Aliases for NUP93 Gene
External Ids for NUP93 Gene
Previous GeneCards Identifiers for NUP93 Gene
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
GeneCards Summary for NUP93 Gene
NUP93 (Nucleoporin 93) is a Protein Coding gene. Diseases associated with NUP93 include Nephrotic Syndrome, Type 12 and Genetic Steroid-Resistant Nephrotic Syndrome. Among its related pathways are Transport of the SLBP independent Mature mRNA and Cellular response to heat stress. Gene Ontology (GO) annotations related to this gene include structural constituent of nuclear pore.
UniProtKB/Swiss-Prot Summary for NUP93 Gene
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725).