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Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleo... See more...
Aliases for NUP98 Gene
Aliases for NUP98 Gene
External Ids for NUP98 Gene
- HGNC: 8068
- NCBI Entrez Gene: 4928
- Ensembl: ENSG00000110713
- OMIM®: 601021
- UniProtKB/Swiss-Prot: P52948
Previous GeneCards Identifiers for NUP98 Gene
- GC11M004267
- GC11M003962
- GC11M003655
- GC11M003660
- GC11M003652
- GC11M003696
- GC11M003430
- GC11M003697
- GC11M003700
Summaries for NUP98 Gene
-
Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]
GeneCards Summary for NUP98 Gene
NUP98 (Nucleoporin 98 And 96 Precursor) is a Protein Coding gene. Diseases associated with NUP98 include Acute Megakaryoblastic Leukemia Without Down Syndrome and Childhood Acute Myeloid Leukemia. Among its related pathways are Cell Cycle, Mitotic and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include transporter activity and structural constituent of nuclear pore.
UniProtKB/Swiss-Prot Summary for NUP98 Gene
-
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134).
-
(Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change ASN-74-ASP is reduced (in vitro) (PubMed:23523133).
Additional gene information for NUP98 Gene
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NUP98 Gene
Genomics for NUP98 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NUP98 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NUP98 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NUP98
- Top Transcription factor binding sites by QIAGEN in the NUP98 gene promoter:
-
- aMEF-2
- Egr-1
- MEF-2A
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
- Pax-4a
- Tal-1
Genomic Locations for NUP98 Gene
Latest Assembly
- chr11:3,671,083-3,797,792
- (GRCh38/hg38)
- Size:
- 126,710 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:3,696,240-3,818,784
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 122,545 bases
- Orientation:
- Minus strand
Genomic View for NUP98 Gene
Genes around NUP98 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p15.4 by HGNC
- 11p15.4 by Entrez Gene
- 11p15.4 by Ensembl
NUP98 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NUP98 Gene
Proteins for NUP98 Gene
-
Protein details for NUP98 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P52948-NUP98_HUMAN
- Recommended name:
- Nuclear pore complex protein Nup98-Nup96
- Protein Accession:
- P52948
- Q8IUT2
- Q8WYB0
- Q96E54
- Q9H3Q4
- Q9NT02
- Q9UF57
- Q9UHX0
- Q9Y6J4
- Q9Y6J5
Protein attributes for NUP98 Gene
- Size:
- 1817 amino acids
- Molecular mass:
- 197579 Da
- Quaternary structure:
-
- Part of the nuclear pore complex (NPC) (PubMed:15229283, PubMed:18287282). Interacts directly with NUP96 (PubMed:12191480). Part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and NUP96; this complex plays a role in RNA export and in tethering NUP98 and NUP153 to the nucleus (PubMed:11684705). Interacts with RAE1 (PubMed:10209021, PubMed:20498086). Does not interact with TPR (PubMed:11684705). Interacts with NUP88 (PubMed:30543681). Interacts directly with NUP88 and NUP214, subunits of the cytoplasmic filaments of the NPC (By similarity). Interacts (via N-terminus) with DHX9 (via DRBM, OB-fold and RGG domains); this interaction occurs in a RNA-dependent manner and stimulates DHX9-mediated ATPase activity (PubMed:28221134).
- (Microbial infection) Interacts with vesicular stomatitis virus protein M (PubMed:11106761).
- SequenceCaution:
-
- Sequence=AAD22395.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=AAD22396.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=AAF19342.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAF19342.1; Type=Frameshift; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for NUP98 Gene
Protein Expression for NUP98 Gene
Post-translational modifications for NUP98 Gene
- Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively (PubMed:10087256, PubMed:20407419, PubMed:12191480, PubMed:18287282). Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96 (PubMed:20407419, PubMed:12191480).
- Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation.
-
Glycosylation at Asn606
- NX_P52948 (NX_P52948-1)
-
Ubiquitination at Lys193, Lys534, Lys572, Lys603, Lys639, Lys757, Lys1019, Lys1040, Lys1052, Lys1222, Lys1341, Lys1405, Lys1601, Lys1608, Lys1668, Lys1722, and Lys1739
- NX_P52948 (NX_P52948-1)
- Modification sites at PhosphoSitePlus
- Glycosylation from GlyConnect
Other Protein References for NUP98 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences NUP98 Antibody
- Novus Biologicals Antibodies for NUP98
-
Abcam antibodies for NUP98
- Invitrogen Antibodies for NUP98 (AFLGC-NUP98)
-
Custom Antibody ServicesProSci Antibodies for NUP98
-
Santa Cruz Biotechnology (SCBT) Antibodies for NUP98
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NUP98
- Origene Custom Protein Services for NUP98
-
Abcam proteins for NUP98
Assay products for research
- antibodies-online: Show 20 available NUP98 Elisa Kits ranked by validation data
- Compare Top NUP98 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for NUP98 Gene
Domains & Families for NUP98 Gene
Gene Families for NUP98 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for NUP98 Gene
- InterPro:
- Blocks:
-
- Nucleoporin autopeptidase
Suggested Antigen Peptide Sequences for NUP98 Gene
- GenScript: Design optimal peptide antigens:
-
- Nuclear pore complex protein Nup98-Nup96 (NUP98_HUMAN)
- Nucleoporin NUP98 (Q9HDC8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P52948UniProtKB/Swiss-Prot:
NUP98_HUMAN :- Contains G-L-F-G repeats. The FG repeat domains in Nup98 have a direct role in the transport.
- Belongs to the nucleoporin GLFG family.
- Domain:
-
- Contains G-L-F-G repeats. The FG repeat domains in Nup98 have a direct role in the transport.
- Family:
-
- Belongs to the nucleoporin GLFG family.
Function for NUP98 Gene
Molecular function for NUP98 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134).
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and may thereby promote the integration of the virus in the host nucleus (in vitro) (PubMed:23523133). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change ASN-74-ASP is reduced (in vitro) (PubMed:23523133).
- GENATLAS Biochemistry:
- nucleoporin,essential component of multiple RNA export pathway,unlikely involved in the nuclear import of protein,fused with HOX9D in acute myeloid leukemia with translocation t(7;11) (p15;p15),and with DDX10 in de novo or therapy related myeloid malignancies with HOXD13 in translocation t(2;11) (q35;p15) with inv11(p15-q22) and with PMX1 in translocation t(1;11) (q23;p15),with RAP1GDS1 in t(4;11)(q21;p15) in T cell acute lymphocitic leukemia,fused with TOP1 in t(11;20)(p15;q11) in therapy related myelodysplastic syndrome
Enzyme Numbers (IUBMB) for NUP98 Gene
Phenotypes From GWAS Catalog for NUP98 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003713 | transcription coactivator activity | IMP | 28221134 |
| GO:0003729 | mRNA binding | IMP | 28221134 |
| GO:0005215 | transporter activity | TAS | 7736573 |
| GO:0005515 | protein binding | IPI | 9348540 |
| GO:0008139 | nuclear localization sequence binding | IEA | -- |
Phenotypes for NUP98 Gene
- MGI mutant phenotypes for NUP98:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for NUP98:
-
- Decreased NF-kappaB reporter expression
- Decreased viability
- shRNA abundance <= 50%
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased shRNA abundance (Z-score > 2)
- Decreased influenza A/WSN/33 replication
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Decreased cell number
- Decreased influenza A virus infection
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Downregulation of NF-kappaB pathway after IL-1beta stimulation
- Decreased replication of vaccinia virus (VACV)
- Nuclear 40S maturation defects
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Nuclear 60S biogenesis defects
- Decreased HIV-1 infection
- Nucleoplasmic pre-40S maturation defects
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NUP98 - Starting at $85 >
- * NUP98 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NUP98
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NUP98
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUP98
miRNA for NUP98 Gene
- miRTarBase miRNAs that target NUP98
-
- mmu-miR-181a-5p (MIRT014169)
- hsa-miR-34a-5p (MIRT025511)
- hsa-miR-98-5p (MIRT027735)
- hsa-miR-652-3p (MIRT039534)
- hsa-miR-18a-3p (MIRT040801)
- hsa-miR-149-5p (MIRT045389)
- hsa-miR-30a-3p (MIRT049913)
- hsa-miR-16-5p (MIRT051267)
- hsa-miR-4726-3p (MIRT059110)
- hsa-miR-6827-5p (MIRT059114)
- hsa-miR-20a-5p (MIRT440068)
- hsa-miR-106b-5p (MIRT440069)
- hsa-miR-7108-5p (MIRT687343)
- hsa-miR-3187-3p (MIRT687344)
- hsa-miR-6514-3p (MIRT687345)
- hsa-miR-6894-3p (MIRT687346)
- hsa-miR-644a (MIRT687347)
- hsa-miR-663b (MIRT687348)
- hsa-miR-4529-5p (MIRT687349)
- hsa-miR-18b-3p (MIRT687350)
- hsa-miR-4324 (MIRT687351)
- hsa-miR-1279 (MIRT687352)
- hsa-miR-3934-5p (MIRT687353)
- hsa-miR-1226-3p (MIRT687354)
- hsa-miR-3651 (MIRT687355)
- hsa-miR-129-2-3p (MIRT687356)
- hsa-miR-129-1-3p (MIRT687357)
- hsa-miR-6779-3p (MIRT687358)
- hsa-miR-4687-5p (MIRT687359)
- hsa-miR-3591-3p (MIRT687360)
- hsa-miR-21-3p (MIRT687361)
- hsa-miR-4314 (MIRT713818)
- hsa-miR-3156-3p (MIRT713819)
- hsa-miR-1260b (MIRT713820)
- hsa-miR-1260a (MIRT713821)
- hsa-miR-188-3p (MIRT713822)
- hsa-miR-920 (MIRT713823)
- hsa-miR-6726-5p (MIRT713824)
- hsa-miR-5591-5p (MIRT713825)
- hsa-miR-4300 (MIRT713826)
- hsa-miR-6090 (MIRT713827)
- hsa-miR-6506-5p (MIRT713828)
- hsa-miR-619-5p (MIRT713829)
- hsa-miR-3192-5p (MIRT713830)
- hsa-miR-4646-5p (MIRT713831)
- hsa-miR-204-3p (MIRT713832)
- hsa-miR-330-5p (MIRT713833)
- hsa-miR-326 (MIRT713834)
- hsa-miR-3607-5p (MIRT713835)
- hsa-miR-4717-3p (MIRT713836)
- hsa-miR-514a-5p (MIRT713837)
- hsa-miR-93-5p (MIRT727048)
- hsa-miR-519d-3p (MIRT727049)
- hsa-miR-20b-5p (MIRT727050)
- hsa-miR-17-5p (MIRT727051)
- hsa-miR-1184 (MIRT735897)
- hsa-miR-1205 (MIRT735985)
- hsa-miR-153-5p (MIRT737885)
- hsa-miR-17-3p (MIRT738003)
- hsa-miR-216b-5p (MIRT739034)
- hsa-miR-3158-5p (MIRT740476)
- hsa-miR-4722-3p (MIRT747568)
- hsa-miR-4769-3p (MIRT748647)
- hsa-miR-5591-3p (MIRT751062)
- hsa-miR-6511b-5p (MIRT753206)
- hsa-miR-6727-3p (MIRT753934)
- hsa-miR-6811-5p (MIRT756693)
- hsa-miR-6817-5p (MIRT756833)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NUP98
- Browse OriGene Inhibitory RNA Products For NUP98
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUP98
Clone products for research
- Applied Biological Materials (abm): Clones for NUP98 - Starting at $45 >
- * NUP98 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211775
- MR211775
- MR211775L3
- MR211775L4
- MR231443
- MR231459
- MR231648
- MR231880
- RC207886
- RC207886L1
- RC207886L2
- RC207886L3
- RC207886L4
- RC213664
- RC214609
- RC214609L3
- RC214609L4
- RC214656
- RG207886
- RG213664
- RG214609
- RG214656
- RR200873
- MR211775L3V
- MR211775L4V
- RC207886L1V
- RC207886L2V
- RC207886L3V
- RC207886L4V
- RC214609L3V
- RC214609L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NUP98
- Addgene plasmids for NUP98
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NUP98
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUP98 Gene
Localization for NUP98 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NUP98 Gene
- Nucleus membrane. Peripheral membrane protein. Nucleoplasmic side. Nucleus, nuclear pore complex. Nucleus, nucleoplasm. Note=Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:11839768). Dissociates from the dissasembled NPC structure early during prophase of mitosis (PubMed:12802065). Colocalized with NUP153 and TPR to the nuclear basket of NPC (PubMed:11839768). Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body) (PubMed:11839768, PubMed:28221134). Remains localized to the nuclear membrane after poliovirus (PV) infection (PubMed:11106761). {ECO:0000269 PubMed:11106761, ECO:0000269 PubMed:11839768, ECO:0000269 PubMed:12802065, ECO:0000269 PubMed:28221134}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | colocalizes_with kinetochore | IDA | 15146057 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005635 | nuclear envelope | TAS | -- |
| GO:0005643 | nuclear pore | IEA,NAS | 10087256 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for NUP98 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of the SLBP independent Mature mRNA |
.55
|
|
| 2 | HIV Life Cycle |
.91
.64
|
.45
|
| 3 | Cell Cycle, Mitotic |
.83
|
.60
|
| 4 | Mitotic Prophase |
.57
|
|
| 5 | Influenza Viral RNA Transcription and Replication | ||
Pathways by source for NUP98 Gene
71 Reactome pathways for NUP98 Gene
3 KEGG pathways for NUP98 Gene
1 Cell Signaling Technology pathway for NUP98 Gene
Interacting Proteins for NUP98 Gene
Selected Interacting proteins:
P52948-NUP98_HUMAN
ENSP00000316032
for NUP98 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for NUP98
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006110 | regulation of glycolytic process | TAS | -- |
| GO:0006406 | mRNA export from nucleus | TAS | -- |
| GO:0006409 | tRNA export from nucleus | TAS | -- |
| GO:0006508 | proteolysis | IEA | -- |
| GO:0006606 | protein import into nucleus | IEA | -- |
Transcripts for NUP98 Gene
mRNA/cDNA for NUP98 Gene
- 9 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000324932 6726 nts (view in UCSC)
- ENST00000355260 5628 nts (view in UCSC)
- ENST00000359171 7023 nts (view in UCSC)
- ENST00000397004 3923 nts (view in UCSC)
- ENST00000397007 3698 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for NUP98 - Starting at $85 >
- * NUP98 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for NUP98
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NUP98
-
Santa Cruz Biotechnology (SCBT) CRISPR for NUP98
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NUP98
- Browse OriGene Inhibitory RNA Products For NUP98
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUP98
Clone products for research
- Applied Biological Materials (abm): Clones for NUP98 - Starting at $45 >
- * NUP98 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211775
- MR211775
- MR211775L3
- MR211775L4
- MR231443
- MR231459
- MR231648
- MR231880
- RC207886
- RC207886L1
- RC207886L2
- RC207886L3
- RC207886L4
- RC213664
- RC214609
- RC214609L3
- RC214609L4
- RC214656
- RG207886
- RG213664
- RG214609
- RG214656
- RR200873
- MR211775L3V
- MR211775L4V
- RC207886L1V
- RC207886L2V
- RC207886L3V
- RC207886L4V
- RC214609L3V
- RC214609L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for NUP98
- Addgene plasmids for NUP98
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NUP98
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29a | · | 29b | ^ | 30a | · | 30b | ^ | 31 | ^ | 32a | · | 32b | ^ | 33a | · | 33b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
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| ExUns: | 34a | · | 34b | · | 34c | · | 34d |
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Relevant External Links for NUP98 Gene
- GeneLoc Exon Structure for
- NUP98
Expression for NUP98 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Serum (29.5) and Peripheral blood mononuclear cells (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NUP98 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NUP98
SOURCE GeneReport for Unigene cluster for NUP98 Gene:
Hs.524750Evidence on tissue expression from TISSUES for NUP98 Gene
- Blood(4.5)
- Liver(4.5)
- Nervous system(3.7)
- Bone marrow(3.1)
- Lung(2.6)
- Skin(2.5)
- Spleen(2.4)
- Intestine(2.4)
- Kidney(2.4)
- Lymph node(2.2)
- Muscle(2.2)
- Heart(2.1)
Primer products for research
-
OriGene qPCR primer pairs for NUP98
-
OriGene qPCR primer pairs and template standards for NUP98
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP98 Gene
Orthologs for NUP98 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NUP98 30 |
|
OneToOne | |
| LOC100609884 29 |
|
||||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | NUP98 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | NUP98 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Nup98 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nup98 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | NUP98 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| NUP98 29 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | NUP98 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nup98 29 |
|
||
| Str.6622 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2522 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | nup98 29 30 |
|
OneToOne | |
| zgc63593 29 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11018 29 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002351 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Nup98-96 29 30 |
|
OneToOne | |
| CG10198 31 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | npp-10 30 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NUP145 30 |
|
OneToOne | |
| NUP100 32 |
|
|
|||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | SAR3 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os03g0172000 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToOne |
- Species where no ortholog for NUP98 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for NUP98 Gene
- ENSEMBL:
- Gene Tree for NUP98 (if available)
- TreeFam:
- Gene Tree for NUP98 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NUP98: view image
- Alliance of Genome Resources:
- Additional Orthologs for NUP98
Paralogs for NUP98 Gene
(1) SIMAP similar genes for NUP98 Gene using alignment to 11 proteins:
- NUP98_HUMAN
- E9PNN0_HUMAN
- H0YCR0_HUMAN
- H0YCT1_HUMAN
- H0YDA1_HUMAN
- H0YDF4_HUMAN
- H0YEN4_HUMAN
- H7BYP8_HUMAN
- H7C3P6_HUMAN
- J3KP29_HUMAN
- Q9HDC8_HUMAN
No data available for Paralogs for NUP98 Gene
Variants for NUP98 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NUP98 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 992658 | Benign: not specified | 3,679,613(-) |
A/G NM_016320.5(NUP98):c.5014T>C (p.Ser1672Pro) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| rs1057519323 | Likely Pathogenic: Hirschsprung disease 1 | 3,676,355(-) |
T/C NM_016320.5(NUP98):c.5207A>G (p.Asn1736Ser) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| rs111586358 | Benign: not provided | 3,683,214(-) |
C/T NM_016320.5(NUP98):c.4904G>A (p.Arg1635Gln) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| rs112872083 | Benign: not provided | 3,744,549(-) |
C/T NM_016320.5(NUP98):c.1368G>A (p.Thr456=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON | |
| rs137931987 | Likely Benign: not provided | 3,693,260(-) |
G/A NM_016320.5(NUP98):c.4283C>T (p.Ala1428Val) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv578n106 | OTHER | inversion | 24896259 |
| esv2664722 | CNV | deletion | 23128226 |
| esv2744047 | CNV | deletion | 23290073 |
| esv2759796 | CNV | gain+loss | 17122850 |
| esv3625147 | CNV | gain | 21293372 |
| esv3625148 | CNV | gain | 21293372 |
| esv3625155 | CNV | loss | 21293372 |
| esv3891910 | CNV | gain | 25118596 |
| nsv1046356 | CNV | gain | 25217958 |
| nsv1070003 | CNV | deletion | 25765185 |
| nsv1136122 | CNV | deletion | 24896259 |
| nsv428247 | CNV | loss | 18775914 |
| nsv526441 | CNV | gain | 19592680 |
| nsv528141 | CNV | loss | 19592680 |
| nsv832051 | CNV | gain | 17160897 |
| nsv832052 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.65;
72.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NUP98 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP98 Gene
Disorders for NUP98 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute megakaryoblastic leukemia without down syndrome |
|
|
| childhood acute myeloid leukemia |
|
|
| myeloid leukemia |
|
|
| myelodysplastic syndrome |
|
|
| hirschsprung disease 1 |
|
|
Search NUP98 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
NUP98_HUMAN- Note=Chromosomal aberrations involving NUP98 have been found in acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9 (PubMed:8563753). Translocation t(11;17)(p15;p13) with PHF23 (PubMed:17287853). {ECO:0000269 PubMed:17287853, ECO:0000269 PubMed:8563753}.
- Note=A chromosomal aberration involving NUP98 has been found in M0 type acute myeloid leukemia. Translocation t(4;11)(q23;p15) with RAP1GDS1. {ECO:0000269 PubMed:16419055}.
- Note=A chromosomal aberration involving NUP98 has been found in T-cell acute lymphocytic leukemia. Translocation t(4;11)(q23;p15) with RAP1GDS1. {ECO:0000269 PubMed:10477737}.
- Note=A chromosomal aberration involving NUP98 has been found in M5 type acute myeloid leukemia. Translocation t(11;12)(p15;p13) with KDM5A. {ECO:0000269 PubMed:23531517}.
- Note=Chromosomal aberrations involving NUP98 have been found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1. {ECO:0000269 PubMed:16028218}.
- Note=Chromosomal aberrations involving NUP98 have been found in M7 type childhood acute myeloid leukemia. Translocation t(11;12)(p15;p13) with KDM5A. {ECO:0000269 PubMed:16419055, ECO:0000269 PubMed:23531517}.
- Note=A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1. {ECO:0000269 PubMed:16028218}.
- Note=A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1. {ECO:0000269 PubMed:16028218}.
- Note=A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. {ECO:0000269 PubMed:16028218}.
- Note=A chromosomal aberration involving NUP98 has been identified in acute leukemias. Translocation t(6;11)(q24.1;p15.5) with CCDC28A. The chimeric transcript is an in-frame fusion of NUP98 exon 13 to CCDC28A exon 2. Ectopic expression of NUP98-CCDC28A in mouse promotes the proliferative capacity and self-renewal potential of hematopoietic progenitors and rapidly induced fatal myeloproliferative neoplasms and defects in the differentiation of the erythro-megakaryocytic lineage. {ECO:0000269 PubMed:16028218}.
Additional Disease Information for NUP98
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for NUP98 Gene
Publications for NUP98 Gene
- Structural constraints on autoprocessing of the human nucleoporin Nup98. (PMID: 18287282) Sun Y ā¦ Guo HC (Protein science : a publication of the Protein Society 2008) 2 3 4 22
- t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia. (PMID: 15725483) Morerio C ā¦ Panarello C (Leukemia research 2005) 3 4 22
- Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PMID: 15229283) Krull S ā¦ Cordes VC (Molecular biology of the cell 2004) 3 4 22
- NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). (PMID: 11986249) Rosati R ā¦ Mecucci C (Blood 2002) 3 4 22
- The three-dimensional structure of the autoproteolytic, nuclear pore-targeting domain of the human nucleoporin Nup98. (PMID: 12191480) Hodel AE ā¦ Powers MA (Molecular cell 2002) 3 4 22
ExternalLinks
Products for NUP98 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for NUP98
- Origene Custom Protein Services for NUP98
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NUP98
- Browse OriGene Inhibitory RNA Products For NUP98
- OriGene qPCR primer pairs for NUP98
- OriGene qPCR primer pairs and template standards for NUP98
- OriGene CRISPR knockouts for NUP98
- MG211775
- MR211775
- MR211775L3
- MR211775L4
- MR231443
- MR231459
- MR231648
- MR231880
- RC207886
- RC207886L1
- RC207886L2
- RC207886L3
- RC207886L4
- RC213664
- RC214609
- RC214609L3
- RC214609L4
- RC214656
- RG207886
- RG213664
- RG214609
- RG214656
- RR200873
- MR211775L3V
- MR211775L4V
- RC207886L1V
- RC207886L2V
- RC207886L3V
- RC207886L4V
- RC214609L3V
- RC214609L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NUP98
- Sino Biological Human cDNA Clone for NUP98
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for NUP98
- Novus Biologicals proteins and lysates for NUP98
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for NUP98
- Abcam proteins for NUP98
- Find your target
- Browse Primary Antibodies
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- Browse Monoclonal Antibodies
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- Invitrogen Antibodies for NUP98 (AFLGC-NUP98)
- VectorBuilder Custom and pre-made DNA vectors for NUP98 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NUP98 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NUP98 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NUP98 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NUP98
- Addgene plasmids for NUP98
- antibodies-online: Show 28 available NUP98 Antibodies ranked by validation data
- Compare Top NUP98 Antibodies
- antibodies-online: Show 20 available NUP98 Elisa Kits ranked by validation data
- Compare Top NUP98 Elisa Kits
- Quality Products:
- antibodies-online: Show 10 available NUP98 Proteins ranked by validation data
- Compare Top NUP98 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for NUP98
- Search Santa Cruz Biotechnology (SCBT) for NUP98 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NUP98
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NUP98
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NUP98
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NUP98
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NUP98
Sources for NUP98 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91)