934 | -- | 3,689,516(-) | G/C | genic_downstream_transcript_variant, intron_variant | |
| rs1000082069 | -- | 3,684,085(-) | G/A/C | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv578n106 | OTHER | inversion | 24896259 |
| esv2664722 | CNV | deletion | 23128226 |
| esv2744047 | CNV | deletion | 23290073 |
| esv2759796 | CNV | gain+loss | 17122850 |
| esv3625147 | CNV | gain | 21293372 |
| esv3625148 | CNV | gain | 21293372 |
| esv3625155 | CNV | loss | 21293372 |
| esv3891910 | CNV | gain | 25118596 |
| nsv1046356 | CNV | gain | 25217958 |
| nsv1070003 | CNV | deletion | 25765185 |
| nsv1136122 | CNV | deletion | 24896259 |
| nsv428247 | CNV | loss | 18775914 |
| nsv526441 | CNV | gain | 19592680 |
| nsv528141 | CNV | loss | 19592680 |
| nsv832051 | CNV | gain | 17160897 |
| nsv832052 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.65;
72.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NUP98 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP98 Gene
Disorders for NUP98 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myeloid leukemia |
|
|
| myelodysplastic syndrome |
|
|
| stomatitis |
|
|
| leukemia, acute monocytic |
|
|
| hematologic cancer |
|
Search NUP98 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
NUP98_HUMAN- Note=A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23. {ECO:0000269 PubMed:16028218}.
- Note=A chromosomal aberration involving NUP98 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1. {ECO:0000269 PubMed:16028218}.
- Note=A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1. {ECO:0000269 PubMed:16028218}.
- Note=A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1. {ECO:0000269 PubMed:16028218}.
- Note=A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. {ECO:0000269 PubMed:16028218}.
- Note=A chromosomal aberration involving NUP98 has been identified in acute leukemias. Translocation t(6;11)(q24.1;p15.5) with CCDC28A. The chimeric transcript is an in-frame fusion of NUP98 exon 13 to CCDC28A exon 2. Ectopic expression of NUP98-CCDC28A in mouse promotes the proliferative capacity and self-renewal potential of hematopoietic progenitors and rapidly induced fatal myeloproliferative neoplasms and defects in the differentiation of the erythro-megakaryocytic lineage. {ECO:0000269 PubMed:16028218}.
Additional Disease Information for NUP98
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for NUP98 Gene
Publications for NUP98 Gene
- Structural constraints on autoprocessing of the human nucleoporin Nup98. (PMID: 18287282) Sun Y … Guo HC (Protein science : a publication of the Protein Society 2008) 3 4 22 58
- t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia. (PMID: 15725483) Morerio C … Panarello C (Leukemia research 2005) 3 4 22 58
- Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PMID: 15229283) Krull S … Cordes VC (Molecular biology of the cell 2004) 3 4 22 58
- NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). (PMID: 11986249) Rosati R … Mecucci C (Blood 2002) 3 4 22 58
- The three-dimensional structure of the autoproteolytic, nuclear pore-targeting domain of the human nucleoporin Nup98. (PMID: 12191480) Hodel AE … Powers MA (Molecular cell 2002) 3 4 22 58
Products for NUP98 Gene
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- Browse OriGene miRNA Products For NUP98
- GenScript: Next-day shipping of latest version cDNA ORF clones for NUP98 in any vector
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- GenScript: Design CRISPR guide RNA sequences for NUP98
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- Gene Mutant Library, Variants up to 10^11
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- Sino Biological Human cDNA Clone for NUP98
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals
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- Invitrogen Antibodies for NUP98 (AFLGC-NUP98)
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- Addgene plasmids for NUP98
- antibodies-online: Search results for 66 available NUP98 Antibodies ranked by validation data
- Compare Top NUP98 Antibodies
- antibodies-online: Search results for 18 available NUP98 Elisa Kits ranked by validation data
- Compare Top NUP98 Elisa Kits
- antibodies-online: Search results for 10 available NUP98 Proteins ranked by validation data
- Compare Top NUP98 Proteins
- GeneTex NUP98 Antibody for NUP98
- Search GeneTex for Proteins for NUP98
- Santa Cruz Biotechnology (SCBT) Antibodies for NUP98
- Search Santa Cruz Biotechnology (SCBT) for NUP98 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NUP98
- genomics-online: cdna clones - Search results for available NUP98 gene related products
- orf clones - Search results for available NUP98 gene related products
- genomics-online: gRNA clones - Search results for available NUP98 gene related products
- genomics-online: primer clones - Search results for available NUP98 gene related products
- genomics-online: shRNA clones - Search results for available NUP98 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NUP98
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NUP98
- GeneCopoeia miRNA 3'UTR Target clone products for NUP98
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUP98
Sources for NUP98 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142)