Aliases for NUP93 Gene
External Ids for NUP93 Gene
Previous GeneCards Identifiers for NUP93 Gene
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
GeneCards Summary for NUP93 Gene
NUP93 (Nucleoporin 93) is a Protein Coding gene. Diseases associated with NUP93 include Nephrotic Syndrome, Type 12 and Genetic Steroid-Resistant Nephrotic Syndrome. Among its related pathways are Metabolism of proteins and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include structural constituent of nuclear pore.
UniProtKB/Swiss-Prot Summary for NUP93 Gene
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725).